CA2298821A1 - Catalyseurs pyridines 4-substitues supernucleophiles, et procedes utiles pour la preparation de ceux-ci - Google Patents
Catalyseurs pyridines 4-substitues supernucleophiles, et procedes utiles pour la preparation de ceux-ci Download PDFInfo
- Publication number
- CA2298821A1 CA2298821A1 CA002298821A CA2298821A CA2298821A1 CA 2298821 A1 CA2298821 A1 CA 2298821A1 CA 002298821 A CA002298821 A CA 002298821A CA 2298821 A CA2298821 A CA 2298821A CA 2298821 A1 CA2298821 A1 CA 2298821A1
- Authority
- CA
- Canada
- Prior art keywords
- processes
- substituted
- substitution
- supernucleophilic
- pyridine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 title abstract 5
- -1 4-substituted-pyridine Chemical class 0.000 title abstract 3
- 239000003054 catalyst Substances 0.000 title abstract 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- 238000006467 substitution reaction Methods 0.000 abstract 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 abstract 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 abstract 1
- 150000003928 4-aminopyridines Chemical class 0.000 abstract 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
- B01J31/0234—Nitrogen-, phosphorus-, arsenic- or antimony-containing compounds
- B01J31/0235—Nitrogen containing compounds
- B01J31/0237—Amines
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
- B01J31/0234—Nitrogen-, phosphorus-, arsenic- or antimony-containing compounds
- B01J31/0235—Nitrogen containing compounds
- B01J31/0244—Nitrogen containing compounds with nitrogen contained as ring member in aromatic compounds or moieties, e.g. pyridine
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J35/00—Catalysts, in general, characterised by their form or physical properties
- B01J35/40—Catalysts, in general, characterised by their form or physical properties characterised by dimensions, e.g. grain size
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J37/00—Processes, in general, for preparing catalysts; Processes, in general, for activation of catalysts
- B01J37/0009—Use of binding agents; Moulding; Pressing; Powdering; Granulating; Addition of materials ameliorating the mechanical properties of the product catalyst
- B01J37/0063—Granulating
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
- B01J2231/40—Substitution reactions at carbon centres, e.g. C-C or C-X, i.e. carbon-hetero atom, cross-coupling, C-H activation or ring-opening reactions
- B01J2231/42—Catalytic cross-coupling, i.e. connection of previously not connected C-atoms or C- and X-atoms without rearrangement
- B01J2231/4205—C-C cross-coupling, e.g. metal catalyzed or Friedel-Crafts type
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pyridine Compounds (AREA)
- Catalysts (AREA)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002602287A CA2602287A1 (fr) | 1997-08-01 | 1998-07-31 | Catalyseurs thermostables des aminopyridines |
CA2602286A CA2602286C (fr) | 1997-08-01 | 1998-07-31 | Processus de preparation des 4-aminopyridines au moyen d'intermediaires de betaines pyridines et de betaines pyridines |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5508697P | 1997-08-01 | 1997-08-01 | |
US5447397P | 1997-08-01 | 1997-08-01 | |
US60/055,086 | 1997-08-01 | ||
US60/054,473 | 1997-08-01 | ||
PCT/US1998/016024 WO1999006370A1 (fr) | 1997-08-01 | 1998-07-31 | Catalyseurs pyridines 4-substitues supernucleophiles, et procedes utiles pour la preparation de ceux-ci |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002602287A Division CA2602287A1 (fr) | 1997-08-01 | 1998-07-31 | Catalyseurs thermostables des aminopyridines |
