CA2316340A1 - Phospholipids having antimicrobial activity with or without the presence of antimicrobials - Google Patents
Phospholipids having antimicrobial activity with or without the presence of antimicrobials Download PDFInfo
- Publication number
- CA2316340A1 CA2316340A1 CA002316340A CA2316340A CA2316340A1 CA 2316340 A1 CA2316340 A1 CA 2316340A1 CA 002316340 A CA002316340 A CA 002316340A CA 2316340 A CA2316340 A CA 2316340A CA 2316340 A1 CA2316340 A1 CA 2316340A1
- Authority
- CA
- Canada
- Prior art keywords
- mppa
- substance
- antimicrobial
- ampicillin
- cfu
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 230000000845 anti-microbial effect Effects 0.000 title claims abstract description 72
- 239000004599 antimicrobial Substances 0.000 title claims abstract description 46
- 150000003904 phospholipids Chemical class 0.000 title abstract description 33
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- 238000004519 manufacturing process Methods 0.000 claims description 11
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 9
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (3)
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| US6690197P | 1997-11-20 | 1997-11-20 | |
| US60/066,901 | 1997-11-20 | ||
| PCT/DK1998/000512 WO1999026632A1 (en) | 1997-11-20 | 1998-11-20 | Phospholipids having antimicrobial activity with or without the presence of antimicrobials |
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|---|---|
| CA2316340A1 true CA2316340A1 (en) | 1999-06-03 |
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| CA002316340A Abandoned CA2316340A1 (en) | 1997-11-20 | 1998-11-20 | Phospholipids having antimicrobial activity with or without the presence of antimicrobials |
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| EP (1) | EP1051180B1 (enExample) |
| JP (1) | JP2001523723A (enExample) |
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| AU (1) | AU747288B2 (enExample) |
| CA (1) | CA2316340A1 (enExample) |
| DE (1) | DE69805100T2 (enExample) |
| DK (1) | DK1051180T3 (enExample) |
| ES (1) | ES2177089T3 (enExample) |
| NZ (1) | NZ505233A (enExample) |
| WO (1) | WO1999026632A1 (enExample) |
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| US7048906B2 (en) | 1995-05-17 | 2006-05-23 | Cedars-Sinai Medical Center | Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions |
| DE69831878D1 (de) * | 1997-11-24 | 2006-02-23 | Zhongming Zeng | Verwendung von dextrin, stärke oder glykogen zur behandlung von bakterieller vaginosis |
| GB9827865D0 (en) * | 1998-12-18 | 1999-02-10 | Woodcock Fiona | Medicament |
| US6838480B1 (en) * | 1999-05-28 | 2005-01-04 | Marie Madeline Wharton | Composition containing sucrafate and a topical anesthetic for humans and animals and method of use thereof |
| US6964949B2 (en) * | 2000-05-24 | 2005-11-15 | Shanghai Jiao Da Onlly Co., Ltd. | Pharmaceutical compositions for promoting the growth of gram-positive bacilli and increasing the acidity in the vagina and the use thereof |
| WO2002092104A1 (en) * | 2001-04-25 | 2002-11-21 | Biosynergen, Inc. | A pharmaceutical composition comprising lysophosphatidic acid |
| CA2449002C (en) | 2001-05-29 | 2011-08-16 | Tap Pharmaceutical Products Inc. | Enhancement of oral bioavailability of non-emulsified formulation of prodrug esters with lecithin |
| RU2259825C9 (ru) | 2001-06-18 | 2006-04-10 | БиоДием Лимитед | Вещества, проявляющие антимикробную, антигрибковую, антипротозойную активности |
| GB0201028D0 (en) * | 2002-01-17 | 2002-03-06 | Britannia Pharmaceuticals Ltd | Prevention of infectious diseases |
| ITMI20021280A1 (it) * | 2002-06-11 | 2003-12-11 | Carlo Ghisalberti | Metodo di trattamento anticellulite |
