CA2295740A1 - Utilisation d'emulsions huile dans eau submicroniques avec des vaccins a adn - Google Patents
Utilisation d'emulsions huile dans eau submicroniques avec des vaccins a adn Download PDFInfo
- Publication number
- CA2295740A1 CA2295740A1 CA002295740A CA2295740A CA2295740A1 CA 2295740 A1 CA2295740 A1 CA 2295740A1 CA 002295740 A CA002295740 A CA 002295740A CA 2295740 A CA2295740 A CA 2295740A CA 2295740 A1 CA2295740 A1 CA 2295740A1
- Authority
- CA
- Canada
- Prior art keywords
- antigen
- vector
- virus
- submicron oil
- viral
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/29—Hepatitis virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/29—Hepatitis virus
- A61K39/292—Serum hepatitis virus, hepatitis B virus, e.g. Australia antigen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Mycology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
Cette invention concerne l'utilisation d'émulsions huile dans eau submicroniques avec des techniques d'immunisation par acides nucléiques. Le procédé comprend l'immunisation avec des compositions vaccinales contenant des molécules d'acides nucléiques codant au moins un antigène spécifique, ainsi que l'administration d'un adjuvant huile dans eau submicronique tel que MF59. L'adjuvant peut être administré avant, après ou bien en même temps que les vaccins à base d'acides nucléiques.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5194497P | 1997-07-08 | 1997-07-08 | |
US60/051,944 | 1997-07-08 | ||
US5475697P | 1997-08-05 | 1997-08-05 | |
US60/054,756 | 1997-08-05 | ||
PCT/US1998/014310 WO1999002132A2 (fr) | 1997-07-08 | 1998-07-08 | Utilisation d'emulsions huile dans eau submicroniques avec des vaccins a adn |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2295740A1 true CA2295740A1 (fr) | 1999-01-21 |
Family
ID=26729981
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002295740A Abandoned CA2295740A1 (fr) | 1997-07-08 | 1998-07-08 | Utilisation d'emulsions huile dans eau submicroniques avec des vaccins a adn |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1006999A2 (fr) |
JP (1) | JP2002509545A (fr) |
AU (1) | AU8298298A (fr) |
CA (1) | CA2295740A1 (fr) |
WO (1) | WO1999002132A2 (fr) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2875700A (en) * | 1999-02-26 | 2000-09-14 | Chiron Corporation | Microemulsions with adsorbed macromoelecules and microparticles |
EA006233B1 (ru) | 1999-05-13 | 2005-10-27 | Уайт Холдингз Корпорейшн | Комбинированные адъювантные композиции для усиления иммунного ответа у позвоночного животного |
AR045702A1 (es) * | 2001-10-03 | 2005-11-09 | Chiron Corp | Composiciones de adyuvantes. |
GB0622282D0 (en) | 2006-11-08 | 2006-12-20 | Novartis Ag | Quality control methods |
WO2009120811A1 (fr) * | 2008-03-25 | 2009-10-01 | Juvaris Biotherapeutics, Inc. | Amélioration d’une réponse immunitaire par l’administration d’un complexe adn-lipide cationique (cldc) |
GB0822001D0 (en) * | 2008-12-02 | 2009-01-07 | Glaxosmithkline Biolog Sa | Vaccine |
MX2012011340A (es) * | 2010-03-29 | 2012-11-16 | Novartis Ag | Composicion que comprende el peptido amiloide beta 1-6acoplado a una particula similar a virus y un auxiliar. |
JP6025721B2 (ja) | 2010-07-06 | 2016-11-16 | ノバルティス アーゲー | カチオン性水中油型エマルジョン |
MX350198B (es) | 2011-07-06 | 2017-08-30 | Novartis Ag | Emulsiones aceite en agua que contienen acidos nucleicos. |
WO2013006837A1 (fr) | 2011-07-06 | 2013-01-10 | Novartis Ag | Emulsions huile dans eau cationiques |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU212924B (en) * | 1989-05-25 | 1996-12-30 | Chiron Corp | Adjuvant formulation comprising a submicron oil droplet emulsion |
ATE302854T1 (de) * | 1993-01-26 | 2005-09-15 | Univ Pennsylvania | Zusammensetzungen und verfahren zur verabreichung von genetischem material |
JPH10501136A (ja) * | 1994-06-02 | 1998-02-03 | カイロン コーポレイション | ウイルスに基づく感染/トランスフェクションシステムを用いる核酸免疫化 |
-
1998
- 1998-07-08 EP EP98933312A patent/EP1006999A2/fr not_active Withdrawn
- 1998-07-08 AU AU82982/98A patent/AU8298298A/en not_active Abandoned
- 1998-07-08 JP JP50895399A patent/JP2002509545A/ja active Pending
- 1998-07-08 CA CA002295740A patent/CA2295740A1/fr not_active Abandoned
- 1998-07-08 WO PCT/US1998/014310 patent/WO1999002132A2/fr not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU8298298A (en) | 1999-02-08 |
JP2002509545A (ja) | 2002-03-26 |
WO1999002132A2 (fr) | 1999-01-21 |
WO1999002132A3 (fr) | 1999-08-12 |
EP1006999A2 (fr) | 2000-06-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
FZDE | Dead |