CA2318493A1 - Administration par voie orale de vaccins d'acides nucleiques au moyen de complexes particulaires - Google Patents
Administration par voie orale de vaccins d'acides nucleiques au moyen de complexes particulaires Download PDFInfo
- Publication number
- CA2318493A1 CA2318493A1 CA002318493A CA2318493A CA2318493A1 CA 2318493 A1 CA2318493 A1 CA 2318493A1 CA 002318493 A CA002318493 A CA 002318493A CA 2318493 A CA2318493 A CA 2318493A CA 2318493 A1 CA2318493 A1 CA 2318493A1
- Authority
- CA
- Canada
- Prior art keywords
- antigen
- mice
- vaccine
- dna
- chitosan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
- A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
- A61K47/6931—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer
- A61K47/6939—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer the polymer being a polysaccharide, e.g. starch, chitosan, chitin, cellulose or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/542—Mucosal route oral/gastrointestinal
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/915—Therapeutic or pharmaceutical composition
- Y10S977/916—Gene therapy
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/918—Immunological
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nanotechnology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
L'invention concerne des coacervats nanoparticulaires d'acides nucléiques et de polycations qui sont des vaccins efficaces lorsqu'ils sont administrés par voie orale. Ces coacervats particulaires peuvent induire une immunité contre une grande variété d'agents pathogènes et susciter une réaction protectrice contre les allergènes.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7167998P | 1998-01-16 | 1998-01-16 | |
US60/071,679 | 1998-01-16 | ||
PCT/US1999/000861 WO1999036090A1 (fr) | 1998-01-16 | 1999-01-15 | Administration par voie orale de vaccins d'acides nucleiques au moyen de complexes particulaires |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2318493A1 true CA2318493A1 (fr) | 1999-07-22 |
Family
ID=22102881
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002318493A Pending CA2318493A1 (fr) | 1998-01-16 | 1999-01-15 | Administration par voie orale de vaccins d'acides nucleiques au moyen de complexes particulaires |
Country Status (9)
Country | Link |
---|---|
US (1) | US6475995B1 (fr) |
EP (1) | EP1045700B1 (fr) |
JP (1) | JP2002509117A (fr) |
AT (1) | ATE281844T1 (fr) |
AU (1) | AU749625B2 (fr) |
CA (1) | CA2318493A1 (fr) |
DE (1) | DE69921773D1 (fr) |
NZ (1) | NZ505877A (fr) |
WO (1) | WO1999036090A1 (fr) |
Families Citing this family (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19940794A1 (de) * | 1999-08-27 | 2001-03-01 | Lohmann Therapie Syst Lts | Pharmazeutische Zubereitung |
US6458387B1 (en) * | 1999-10-18 | 2002-10-01 | Epic Therapeutics, Inc. | Sustained release microspheres |
WO2001091808A2 (fr) * | 2000-06-01 | 2001-12-06 | The Board Of Regents For Oklahoma State University | Bioconjugues de nanoparticules en tant que produits radiopharmaceutiques |
AUPR011700A0 (en) | 2000-09-14 | 2000-10-05 | Austin Research Institute, The | Composition comprising immunogenic virus sized particles (VSP) |
ES2326209T3 (es) | 2000-10-27 | 2009-10-05 | Baxter Healthcare S.A. | Produccion de microesferas. |