| US20050036972A1 (en) * | 2003-03-10 | 2005-02-17 | Hy-Gene Biomedical Corporation | System for managing pathogens and irritants and monitoring usage of anti-bacterial formulations |
| AP2626A (en) * | 2005-08-29 | 2013-03-26 | Sepsicure Llc | Method for treatment or prevention of conditions caused by gram-positive bacteria |
| EP1869981A1 (de) * | 2006-06-21 | 2007-12-26 | Staatliches Weinbauinstitut Freiburg | Alkylphospholipide und Lyso-Phospholipide zur Bekämpfung von Pflanzenpathogenen |
| KR100870232B1 (ko) * | 2006-12-07 | 2008-11-24 | 재단법인서울대학교산학협력재단 | 치아용 미백기능성 물질 전달시스템 |
| WO2009057768A1 (ja) * | 2007-11-02 | 2009-05-07 | Nagase Chemtex Corporation | 抗真菌剤及び抗菌剤 |
| WO2009110938A2 (en) * | 2007-12-10 | 2009-09-11 | Novobiotic Pharmaceuticals Llc | Novel macrocyclic polyene lactams |
| US9314524B2 (en) * | 2007-12-31 | 2016-04-19 | Calla Therapeutics Llc | Topical formulations of Flucytosine |
| PH12012500360A1 (en) * | 2009-08-21 | 2019-07-10 | Targeted Delivery Tech Limited | Vesicular formulations |
| US9693564B2 (en) * | 2011-06-21 | 2017-07-04 | Safehands Solutions, LLC | Water based antimicrobial composition using benzalkonium chloride and cocamidopropyl PG-dimonium chloride phosphate |
| KR101315483B1 (ko) * | 2011-06-23 | 2013-10-07 | 주식회사 아리바이오 | 항생제 및 라이소포스파티딜콜린을 포함하는 면역 증강 또는 세균성 감염 질환 치료용 조성물 |
| GB201205642D0 (en) | 2012-03-29 | 2012-05-16 | Sequessome Technology Holdings Ltd | Vesicular formulations |
| EP2805612A1 (en) | 2013-05-22 | 2014-11-26 | University of Graz | Lysophospholipids against American Foulbrood |
| US11660344B2 (en) * | 2013-11-17 | 2023-05-30 | Medrx Co., Ltd. | Transdermal colloidal solution agent |
| KR20160091315A (ko) | 2013-11-28 | 2016-08-02 | 큐피가부시키가이샤 | 다제내성 그램 양성균 항균제 및 외용제 |
| WO2017001625A1 (en) | 2015-06-30 | 2017-01-05 | Sequessome Technology Holdings Limited | Multiphasic compositions |
| AU2018335869B2 (en) * | 2017-09-21 | 2024-06-13 | Avanti Polar Lipids, Llc | Novel therapies for treating and preventing chronic rhinosinusitis |
| KR102641583B1 (ko) * | 2018-10-23 | 2024-02-28 | 건국대학교 산학협력단 | 지도부딘을 포함하는 식물병 방제용 조성물 |
| WO2023111173A1 (en) * | 2021-12-16 | 2023-06-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | An ezh2 degrader or inhibitor for use in the treatment of resistant acute myeloid leukemia |
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| US4588578A (en) * | 1983-08-08 | 1986-05-13 | The Liposome Company, Inc. | Lipid vesicles prepared in a monophase |
| CA1237670A (en) * | 1983-05-26 | 1988-06-07 | Andrew S. Janoff | Drug preparations of reduced toxicity |
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| US5135922A (en) * | 1984-06-15 | 1992-08-04 | Med-Tal, Inc. | Prevention and treatment of microbial infection by phosphoglycerides |
| US5409704A (en) * | 1985-06-26 | 1995-04-25 | The Liposome Company, Inc. | Liposomes comprising aminoglycoside phosphates and methods of production and use |
| JPS6216431A (ja) * | 1985-07-15 | 1987-01-24 | Nakanishi Michio | 医薬組成物 |
| US4923854A (en) * | 1986-01-22 | 1990-05-08 | The Liposome Company, Inc. | Solubilization of hydrophobic materials using lysophospholipid |
| JPH0774132B2 (ja) * | 1986-10-06 | 1995-08-09 | 旭電化工業株式会社 | 界面活性を有する静菌性組成物 |
| NZ223660A (en) * | 1987-03-05 | 1990-11-27 | Liposome Co Inc | Low toxicity drug-lipid complexes; methods of making them; and method of determining their toxicity |
| EP0394265B1 (en) * | 1987-07-29 | 1994-11-02 | The Liposome Company, Inc. | Method for size separation of particles |
| US5624958A (en) * | 1987-12-31 | 1997-04-29 | Isaacs; Charles E. | Disinfecting contact lenses |
| US5466714A (en) * | 1987-12-31 | 1995-11-14 | Research Foundation For Mental Health Hygiene, Inc. | Spermicidal and cytocidal fatty acid compositions |
| US5434182A (en) * | 1987-12-31 | 1995-07-18 | Isaacs; Charles E. | Antibacterial fatty acid compositions |
