CA2288027A1 - Analogues de bradykinine inhibiteurs selectifs de l'activation cellulaire - Google Patents

Analogues de bradykinine inhibiteurs selectifs de l'activation cellulaire Download PDF

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Publication number
CA2288027A1
CA2288027A1 CA002288027A CA2288027A CA2288027A1 CA 2288027 A1 CA2288027 A1 CA 2288027A1 CA 002288027 A CA002288027 A CA 002288027A CA 2288027 A CA2288027 A CA 2288027A CA 2288027 A1 CA2288027 A1 CA 2288027A1
Authority
CA
Canada
Prior art keywords
pro
arg
amino acids
thrombin
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002288027A
Other languages
English (en)
Inventor
Alvin H. Schmaier
Ahmed A.K. Hasan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Michigan
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2288027A1 publication Critical patent/CA2288027A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C07K5/0817—Tripeptides with the first amino acid being basic the first amino acid being Arg
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/043—Kallidins; Bradykinins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8139—Cysteine protease (E.C. 3.4.22) inhibitors, e.g. cystatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/18—Kallidins; Bradykinins; Related peptides

Abstract

La présente invention concerne des analogues de la bradykinine, des compositions à base de tels peptides, et des procédés permettant d'inhiber l'activation plaquettaire ou cellulaire induite par la thrombine. Ces analogues de bradykinine sont mono ou multisegments. L'invention concerne également un procédé permettant d'identifier des composés inhibant sélectivement l'activation plaquettaire ou cellulaire induite par la thrombine.
CA002288027A 1997-04-23 1998-04-21 Analogues de bradykinine inhibiteurs selectifs de l'activation cellulaire Abandoned CA2288027A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4608597P 1997-04-23 1997-04-23
US60/046,085 1997-04-23
PCT/US1998/008015 WO1998047522A1 (fr) 1997-04-23 1998-04-21 Analogues de bradykinine inhibiteurs selectifs de l'activation cellulaire

Publications (1)

Publication Number Publication Date
CA2288027A1 true CA2288027A1 (fr) 1998-10-29

Family

ID=21941533

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002288027A Abandoned CA2288027A1 (fr) 1997-04-23 1998-04-21 Analogues de bradykinine inhibiteurs selectifs de l'activation cellulaire

Country Status (5)

Country Link
EP (1) EP1019070A4 (fr)
JP (1) JP2001518119A (fr)
CA (1) CA2288027A1 (fr)
IL (1) IL132546A0 (fr)
WO (1) WO1998047522A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6544750B1 (en) * 1999-08-17 2003-04-08 Thromgen, Inc. Peptide analogs as selective inhibitors of thrombin activation of protease activated receptor 1
US7879792B2 (en) * 2005-06-02 2011-02-01 The Regents Of The University Of Michigan Synthetic peptide inhibitors of thrombin and thrombin activation of protease activated receptors 1 and 4
JP5937612B2 (ja) 2010-12-02 2016-06-22 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ 血液安定剤を含む採血用デバイス

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4585757A (en) * 1984-07-27 1986-04-29 Texas Tech University Health Sciences Center Hypotensive active peptides
ATE114160T1 (de) * 1989-01-24 1994-12-15 Aphton Corp Immunogenische zusammensetzungen gegen gastrin- peptide.
SE468516B (sv) * 1991-06-14 1993-02-01 Kabigen Ab Nya polypeptider vilka kan utvinnas fraan tunntarmen och deras anvaendning
US5472945A (en) * 1991-08-13 1995-12-05 Temple University- Of The Commonwealth System Of Higher Education Modulation of blood pressure and inhibition of platelet activation with kininogen fragment
EP0871464B1 (fr) * 1995-06-09 2003-04-02 The Regents Of The University Of Michigan Analogues de la bradykinine utilises comme inhibiteurs selectifs de la thrombine

Also Published As

Publication number Publication date
AU7252898A (en) 1998-11-13
WO1998047522A1 (fr) 1998-10-29
EP1019070A4 (fr) 2001-05-16
EP1019070A1 (fr) 2000-07-19
JP2001518119A (ja) 2001-10-09
IL132546A0 (en) 2001-03-19
AU734935B2 (en) 2001-06-28

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued
FZDE Discontinued

Effective date: 20110421