CA2602286A Division CA2602286C (fr) | 1997-08-01 | 1998-07-31 | Processus de preparation des 4-aminopyridines au moyen d'intermediaires de betaines pyridines et de betaines pyridines |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2298821A1 true CA2298821A1 (fr) | 1999-02-11 |
CA2298821C CA2298821C (fr) | 2007-11-20 |
Family
ID=26733072
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002298821A Expired - Lifetime CA2298821C (fr) | 1997-08-01 | 1998-07-31 | Catalyseurs pyridines 4-substitues supernucleophiles, et procedes utiles pour la preparation de ceux-ci |
Country Status (12)
Country | Link |
---|---|
US (4) | US6369230B1 (fr) |
EP (1) | EP1012141B1 (fr) |
JP (2) | JP4150497B2 (fr) |
KR (1) | KR20010022497A (fr) |
CN (3) | CN1239484C (fr) |
AT (2) | ATE416165T1 (fr) |
AU (1) | AU8681498A (fr) |
CA (1) | CA2298821C (fr) |
DE (2) | DE69829188T2 (fr) |
ES (2) | ES2318083T3 (fr) |
TW (1) | TW580408B (fr) |
WO (1) | WO1999006370A1 (fr) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1239484C (zh) * | 1997-08-01 | 2006-02-01 | 莱利工业公司 | 制备4-(仲或叔)氨基吡啶化合物的方法 |
EP1144379A4 (fr) * | 1999-01-21 | 2003-04-16 | Reilly Ind Inc | Produits fluides a base d'aminopyridine se transformant peu en poussiere |
US8075812B2 (en) | 2007-04-04 | 2011-12-13 | Sabic Innovative Plastics Ip B.V. | Method of separating a poly(arylene ether) composition from a solvent, and poly(arylene ether) composition prepared thereby |
CN101845015B (zh) * | 2010-06-04 | 2012-09-05 | 安徽省郎溪县联科实业有限公司 | 一种4-二甲氨基吡啶的精制分离及干燥方法 |
IT1400395B1 (it) * | 2010-06-08 | 2013-05-31 | Procos Spa | Processo one-pot per la sintesi di dalfampridine. |
CN103787963A (zh) * | 2013-12-20 | 2014-05-14 | 安徽国星生物化学有限公司 | 高效制备4-二甲氨基吡啶 |
CN110655489A (zh) * | 2019-11-11 | 2020-01-07 | 安徽瑞邦生物科技有限公司 | 一种挥发再结晶提纯4-氰基吡啶的方法 |
CN111592488A (zh) * | 2019-11-18 | 2020-08-28 | 河南郑大嘉源环保技术有限公司 | 一种高效制备4-二甲氨基吡啶的方法 |
CN111454201B (zh) * | 2020-04-15 | 2022-01-04 | 杭州瑞思新材料有限公司 | 一种制备高效酰化催化剂材料的新方法 |
CN111320572B (zh) * | 2020-04-15 | 2021-07-23 | 杭州瑞思新材料有限公司 | 一种取代吡啶的制备方法 |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3452018A (en) * | 1966-08-29 | 1969-06-24 | American Home Prod | 1 - (2 - substituted - 6 - arylsulfonamidopyrimidin - 4 - yl)pyridinium hydroxide inner salts |
US3509165A (en) * | 1967-03-24 | 1970-04-28 | Us Agriculture | Process for preparing pyridinium betaines and derivatives |
US4012437A (en) * | 1972-02-07 | 1977-03-15 | Rohm And Haas Company | Method of producing betaines, monomers and polymers containing betaine-type units and novel and useful copolymers thereby obtained |
US4013437A (en) | 1975-05-15 | 1977-03-22 | Owens-Illinois, Inc. | Method for forming glass bottles |
US4120859A (en) * | 1977-01-27 | 1978-10-17 | Cilag-Chemie A.G. | (N-Substituted-pyridyl)-alkyl sulfonic acid betaines as electroplating additives |
US4150232A (en) * | 1977-07-15 | 1979-04-17 | Cilag-Chemie A.G. | 1-Carboxymethyl-3-sulfoloweralkyl pyridinium betaine inner salts |
US4158093A (en) * | 1977-12-15 | 1979-06-12 | Reilly Tar & Chemical Corporation | Process for substituting and dequaternizing pyridylethyl quaternary salts of pyridine and bypyridine bases |
EP0012192B1 (fr) | 1978-12-08 | 1983-01-12 | Santrade Ltd. | Dispositif pour extruder des masses fluides d'un récipient |
US4287338A (en) * | 1980-03-10 | 1981-09-01 | The Upjohn Company | Sulfooxy-pyrimidinium, -pyridinium, and -triazinium hydroxide inner salts |
JPS5890580A (ja) * | 1981-09-11 | 1983-05-30 | レイリー・インダストリーズ・インコーポレーテッド | 4−(4′−メチルピペリジノ)ピリジン |
DE3215451A1 (de) * | 1982-04-24 | 1983-10-27 | Hoechst Ag, 6230 Frankfurt | Betain-aminoxide, verfahren zu ihrer herstellung und ihre verwendung als tenside |
US4591625A (en) * | 1984-11-26 | 1986-05-27 | University Of Southern Mississippi | Monomer and polymers containing 4-aminopyridine |
