CA2319456C - Imaging and characterization of brain tissue - Google Patents
Imaging and characterization of brain tissue Download PDFInfo
- Publication number
- CA2319456C CA2319456C CA2319456A CA2319456A CA2319456C CA 2319456 C CA2319456 C CA 2319456C CA 2319456 A CA2319456 A CA 2319456A CA 2319456 A CA2319456 A CA 2319456A CA 2319456 C CA2319456 C CA 2319456C
- Authority
- CA
- Canada
- Prior art keywords
- light
- tissue
- optical
- detector
- processor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 210000005013 brain tissue Anatomy 0.000 title claims abstract description 27
- 238000003384 imaging method Methods 0.000 title description 97
- 238000012512 characterization method Methods 0.000 title description 6
- 230000003287 optical effect Effects 0.000 claims abstract description 249
- 238000001514 detection method Methods 0.000 claims abstract description 76
- 239000008280 blood Substances 0.000 claims abstract description 61
- 210000004369 blood Anatomy 0.000 claims abstract description 61
- 238000000034 method Methods 0.000 claims abstract description 36
- 238000013508 migration Methods 0.000 claims abstract description 33
- 230000005012 migration Effects 0.000 claims abstract description 33
- 238000006213 oxygenation reaction Methods 0.000 claims abstract description 21
- 230000002159 abnormal effect Effects 0.000 claims abstract description 15
- 238000001727 in vivo Methods 0.000 claims abstract description 12
- 230000005855 radiation Effects 0.000 claims description 43
- 238000004422 calculation algorithm Methods 0.000 claims description 28
- 108010054147 Hemoglobins Proteins 0.000 claims description 23
- 102000001554 Hemoglobins Human genes 0.000 claims description 23
- 238000006392 deoxygenation reaction Methods 0.000 claims description 19
- 238000003325 tomography Methods 0.000 claims description 16
- 239000000470 constituent Substances 0.000 claims description 15
- 230000010363 phase shift Effects 0.000 claims description 13
- 230000008859 change Effects 0.000 claims description 12
- 239000002872 contrast media Substances 0.000 claims description 11
- 230000001678 irradiating effect Effects 0.000 claims description 11
- 239000000049 pigment Substances 0.000 claims description 11
- 238000000149 argon plasma sintering Methods 0.000 claims description 6
- 238000012545 processing Methods 0.000 claims description 6
- 230000035945 sensitivity Effects 0.000 claims description 6
- 238000009826 distribution Methods 0.000 claims description 5
- 230000008569 process Effects 0.000 claims description 5
- 238000013334 tissue model Methods 0.000 claims description 5
- 210000001519 tissue Anatomy 0.000 description 185
- 210000004556 brain Anatomy 0.000 description 44
- 230000004044 response Effects 0.000 description 23
- 206010028980 Neoplasm Diseases 0.000 description 20
- 230000011514 reflex Effects 0.000 description 19
- 238000010521 absorption reaction Methods 0.000 description 18
- 230000000638 stimulation Effects 0.000 description 18
- 238000001816 cooling Methods 0.000 description 12
- 238000010586 diagram Methods 0.000 description 12
- 230000001965 increasing effect Effects 0.000 description 12
- 230000001537 neural effect Effects 0.000 description 10
- 230000033115 angiogenesis Effects 0.000 description 8
- 230000001149 cognitive effect Effects 0.000 description 8
- 230000000694 effects Effects 0.000 description 8
- 210000001061 forehead Anatomy 0.000 description 8
- 210000003128 head Anatomy 0.000 description 8
- 238000000926 separation method Methods 0.000 description 8
- 210000003811 finger Anatomy 0.000 description 7
- 238000002595 magnetic resonance imaging Methods 0.000 description 7
- 238000010606 normalization Methods 0.000 description 7
- 230000001936 parietal effect Effects 0.000 description 7
- 210000003625 skull Anatomy 0.000 description 7
- 238000005259 measurement Methods 0.000 description 6
- 230000001575 pathological effect Effects 0.000 description 6
- 239000000523 sample Substances 0.000 description 6
- 230000001953 sensory effect Effects 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- INGWEZCOABYORO-UHFFFAOYSA-N 2-(furan-2-yl)-7-methyl-1h-1,8-naphthyridin-4-one Chemical compound N=1C2=NC(C)=CC=C2C(O)=CC=1C1=CC=CO1 INGWEZCOABYORO-UHFFFAOYSA-N 0.000 description 5
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 5
- 238000002835 absorbance Methods 0.000 description 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 5
- 108010002255 deoxyhemoglobin Proteins 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 230000009977 dual effect Effects 0.000 description 5
- 238000012634 optical imaging Methods 0.000 description 5
- 229910052760 oxygen Inorganic materials 0.000 description 5
- 239000001301 oxygen Substances 0.000 description 5
- 238000012636 positron electron tomography Methods 0.000 description 5
- 229910052710 silicon Inorganic materials 0.000 description 5
- 239000010703 silicon Substances 0.000 description 5
- 210000003478 temporal lobe Anatomy 0.000 description 5
- 230000008901 benefit Effects 0.000 description 4
- 239000003990 capacitor Substances 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 230000005714 functional activity Effects 0.000 description 4
- 210000002442 prefrontal cortex Anatomy 0.000 description 4
- 230000002360 prefrontal effect Effects 0.000 description 4
- 206010020674 Hypermetabolism Diseases 0.000 description 3
- 230000004913 activation Effects 0.000 description 3
- 230000003925 brain function Effects 0.000 description 3
- 230000002490 cerebral effect Effects 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 238000009792 diffusion process Methods 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000004060 metabolic process Effects 0.000 description 3
- 210000001152 parietal lobe Anatomy 0.000 description 3
- CVOFKRWYWCSDMA-UHFFFAOYSA-N 2-chloro-n-(2,6-diethylphenyl)-n-(methoxymethyl)acetamide;2,6-dinitro-n,n-dipropyl-4-(trifluoromethyl)aniline Chemical compound CCC1=CC=CC(CC)=C1N(COC)C(=O)CCl.CCCN(CCC)C1=C([N+]([O-])=O)C=C(C(F)(F)F)C=C1[N+]([O-])=O CVOFKRWYWCSDMA-UHFFFAOYSA-N 0.000 description 2
- 208000024827 Alzheimer disease Diseases 0.000 description 2
- 238000012935 Averaging Methods 0.000 description 2
- 208000032843 Hemorrhage Diseases 0.000 description 2
- 206010021143 Hypoxia Diseases 0.000 description 2
- 241000234295 Musa Species 0.000 description 2
- 235000018290 Musa x paradisiaca Nutrition 0.000 description 2
- 108010064719 Oxyhemoglobins Proteins 0.000 description 2
- 208000018737 Parkinson disease Diseases 0.000 description 2
- 230000005856 abnormality Effects 0.000 description 2
- 230000001656 angiogenetic effect Effects 0.000 description 2
- 230000002491 angiogenic effect Effects 0.000 description 2
