CA2292843A1 - Reactifs et methodes utiles pour detecter des pathologies mammaires - Google Patents

Reactifs et methodes utiles pour detecter des pathologies mammaires Download PDF

Info

Publication number
CA2292843A1
CA2292843A1 CA002292843A CA2292843A CA2292843A1 CA 2292843 A1 CA2292843 A1 CA 2292843A1 CA 002292843 A CA002292843 A CA 002292843A CA 2292843 A CA2292843 A CA 2292843A CA 2292843 A1 CA2292843 A1 CA 2292843A1
Authority
CA
Canada
Prior art keywords
sequence
polypeptide
polynucleotide
antigen
fragments
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002292843A
Other languages
English (en)
Inventor
Patricia A. Billing-Medel
Maurice Cohen
Tracey L. Colpitts
Paula N. Friedman
Julian Gordon
Edward N. Granados
Steven C. Hodges
Michael R. Klass
Jon D. Kratochvil
John C. Russell
Stephen D. Stroupe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2292843A1 publication Critical patent/CA2292843A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3015—Breast
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57415—Specifically defined cancers of breast
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Pathology (AREA)
  • Oncology (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • General Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)

Abstract

L'invention concerne une série de séquences ARNc contiguës et se chevauchant partiellement, ainsi que des polypeptides codés par celles-ci, appelées BS202 et transcrites à partir de tissu mammaire. Ces séquences sont utiles pour la détection, le diagnostic, l'évolution, la surveillance, le pronostic, la prévention ou le traitement de maladies et d'états pathologiques mammaires, tels que le cancer du sein, ou encore pour la détermination de la prédisposition d'un individu à ceux-ci. L'invention concerne également des anticorps qui se lient spécifiquement à un polypeptide ou à une protéine codés par BS202, ainsi que des agonistes ou des inhibiteurs qui préviennent l'action du polypeptide BS202 spécifique au tissu, ces molécules étant utiles pour le traitement thérapeutique de pathologies, tumeurs ou métastases mammaires.
CA002292843A 1997-07-07 1998-07-07 Reactifs et methodes utiles pour detecter des pathologies mammaires Abandoned CA2292843A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US88889497A 1997-07-07 1997-07-07
US08/888,894 1997-07-07
PCT/US1998/014046 WO1999002559A1 (fr) 1997-07-07 1998-07-07 Reactifs et methodes utiles pour detecter des pathologies mammaires

Publications (1)

Publication Number Publication Date
CA2292843A1 true CA2292843A1 (fr) 1999-01-21

Family

ID=25394122

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002292843A Abandoned CA2292843A1 (fr) 1997-07-07 1998-07-07 Reactifs et methodes utiles pour detecter des pathologies mammaires

Country Status (3)

Country Link
EP (1) EP1003779A1 (fr)
CA (1) CA2292843A1 (fr)
WO (1) WO1999002559A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3422776B2 (ja) * 1998-08-04 2003-06-30 ダイアデクスアス・インコーポレーテッド 乳癌を診断、監視、病期決定、造影及び治療する新規な方法
US6737040B1 (en) 1998-08-04 2004-05-18 Diadexus, Inc. Method and antibody for imaging breast cancer
US6730477B1 (en) 1998-08-04 2004-05-04 Diadexus, Inc. Method of diagnosing, monitoring and staging breast cancer
US20020034740A1 (en) * 1999-01-21 2002-03-21 Patricia A. Billing-Medel Reagents and methods useful for detecting diseases of the breast
JP2002540761A (ja) * 1999-01-21 2002-12-03 アボット・ラボラトリーズ 乳房の疾患を検出するために有用な試薬と方法
AU2002230736A1 (en) * 2000-10-30 2002-05-15 Diadexus, Inc. Compositions and methods relating to breast specific genes and proteins
WO2002040672A2 (fr) * 2000-11-20 2002-05-23 Diadexus, Inc. Compositions et methodes relatives a des genes et des proteines specifiques aux seins
GB0720156D0 (en) * 2007-10-15 2007-11-28 Univ Nottingham Trent Breast cancer associated antigen

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6114114A (en) * 1992-07-17 2000-09-05 Incyte Pharmaceuticals, Inc. Comparative gene transcript analysis
US5889159A (en) * 1993-10-29 1999-03-30 Dana-Farber Cancer Institute, Inc. Monoclonal antibodies to tumor marker TC1 and methods for use of same
WO1996005308A1 (fr) * 1994-08-12 1996-02-22 Myriad Genetics, Inc. Procede pour diagnostiquer une predisposition au cancer du sein et des ovaires
AU6024596A (en) * 1995-05-23 1996-12-11 Regents Of The University Of California, The Abundant extracellular products and methods for their production and use
JP2002508652A (ja) * 1996-08-23 2002-03-19 ヒューマン ジノーム サイエンシーズ，インコーポレイテッド 新規なヒト増殖因子

Also Published As

Publication number Publication date
EP1003779A1 (fr) 2000-05-31
WO1999002559A1 (fr) 1999-01-21

Similar Documents

Publication Publication Date Title
CA2269634C (fr) Reactifs et procedes pour le depistage de pathologies mammaires
US20050255519A1 (en) Reagents and methods useful for detecting diseases of the prostate
WO2000056352A2 (fr) Reactifs et procedes utiles pour detecter les maladies de la prostate
EP1144449B1 (fr) Reactifs et procedes utiles pour detecter des maladies mammaires
CA2309758A1 (fr) Reactifs et procedes utiles pour detecter des maladies de la poitrine
WO1999002714A1 (fr) Reactifs et procedes utilises pour detecter les maladies du sein
CA2292843A1 (fr) Reactifs et methodes utiles pour detecter des pathologies mammaires
CA2292788A1 (fr) Reactifs et procedes utiles dans la detection de maladies pulmonaires
US20060029963A1 (en) Reagents and methods useful for detecting diseases of the breast
US20020018990A1 (en) Reagents and methods useful for detecting diseases of the breast
US20030130492A1 (en) Reagents and methods useful for detecting diseases of the breast
WO1998055656A1 (fr) Reactifs et procedes utiles en vue de la detection de maladies des voies urinaires
CA2309756A1 (fr) Reactifs et procedes utiles pour detecter les pathologies mammaires
EP1027457A1 (fr) Reactifs et procedes utiles pour detecter des maladies du sein
CA2315263A1 (fr) Reactifs et methodes s'utilisant pour detecter des affections du pancreas
CA2303404A1 (fr) Reactifs et methodes servant a detecter les maladies de la prostate
US20020188115A1 (en) Reagents and methods useful for detecting diseases of the breast
US20040072210A1 (en) Reagents and methods useful for detecting diseases of the breast
EP1042506A1 (fr) Reactifs et procedes utiles pour deceler les maladies du sein
CA2304368A1 (fr) Reactifs et procedes utiles pour detecter des maladies de la prostate, du sein et des ovaires
WO1999002734A1 (fr) Reactifs et procedes utilises pour deceler des maladies des voies urinaires

Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead