CA2310423A1 - Compositions pharmaceutiques ayant la forme de poudres de polymeres reticules charges de medicaments et procede de preparation correspondant au moyen de fluides supercritiques - Google Patents

Compositions pharmaceutiques ayant la forme de poudres de polymeres reticules charges de medicaments et procede de preparation correspondant au moyen de fluides supercritiques Download PDF

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Publication number
CA2310423A1
CA2310423A1 CA002310423A CA2310423A CA2310423A1 CA 2310423 A1 CA2310423 A1 CA 2310423A1 CA 002310423 A CA002310423 A CA 002310423A CA 2310423 A CA2310423 A CA 2310423A CA 2310423 A1 CA2310423 A1 CA 2310423A1
Authority
CA
Canada
Prior art keywords
cross
drug
linked
polymer
supercritical fluid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002310423A
Other languages
English (en)
Inventor
Fabio Carli
Italo Colombo
Paolo Alessi
Ireneo Kikic
Angelo Cortesi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Adare Pharmaceuticals SRL
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2310423A1 publication Critical patent/CA2310423A1/fr
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

On prépare des compositions pharmaceutiques sous forme de poudres, en chargeant sur des polymères réticulés des médicaments mis en solution dans des fluides supercritiques. Ce procédé de chargement est réalisé en deux étapes. Dans la première étape, le fluide supercritique est saturé avec le médicament dans des conditions de température et de pression appropriées. Dans la seconde étape, le fluide supercritique contenant le médicament est mis en contact avec le polymère réticulé. Grâce à ses propriétés particulières, le fluide supercritique pénètre dans le polymère et permet au médicament d'imprégner le polymère. Après le retrait du fluide, le médicament reste dans le polymère.
CA002310423A 1997-11-19 1998-11-16 Compositions pharmaceutiques ayant la forme de poudres de polymeres reticules charges de medicaments et procede de preparation correspondant au moyen de fluides supercritiques Abandoned CA2310423A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI97A002571 1997-11-19
IT97MI002571A IT1296464B1 (it) 1997-11-19 1997-11-19 Composizioni farmaceutiche in forma di polveri di polimeri reticolati caricati con farmaci e relativo processo di preparazione mediante
PCT/EP1998/007311 WO1999025322A2 (fr) 1997-11-19 1998-11-16 Compositions pharmaceutiques ayant la forme de poudres de polymeres reticules charges de medicaments et procede de preparation correspondant au moyen de fluides supercritiques

Publications (1)

Publication Number Publication Date
CA2310423A1 true CA2310423A1 (fr) 1999-05-27

Family

ID=11378230

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002310423A Abandoned CA2310423A1 (fr) 1997-11-19 1998-11-16 Compositions pharmaceutiques ayant la forme de poudres de polymeres reticules charges de medicaments et procede de preparation correspondant au moyen de fluides supercritiques

Country Status (9)