- 230000002238 attenuated effect Effects 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 208000034158 bleeding Diseases 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 208000010353 central nervous system vasculitis Diseases 0.000 description 2
- 238000012937 correction Methods 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 230000005684 electric field Effects 0.000 description 2
- 230000005670 electromagnetic radiation Effects 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 210000001652 frontal lobe Anatomy 0.000 description 2
- 238000002599 functional magnetic resonance imaging Methods 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 230000007954 hypoxia Effects 0.000 description 2
- 230000002503 metabolic effect Effects 0.000 description 2
- 201000006417 multiple sclerosis Diseases 0.000 description 2
- 210000000869 occipital lobe Anatomy 0.000 description 2
- 239000013307 optical fiber Substances 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 210000003455 parietal bone Anatomy 0.000 description 2
- 230000007170 pathology Effects 0.000 description 2
- 230000007310 pathophysiology Effects 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 230000035807 sensation Effects 0.000 description 2
- 238000004088 simulation Methods 0.000 description 2
- 210000000278 spinal cord Anatomy 0.000 description 2
- 230000001960 triggered effect Effects 0.000 description 2
- 210000004881 tumor cell Anatomy 0.000 description 2
- 230000004614 tumor growth Effects 0.000 description 2
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 2
- 229910052721 tungsten Inorganic materials 0.000 description 2
- 239000010937 tungsten Substances 0.000 description 2
- 230000004862 vasculogenesis Effects 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- 206010052346 Brain contusion Diseases 0.000 description 1
- 206010048962 Brain oedema Diseases 0.000 description 1
- 229920000298 Cellophane Polymers 0.000 description 1
- 206010018985 Haemorrhage intracranial Diseases 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 208000008574 Intracranial Hemorrhages Diseases 0.000 description 1
- 206010027476 Metastases Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 208000012902 Nervous system disease Diseases 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 239000011358 absorbing material Substances 0.000 description 1
- 210000000577 adipose tissue Anatomy 0.000 description 1
- 230000001640 apoptogenic effect Effects 0.000 description 1
- 238000003491 array Methods 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000004397 blinking Effects 0.000 description 1
- 238000009534 blood test Methods 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000007177 brain activity Effects 0.000 description 1
- 208000006752 brain edema Diseases 0.000 description 1
- 230000037185 brain physiology Effects 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 210000003710 cerebral cortex Anatomy 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000002591 computed tomography Methods 0.000 description 1
- 238000004590 computer program Methods 0.000 description 1
- 210000004246 corpus luteum Anatomy 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000002059 diagnostic imaging Methods 0.000 description 1
- 230000003292 diminished effect Effects 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 210000000624 ear auricle Anatomy 0.000 description 1
- 230000013020 embryo development Effects 0.000 description 1
- 210000004696 endometrium Anatomy 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000000763 evoking effect Effects 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 210000004709 eyebrow Anatomy 0.000 description 1
- 230000008175 fetal development Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000006261 foam material Substances 0.000 description 1
- 229920001821 foam rubber Polymers 0.000 description 1
- 210000002454 frontal bone Anatomy 0.000 description 1
- 210000004209 hair Anatomy 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 238000011503 in vivo imaging Methods 0.000 description 1
- MOFVSTNWEDAEEK-UHFFFAOYSA-M indocyanine green Chemical compound [Na+].[O-]S(=O)(=O)CCCCN1C2=CC=C3C=CC=CC3=C2C(C)(C)C1=CC=CC=CC=CC1=[N+](CCCCS([O-])(=O)=O)C2=CC=C(C=CC=C3)C3=C2C1(C)C MOFVSTNWEDAEEK-UHFFFAOYSA-M 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 230000005865 ionizing radiation Effects 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 210000004932 little finger Anatomy 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 230000009401 metastasis Effects 0.000 description 1
- 230000001394 metastastic effect Effects 0.000 description 1
- 206010061289 metastatic neoplasm Diseases 0.000 description 1
- 210000004088 microvessel Anatomy 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 210000000337 motor cortex Anatomy 0.000 description 1
- 230000001338 necrotic effect Effects 0.000 description 1
- 230000014399 negative regulation of angiogenesis Effects 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 238000002610 neuroimaging Methods 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 230000004490 oculocephalic reflex Effects 0.000 description 1
- -1 oxy- Chemical class 0.000 description 1
- 230000008557 oxygen metabolism Effects 0.000 description 1
- 238000012831 peritoneal equilibrium test Methods 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 230000006461 physiological response Effects 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 238000012877 positron emission topography Methods 0.000 description 1
- 230000001144 postural effect Effects 0.000 description 1
- 230000009484 prefrontal function Effects 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000000272 proprioceptive effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 210000004761 scalp Anatomy 0.000 description 1
- 230000036362 sensorimotor function Effects 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 210000003009 spinothalamic tract Anatomy 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 230000002277 temperature effect Effects 0.000 description 1
- 210000003582 temporal bone Anatomy 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 230000000542 thalamic effect Effects 0.000 description 1
- 210000001103 thalamus Anatomy 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- 230000005747 tumor angiogenesis Effects 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 210000000857 visual cortex Anatomy 0.000 description 1
- 230000002747 voluntary effect Effects 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
- A61B5/14553—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases specially adapted for cerebral tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0033—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room
- A61B5/004—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part