US4672121A (en) * | 1985-01-16 | 1987-06-09 | Nepera Chemical Co. | Preparation of 4-substituted pyridines using quaternary pyridine salts |
US4772713A (en) * | 1985-01-16 | 1988-09-20 | Nepera, Inc. | Quaternary pyridine salts useful for preparation of 4-substituted pyridines |
US4882405A (en) | 1985-12-30 | 1989-11-21 | Exxon Research And Engineering Company | Terpolymers of acrylamide, alkylacrylamide and betaine monomers |
US4742135A (en) | 1985-12-30 | 1988-05-03 | Exxon Research And Engineering Company | Terpolymers of acrylamide, alkylacrylamide and betaine monomers |
US5234918A (en) * | 1988-04-04 | 1993-08-10 | American Cyanamid Company | Certain phosphinyl-oxy-phenyl-methyl-pyridinium-hydroxide inner salts useful as antagonists of PAF |
DE4013349A1 (de) * | 1990-04-23 | 1991-10-24 | Schering Ag | 1-(2-sulfoaethyl)pyridiniumbetain, verfahren zu dessen herstellung sowie saure nickelbaeder enthaltend diese verbindung |
US5006628A (en) * | 1990-08-15 | 1991-04-09 | Eastman Kodak Company | Melt phase polyarylate process |
US5136092A (en) * | 1991-03-18 | 1992-08-04 | Ethyl Corporation | Process for treating tertiary amines |
US5359139A (en) * | 1991-03-18 | 1994-10-25 | Albemarle Corporation | Tertiary amine treatment |
NL9101702A (nl) * | 1991-10-11 | 1993-05-03 | Dsm Nv | Uithardingskatalysator voor de reaktie tussen carboxyl-functionele polymeren en epoxyfunctionele verbindingen als basis van poedercoatings. |
WO1993008150A1 (fr) * | 1991-10-15 | 1993-04-29 | Indiana University Foundation | Esters d'hydrolyse utilisant des catalyseurs a base de 4-amino-pyridyle siloxane |
DE4211190A1 (de) | 1992-04-03 | 1993-10-07 | Hoechst Ag | Verfahren zur Herstellung von wäßrigen Betainlösungen |
US5245036A (en) * | 1992-05-07 | 1993-09-14 | Dowelanco | Process for the preparation of 4-phenoxyquinoline compounds |
DE4232157A1 (de) * | 1992-09-25 | 1994-03-31 | Hoechst Ag | Verfahren zur Herstellung von reinen wäßrigen Betainlösungen |
CN1239484C (zh) * | 1997-08-01 | 2006-02-01 | 莱利工业公司 | 制备4-(仲或叔)氨基吡啶化合物的方法 |
-
1998
- 1998-07-31 CN CNB021302286A patent/CN1239484C/zh not_active Expired - Lifetime
- 1998-07-31 AU AU86814/98A patent/AU8681498A/en not_active Abandoned
- 1998-07-31 DE DE69829188T patent/DE69829188T2/de not_active Expired - Lifetime
- 1998-07-31 ES ES03027035T patent/ES2318083T3/es not_active Expired - Lifetime
- 1998-07-31 CN CNB02130226XA patent/CN1159104C/zh not_active Expired - Lifetime
- 1998-07-31 US US09/463,902 patent/US6369230B1/en not_active Expired - Lifetime
- 1998-07-31 ES ES98938244T patent/ES2236927T3/es not_active Expired - Lifetime
- 1998-07-31 WO PCT/US1998/016024 patent/WO1999006370A1/fr active IP Right Grant
- 1998-07-31 JP JP2000505129A patent/JP4150497B2/ja not_active Expired - Fee Related
- 1998-07-31 AT AT03027035T patent/ATE416165T1/de active
- 1998-07-31 US US09/127,542 patent/US6046336A/en not_active Expired - Lifetime
- 1998-07-31 CA CA002298821A patent/CA2298821C/fr not_active Expired - Lifetime
- 1998-07-31 AT AT98938244T patent/ATE289993T1/de active
- 1998-07-31 DE DE69840305T patent/DE69840305D1/de not_active Expired - Lifetime
- 1998-07-31 EP EP98938244A patent/EP1012141B1/fr not_active Expired - Lifetime
- 1998-07-31 KR KR1020007001083A patent/KR20010022497A/ko not_active Application Discontinuation
- 1998-07-31 CN CNB988095661A patent/CN1280274C/zh not_active Expired - Lifetime
- 1998-08-01 TW TW087112697A patent/TW580408B/zh not_active IP Right Cessation
-
2001
- 2001-11-06 US US09/993,046 patent/US6603010B2/en not_active Expired - Lifetime
-
2003
- 2003-04-29 US US10/425,504 patent/US6958400B2/en not_active Expired - Lifetime
-
2007
- 2007-08-03 JP JP2007202584A patent/JP2008030037A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