ES2307779T3 (es) * | 2001-08-16 | 2008-12-01 | Baxter International Inc. | Formulaciones de microparticulas a base de propelentes. |
WO2003028657A2 (fr) * | 2001-10-03 | 2003-04-10 | The Johns Hopkins University | Compositions pour therapie genique orale et procedes d'utilisation associes |
US8178128B2 (en) * | 2001-12-05 | 2012-05-15 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Nanoparticles containing polymeric nucleic acid homologs |
US20040038303A1 (en) * | 2002-04-08 | 2004-02-26 | Unger Gretchen M. | Biologic modulations with nanoparticles |
CA2484251C (fr) | 2002-04-30 | 2015-06-23 | University Of South Florida | Matieres et procedes visant a prevenir et a traiter des maladies provoquees par des virus a arn |
US20050175625A1 (en) * | 2002-07-12 | 2005-08-11 | The Johns Hopkins University | Mesothelin vaccines and model systems |
US9200036B2 (en) | 2002-07-12 | 2015-12-01 | The Johns Hopkins University | Mesothelin vaccines and model systems |
US20090110702A1 (en) | 2002-07-12 | 2009-04-30 | The Johns Hopkins University | Mesothelin Vaccines and Model Systems and Control of Tumors |
US20040014698A1 (en) * | 2002-07-18 | 2004-01-22 | Gonzalo Hortelano | Oral administration of therapeutic agent coupled to transporting agent |
US20040014704A1 (en) * | 2002-07-18 | 2004-01-22 | Gonzalo Hortelano | Oral administration of therapeutic agent coupled to transporting agent induces tolerance |
US7595303B1 (en) * | 2002-09-05 | 2009-09-29 | University Of South Florida | Genetic adjuvants for immunotherapy |
US20050026859A1 (en) * | 2002-11-12 | 2005-02-03 | John Hilfinger | Methods and compositions of gene delivery agents for systemic and local therapy |
US20080026077A1 (en) * | 2002-11-12 | 2008-01-31 | John Hilfinger | Methods and compositions of gene delivery agents for systemic and local therapy |
WO2005002643A2 (fr) * | 2003-06-24 | 2005-01-13 | Johns Hopkins University | Methode et produits permettant de distribuer des molecules biologiques a des cellules au moyen de nanostructures multicomposants |
US20050084513A1 (en) * | 2003-10-21 | 2005-04-21 | Board Of Regents | Nanocoating for improving biocompatibility of medical implants |
US20050208032A1 (en) * | 2004-01-16 | 2005-09-22 | Gonzalo Hortelano | Oral administration of therapeutic agent coupled to transporting agent |
US20040224019A1 (en) * | 2004-03-03 | 2004-11-11 | Adi Shefer | Oral controlled release system for targeted drug delivery into the cell and its nucleus for gene therapy, DNA vaccination, and administration of gene based drugs |
JP4674288B2 (ja) * | 2004-03-31 | 2011-04-20 | 恵雄 岡畑 | 歯科用材料。 |
US20050266093A1 (en) * | 2004-04-27 | 2005-12-01 | Mohapatra Shyam S | Nanogene therapy for cell proliferation disorders |
US8728525B2 (en) | 2004-05-12 | 2014-05-20 | Baxter International Inc. | Protein microspheres retaining pharmacokinetic and pharmacodynamic properties |
EP1758558B1 (fr) | 2004-05-12 | 2013-10-16 | Baxter International Inc. | Administration de microspheres d'oligonucleotides antisens pour induire une tolerance de cellules dendritiques pour le traitement du diabete de type 1 insulino-dependant |
DE602005009954D1 (de) | 2004-05-12 | 2008-11-06 | Baxter Int | Nukleinsäure-mikrokügelchen, ihre herstellung und abgabe |