- A61B5/0042—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part for the brain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0073—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by tomography, i.e. reconstruction of 3D images from 2D projections
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/02—Details of sensors specially adapted for in-vivo measurements
- A61B2562/0233—Special features of optical sensors or probes classified in A61B5/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/02—Details of sensors specially adapted for in-vivo measurements
- A61B2562/0233—Special features of optical sensors or probes classified in A61B5/00
- A61B2562/0242—Special features of optical sensors or probes classified in A61B5/00 for varying or adjusting the optical path length in the tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/04—Arrangements of multiple sensors of the same type
- A61B2562/046—Arrangements of multiple sensors of the same type in a matrix array
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/40—Detecting, measuring or recording for evaluating the nervous system
- A61B5/4058—Detecting, measuring or recording for evaluating the nervous system for evaluating the central nervous system
- A61B5/4064—Evaluating the brain
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Medical Informatics (AREA)
- Radiology & Medical Imaging (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Optics & Photonics (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7429698P | 1998-02-11 | 1998-02-11 | |
| US60/074,296 | 1998-02-11 | ||
| US9801898P | 1998-08-26 | 1998-08-26 | |
| US60/098,018 | 1998-08-26 | ||
| PCT/US1999/003030 WO1999040841A1 (en) | 1998-02-11 | 1999-02-11 | Imaging and characterization of brain tissue |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2319456A1 CA2319456A1 (en) | 1999-08-19 |
| CA2319456C true CA2319456C (en) | 2011-01-04 |
Family
ID=26755485
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2319456A Expired - Fee Related CA2319456C (en) | 1998-02-11 | 1999-02-11 | Imaging and characterization of brain tissue |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7610082B2 (enExample) |
| EP (1) | EP1054619B1 (enExample) |
| JP (2) | JP4733265B2 (enExample) |
| CA (1) | CA2319456C (enExample) |
| DE (1) | DE69937602T2 (enExample) |
| WO (1) | WO1999040841A1 (enExample) |
Families Citing this family (126)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070167704A1 (en) * | 1998-02-13 | 2007-07-19 | Britton Chance | Transabdominal examination, monitoring and imaging of tissue |
| US6949081B1 (en) | 1998-08-26 | 2005-09-27 | Non-Invasive Technology, Inc. | Sensing and interactive drug delivery |
| US7904139B2 (en) | 1999-08-26 | 2011-03-08 | Non-Invasive Technology Inc. | Optical examination of biological tissue using non-contact irradiation and detection |
| US7840257B2 (en) | 2003-01-04 | 2010-11-23 | Non Invasive Technology, Inc. | Examination of biological tissue using non-contact optical probes |
| TW453862B (en) * | 1999-08-30 | 2001-09-11 | Cas Medical Systems Inc | Near infrared spectrophotometric monitoring assembly for non-invasive monitoring of blood oxygenation levels in a subjects's body |
| EP1221035B1 (en) * | 1999-09-14 | 2012-05-23 | The Research Foundation Of State University Of New York | System and method for tomographic imaging of dynamic properties of a scattering medium |
| JP3796086B2 (ja) * | 1999-12-27 | 2006-07-12 | 株式会社日立製作所 | 生体光計測装置 |
| US7006676B1 (en) | 2000-01-21 | 2006-02-28 | Medical Optical Imaging, Inc. | Method and apparatus for detecting an abnormality within a host medium utilizing frequency-swept modulation diffusion tomography |
| EP1327418B1 (en) * | 2000-10-16 | 2010-05-19 | Hitachi Medical Corporation | Organism optical measurement instrument |
| JP4499270B2 (ja) * | 2000-10-30 | 2010-07-07 | 浜松ホトニクス株式会社 | 散乱吸収体計測装置の校正方法、及びそれを用いた散乱吸収体計測装置 |
| US7383076B2 (en) | 2000-11-27 | 2008-06-03 | The General Hospital Corporation | Fluorescence-mediated molecular tomography |
| US6615063B1 (en) * | 2000-11-27 | 2003-09-02 | The General Hospital Corporation | Fluorescence-mediated molecular tomography |
| US7299096B2 (en) * | 2001-03-08 | 2007-11-20 | Northstar Neuroscience, Inc. | System and method for treating Parkinson's Disease and other movement disorders |
| US8078262B2 (en) * | 2001-04-16 | 2011-12-13 | The Johns Hopkins University | Method for imaging and spectroscopy of tumors and determination of the efficacy of anti-tumor drug therapies |
| JP4112882B2 (ja) * | 2001-07-19 | 2008-07-02 | 株式会社日立メディコ | 生体光計測装置 |
| GB0213836D0 (en) * | 2002-06-14 | 2002-07-24 | Electrode Company The Ltd | Analytical apparatus |
| US7045763B2 (en) | 2002-06-28 | 2006-05-16 | Hewlett-Packard Development Company, L.P. | Object-recognition lock |
| JP2004121702A (ja) | 2002-10-07 | 2004-04-22 | Hitachi Ltd | 生体光計測装置 |
| WO2006024038A2 (en) * | 2004-08-27 | 2006-03-02 | Codman & Shurtleff | Light-based implant for treating alzheimer’s disease |
| SG120995A1 (en) * | 2004-09-10 | 2006-04-26 | Agency Science Tech & Res | A method and apparatus for determining asymmetry in an image |
| JP4118871B2 (ja) | 2004-12-03 | 2008-07-16 | 株式会社日立製作所 | 生体光計測用プローブ及びそれを用いた生体光計測装置 |
| US8951202B2 (en) * | 2004-12-23 | 2015-02-10 | David Borsook | Recognizing awareness in an anesthetized subject |
| USRE47266E1 (en) * | 2005-03-14 | 2019-03-05 | DePuy Synthes Products, Inc. | Light-based implants for treating Alzheimer's disease |
| US8055321B2 (en) | 2005-03-14 | 2011-11-08 | Peter Bernreuter | Tissue oximetry apparatus and method |
| US7288108B2 (en) * | 2005-03-14 | 2007-10-30 | Codman & Shurtleff, Inc. | Red light implant for treating Parkinson's disease |
| US7865223B1 (en) | 2005-03-14 | 2011-01-04 | Peter Bernreuter | In vivo blood spectrometry |
| US7351253B2 (en) * | 2005-06-16 | 2008-04-01 | Codman & Shurtleff, Inc. | Intranasal red light probe for treating Alzheimer's disease |
| US7753862B2 (en) | 2005-07-13 | 2010-07-13 | Thomas P. Branch | Apparatus and method for evaluating ligaments |
| US7355688B2 (en) * | 2005-09-08 | 2008-04-08 | Vioptix, Inc. | Optical probe for optical imaging system |
| US7819907B2 (en) * | 2005-10-31 | 2010-10-26 | Codman & Shurtleff, Inc. | Device and method for fixing adjacent bone plates |
| US7402713B2 (en) * | 2006-03-07 | 2008-07-22 | E.I. Du Pont De Nemours And Company | Processes for conversion of tyrosine to p-hydroxystyrene and p-acetoxystyrene |
| GB0607270D0 (en) | 2006-04-11 | 2006-05-17 | Univ Nottingham | The pulsing blood supply |
| JP5887047B2 (ja) | 2006-06-22 | 2016-03-16 | コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. | 断層撮影装置及びコンピュータ断層撮影の再構成方法 |
| US8457705B2 (en) * | 2006-10-25 | 2013-06-04 | University Of Denver | Brain imaging system and methods for direct prosthesis control |
