CA2304516A1 - Pharmaceutical composition for the treatment of inflammatory bowel disease and irritable bowel syndrome - Google Patents
Pharmaceutical composition for the treatment of inflammatory bowel disease and irritable bowel syndrome Download PDFInfo
- Publication number
- CA2304516A1 CA2304516A1 CA002304516A CA2304516A CA2304516A1 CA 2304516 A1 CA2304516 A1 CA 2304516A1 CA 002304516 A CA002304516 A CA 002304516A CA 2304516 A CA2304516 A CA 2304516A CA 2304516 A1 CA2304516 A1 CA 2304516A1
- Authority
- CA
- Canada
- Prior art keywords
- nitric oxide
- composition
- disease
- oxide donor
- glyceryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4891—Coated capsules; Multilayered drug free capsule shells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9720797.1A GB9720797D0 (en) | 1997-09-30 | 1997-09-30 | Pharmaceutical composition for the treatment of inflammatory bowel disease and irritable bowel syndrome |
GB9720797.1 | 1997-09-30 | ||
PCT/GB1998/002933 WO1999016436A1 (en) | 1997-09-30 | 1998-09-29 | Pharmaceutical composition for the treatment of inflammatory bowel disease and irritable bowel syndrome |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2304516A1 true CA2304516A1 (en) | 1999-04-08 |
Family
ID=10819864
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002304516A Abandoned CA2304516A1 (en) | 1997-09-30 | 1998-09-29 | Pharmaceutical composition for the treatment of inflammatory bowel disease and irritable bowel syndrome |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1019038A1 (xx) |
JP (1) | JP2001517697A (xx) |
AU (1) | AU9273198A (xx) |
CA (1) | CA2304516A1 (xx) |
GB (1) | GB9720797D0 (xx) |
WO (1) | WO1999016436A1 (xx) |
ZA (1) | ZA988920B (xx) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1225897B1 (en) * | 1999-11-01 | 2004-09-08 | RHODES, John | Composition for treatment of constipation and irritable bowel syndrome |
US7081475B2 (en) | 2001-09-14 | 2006-07-25 | Prolx Pharmaceuticals Corp. | Wortmannin analogs and methods of using same |
WO2006084913A2 (en) * | 2005-02-11 | 2006-08-17 | Nolabs Ab | Device for treatment of rectal disorders, and manufacturing process for the same, involving nitric oxide |
EP1690557A1 (en) * | 2005-02-11 | 2006-08-16 | NOLabs AB | Device for treatment of rectal disorders, and manufacturing process for the same |
US7507842B2 (en) | 2005-08-12 | 2009-03-24 | Radiorx, Inc. | Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof |
AU2012203798B2 (en) * | 2005-08-12 | 2013-11-07 | Northrop Grumman Systems Corporation | O-nitro compounds, pharmaceutical compositons thereof and uses thereof |
US20070135380A1 (en) * | 2005-08-12 | 2007-06-14 | Radiorx, Inc. | O-nitro compounds, pharmaceutical compositions thereof and uses thereof |
EP1941876A1 (en) * | 2006-12-28 | 2008-07-09 | Lacer, S.A. | Isosorbide mononitrate derivatives for the treatment of Inflammation and ocular hypertension |
US8471041B2 (en) | 2010-02-09 | 2013-06-25 | Alliant Techsystems Inc. | Methods of synthesizing and isolating N-(bromoacetyl)-3,3-dinitroazetidine and a composition including the same |
US8664247B2 (en) | 2011-08-26 | 2014-03-04 | Radiorx, Inc. | Acyclic organonitro compounds for use in treating cancer |
WO2013052803A2 (en) | 2011-10-07 | 2013-04-11 | Radiorx, Inc. | Methods and compositions comprising a nitrite-reductase promoter for treatment of medical disorders and preservation of blood products |