WO2006023207A2 (fr) * | 2004-08-19 | 2006-03-02 | The United States Of America As Represented By The Secretary Of Health And Human Services, Nih | Microparticules coacervees utiles pour l'administration a liberation prolongee d'agents therapeutiques |
US7449200B2 (en) * | 2006-04-17 | 2008-11-11 | Gp Medical, Inc. | Nanoparticles for protein/peptide delivery and delivery means |
US7901711B1 (en) | 2006-04-17 | 2011-03-08 | Gp Medical, Inc. | Nanoparticles for protein/peptide delivery and delivery means thereof |
US8137697B1 (en) * | 2004-10-05 | 2012-03-20 | Gp Medical, Inc. | Nanoparticles for protein/peptide delivery and delivery means thereof |
WO2006086428A2 (fr) * | 2005-02-08 | 2006-08-17 | Board Of Regents, The University Of Texas System | Particules d'inactivation de toxines |
ES2277743B2 (es) * | 2005-06-02 | 2008-12-16 | Universidade De Santiago De Compostela | Nanoparticulas que comprenden quitosano y ciclodextrina. |
US20100272769A1 (en) * | 2005-08-03 | 2010-10-28 | Amcol International | Virus-, Bacteria-, and Fungi-Interacting Layered Phyllosilicates and Methods of Use |
US20080184618A1 (en) * | 2005-08-03 | 2008-08-07 | Amcol International | Virus-Interacting Layered Phyllosilicates and Methods of Use |
EP2034954B1 (fr) * | 2006-03-30 | 2019-02-20 | Engene, Inc. | Compositions non virales et procédés de transfection de cellules intestinales in vivo |
US8449915B1 (en) | 2006-04-17 | 2013-05-28 | Gp Medical, Inc. | Pharmaceutical composition of nanoparticles |
MX2009001226A (es) | 2006-08-04 | 2009-03-20 | Baxter Int | Composicion basada en microesferas para prevenir y/o revertir la diabetes autoinmune de nuevo inicio. |
NZ599605A (en) | 2007-02-19 | 2013-11-29 | Marinepolymer Tech Inc | Hemostatic compositions and therapeutic regimens |
KR100813224B1 (ko) * | 2007-08-24 | 2008-03-13 | 한양대학교 산학협력단 | 단백질 약물전달용 온도 가역성 코아세르베이트 조합 겔 |
US20090163437A1 (en) * | 2007-10-16 | 2009-06-25 | Regado Biosciences, Inc. | Steady-state subcutaneous administration of aptamers |
FR2924349B1 (fr) * | 2007-12-03 | 2010-01-01 | Dbv Tech | Methode de desensibilitation aux allergenes |
EP2123261A1 (fr) | 2008-05-20 | 2009-11-25 | Stallergenes S.A. | Formulation à particules mucoadhésives pour induire la tolérance immune spécifique à antigène |
US20110305768A1 (en) * | 2008-07-01 | 2011-12-15 | The Johns Hopkins University | Quick-dissolving oral thin film for targeted delivery of therapeutic agents |
US8323685B2 (en) | 2008-08-20 | 2012-12-04 | Baxter International Inc. | Methods of processing compositions containing microparticles |
US8323615B2 (en) | 2008-08-20 | 2012-12-04 | Baxter International Inc. | Methods of processing multi-phasic dispersions |
US8367427B2 (en) | 2008-08-20 | 2013-02-05 | Baxter International Inc. | Methods of processing compositions containing microparticles |
ES2567455T3 (es) | 2008-10-10 | 2016-04-22 | Dara Biosciences, Inc. | Nanoemulsiones que comprenden derivados de espicamicina para su uso en el tratamiento del dolor |
WO2010049562A1 (fr) | 2008-10-28 | 2010-05-06 | Universidade De Santiago De Compostela | Systèmes nanoparticulaires élaborés à base de polymères anioniques |
EP2373338B1 (fr) | 2008-12-03 | 2017-02-15 | The Johns Hopkins University | Annexina2 en tant que cible immunologique |
AU2010256511B2 (en) | 2009-06-03 | 2016-01-14 | Tobira Therapeutics, Inc. | Nucleic acid modulators of glycoprotein VI |
KR20130122632A (ko) | 2010-10-14 | 2013-11-07 | 레가도 바이오사이언스, 인코포레이티드 | Clec-2의 핵산 모듈레이터 |
