IL132546A0 - Bradykinin analogs as selective inhibitors of cell activation - Google Patents

Bradykinin analogs as selective inhibitors of cell activation

Info

Publication number
IL132546A0
IL132546A0 IL13254698A IL13254698A IL132546A0 IL 132546 A0 IL132546 A0 IL 132546A0 IL 13254698 A IL13254698 A IL 13254698A IL 13254698 A IL13254698 A IL 13254698A IL 132546 A0 IL132546 A0 IL 132546A0
Authority
IL
Israel
Prior art keywords
cell activation
selective inhibitors
bradykinin analogs
bradykinin
analogs
Prior art date
Application number
IL13254698A
Other languages
English (en)
Original Assignee
Univ Michigan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Michigan filed Critical Univ Michigan
Publication of IL132546A0 publication Critical patent/IL132546A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C07K5/0817—Tripeptides with the first amino acid being basic the first amino acid being Arg
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/043—Kallidins; Bradykinins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8139—Cysteine protease (E.C. 3.4.22) inhibitors, e.g. cystatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/18—Kallidins; Bradykinins; Related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
IL13254698A 1997-04-23 1998-04-21 Bradykinin analogs as selective inhibitors of cell activation IL132546A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4608597P 1997-04-23 1997-04-23
PCT/US1998/008015 WO1998047522A1 (en) 1997-04-23 1998-04-21 Bradykinin analogs as selective inhibitors of cell activation

Publications (1)

Publication Number Publication Date
IL132546A0 true IL132546A0 (en) 2001-03-19

Family

ID=21941533

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13254698A IL132546A0 (en) 1997-04-23 1998-04-21 Bradykinin analogs as selective inhibitors of cell activation

Country Status (5)

Country Link
EP (1) EP1019070A4 (xx)
JP (1) JP2001518119A (xx)
CA (1) CA2288027A1 (xx)
IL (1) IL132546A0 (xx)
WO (1) WO1998047522A1 (xx)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6544750B1 (en) * 1999-08-17 2003-04-08 Thromgen, Inc. Peptide analogs as selective inhibitors of thrombin activation of protease activated receptor 1
US7879792B2 (en) * 2005-06-02 2011-02-01 The Regents Of The University Of Michigan Synthetic peptide inhibitors of thrombin and thrombin activation of protease activated receptors 1 and 4
AU2011336345B2 (en) 2010-12-02 2016-07-07 Becton, Dickinson And Company Blood collection devices containing blood stabilization agent

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4585757A (en) * 1984-07-27 1986-04-29 Texas Tech University Health Sciences Center Hypotensive active peptides
ES2063912T3 (es) * 1989-01-24 1995-01-16 Aphton Corp Composiciones inmunogenicas frente a peptidos de gastrina.
SE468516B (sv) * 1991-06-14 1993-02-01 Kabigen Ab Nya polypeptider vilka kan utvinnas fraan tunntarmen och deras anvaendning
AU2548992A (en) * 1991-08-13 1993-03-16 Temple University - Of The Commonwealth System Of Higher Education Modulation of blood pressure and inhibition of platelet activation with kininogen fragment
AU703256B2 (en) * 1995-06-09 1999-03-25 Regents Of The University Of Michigan, The Bradykinin analogs as selective thrombin inhibitors

Also Published As

Publication number Publication date
JP2001518119A (ja) 2001-10-09
WO1998047522A1 (en) 1998-10-29
EP1019070A1 (en) 2000-07-19
AU7252898A (en) 1998-11-13
AU734935B2 (en) 2001-06-28
EP1019070A4 (en) 2001-05-16
CA2288027A1 (en) 1998-10-29

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