| WO2008063527A2 (en) * | 2006-11-13 | 2008-05-29 | Faro Scott H | Detection of deception and truth-telling using fmri of the brain |
| EP2120684B1 (en) * | 2006-12-22 | 2015-09-09 | Washington University | High performance imaging system for diffuse optical tomography and associated method of use |
| CA2620949C (en) * | 2006-12-22 | 2015-08-04 | New Art Advanced Research Technologies Inc. | Method and apparatus for optical image reconstruction using contour determination |
| US20080177163A1 (en) * | 2007-01-19 | 2008-07-24 | O2 Medtech, Inc. | Volumetric image formation from optical scans of biological tissue with multiple applications including deep brain oxygenation level monitoring |
| US8100834B2 (en) * | 2007-02-27 | 2012-01-24 | J&M Shuler, Inc. | Method and system for monitoring oxygenation levels of a compartment for detecting conditions of a compartment syndrome |
| DE102007015306A1 (de) * | 2007-03-27 | 2008-10-02 | Siemens Ag | Ermittlungsverfahren für einen zeitlichen Verlauf einer örtlich dreidimensional aufgelösten Anwesenheitswahrscheinlichkeitsverteilung einer Substanz in einem Gefäßsystem |
| US8323694B2 (en) * | 2007-05-09 | 2012-12-04 | Nanoprobes, Inc. | Gold nanoparticles for selective IR heating |
| EP2208462A1 (en) * | 2007-09-25 | 2010-07-21 | Gifu University | Magnetic resonance imaging apparatus and its operating method, diagnostic imaging system, and diagnosis method |
| US8380272B2 (en) * | 2007-12-21 | 2013-02-19 | Covidien Lp | Physiological sensor |
| JP5481032B2 (ja) | 2008-02-20 | 2014-04-23 | 株式会社日立製作所 | 生体光計測用プローブ及びそれを用いた生体光計測装置 |
| US9320914B2 (en) | 2008-03-03 | 2016-04-26 | DePuy Synthes Products, Inc. | Endoscopic delivery of red/NIR light to the subventricular zone |
| US9480425B2 (en) * | 2008-04-17 | 2016-11-01 | Washington University | Task-less optical mapping of dynamic brain function using resting state functional connectivity |
| ES2715633T3 (es) | 2008-05-20 | 2019-06-05 | Univ Health Network | Dispositivo y método para formación de imágenes y supervisión por fluorescencia |
| US20110301500A1 (en) * | 2008-10-29 | 2011-12-08 | Tim Maguire | Automated vessel puncture device using three-dimensional(3d) near infrared (nir) imaging and a robotically driven needle |
| WO2010056973A1 (en) * | 2008-11-14 | 2010-05-20 | Nonin Medical, Inc. | Optical sensor path selection |
| US20100198316A1 (en) * | 2009-02-04 | 2010-08-05 | Richard Toselli | Intracranial Red Light Treatment Device For Chronic Pain |
| KR101034798B1 (ko) * | 2009-03-18 | 2011-05-17 | 한국과학기술연구원 | 뇌 상태 측정 장치 |
| US8583565B2 (en) * | 2009-08-03 | 2013-11-12 | Colorado Seminary, Which Owns And Operates The University Of Denver | Brain imaging system and methods for direct prosthesis control |
| WO2011035408A1 (en) | 2009-09-22 | 2011-03-31 | La Corporation De L'ecole Polytechnique De Montreal B.R.C.D.T. | Method and system for optical data acquisition and tomography imaging of a turbid medium object |
| EP2501288B1 (en) * | 2009-11-19 | 2016-12-21 | Modulated Imaging Inc. | Method and apparatus for analysis of turbid media via single-element detection using structured illumination |
| US20110123452A1 (en) * | 2009-11-25 | 2011-05-26 | Nanoprobes, Inc. | Metal oligomers and polymers and their use in biology and medicine |
| WO2011084480A1 (en) | 2009-12-15 | 2011-07-14 | Government Of The U.S.A., As Represented By The Secretary, Department Of Health And Human Services | Method for detecting hematoma, portable detection and discrimination device and related systems and apparatuses |
| US9775545B2 (en) | 2010-09-28 | 2017-10-03 | Masimo Corporation | Magnetic electrical connector for patient monitors |
| WO2012050847A2 (en) | 2010-09-28 | 2012-04-19 | Masimo Corporation | Depth of consciousness monitor including oximeter |
| WO2012054768A1 (en) * | 2010-10-20 | 2012-04-26 | Advanced Mri Technologies, Llc | Multiplexed shifted echo planar imaging |
| KR20120075084A (ko) * | 2010-12-28 | 2012-07-06 | 성균관대학교산학협력단 | 뇌혈류 역학의 광학 이미징 분석 방법 |
| WO2013013156A2 (en) * | 2011-07-20 | 2013-01-24 | Boston Scientific Scimed, Inc. | Percutaneous devices and methods to visualize, target and ablate nerves |
| US9247896B2 (en) | 2012-01-04 | 2016-02-02 | Nellcor Puritan Bennett Ireland | Systems and methods for determining respiration information using phase locked loop |
| WO2013112709A1 (en) * | 2012-01-24 | 2013-08-01 | Niedre Mark | Systems and methods for sensing, enumerating and imaging rare cells with diffuse light |
| EP2861132B1 (en) * | 2012-06-13 | 2020-11-18 | Dean Nahman | Devices for detection of internal bleeding and hematoma |
| AU2013341165B2 (en) | 2012-11-07 | 2019-08-01 | Modulated Imaging, Inc. | Efficient modulated imaging |
| US9560978B2 (en) | 2013-02-05 | 2017-02-07 | Covidien Lp | Systems and methods for determining respiration information from a physiological signal using amplitude demodulation |
| KR101270405B1 (ko) | 2013-02-14 | 2013-06-07 | 성균관대학교산학협력단 | 뇌혈류 역학의 광학 이미징 분석 방법 |
| US9554712B2 (en) | 2013-02-27 | 2017-01-31 | Covidien Lp | Systems and methods for generating an artificial photoplethysmograph signal |
| CN103610467B (zh) * | 2013-11-05 | 2016-08-03 | 李鲁亚 | 并行近红外光电传感装置及动物器官组织检测系统与方法 |
| US20160296154A1 (en) * | 2013-11-15 | 2016-10-13 | Archeoptix Biomedical Inc. | Apparatus and method of intracranial imaging |
| USD763938S1 (en) | 2014-04-02 | 2016-08-16 | Cephalogics, LLC | Optical sensor array |
| USD763939S1 (en) | 2014-04-02 | 2016-08-16 | Cephalogics, LLC | Optical sensor array liner with optical sensor array pad |
| WO2015198373A1 (ja) * | 2014-06-23 | 2015-12-30 | 株式会社日立製作所 | 生体光計測装置、及び方法 |
| PL3171765T3 (pl) | 2014-07-24 | 2022-01-03 | University Health Network | Zbieranie i analiza danych do celów diagnostycznych |
| US10154815B2 (en) | 2014-10-07 | 2018-12-18 | Masimo Corporation | Modular physiological sensors |
| USD775634S1 (en) * | 2014-10-30 | 2017-01-03 | Kardium Inc. | Display screen or portion thereof with animated graphical user interface for a monitoring and control device for an intra-cardiac procedure system |
| USD775141S1 (en) * | 2014-10-30 | 2016-12-27 | Kardium Inc. | Display screen or portion thereof with animated graphical user interface for a monitoring and control device for an intra-cardiac procedure system |
| TWI554248B (zh) * | 2015-02-25 | 2016-10-21 | 國立交通大學 | 光偵測裝置及使用該光偵測裝置之影像重建方法 |
| US9730649B1 (en) | 2016-09-13 | 2017-08-15 | Open Water Internet Inc. | Optical imaging of diffuse medium |
| JP2019141373A (ja) * | 2018-02-22 | 2019-08-29 | セイコーエプソン株式会社 | 脳機能測定装置 |
| US10778911B2 (en) | 2018-03-31 | 2020-09-15 | Open Water Internet Inc. | Optical transformation device for imaging |
| US10506181B2 (en) | 2018-03-31 | 2019-12-10 | Open Water Internet Inc. | Device for optical imaging |
| US10778912B2 (en) | 2018-03-31 | 2020-09-15 | Open Water Internet Inc. | System and device for optical transformation |