WO2013163176A1 (fr) | 2012-04-23 | 2013-10-31 | Allertein Therapeutics, Llc | Nanoparticules pour le traitement d'allergies |
MX2015005636A (es) | 2012-10-30 | 2015-11-16 | Univ Monash | Moléculas inmunoterapéuticas novedosas y sus usos. |
ITTO20121107A1 (it) * | 2012-12-19 | 2014-06-20 | Idea Medical Devices S R L | Composizione a base di polidesossiribonucleotidi e relativi usi |
AU2014248090B2 (en) | 2013-04-03 | 2018-08-02 | N-Fold Llc | Novel nanoparticle compositions |
KR20160075532A (ko) | 2013-09-25 | 2016-06-29 | 아라백스 피티와이 엘티디 | 신규한 면역치료제 조성물 및 이의 용도 |
CN103626860A (zh) * | 2013-12-04 | 2014-03-12 | 江南大学 | 一种表达低过敏性花生过敏原的乳酸乳球菌重组菌及其应用 |
CN111700877A (zh) | 2014-09-03 | 2020-09-25 | 吉倪塞思公司 | 治疗性纳米粒子和相关的组合物、方法和系统 |
JP6084759B1 (ja) * | 2015-08-17 | 2017-02-22 | 積水メディカル株式会社 | 免疫学的検出方法及びこれに用いるテストストリップ |
US10874737B2 (en) | 2018-06-01 | 2020-12-29 | Iowa State University Research Foundation, Inc. | Influenza nanovaccine |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6024983A (en) * | 1986-10-24 | 2000-02-15 | Southern Research Institute | Composition for delivering bioactive agents for immune response and its preparation |
US5585264A (en) * | 1988-07-15 | 1996-12-17 | University Of Saskatchewan | Nucleotide sequences encoding recombinant bovine herpesvirus type-1 GI, GIII and GIV polypeptides |
CA2142007C (fr) * | 1992-08-11 | 2007-10-30 | Robert Glen Urban | Peptides immunomodulateurs |
CA2193954A1 (fr) * | 1994-06-27 | 1996-01-04 | Vu L. Truong | Systeme de transport de gene cible |
US5674495A (en) * | 1995-02-27 | 1997-10-07 | Purdue Research Foundation | Alginate-based vaccine compositions |
US5935568A (en) * | 1995-05-18 | 1999-08-10 | National Jewish Medical & Research Center | Gene therapy for effector cell regulation |
JP2000514440A (ja) * | 1996-07-09 | 2000-10-31 | ザ ジョーンズ ホプキンス ユニバーシティー | 遺伝子輸送システム |
US5783567A (en) * | 1997-01-22 | 1998-07-21 | Pangaea Pharmaceuticals, Inc. | Microparticles for delivery of nucleic acid |
US5990091A (en) * | 1997-03-12 | 1999-11-23 | Virogenetics Corporation | Vectors having enhanced expression, and methods of making and uses thereof |
-
1999
- 1999-01-15 CA CA002318493A patent/CA2318493A1/fr active Pending
- 1999-01-15 DE DE69921773T patent/DE69921773D1/de not_active Expired - Lifetime
- 1999-01-15 NZ NZ505877A patent/NZ505877A/xx unknown
- 1999-01-15 US US09/232,167 patent/US6475995B1/en not_active Expired - Lifetime
- 1999-01-15 AT AT99902272T patent/ATE281844T1/de not_active IP Right Cessation
- 1999-01-15 AU AU22292/99A patent/AU749625B2/en not_active Ceased
- 1999-01-15 JP JP2000539863A patent/JP2002509117A/ja active Pending
- 1999-01-15 EP EP99902272A patent/EP1045700B1/fr not_active Expired - Lifetime
- 1999-01-15 WO PCT/US1999/000861 patent/WO1999036090A1/fr active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
WO1999036090A9 (fr) | 1999-10-14 |
US6475995B1 (en) | 2002-11-05 |
ATE281844T1 (de) | 2004-11-15 |
DE69921773D1 (de) | 2004-12-16 |
AU2229299A (en) | 1999-08-02 |
EP1045700A1 (fr) | 2000-10-25 |
EP1045700B1 (fr) | 2004-11-10 |
WO1999036090A1 (fr) | 1999-07-22 |
AU749625B2 (en) | 2002-06-27 |
JP2002509117A (ja) | 2002-03-26 |
NZ505877A (en) | 2002-10-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
FZDE | Discontinued | ||
FZDC | Discontinued application reinstated |