CA2303205C - Analytical method and device involving continuous titration - Google Patents
Analytical method and device involving continuous titration Download PDFInfo
- Publication number
- CA2303205C CA2303205C CA2303205A CA2303205A CA2303205C CA 2303205 C CA2303205 C CA 2303205C CA 2303205 A CA2303205 A CA 2303205A CA 2303205 A CA2303205 A CA 2303205A CA 2303205 C CA2303205 C CA 2303205C
- Authority
- CA
- Canada
- Prior art keywords
- gradient
- pka
- fluid
- test mixture
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000004448 titration Methods 0.000 title claims abstract 5
- 238000004458 analytical method Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 claims abstract 18
- 238000000034 method Methods 0.000 claims abstract 9
- 150000001875 compounds Chemical class 0.000 claims abstract 3
- 239000012530 fluid Substances 0.000 claims 12
- 238000001514 detection method Methods 0.000 claims 4
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
- 230000002378 acidificating effect Effects 0.000 claims 2
- 239000000872 buffer Substances 0.000 claims 2
- 239000007853 buffer solution Substances 0.000 claims 2
- 238000004891 communication Methods 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- 239000007836 KH2PO4 Substances 0.000 claims 1
- 230000004075 alteration Effects 0.000 claims 1
- 239000003125 aqueous solvent Substances 0.000 claims 1
- 238000000149 argon plasma sintering Methods 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 238000002983 circular dichroism Methods 0.000 claims 1
- 235000015165 citric acid Nutrition 0.000 claims 1
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 claims 1
- 235000019797 dipotassium phosphate Nutrition 0.000 claims 1
- 229910000396 dipotassium phosphate Inorganic materials 0.000 claims 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 235000019796 monopotassium phosphate Nutrition 0.000 claims 1
- 229910000402 monopotassium phosphate Inorganic materials 0.000 claims 1
- 230000003287 optical effect Effects 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 230000002572 peristaltic effect Effects 0.000 claims 1
- 239000001508 potassium citrate Substances 0.000 claims 1
- 229960002635 potassium citrate Drugs 0.000 claims 1
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 claims 1
- 235000011082 potassium citrates Nutrition 0.000 claims 1
- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 claims 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N31/00—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
- G01N31/16—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using titration
- G01N31/166—Continuous titration of flowing liquids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
- G01N21/79—Photometric titration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00702—Processes involving means for analysing and characterising the products
- B01J2219/00707—Processes involving means for analysing and characterising the products separated from the reactor apparatus
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Plasma & Fusion (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Sampling And Sample Adjustment (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9719142.3 | 1997-09-09 | ||
| GBGB9719142.3A GB9719142D0 (en) | 1997-09-09 | 1997-09-09 | Analytical method and apparatus therefor |
| PCT/GB1998/002711 WO1999013328A1 (en) | 1997-09-09 | 1998-09-09 | Analytical method and apparatus therefor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2303205A1 CA2303205A1 (en) | 1999-03-18 |