| US10966612B2 (en) | 2018-06-14 | 2021-04-06 | Open Water Internet Inc. | Expanding beam optical element |
| US11571205B2 (en) * | 2018-07-16 | 2023-02-07 | Cilag Gmbh International | Surgical visualization feedback system |
| MX2021000628A (es) | 2018-07-16 | 2021-05-27 | Bbi Medical Innovations Llc | Medicion de perfusion y oxigenacion. |
| US10962929B2 (en) | 2018-09-14 | 2021-03-30 | Open Water Internet Inc. | Interference optics for optical imaging device |
| US10874370B2 (en) | 2019-01-28 | 2020-12-29 | Open Water Internet Inc. | Pulse measurement in optical imaging |
| US10955406B2 (en) | 2019-02-05 | 2021-03-23 | Open Water Internet Inc. | Diffuse optical imaging with multiple beams |
| US12257013B2 (en) | 2019-03-15 | 2025-03-25 | Cilag Gmbh International | Robotic surgical systems with mechanisms for scaling camera magnification according to proximity of surgical tool to tissue |
| CN113424048A (zh) * | 2019-03-25 | 2021-09-21 | 人工智能生物医学公司 | 组织检测系统及其使用方法 |
| US11599994B2 (en) * | 2019-03-28 | 2023-03-07 | Purdue Research Foundation | System and methods for clear optimally matched panoramic channel technique for deep brain photonic interface |
| US11320370B2 (en) | 2019-06-26 | 2022-05-03 | Open Water Internet Inc. | Apparatus for directing optical and acoustic signals |
| US11581696B2 (en) * | 2019-08-14 | 2023-02-14 | Open Water Internet Inc. | Multi-channel laser |
| US11622686B2 (en) | 2019-11-22 | 2023-04-11 | Open Water Internet, Inc. | Optical imaging with unshifted reference beam |
| US12002571B2 (en) | 2019-12-30 | 2024-06-04 | Cilag Gmbh International | Dynamic surgical visualization systems |
| CN111227790B (zh) * | 2020-01-08 | 2021-06-29 | 北京师范大学 | 一种基于脑功能区定位的近红外探头排布方法及头帽 |
| US11969259B2 (en) | 2020-02-21 | 2024-04-30 | Hi Llc | Detector assemblies for a wearable module of an optical measurement system and including spring-loaded light-receiving members |
| WO2021167877A1 (en) | 2020-02-21 | 2021-08-26 | Hi Llc | Multimodal wearable measurement systems and methods |
| US12029558B2 (en) | 2020-02-21 | 2024-07-09 | Hi Llc | Time domain-based optical measurement systems and methods configured to measure absolute properties of tissue |
| US11950879B2 (en) | 2020-02-21 | 2024-04-09 | Hi Llc | Estimation of source-detector separation in an optical measurement system |
| US11630310B2 (en) | 2020-02-21 | 2023-04-18 | Hi Llc | Wearable devices and wearable assemblies with adjustable positioning for use in an optical measurement system |
| US12144653B2 (en) | 2020-02-21 | 2024-11-19 | Hi Llc | Systems, circuits, and methods for reducing common-mode noise in biopotential recordings |
| US11096620B1 (en) | 2020-02-21 | 2021-08-24 | Hi Llc | Wearable module assemblies for an optical measurement system |
| US11771362B2 (en) | 2020-02-21 | 2023-10-03 | Hi Llc | Integrated detector assemblies for a wearable module of an optical measurement system |
| US11864867B2 (en) | 2020-03-20 | 2024-01-09 | Hi Llc | Control circuit for a light source in an optical measurement system by applying voltage with a first polarity to start an emission of a light pulse and applying voltage with a second polarity to stop the emission of the light pulse |
| US11645483B2 (en) | 2020-03-20 | 2023-05-09 | Hi Llc | Phase lock loop circuit based adjustment of a measurement time window in an optical measurement system |
| US11607132B2 (en) | 2020-03-20 | 2023-03-21 | Hi Llc | Temporal resolution control for temporal point spread function generation in an optical measurement system |
| US12138068B2 (en) | 2020-03-20 | 2024-11-12 | Hi Llc | Techniques for characterizing a nonlinearity of a time-to-digital converter in an optical measurement system |
| US11877825B2 (en) | 2020-03-20 | 2024-01-23 | Hi Llc | Device enumeration in an optical measurement system |
| US11245404B2 (en) | 2020-03-20 | 2022-02-08 | Hi Llc | Phase lock loop circuit based signal generation in an optical measurement system |
| US11819311B2 (en) | 2020-03-20 | 2023-11-21 | Hi Llc | Maintaining consistent photodetector sensitivity in an optical measurement system |
| WO2021188496A1 (en) | 2020-03-20 | 2021-09-23 | Hi Llc | Photodetector calibration of an optical measurement system |
| US12085789B2 (en) | 2020-03-20 | 2024-09-10 | Hi Llc | Bias voltage generation in an optical measurement system |
| US11857348B2 (en) | 2020-03-20 | 2024-01-02 | Hi Llc | Techniques for determining a timing uncertainty of a component of an optical measurement system |
| US12059262B2 (en) | 2020-03-20 | 2024-08-13 | Hi Llc | Maintaining consistent photodetector sensitivity in an optical measurement system |
| US11187575B2 (en) * | 2020-03-20 | 2021-11-30 | Hi Llc | High density optical measurement systems with minimal number of light sources |
| US11819318B2 (en) | 2020-04-27 | 2023-11-21 | Open Water Internet Inc. | Optical imaging from light coherence |
| US11259706B2 (en) | 2020-05-19 | 2022-03-01 | Open Water Internet Inc. | Dual wavelength imaging and out of sample optical imaging |
| US11559208B2 (en) | 2020-05-19 | 2023-01-24 | Open Water Internet Inc. | Imaging with scattering layer |
| GB2599719A (en) * | 2020-10-09 | 2022-04-13 | Comind Tech Limited | Event related optical signal neuroimaging and analysis systems and methods |
| CN112401881B (zh) * | 2020-10-27 | 2021-08-10 | 北京航空航天大学 | 一种穿戴式fNIRS脑成像系统 |
| US11744535B2 (en) * | 2021-03-23 | 2023-09-05 | International Business Machines Corporation | Automated population based assessment of contrast absorption phases |
| US12161498B2 (en) | 2021-05-11 | 2024-12-10 | Analog Devices, Inc. | Baseline restoration technique for photon counting computed tomography using active reference |
| US20240188918A1 (en) * | 2022-12-13 | 2024-06-13 | Analog Devices, Inc. | Timer-based amplitude correction method for photon counting computed tomography |
| KR102693248B1 (ko) * | 2023-09-20 | 2024-08-09 | 주식회사 현대이디에스 | 기능적 근적외선 분광법과 뇌전도를 이용한 개인용 안대형 수면 데이터 취득 장치 |
Family Cites Families (136)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE208297C (enExample) | 1900-01-01 | |||
| US2706927A (en) | 1949-08-04 | 1955-04-26 | Research Corp | Apparatus for determining percentage oxygen-saturation of blood |
| US2790438A (en) | 1956-01-13 | 1957-04-30 | Taplin Ronald Harold | Earpieces for oximeters |
| US3068742A (en) | 1959-06-15 | 1962-12-18 | American Optical Corp | Means for performing colorimetry |
| US3412729A (en) | 1965-08-30 | 1968-11-26 | Nasa Usa | Method and apparatus for continuously monitoring blood oxygenation, blood pressure, pulse rate and the pressure pulse curve utilizing an ear oximeter as transducer |
| US3461856A (en) | 1965-10-23 | 1969-08-19 | American Optical Corp | Oximeters |
| US3638640A (en) | 1967-11-01 | 1972-02-01 | Robert F Shaw | Oximeter and method for in vivo determination of oxygen saturation in blood using three or more different wavelengths |
| US3704706A (en) | 1969-10-23 | 1972-12-05 | Univ Drexel | Heart rate and respiratory monitor |
| US3709612A (en) | 1971-03-10 | 1973-01-09 | Miles Lab | Apparatus for measuring reflected light under stabilized light source conditions |
| US3866599A (en) | 1972-01-21 | 1975-02-18 | Univ Washington | Fiberoptic catheter |
| CH581836A5 (enExample) | 1974-08-20 | 1976-11-15 | Contraves Ag | |
| JPS5725217B2 (enExample) | 1974-10-14 | 1982-05-28 | ||
| US3958560A (en) | 1974-11-25 | 1976-05-25 | Wayne Front March | Non-invasive automatic glucose sensor system |
| US4014321A (en) | 1974-11-25 | 1977-03-29 | March Wayne F | Non-invasive glucose sensor system |
| CA1037285A (en) | 1975-04-30 | 1978-08-29 | Glenfield Warner | Ear oximetry process and apparatus |
| US4029085A (en) | 1976-03-26 | 1977-06-14 | Purdue Research Foundation | Method for determining bilirubin concentration from skin reflectance |
| US4119406A (en) | 1976-05-06 | 1978-10-10 | Miles Laboratories, Inc. | Calibration apparatus |
| US4167331A (en) | 1976-12-20 | 1979-09-11 | Hewlett-Packard Company | Multi-wavelength incremental absorbence oximeter |
| US4129125A (en) | 1976-12-27 | 1978-12-12 | Camin Research Corp. | Patient monitoring system |
| US4086652A (en) | 1977-01-19 | 1978-04-25 | Block Engineering, Inc. | Method and apparatus for analyzing a time-dependent phenomenon |
| US4281645A (en) | 1977-06-28 | 1981-08-04 | Duke University, Inc. | Method and apparatus for monitoring metabolism in body organs |
| US4222389A (en) | 1977-10-18 | 1980-09-16 | Institute Of Applied Biology Special Cancer Research Project | Objective determination of the rate of oxygen utilization in peripheral tissue |
| US4162405A (en) | 1978-05-23 | 1979-07-24 | Britton Chance | Flying spot fluoro-meter for oxidized flavoprotein and reduced pyridine nucleotide |
| JPS5524004A (en) | 1978-06-22 | 1980-02-20 | Minolta Camera Kk | Oxymeter |
| US4224948A (en) | 1978-11-24 | 1980-09-30 | Cramer Frank B | Wrist borne pulse meter/chronometer |
| US4416285A (en) | 1978-11-29 | 1983-11-22 | Oximetrix, Inc. | Improved optical catheter and method for making same |
| US4469107A (en) | 1979-01-02 | 1984-09-04 | Asmar Raymond A | Automatic blood pressure measurement device with threshold compensation circuitry and method for performing the same |
| US4259963A (en) | 1979-07-03 | 1981-04-07 | Albert Huch | Multi-purpose transducer for transcutaneous blood measurements |
| US4515165A (en) | 1980-02-04 | 1985-05-07 | Energy Conversion Devices, Inc. | Apparatus and method for detecting tumors |
| GB2068537B (en) | 1980-02-04 | 1984-11-14 | Energy Conversion Devices Inc | Examining biological materials |
| FI64398C (fi) | 1980-08-04 | 1983-11-10 | Outokumpu Oy | Gasblaosroer foer inmatning av reaktionsaemnen i metallurgiskasmaeltor |
| JPS57110928A (en) | 1980-12-27 | 1982-07-10 | Sharp Corp | Thermometer |
| DE3100610C2 (de) | 1981-01-12 | 1983-07-07 | Vladimir Dr.-Ing. Blazek | Meßeinrichtung zur nichtinvasiven Feststellung venöser bzw. arterieller Abfluß- und Durchflußstörungen |
| JPS5826802A (ja) | 1981-08-10 | 1983-02-17 | Sankyo Co Ltd | 農園芸用殺菌剤 |
| US4510165A (en) * | 1981-12-21 | 1985-04-09 | Heat And Control, Inc. | Taco shell forming and cooking method |
| US4452250A (en) | 1982-04-29 | 1984-06-05 | Britton Chance | NMR System for the non-invasive study of phosphorus metabilism |
| US4576173A (en) | 1982-06-28 | 1986-03-18 | The Johns Hopkins University | Electro-optical device and method for monitoring instanteous singlet oxygen concentration produced during photoradiation using a CW excitation source |
| AU1687983A (en) | 1982-07-19 | 1984-01-26 | Spectrascan Inc. | Diaphanoscopy method and apparatus |
| US4700708A (en) | 1982-09-02 | 1987-10-20 | Nellcor Incorporated | Calibrated optical oximeter probe |
| EP0102816A3 (en) | 1982-09-02 | 1985-08-28 | Nellcor Incorporated | Pulse oximeter |
| DE3323365C2 (de) | 1982-09-04 | 1994-10-20 | Gsf Forschungszentrum Umwelt | Verfahren und Vorrichtung zur Ausleuchtung von Hohlräumen |
| US4541438A (en) | 1983-06-02 | 1985-09-17 | The Johns Hopkins University | Localization of cancerous tissue by monitoring infrared fluorescence emitted by intravenously injected porphyrin tumor-specific markers excited by long wavelength light |
| US5139025A (en) | 1983-10-14 | 1992-08-18 | Somanetics Corporation | Method and apparatus for in vivo optical spectroscopic examination |
| US4714341A (en) | 1984-02-23 | 1987-12-22 | Minolta Camera Kabushiki Kaisha | Multi-wavelength oximeter having a means for disregarding a poor signal |
| IT1206462B (it) | 1984-08-07 | 1989-04-27 | Anic Spa | Fotometro a luce impulsata a lunghezza d'onda multipla per monitoraggio non-invasivo. |
| US4807637A (en) | 1984-08-20 | 1989-02-28 | American Science And Engineering, Inc. | Diaphanography method and apparatus |
| US4648892A (en) | 1985-03-22 | 1987-03-10 | Massachusetts Institute Of Technology | Method for making optical shield for a laser catheter |
| US5106387A (en) | 1985-03-22 | 1992-04-21 | Massachusetts Institute Of Technology | Method for spectroscopic diagnosis of tissue |
| FR2579092B1 (fr) | 1985-03-22 | 1989-06-16 | Univ Toulouse | Capteur implantable de pression intracranienne |
| EP0196396B1 (en) | 1985-04-01 | 1991-01-16 | COSMED S.r.l. | Portable breathing monitor for telemetric measurement by a central processing station |
| US4655225A (en) | 1985-04-18 | 1987-04-07 | Kurabo Industries Ltd. | Spectrophotometric method and apparatus for the non-invasive |
| US4774679A (en) | 1986-02-20 | 1988-09-27 | Carlin John A | Stride evaluation system |
| JPS6323645A (ja) | 1986-05-27 | 1988-01-30 | 住友電気工業株式会社 | 反射加温型オキシメ−タ |
| US5026431A (en) * | 1986-06-09 | 1991-06-25 | Skolnik Industries, Inc. | Process of koshering containers |
| US4800495A (en) | 1986-08-18 | 1989-01-24 | Physio-Control Corporation | Method and apparatus for processing signals used in oximetry |
| WO1988001485A1 (en) | 1986-09-02 | 1988-03-10 | Singer Jerome R | Infrared radiation imaging system and method |
| US4824242A (en) | 1986-09-26 | 1989-04-25 | Sensormedics Corporation | Non-invasive oximeter and method |
| JPS63148307A (ja) | 1986-12-12 | 1988-06-21 | Hitachi Ltd | Nc情報作成装置 |
| US4940453A (en) | 1987-01-28 | 1990-07-10 | Cadwell Industries, Inc. | Method and apparatus for magnetically stimulating neurons |
| NO880891L (no) | 1987-03-03 | 1988-09-05 | Elizabeth May Dowling | Fremgangsmaate og apparat for maaling eller deteksjon av konsentrasjonen av en substans. |
| US4880304A (en) | 1987-04-01 | 1989-11-14 | Nippon Colin Co., Ltd. | Optical sensor for pulse oximeter |
| US4773422A (en) | 1987-04-30 | 1988-09-27 | Nonin Medical, Inc. | Single channel pulse oximeter |
| JPS63277039A (ja) | 1987-05-08 | 1988-11-15 | Hamamatsu Photonics Kk | 診断装置 |
| FR2617602B1 (fr) | 1987-07-03 | 1989-10-20 | Thomson Csf | Procede et systeme d'imagerie par transillumination a marquage en frequence des photons |
| US4805623A (en) | 1987-09-04 | 1989-02-21 | Vander Corporation | Spectrophotometric method for quantitatively determining the concentration of a dilute component in a light- or other radiation-scattering environment |
| US4836207A (en) | 1987-09-09 | 1989-06-06 | The Beth Israel Hospital Association | Method and apparatus to monitor cholesterol levels with photon correlation spectroscopy |
| US4800885A (en) | 1987-12-02 | 1989-01-31 | The Boc Group, Inc. | Blood constituent monitoring apparatus and methods with frequency division multiplexing |
| US4846183A (en) | 1987-12-02 | 1989-07-11 | The Boc Group, Inc. | Blood parameter monitoring apparatus and methods |
| DE3810411A1 (de) | 1988-03-26 | 1989-10-12 | Nicolay Gmbh | Vorrichtung zum fixieren eines messaufnehmers, insbesondere eines messaufnehmers fuer oximetrische messungen |
| US4869254A (en) | 1988-03-30 | 1989-09-26 | Nellcor Incorporated | Method and apparatus for calculating arterial oxygen saturation |
| US5137355A (en) | 1988-06-08 | 1992-08-11 | The Research Foundation Of State University Of New York | Method of imaging a random medium |
| US4951682A (en) | 1988-06-22 | 1990-08-28 | The Cleveland Clinic Foundation | Continuous cardiac output by impedance measurements in the heart |
| US4972331A (en) | 1989-02-06 | 1990-11-20 | Nim, Inc. | Phase modulated spectrophotometry |
| US5564417A (en) * | 1991-01-24 | 1996-10-15 | Non-Invasive Technology, Inc. | Pathlength corrected oximeter and the like |
| US5122974A (en) | 1989-02-06 | 1992-06-16 | Nim, Inc. | Phase modulated spectrophotometry |
| US5402778A (en) | 1993-01-19 | 1995-04-04 | Nim Incorporated | Spectrophotometric examination of tissue of small dimension |
| US5873821A (en) | 1992-05-18 | 1999-02-23 | Non-Invasive Technology, Inc. | Lateralization spectrophotometer |
| US5596987A (en) | 1988-11-02 | 1997-01-28 | Noninvasive Technology, Inc. | Optical coupler for in vivo examination of biological tissue |
| US5111821A (en) | 1988-11-08 | 1992-05-12 | Health Research, Inc. | Fluorometric method for detecting abnormal tissue using dual long-wavelength excitation |
| US4937526A (en) | 1988-11-23 | 1990-06-26 | Mayo Foundation For Medical Education And Research | Adaptive method for reducing motion and flow artifacts in NMR images |
| JPH06103257B2 (ja) | 1988-12-19 | 1994-12-14 | 大塚電子株式会社 | 光散乱を用いた物質の吸光係数測定方法および装置 |
| US5782755A (en) * | 1993-11-15 | 1998-07-21 | Non-Invasive Technology, Inc. | Monitoring one or more solutes in a biological system using optical techniques |
| US5553614A (en) | 1988-12-21 | 1996-09-10 | Non-Invasive Technology, Inc. | Examination of biological tissue using frequency domain spectroscopy |
| US5119815A (en) | 1988-12-21 | 1992-06-09 | Nim, Incorporated | Apparatus for determining the concentration of a tissue pigment of known absorbance, in vivo, using the decay characteristics of scintered electromagnetic radiation |
| US5353799A (en) | 1991-01-22 | 1994-10-11 | Non Invasive Technology, Inc. | Examination of subjects using photon migration with high directionality techniques |
| US5555885A (en) * | 1988-12-21 | 1996-09-17 | Non-Invasive Technology, Inc. | Examination of breast tissue using time-resolved spectroscopy |
| US5187672A (en) | 1989-02-06 | 1993-02-16 | Nim Incorporated | Phase modulation spectroscopic system |
| US5386827A (en) * | 1993-03-30 | 1995-02-07 | Nim Incorporated | Quantitative and qualitative in vivo tissue examination using time resolved spectroscopy |
| WO1990009637A1 (en) | 1989-02-13 | 1990-08-23 | Research Corporation Technologies, Inc. | Method and means for parallel frequency acquisition in frequency domain fluorometry |
| US5090415A (en) | 1989-02-14 | 1992-02-25 | Hamamatsu Photonics Kabushiki Kaisha | Examination apparatus |
| GB2228314B (en) | 1989-02-16 | 1992-11-18 | Hamamatsu Photonics Kk | Examination apparatus |
| DD298677A5 (de) | 1989-11-16 | 1992-03-05 | ��������`������������@�������@�������@M�������]k�� | Verfahren zur bestimmung des volumenflusses |
| US5178142A (en) | 1989-05-23 | 1993-01-12 | Vivascan Corporation | Electromagnetic method and apparatus to measure constituents of human or animal tissue |
| JP2798450B2 (ja) | 1989-12-08 | 1998-09-17 | 株式会社日立製作所 | 生体計測装置 |
| GB9011887D0 (en) | 1990-05-26 | 1990-07-18 | Le Fit Ltd | Pulse responsive device |
| WO1991018549A1 (en) * | 1990-05-29 | 1991-12-12 | Yue Samuel K | Fetal probe apparatus |
| US5143081A (en) | 1990-07-27 | 1992-09-01 | New York University | Randomized double pulse stimulus and paired event analysis |
| US5845639A (en) * | 1990-08-10 | 1998-12-08 | Board Of Regents Of The University Of Washington | Optical imaging methods |
| US5251128A (en) | 1990-11-19 | 1993-10-05 | General Electric Company | Motion artifact reduction in projection imaging |
| US5198977A (en) | 1990-11-27 | 1993-03-30 | Jesse Salb | System and method for localization of functional activity in the human brain |
| US5213105A (en) | 1990-12-04 | 1993-05-25 | Research Corporation Technologies, Inc. | Frequency domain optical imaging using diffusion of intensity modulated radiation |
| SG85573A1 (en) | 1991-01-24 | 2002-01-15 | Non Invasive Technology Inc | Quantitation and localization of tissue hypoxia by time and frequency domain spectroscopy |
| US5300097A (en) | 1991-02-13 | 1994-04-05 | Lerner Ethan A | Fiber optic psoriasis treatment device |
| US5067183A (en) | 1991-03-04 | 1991-11-26 | Omar Urquiola | Convertible infant bed assembly |
| US5218962A (en) | 1991-04-15 | 1993-06-15 | Nellcor Incorporated | Multiple region pulse oximetry probe and oximeter |
| DE69229554T2 (de) | 1991-05-16 | 2000-02-10 | Non-Invasive Technology, Inc. | Hämoglobin-messung zur bestimmung von stoffwechselgrössen einer person |
| US5203339A (en) | 1991-06-28 | 1993-04-20 | The Government Of The United States Of America As Represented By The Secretary Of The Department Health And Human Services | Method and apparatus for imaging a physical parameter in turbid media using diffuse waves |
| DE69227545T2 (de) | 1991-07-12 | 1999-04-29 | Robinson, Mark R., Albuquerque, N.Mex. | Oximeter zur zuverlässigen klinischen Bestimmung der Blutsauerstoffsättigung in einem Fötus |
| DE4129438A1 (de) | 1991-09-04 | 1993-03-18 | Siemens Ag | Messanordnung fuer die untersuchung eines objektes mit sichtbarem, nir- oder ir-licht |
| US5309912A (en) | 1991-11-08 | 1994-05-10 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Multidimensional imaging using a single point detector for a phase encoded modulated optical carrier |
| US5277181A (en) | 1991-12-12 | 1994-01-11 | Vivascan Corporation | Noninvasive measurement of hematocrit and hemoglobin content by differential optical analysis |