| FR2636331B1 (fr) * | 1988-09-12 | 1990-11-16 | Bioeurope | Procede de preparation d'acides lysophosphatidiques et de sels de ceux-ci |
| US4999199A (en) * | 1988-11-10 | 1991-03-12 | Board Of Regents, The University Of Texas System | Pharmaceutical formulations: liposomes incorporating aromatic polyene antibiotics |
| JP2794072B2 (ja) * | 1989-09-29 | 1998-09-03 | 株式会社ヤクルト本社 | 抗菌剤 |
| HK1007679A1 (en) * | 1990-12-21 | 1999-04-23 | Antex Biologics, Inc. | Use of host cell phospholipids for inhibiting bacterial colonization |
| IT1247165B (it) * | 1991-03-15 | 1994-12-12 | Fidia Spa | Uso terapeutico della fosfatidilserina e derivati in patologie degenerative anche associate a disfunsioni immunitarie. |
| US5648348A (en) * | 1991-10-28 | 1997-07-15 | Mona Industries, Inc. | Phospholipid antimicrobial compositions |
| AU662367B2 (en) * | 1991-10-28 | 1995-08-31 | Mona Industries, Inc. | Phospholipid antimicrobial compositions |
| FR2683721B1 (fr) * | 1991-11-15 | 1995-06-09 | Inocosm Laboratoires | Composition lipidique polaire permettant de vehiculer un agent actif et/ou de le faire penetrer dans une cellule cible. |
| US5292513A (en) * | 1992-05-18 | 1994-03-08 | Anthony G. Gristina | Method for nonspecific cellular immune stimulation |
| JP2604940B2 (ja) * | 1992-05-19 | 1997-04-30 | 株式会社リケン | イオンプレーティング用蒸発材 |
| JP2809573B2 (ja) * | 1993-03-08 | 1998-10-08 | 科学技術振興事業団 | 新規リゾホスファチジルイノシトール及びその製造法 |
| US5478819A (en) * | 1993-06-23 | 1995-12-26 | Simo Tarpila | Phospholipid composition and use thereof |
| US5480877A (en) * | 1993-11-02 | 1996-01-02 | Wisconsin Alumni Research Foundation | Use of lysophosphatidic acids to enhance fibronectin binding |
| JPH07147953A (ja) * | 1993-11-29 | 1995-06-13 | Yakult Honsha Co Ltd | 抗菌剤及び抗菌剤の使用方法 |
| AU3333695A (en) * | 1994-05-31 | 1995-12-21 | David P. Franklin | Methods and products for the control of pathogenic bacteria |
| WO1995035090A1 (en) * | 1994-06-21 | 1995-12-28 | Institute For Advanced Skin Research Inc. | Skin activator having glycosaminoglycan production accelerator activity |
| FR2745184A1 (fr) * | 1996-02-28 | 1997-08-29 | Chanseau Sylvain | Utilisation de la lecithine de soja pour la preparation d' un medicament contre le sida |
-
1998
- 1998-11-19 US US09/196,354 patent/US6165997A/en not_active Expired - Fee Related
- 1998-11-20 ES ES98956826T patent/ES2177089T3/es not_active Expired - Lifetime
- 1998-11-20 AU AU13337/99A patent/AU747288B2/en not_active Ceased
- 1998-11-20 NZ NZ505233A patent/NZ505233A/en unknown
- 1998-11-20 JP JP2000521834A patent/JP2001523723A/ja active Pending
- 1998-11-20 DK DK98956826T patent/DK1051180T3/da active
- 1998-11-20 AT AT98956826T patent/ATE216585T1/de active
- 1998-11-20 DE DE69805100T patent/DE69805100T2/de not_active Expired - Lifetime
- 1998-11-20 CA CA002316340A patent/CA2316340A1/en not_active Abandoned
- 1998-11-20 WO PCT/DK1998/000512 patent/WO1999026632A1/en not_active Ceased
- 1998-11-20 EP EP98956826A patent/EP1051180B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US6165997A (en) | 2000-12-26 |
| AU1333799A (en) | 1999-06-15 |
| DE69805100D1 (de) | 2002-05-29 |
| NZ505233A (en) | 2002-07-26 |
| EP1051180A1 (en) | 2000-11-15 |
| AU747288B2 (en) | 2002-05-16 |
| EP1051180B1 (en) | 2002-04-24 |
| WO1999026632B1 (en) | 1999-07-22 |
| ES2177089T3 (es) | 2002-12-01 |
| WO1999026632A8 (en) | 1999-09-02 |
| JP2001523723A (ja) | 2001-11-27 |
| ATE216585T1 (de) | 2002-05-15 |
| WO1999026632A1 (en) | 1999-06-03 |
| DK1051180T3 (da) | 2002-08-19 |
| DE69805100T2 (de) | 2002-12-05 |
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| Date | Code | Title | Description |
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| FZDE | Discontinued |