| CA2303205C true CA2303205C (en) | 2010-06-01 |
Family
ID=10818787
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2303205A Expired - Fee Related CA2303205C (en) | 1997-09-09 | 1998-09-09 | Analytical method and device involving continuous titration |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6913930B2 (enExample) |
| EP (1) | EP1012599B1 (enExample) |
| JP (1) | JP2001516054A (enExample) |
| CN (1) | CN1157600C (enExample) |
| AT (1) | ATE420350T1 (enExample) |
| AU (1) | AU742335B2 (enExample) |
| CA (1) | CA2303205C (enExample) |
| DE (1) | DE69840450D1 (enExample) |
| ES (1) | ES2319469T3 (enExample) |
| GB (1) | GB9719142D0 (enExample) |
| HU (1) | HUP0004774A3 (enExample) |
| WO (1) | WO1999013328A1 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6569686B2 (en) | 2000-01-28 | 2003-05-27 | Pion, Inc. | Measurement of solubility-pH profiles |
| US7790025B2 (en) | 2003-05-16 | 2010-09-07 | Cryobiophysica, Inc. | External gradient chromatofocusing |
| US7926024B2 (en) * | 2004-06-14 | 2011-04-12 | Hyperformix, Inc. | Method and apparatus for managing complex processes |
| WO2007087433A2 (en) * | 2006-01-26 | 2007-08-02 | University Of Montana | Titration method using a tracer to quantify the titrant |
| JP2007263632A (ja) * | 2006-03-28 | 2007-10-11 | Miura Co Ltd | キレート剤の測定方法およびキレート剤の測定キット |
| US7425263B2 (en) * | 2006-08-29 | 2008-09-16 | Cryobiophysica | Multi-component, simultaneous, independent multi-gradient system for liquid chromatography |
| JP5151904B2 (ja) * | 2008-10-23 | 2013-02-27 | 株式会社三菱化学アナリテック | 電位差滴定方法および電位差滴定装置 |
| US8382974B2 (en) * | 2009-08-18 | 2013-02-26 | Ceramatec, Inc. | Sensor to measure a concentration of alkali alcoholate |
| US8706426B2 (en) | 2010-04-16 | 2014-04-22 | University Of Central Florida Research Foundation, Inc. | Systems and methods for identifying classes of substances |
| WO2012011074A2 (en) | 2010-07-22 | 2012-01-26 | Hach Company | Lab-on-a-chip for alkalinity analysis |
| US9321851B2 (en) * | 2011-03-07 | 2016-04-26 | Hercules Incorporated | Water soluble polymer powder formulation having improved dispersing properties |
| JP5681548B2 (ja) * | 2011-03-31 | 2015-03-11 | 日本光電工業株式会社 | 培地溶液のｐＨ計測方法及びｐＨ計測装置 |
| US9180449B2 (en) | 2012-06-12 | 2015-11-10 | Hach Company | Mobile water analysis |
| USD768872S1 (en) | 2012-12-12 | 2016-10-11 | Hach Company | Cuvette for a water analysis instrument |
| US8921113B2 (en) | 2012-12-21 | 2014-12-30 | Dionex Corporation | Buffer kit and method of generating a linear pH gradient |
| CN105301174B (zh) * | 2014-07-16 | 2017-07-18 | 中国科学院苏州纳米技术与纳米仿生研究所 | 用于微流控芯片的试剂滴定方法及装置、微流控芯片 |
| KR20160081669A (ko) * | 2014-12-31 | 2016-07-08 | 삼성전자주식회사 | 반응 장치, 검사 장치 및 검사 방법 |
| CN105115918A (zh) * | 2015-08-12 | 2015-12-02 | 泉州装备制造研究所 | 基于吸收光谱的pH值快速在线检测装置及方法 |
| US10871475B2 (en) * | 2017-02-21 | 2020-12-22 | Becs Technology, Inc. | Automated titration in a recirculating fluid system |
| US11231360B2 (en) | 2017-06-29 | 2022-01-25 | Hydrite Chemical Co. | Automatic titration device |
| US11397171B2 (en) * | 2017-09-18 | 2022-07-26 | Ecolab Usa Inc. | Adaptive range flow titration systems and methods with sample conditioning |
| AU2019253603B2 (en) * | 2018-04-09 | 2024-08-08 | Ecolab Usa Inc. | Methods for colorimetric endpoint detection and multiple analyte titration systems |
| US11397170B2 (en) * | 2018-04-16 | 2022-07-26 | Ecolab Usa Inc. | Repetition time interval adjustment in adaptive range titration systems and methods |
| CN110161164A (zh) * | 2019-04-16 | 2019-08-23 | 大连诚泽检测有限公司 | 一种流动式化学计量点测定装置及其应用 |