DE69829188T2 (de) | 2005-12-29 |
US6046336A (en) | 2000-04-04 |
CN1404923A (zh) | 2003-03-26 |
US20030232995A1 (en) | 2003-12-18 |
EP1012141A4 (fr) | 2000-12-27 |
KR20010022497A (ko) | 2001-03-15 |
JP4150497B2 (ja) | 2008-09-17 |
ES2318083T3 (es) | 2009-05-01 |
ES2236927T3 (es) | 2005-07-16 |
ATE416165T1 (de) | 2008-12-15 |
DE69829188D1 (de) | 2005-04-07 |
US6603010B2 (en) | 2003-08-05 |
US6369230B1 (en) | 2002-04-09 |
CN1159104C (zh) | 2004-07-28 |
TW580408B (en) | 2004-03-21 |
JP2008030037A (ja) | 2008-02-14 |
CA2298821C (fr) | 2007-11-20 |
AU8681498A (en) | 1999-02-22 |
CN1491943A (zh) | 2004-04-28 |
WO1999006370A1 (fr) | 1999-02-11 |
JP2001512102A (ja) | 2001-08-21 |
CN1280274C (zh) | 2006-10-18 |
CN1239484C (zh) | 2006-02-01 |
EP1012141B1 (fr) | 2005-03-02 |
US20020165087A1 (en) | 2002-11-07 |
CN1271344A (zh) | 2000-10-25 |
DE69840305D1 (de) | 2009-01-15 |
ATE289993T1 (de) | 2005-03-15 |
EP1012141A1 (fr) | 2000-06-28 |
US6958400B2 (en) | 2005-10-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HUP0100324A3 (en) | Substituted pyridine and biphenyl derivatives as anti-hypercholesterinemic, anti-hyperlipoproteinemic and anti-hyperglycemic agents, process for producing them and pharmaceutical compositions containing them | |
CA2298821A1 (fr) | Catalyseurs pyridines 4-substitues supernucleophiles, et procedes utiles pour la preparation de ceux-ci | |
IL89175A0 (en) | Ultrasonic contrast agents and processes for the preparation thereof | |
EP0636617A3 (fr) | Procédé pour la préparation de N-(2-hydroxyéthyle)pipérazine. | |
PL325554A1 (en) | Method of obtaining difluoromethane | |
WO1998054183A3 (fr) | Derives d'ergoline | |
CA2135491A1 (fr) | Methode pour l'obtention d'amines aromatiques substituees | |
HUP9800865A3 (en) | Condensed piperidine-derivatives, process for producing them and pharmaceutical compositions containing them | |
ES2006079A6 (es) | Un procedimiento de preparacion de polimeros yodados. | |
WO2001000577A3 (fr) | Preparation de piperidine-4-ones substituees | |
EP1422222A3 (fr) | Catalyseurs supernucleophiles dérivés de la 4-[(di)alkylamino]pyridine et procédé pour leur préparation | |
MY130818A (en) | Process for the preparation of salt melts using an extruder, and the use thereof | |
EP0381130A3 (fr) | Préparation d'amines alpha-insaturées | |
IL135710A0 (en) | Method of synthesis of pyrrole amides | |
AU9258798A (en) | Substituted tetrahydropyrane derivatives, method for producing same, the ir use as medicine or diagnostic agent, as well as medicine containing same | |
CA2054105A1 (fr) | Methode de preparation d'un sel de 4-hydroxystyrene et de preparation du 4-tertio-butoxycarbonyloxystyrene a partir de celui-ci | |
CA2174797A1 (fr) | Halogenure de cyanobenzenesulfenyle et methode de preparation de derive de substitution en 3 de benzisothiazole a l'aide de ce compose | |
CA2298805A1 (fr) | Procede pour la preparation d'acide 3-cyano-2,4-dihalogene-5-fluor-benzoique | |
HRP20010457B1 (en) | Method for preparing polyhalogenated paratrifluoromethylanilines | |
IL141049A0 (en) | Methoximinophenylacetic acid amides | |
HK1027560A1 (en) | Method for producing 1,3-disubstituted 2-nitroguanidines | |
AU2629695A (en) | Novel amine derivative, process for producing the same, and use thereof as antiarrhythmic | |
WO2002102769A3 (fr) | Methodes de synthese de pyrimidines substituees | |
IL124820A0 (en) | Process for preparing 3,3-dimethylbutyric acid | |
CA2338649A1 (fr) | Nouveaux derives phenylethylamines, leurs procedes de preparation et leur utilisation comme compositions pharmaceutiques |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKEX | Expiry |
Effective date: 20180731 |