CA2293708C - Enzymatic kinetic resolution of an intermediate useful for preparing substituted tricyclics - Google Patents

Enzymatic kinetic resolution of an intermediate useful for preparing substituted tricyclics Download PDF

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Publication number
CA2293708C
CA2293708C CA002293708A CA2293708A CA2293708C CA 2293708 C CA2293708 C CA 2293708C CA 002293708 A CA002293708 A CA 002293708A CA 2293708 A CA2293708 A CA 2293708A CA 2293708 C CA2293708 C CA 2293708C
Authority
CA
Canada
Prior art keywords
trifluoroethyl
formula
compound
acylation
acylating agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002293708A
Other languages
English (en)
French (fr)
Other versions
CA2293708A1 (en
Inventor
William Brian Morgan
Jinchu Liu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of CA2293708A1 publication Critical patent/CA2293708A1/en
Application granted granted Critical
Publication of CA2293708C publication Critical patent/CA2293708C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
    • C12P41/007—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures by reactions involving acyl derivatives of racemic amines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • C12P17/165—Heterorings having nitrogen atoms as the only ring heteroatoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA002293708A 1997-06-17 1998-06-15 Enzymatic kinetic resolution of an intermediate useful for preparing substituted tricyclics Expired - Fee Related CA2293708C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87767597A 1997-06-17 1997-06-17
US08/877,675 1997-06-17
PCT/US1998/011501 WO1998058073A1 (en) 1997-06-17 1998-06-15 Enzymatic kinetic resolution of an intermediate useful for preparing substituted tricyclics

Publications (2)

Publication Number Publication Date
CA2293708A1 CA2293708A1 (en) 1998-12-23
CA2293708C true CA2293708C (en) 2004-05-11

Family

ID=25370483

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002293708A Expired - Fee Related CA2293708C (en) 1997-06-17 1998-06-15 Enzymatic kinetic resolution of an intermediate useful for preparing substituted tricyclics

Country Status (9)

Country Link
EP (1) EP1002123A1 (OSRAM)
JP (1) JP3421355B2 (OSRAM)
AR (1) AR015892A1 (OSRAM)
AU (1) AU8058398A (OSRAM)
CA (1) CA2293708C (OSRAM)
IN (1) IN187248B (OSRAM)
MY (1) MY133532A (OSRAM)
WO (1) WO1998058073A1 (OSRAM)
ZA (1) ZA985217B (OSRAM)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6706883B1 (en) 1998-07-02 2004-03-16 Schering Corporation Process for producing (8-chloro-3,10-dibromo-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-B]pyridin-11-YL)-1-piperdine
JP2002519419A (ja) * 1998-07-02 2002-07-02 シェーリング コーポレイション （８−クロロ−３，１０−ジブロモ−６，１１−ジヒドロ−５ｈ−ベンゾ［５，６］シクロヘプタ［１，２−ｂ］ピリジン−１１−イル）−１−ピペリジンを生成するためのプロセス
ES2274854T3 (es) * 2000-05-08 2007-06-01 Pfizer Products Inc. Resolucion enzimatica de moduladores selectivos del receptor de estrogeno.

Also Published As

Publication number Publication date
JP2000512862A (ja) 2000-10-03
ZA985217B (en) 1999-01-07
CA2293708A1 (en) 1998-12-23
WO1998058073A1 (en) 1998-12-23
AR015892A1 (es) 2001-05-30
IN187248B (OSRAM) 2002-03-09
EP1002123A1 (en) 2000-05-24
MY133532A (en) 2007-11-30
AU8058398A (en) 1999-01-04
JP3421355B2 (ja) 2003-06-30

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