WO2013052164A1 (en) | 2011-10-07 | 2013-04-11 | Radiorx, Inc. | Organonitro thioether compounds and medical uses thereof |
US10342778B1 (en) | 2015-10-20 | 2019-07-09 | Epicentrx, Inc. | Treatment of brain metastases using organonitro compound combination therapy |
US9987270B1 (en) | 2015-10-29 | 2018-06-05 | Epicentrix, Inc. | Treatment of gliomas using organonitro compound combination therapy |
DK3402480T3 (da) | 2016-01-11 | 2021-06-28 | Epicentrx Inc | Sammensætninger og fremgangsmåder til intravenøs administration af 2-brom-1-(3,3-dinitroazetidin-1-yl)ethanon |
WO2017137489A1 (en) * | 2016-02-12 | 2017-08-17 | Dsm Ip Assets B.V. | Anti-methanogenic compositions and uses thereof |
SG11201903312VA (en) | 2016-10-14 | 2019-05-30 | Epicentrix Inc | Sulfoxyalkyl organonitro and related compounds and pharmaceutical compositions for use in medicine |
BR112020000196A2 (pt) | 2017-07-07 | 2020-07-07 | Epicentrx, Inc. | composições para administração parenteral de agentes terapêuticos |
US11510901B2 (en) | 2018-01-08 | 2022-11-29 | Epicentrx, Inc. | Methods and compositions utilizing RRx-001 combination therapy for radioprotection |
CN110200921B (zh) * | 2019-06-19 | 2020-11-17 | 华中科技大学 | 一种具有靶向作用的抗炎脂质体及其制备与应用 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4428925A (en) * | 1981-12-18 | 1984-01-31 | Key Pharmaceuticals, Inc. | Sustained release glycerol trinitrate |
DE3728563A1 (de) * | 1987-08-27 | 1989-03-09 | Pohl Boskamp Gmbh Chem Pharma | N-alkylscopolaminiumsalz und nitroglycerin enthaltendes arzneimittel, verfahren zu dessen herstellung und dessen verwendung |
US5004601A (en) * | 1988-10-14 | 1991-04-02 | Zetachron, Inc. | Low-melting moldable pharmaceutical excipient and dosage forms prepared therewith |
WO1993012068A1 (en) * | 1991-12-11 | 1993-06-24 | Brigham And Women's Hospital | S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof |
US5632981A (en) * | 1992-08-24 | 1997-05-27 | The United States Of America As Represented By The Department Of Health And Human Services | Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same |
RU2121830C1 (ru) * | 1992-09-18 | 1998-11-20 | Яманоути Фармасьютикал Ко., ЛТД | Гидрогелевый препарат с длительным высвобождением лекарства |
JPH06227969A (ja) * | 1993-02-02 | 1994-08-16 | Masayasu Sugihara | 薬品の腸溶性改善方法およびそれにより得られた薬品組成物 |
US5565466A (en) * | 1993-08-13 | 1996-10-15 | Zonagen, Inc. | Methods for modulating the human sexual response |
DE4420523A1 (de) * | 1994-06-13 | 1995-12-14 | Cassella Ag | Verwendung von NO-freisetzenden Verbindungen zur Behandlung und Vorbeugung von systemischen Entzündungssyndromen |
US5840332A (en) * | 1996-01-18 | 1998-11-24 | Perio Products Ltd. | Gastrointestinal drug delivery system |
-
1997
- 1997-09-30 GB GBGB9720797.1A patent/GB9720797D0/en not_active Ceased
-
1998
- 1998-09-29 JP JP2000513572A patent/JP2001517697A/ja active Pending
- 1998-09-29 CA CA002304516A patent/CA2304516A1/en not_active Abandoned
- 1998-09-29 EP EP98945401A patent/EP1019038A1/en not_active Withdrawn
- 1998-09-29 AU AU92731/98A patent/AU9273198A/en not_active Abandoned
- 1998-09-29 WO PCT/GB1998/002933 patent/WO1999016436A1/en not_active Application Discontinuation
- 1998-09-30 ZA ZA988920A patent/ZA988920B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
JP2001517697A (ja) | 2001-10-09 |
AU9273198A (en) | 1999-04-23 |
ZA988920B (en) | 1999-06-09 |
EP1019038A1 (en) | 2000-07-19 |
WO1999016436A1 (en) | 1999-04-08 |
GB9720797D0 (en) | 1997-12-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |