CA2302874C - Jnk3 modulators and methods of use - Google Patents

Jnk3 modulators and methods of use Download PDF

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Publication number
CA2302874C
CA2302874C CA2302874A CA2302874A CA2302874C CA 2302874 C CA2302874 C CA 2302874C CA 2302874 A CA2302874 A CA 2302874A CA 2302874 A CA2302874 A CA 2302874A CA 2302874 C CA2302874 C CA 2302874C
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Prior art keywords
jnk3
compound
leu
cell
ser
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Expired - Fee Related
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CA2302874A
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English (en)
French (fr)
Other versions
CA2302874A1 (en
Inventor
Roger J. Davis
Richard A. Flavell
Pasko Rakic
Alan J. Whitmarsh
Chia-Yi Kuan
Di Yang
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Yale University
University of Massachusetts Amherst
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Yale University
University of Massachusetts Amherst
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K67/0276Knock-out vertebrates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00Drugs for disorders of the nervous system
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00Drugs for disorders of the nervous system
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00Drugs for disorders of the nervous system
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    • A61P25/00Drugs for disorders of the nervous system
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747Apoptosis related proteins
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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/12Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • AHUMAN NECESSITIES
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    • A01K2217/00Genetically modified animals
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    • A01K2217/00Genetically modified animals
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    • AHUMAN NECESSITIES
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    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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    • A01K2267/0306Animal model for genetic diseases
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    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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    • A01K2267/03Animal model, e.g. for test or diseases
    • A01K2267/035Animal model for multifactorial diseases
    • A01K2267/0356Animal model for processes and diseases of the central nervous system, e.g. stress, learning, schizophrenia, pain, epilepsy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Environmental Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Psychology (AREA)
  • Oncology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Plant Pathology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
CA2302874A 1997-10-03 1998-10-05 Jnk3 modulators and methods of use Expired - Fee Related CA2302874C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6099597P 1997-10-03 1997-10-03
US60/060,995 1997-10-03
PCT/US1998/020904 WO1999018193A1 (en) 1997-10-03 1998-10-05 Jnk3 modulators and methods of use

Publications (2)

Publication Number Publication Date
CA2302874A1 CA2302874A1 (en) 1999-04-15
CA2302874C true CA2302874C (en) 2011-07-12

Family

ID=22033003

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2302874A Expired - Fee Related CA2302874C (en) 1997-10-03 1998-10-05 Jnk3 modulators and methods of use

Country Status (7)

Country Link
US (3) US6943000B2 (https=)
EP (1) EP1027429B1 (https=)
JP (2) JP2001519146A (https=)
AU (1) AU756401B2 (https=)
CA (1) CA2302874C (https=)
DE (2) DE69837931T2 (https=)
WO (1) WO1999018193A1 (https=)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6294350B1 (en) * 1997-06-05 2001-09-25 Dalhousie University Methods for treating fibroproliferative diseases
US5877309A (en) * 1997-08-13 1999-03-02 Isis Pharmaceuticals, Inc. Antisense oligonucleotides against JNK
US6943000B2 (en) * 1997-10-03 2005-09-13 University Of Massachusetts JNK3 modulators and methods of use
US7383135B1 (en) * 1998-05-04 2008-06-03 Vertex Pharmaceuticals Incorporated Methods of designing inhibitors for JNK kinases
US6811992B1 (en) * 1998-05-14 2004-11-02 Ya Fang Liu Method for identifying MLK inhibitors for the treatment of neurological conditions
US6653064B1 (en) 1999-09-23 2003-11-25 Boehringer Ingelheim International Gmbh Method for identifying compounds useful in the therapy of bone disorders
EP1087230A1 (en) * 1999-09-24 2001-03-28 Boehringer Ingelheim International GmbH Method for identifying compounds useful in the therapy of bone disorders
DE10036501B4 (de) * 2000-07-25 2004-08-19 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Verfahren zur Messung der JNK/SAPKs-Aktivität mittels der Bestimmung der Phosphorylierung von Transkriptionsfaktoren
DE10037759A1 (de) * 2000-08-03 2002-07-04 Gruenenthal Gmbh Screeningverfahren
US7049080B2 (en) * 2000-08-11 2006-05-23 Joachim Kramer Process for detecting serine/threonine kinase activity
EP1860199B1 (en) 2001-01-12 2014-03-05 Exelixis, Inc. Modulating insulin receptor signaling
DE60312656T2 (de) * 2002-01-31 2007-11-29 Daiichi Pharmaceutical Co., Ltd. Arzneimittel zur behandlung von störungen des zirkadianen rhythmus
US9061009B2 (en) * 2007-06-08 2015-06-23 University Of Massachusetts Mixed lineage kinases and metabolic disorders
WO2009009045A2 (en) * 2007-07-10 2009-01-15 The Scripps Research Institute Escape libraries of target polypeptides
US20120077753A1 (en) 2009-06-25 2012-03-29 Laxman Gangwani Jnk inhibitors for use in treating spinal muscular atrophy
WO2018152223A1 (en) * 2017-02-15 2018-08-23 University Of Massachusetts Methods of treating angiogenesis-related disorders using jnk3 inhibitors

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5593844A (en) * 1990-11-19 1997-01-14 Genentech, Inc. Ligand-mediated immunofunctional hormone binding protein assay method
US5534426A (en) 1993-07-19 1996-07-09 The Regents Of The University Of California Oncoprotein protein kinase
US6514745B1 (en) 1993-07-19 2003-02-04 The Regents Of The University Of California Oncoprotein protein kinase
US6001584A (en) 1993-07-19 1999-12-14 The Regents Of The University Of California Oncoprotein protein kinase
US5736381A (en) 1995-05-19 1998-04-07 Davis; Roger J. Cytokine-, stress-, and oncoprotein-activated human protein kinase kinases
US6043083A (en) 1997-04-28 2000-03-28 Davis; Roger J. Inhibitors of the JNK signal transduction pathway and methods of use
US6420338B1 (en) * 1997-06-13 2002-07-16 New York University Medical Center Inhibition of the Src kinase family pathway as a method of treating HBV infection and hepatocellular carcinoma
AU7937398A (en) 1997-07-03 1999-01-25 Asahi Kasei Kogyo Kabushiki Kaisha Novel mapk kinase
US5877309A (en) * 1997-08-13 1999-03-02 Isis Pharmaceuticals, Inc. Antisense oligonucleotides against JNK
US6943000B2 (en) * 1997-10-03 2005-09-13 University Of Massachusetts JNK3 modulators and methods of use

Also Published As

Publication number Publication date
WO1999018193A1 (en) 1999-04-15
AU756401B2 (en) 2003-01-09
CA2302874A1 (en) 1999-04-15
US20060035303A1 (en) 2006-02-16
EP1027429B1 (en) 2007-06-13
AU1186099A (en) 1999-04-27
DE69841792D1 (de) 2010-09-09
DE69837931D1 (de) 2007-07-26
US6943000B2 (en) 2005-09-13
US20120240247A1 (en) 2012-09-20
JP2001519146A (ja) 2001-10-23
HK1031128A1 (en) 2001-06-01
EP1027429A1 (en) 2000-08-16
DE69837931T2 (de) 2008-02-21
US20030023990A1 (en) 2003-01-30
JP2010233570A (ja) 2010-10-21
EP1027429A4 (en) 2002-11-20

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