Country Link
EP (1) EP1033977A2 (fr)
JP (1) JP2001522873A (fr)
KR (1) KR20010032251A (fr)
AU (1) AU738748B2 (fr)
BR (1) BR9814656A (fr)
CA (1) CA2310423A1 (fr)
IT (1) IT1296464B1 (fr)
NZ (1) NZ505290A (fr)
WO (1) WO1999025322A2 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9920558D0 (en) * 1999-08-31 1999-11-03 Bradford Particle Design Ltd Methods for particle formation and their products
ATE298266T1 (de) * 2000-01-17 2005-07-15 Fraunhofer Ges Forschung Verfahren zur modifizierung der oberflächen von feinporösen adsorbentien
IT1318404B1 (it) * 2000-03-17 2003-08-25 Eurand Int Processo per la preparazione di formulazioni a rilascio accelerato conimpiego di fluidi compressi.
EP1258241A1 (fr) * 2001-05-16 2002-11-20 BIOPROGRESS S.p.A. Procédé permettant d'accroitre la biodisponibilité de nimesulide
CN1255099C (zh) * 2001-05-30 2006-05-10 South African Scientific and Industrial Research Center 包封活性物质的方法
US20030044514A1 (en) * 2001-06-13 2003-03-06 Richard Robert E. Using supercritical fluids to infuse therapeutic on a medical device
DE10132366A1 (de) * 2001-07-04 2003-01-30 Degussa Verfahren zur physikalischen Behandlung von Stärke(-Derivaten)
FR2830760B1 (fr) 2001-10-12 2004-06-04 Pf Medicament Procede de preparation d'un compose d'interaction de substances actives avec un support poreux par fluide supercritique
GB0127786D0 (en) * 2001-11-20 2002-01-09 Univ Nottingham Impregnation of antimicrobial substances
ATE422156T1 (de) * 2002-03-07 2009-02-15 Eurand Pharmaceuticals Ltd Verfahren zum laden und thermodynamischen aktivieren von arzneimitteln auf polymeren mit superkritischen flüssigkeiten
KR100508518B1 (ko) * 2002-11-13 2005-08-17 한미약품 주식회사 초임계유체 공정을 이용한 파클리탁셀 고체분산체의 제조방법 및 이 방법으로 제조된 파클리탁셀 고체분산체
FR2854079B1 (fr) 2003-04-25 2007-11-30 Pf Medicament Procede de preparation de complexes moleculaires
US7507823B2 (en) 2004-05-06 2009-03-24 Bristol-Myers Squibb Company Process of making aripiprazole particles
EP1611877A1 (fr) 2004-06-28 2006-01-04 Universidade de Coimbra Méthodes pour la préparation d'articles ophthalmiques thérapeutiques à la libération prolongée en utilisant des fluides compressés pour l'imprégnation des medicaments
GB2417900A (en) * 2004-09-11 2006-03-15 Medway Science Technologies Lt Composition for oral drug delivery
AU2006340003A1 (en) * 2005-11-09 2007-09-20 Novartis Ag Process for making pharmaceutical compositions with a transient plasticizer
GB0812742D0 (en) 2008-07-11 2008-08-20 Critical Pharmaceuticals Ltd Process
FR2945449B1 (fr) * 2009-05-15 2012-10-05 Pf Medicament Procede d'impregnation par co2 supercritique
CN105687141A (zh) * 2016-03-04 2016-06-22 中国药科大学 超临界抗溶剂法制备尼美舒利-左旋聚乳酸(Nim-PLLA)复合微球的工艺研究
CN112812355B (zh) * 2020-12-31 2022-09-23 厦门天生爱科技有限公司 一种具有缓释挥发性中草药有效成分的功能高分子发泡材料、制备方法和用途
CN113425895A (zh) * 2021-07-12 2021-09-24 大连大学 一种载药骨修复内固定材料及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE63321B1 (en) * 1986-02-03 1995-04-05 Elan Corp Plc Drug delivery system
FR2635043B1 (fr) * 1988-08-05 1990-09-28 Michelin & Cie Appareil de fabrication d'un renforcement pour pneumatiques, ledit renforcement etant constitue a partir d'un seul fil
CH677876A5 (en) * 1988-10-21 1991-07-15 Siegfried Ag Prepn. of coronary active 1,4-di:hydro-pyridine(s) in sorbed form - by pptn. on and/or in polyacrylate particles to improve bio-availability
IT1252867B (it) * 1991-12-31 1995-06-28 Gentili Ist Spa Composizioni farmaceutiche contenenti progesterone ad elevata biodisponibilita'
DE4202320A1 (de) * 1992-01-29 1993-08-05 Dierk Dr Knittel Verfahren zum impraegnieren von substraten
US5340614A (en) * 1993-02-11 1994-08-23 Minnesota Mining And Manufacturing Company Methods of polymer impregnation

Also Published As

Publication number Publication date
WO1999025322A2 (fr) 1999-05-27
BR9814656A (pt) 2000-10-03
ITMI972571A1 (it) 1999-05-19
KR20010032251A (ko) 2001-04-16
NZ505290A (en) 2002-08-28
AU738748B2 (en) 2001-09-27
WO1999025322A3 (fr) 1999-08-19
AU2153199A (en) 1999-06-07
IT1296464B1 (it) 1999-06-25
JP2001522873A (ja) 2001-11-20
EP1033977A2 (fr) 2000-09-13

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