| US5413098A (en) | 1991-12-24 | 1995-05-09 | Sextant Medical Corporation | Path constrained spectrophotometer and method for determination of spatial distribution of light or other radiation scattering and absorbing substances in a radiation scattering medium |
| US5853370A (en) * | 1996-09-13 | 1998-12-29 | Non-Invasive Technology, Inc. | Optical system and method for non-invasive imaging of biological tissue |
| JP3107914B2 (ja) * | 1992-07-20 | 2000-11-13 | 浜松ホトニクス株式会社 | 散乱吸収体内部の吸収情報計測装置及び方法 |
| US5949077A (en) | 1992-08-10 | 1999-09-07 | Alfano; Robert R. | Technique for imaging an object in or behind a scattering medium |
| US5408093A (en) | 1992-08-31 | 1995-04-18 | Hitachi, Ltd. | Optical computed tomography equipment having image inverting optical device |
| IL107396A (en) | 1992-11-09 | 1997-02-18 | Boehringer Mannheim Gmbh | Method and apparatus for analytical determination of glucose in a biological matrix |
| US5551423A (en) | 1993-01-26 | 1996-09-03 | Nihon Kohden Corporation | Pulse oximeter probe |
| US5416582A (en) | 1993-02-11 | 1995-05-16 | The United States Of America As Represented By The Department Of Health And Human Services | Method and apparatus for localization and spectroscopy of objects using optical frequency modulation of diffusion waves |
| US6058324A (en) | 1993-06-17 | 2000-05-02 | Non-Invasive Technology, Inc. | Examination and imaging of biological tissue |
| US5673701A (en) * | 1994-10-07 | 1997-10-07 | Non Invasive Technology, Inc. | Optical techniques for examination of biological tissue |
| US5983125A (en) | 1993-12-13 | 1999-11-09 | The Research Foundation Of City College Of New York | Method and apparatus for in vivo examination of subcutaneous tissues inside an organ of a body using optical spectroscopy |
| US5497769A (en) | 1993-12-16 | 1996-03-12 | I.S.S. (Usa) Inc. | Photosensor with multiple light sources |
| US5358503A (en) | 1994-01-25 | 1994-10-25 | Bertwell Dale E | Photo-thermal therapeutic device and method |
| US6215587B1 (en) | 1994-02-14 | 2001-04-10 | Robert R. Alfano | Microscope imaging inside highly scattering media |
| JP3310782B2 (ja) * | 1994-07-14 | 2002-08-05 | 株式会社日立製作所 | 吸収物質濃度の空間分布画像化装置 |
| US5625458A (en) | 1994-11-10 | 1997-04-29 | Research Foundation Of City College Of New York | Method and system for imaging objects in turbid media using diffusive fermat photons |
| US5706821A (en) | 1994-12-30 | 1998-01-13 | Hamamatsu Photonics K.K. | Spectroscopic method for quantitatively determining the change of concentration of a light or other radiation absorbing compound in a medium which is interrogated through an intervening medium |
| CN1230118C (zh) * | 1995-01-03 | 2005-12-07 | 无创伤诊断技术公司 | 用于生物组织体内测量的光耦合器 |
| DE19510024C2 (de) * | 1995-03-20 | 1997-02-06 | Hoechst Ag | Verfahren zur Herstellung von Pentafluorethan (R 125) |
| US5655530A (en) | 1995-08-09 | 1997-08-12 | Rio Grande Medical Technologies, Inc. | Method for non-invasive blood analyte measurement with improved optical interface |
| US6108576A (en) | 1996-03-18 | 2000-08-22 | The Research Foundation Of City College Of New York | Time-resolved diffusion tomographic 2D and 3D imaging in highly scattering turbid media |
| US6006001A (en) | 1996-12-02 | 1999-12-21 | The Research Foundation Of Cuny | Fiberoptic assembly useful in optical spectroscopy |
| AU5895998A (en) | 1996-12-04 | 1998-06-29 | Research Foundation Of City College Of New York, The | A system and method for performing selected optical measurements |
| US6091983A (en) | 1997-02-07 | 2000-07-18 | Alfano; Robert R. | Imaging of objects in turbid media based upon the preservation of polarized luminescence emitted from contrast agents |
| US5943122A (en) * | 1998-07-10 | 1999-08-24 | Nanometrics Incorporated | Integrated optical measurement instruments |
-
1999
- 1999-02-11 JP JP2000531103A patent/JP4733265B2/ja not_active Expired - Fee Related
- 1999-02-11 CA CA2319456A patent/CA2319456C/en not_active Expired - Fee Related
- 1999-02-11 EP EP99906954A patent/EP1054619B1/en not_active Expired - Lifetime
- 1999-02-11 DE DE69937602T patent/DE69937602T2/de not_active Expired - Lifetime
- 1999-02-11 WO PCT/US1999/003030 patent/WO1999040841A1/en not_active Ceased
-
2004
- 2004-11-05 US US10/982,542 patent/US7610082B2/en not_active Expired - Fee Related
-
2009
- 2009-10-26 US US12/589,636 patent/US20100174160A1/en not_active Abandoned
-
2011
- 2011-03-07 JP JP2011048944A patent/JP2011104428A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2011104428A (ja) | 2011-06-02 |
| DE69937602T2 (de) | 2008-10-23 |
| US20100174160A1 (en) | 2010-07-08 |
| JP2002502653A (ja) | 2002-01-29 |
| EP1054619A1 (en) | 2000-11-29 |
| US20050228291A1 (en) | 2005-10-13 |
| WO1999040841A1 (en) | 1999-08-19 |
| CA2319456A1 (en) | 1999-08-19 |
| US7610082B2 (en) | 2009-10-27 |
| DE69937602D1 (de) | 2008-01-03 |
| EP1054619A4 (en) | 2004-08-25 |
| JP4733265B2 (ja) | 2011-07-27 |
| EP1054619B1 (en) | 2007-11-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2319456C (en) | Imaging and characterization of brain tissue | |
| EP1054620B1 (en) | Transabdominal examination, monitoring and imaging of tissue | |
| EP1054618B1 (en) | Detection, imaging and characterization of breast tumors | |
| Chance et al. | Optical investigations of physiology. A study of intrinsic and extrinsic biomedical contrast | |
| Durduran | Non-invasive measurements of tissue hemodynamics with hybrid diffuse optical methods | |
| EP0926981B1 (en) | Non-invasive imaging of biological tissue | |
| US20090281402A1 (en) | Transabdominal examination, monitoring and imaging of tissue | |
| US6397099B1 (en) | Non-invasive imaging of biological tissue | |
| JP3839202B2 (ja) | 生体光計測装置及びこの装置を機能させるためのプログラム | |
| CN103735274B (zh) | 一种局部脑组织血氧血容绝对量检测装置及检测方法 | |
| Gratton et al. | The event-related optical signal: a new tool for studying brain function | |
| Kacprzak et al. | Time-resolved optical imager for assessment of cerebral oxygenation | |
| US20040064052A1 (en) | Non-invasive imaging of biological tissue | |
| WO1998010698A9 (en) | Non-invasive imaging of biological tissue | |
| Maniewski et al. | Time resolved optical spectroscopy system for cerebral oxygenation imaging | |
| Yamamoto et al. | Noninvasive brain function measurement system: optical topography | |
| Frostig | IN\| l\| ll IIPTIBIII IMAGINE [IF BRAIN FIINBTIIIN | |
| PRESS | IN VIVO OPTICAL IMAGING OF BRAIN FONCTION | |
| Dunn et al. | 3 Noninvasive lmaging | |
| Nissilä | Instrumentation for medical optical tomography with applications | |
| Boas et al. | 8 Noninvasive Imaging | |
| YUKSEL | PREPARED BY: SENIHA ESEN YUKSEL CVIP Lab University of Louisville Electrical and Computer Engineering |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20160211 |