| US11022585B2 (en) | 2019-06-09 | 2021-06-01 | Dionex Corporation | Methods and systems for optimizing buffer conditions with liquid chromatography |
| DE102019120415A1 (de) * | 2019-07-29 | 2021-02-04 | Endress+Hauser Conducta Gmbh+Co. Kg | Verfahren zur Bestimmung einer chemischen Aufnahmekapazität eines Prozessmediums in einer Messstelle sowie Messstelle zur Bestimmung einer chemischen Aufnahmekapazität eines Prozessmediums |
| EP3901621B1 (de) * | 2020-04-22 | 2022-05-04 | Safechem Europe GmbH | Vorrichtung und verfahren zur bestimmung von flüssigkeitsspezifischen parametern und/oder bestandteilen |
| CN116440724A (zh) * | 2023-04-19 | 2023-07-18 | 四川中测标物科技有限公司 | 一种基于临界流技术的浓度连续可调的稀释装置 |
| CN119619398B (zh) * | 2024-12-18 | 2025-10-14 | 湖北百杰瑞新材料股份有限公司 | 测定磷酸二氢锂纯度的方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3484170A (en) | 1966-04-14 | 1969-12-16 | Technicon Corp | Automatic analysis method and apparatus |
| US3732164A (en) * | 1971-08-30 | 1973-05-08 | Administrator Of The Environme | Nitrogen removal from waste water by breakpoint chlorination |
| HU174711B (hu) | 1976-04-20 | 1980-03-28 | Egyt Gyogyszervegyeszeti Gyar | Sposob i ustrojstvo analiza prob zhidkostej |
| HUT61104A (en) | 1987-03-11 | 1992-11-30 | Gyoergy Horvai | Method for potenciometric detecting concentration of a component in a liquid sample |
| JPS6478164A (en) * | 1987-09-19 | 1989-03-23 | Nihon Parkerizing | Automatic analysis apparatus for phosphate chemical conversion bath liquid |
| US4810331A (en) | 1987-10-13 | 1989-03-07 | The Clorox Company | Surfactant sensing electrode for potentiometric titrations |
| US5149661A (en) * | 1988-06-08 | 1992-09-22 | Sarasep, Inc. | Fluid analysis with particulate reagent suspension |
| US5192509A (en) * | 1991-08-22 | 1993-03-09 | Halliburton Company | Apparatus for automatic titration |
| US5447612A (en) * | 1993-02-01 | 1995-09-05 | Protein Technologies, Inc. | Buffering system and its use in electrophoretic processes |
-
1997
- 1997-09-09 GB GBGB9719142.3A patent/GB9719142D0/en not_active Ceased
-
1998
- 1998-09-09 HU HU0004774A patent/HUP0004774A3/hu unknown
- 1998-09-09 DE DE69840450T patent/DE69840450D1/de not_active Expired - Lifetime
- 1998-09-09 CA CA2303205A patent/CA2303205C/en not_active Expired - Fee Related
- 1998-09-09 JP JP2000511061A patent/JP2001516054A/ja active Pending
- 1998-09-09 ES ES98942856T patent/ES2319469T3/es not_active Expired - Lifetime
- 1998-09-09 AT AT98942856T patent/ATE420350T1/de not_active IP Right Cessation
- 1998-09-09 AU AU90834/98A patent/AU742335B2/en not_active Ceased
- 1998-09-09 CN CNB988106876A patent/CN1157600C/zh not_active Expired - Fee Related
- 1998-09-09 EP EP98942856A patent/EP1012599B1/en not_active Expired - Lifetime
- 1998-09-09 WO PCT/GB1998/002711 patent/WO1999013328A1/en not_active Ceased
-
2003
- 2003-08-05 US US10/633,517 patent/US6913930B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69840450D1 (de) | 2009-02-26 |
| CN1157600C (zh) | 2004-07-14 |
| EP1012599A1 (en) | 2000-06-28 |
| CN1278331A (zh) | 2000-12-27 |
| HK1026479A1 (en) | 2000-12-15 |
| HUP0004774A3 (en) | 2003-11-28 |
| AU742335B2 (en) | 2001-12-20 |
| AU9083498A (en) | 1999-03-29 |
| US6913930B2 (en) | 2005-07-05 |
| WO1999013328A1 (en) | 1999-03-18 |
| ES2319469T3 (es) | 2009-05-07 |
| CA2303205A1 (en) | 1999-03-18 |
| HUP0004774A2 (hu) | 2001-06-28 |
| EP1012599B1 (en) | 2009-01-07 |
| JP2001516054A (ja) | 2001-09-25 |
| US20040023405A1 (en) | 2004-02-05 |
| GB9719142D0 (en) | 1997-11-12 |
| ATE420350T1 (de) | 2009-01-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20140909 |