EP1019070A4 - Bradykinin analogs as selective inhibitors of cell activation - Google Patents

Bradykinin analogs as selective inhibitors of cell activation

Info

Publication number
EP1019070A4
EP1019070A4 EP98919827A EP98919827A EP1019070A4 EP 1019070 A4 EP1019070 A4 EP 1019070A4 EP 98919827 A EP98919827 A EP 98919827A EP 98919827 A EP98919827 A EP 98919827A EP 1019070 A4 EP1019070 A4 EP 1019070A4
Authority
EP
European Patent Office
Prior art keywords
cell activation
selective inhibitors
bradykinin analogs
bradykinin
analogs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98919827A
Other languages
German (de)
French (fr)
Other versions
EP1019070A1 (en
Inventor
Alvin H Schmaier
Ahmed A K Hasan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Michigan
Original Assignee
University of Michigan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Michigan filed Critical University of Michigan
Publication of EP1019070A1 publication Critical patent/EP1019070A1/en
Publication of EP1019070A4 publication Critical patent/EP1019070A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C07K5/0817—Tripeptides with the first amino acid being basic the first amino acid being Arg
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/043—Kallidins; Bradykinins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8139—Cysteine protease (E.C. 3.4.22) inhibitors, e.g. cystatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/18—Kallidins; Bradykinins; Related peptides
EP98919827A 1997-04-23 1998-04-21 Bradykinin analogs as selective inhibitors of cell activation Withdrawn EP1019070A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4608597P 1997-04-23 1997-04-23
US46085P 1997-04-23
PCT/US1998/008015 WO1998047522A1 (en) 1997-04-23 1998-04-21 Bradykinin analogs as selective inhibitors of cell activation

Publications (2)

Publication Number Publication Date
EP1019070A1 EP1019070A1 (en) 2000-07-19
EP1019070A4 true EP1019070A4 (en) 2001-05-16

Family

ID=21941533

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98919827A Withdrawn EP1019070A4 (en) 1997-04-23 1998-04-21 Bradykinin analogs as selective inhibitors of cell activation

Country Status (5)

Country Link
EP (1) EP1019070A4 (en)
JP (1) JP2001518119A (en)
CA (1) CA2288027A1 (en)
IL (1) IL132546A0 (en)
WO (1) WO1998047522A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6544750B1 (en) * 1999-08-17 2003-04-08 Thromgen, Inc. Peptide analogs as selective inhibitors of thrombin activation of protease activated receptor 1
US7879792B2 (en) * 2005-06-02 2011-02-01 The Regents Of The University Of Michigan Synthetic peptide inhibitors of thrombin and thrombin activation of protease activated receptors 1 and 4
EP2645932B1 (en) 2010-12-02 2016-03-02 Becton, Dickinson and Company Blood collection devices containing blood stabilization agent

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4585757A (en) * 1984-07-27 1986-04-29 Texas Tech University Health Sciences Center Hypotensive active peptides
US5489575A (en) * 1991-06-14 1996-02-06 Hans G. Boman Polypeptides and their use
WO1996041640A1 (en) * 1995-06-09 1996-12-27 The Regents Of The University Of Michigan Bradykinin analogs as selective thrombin inhibitors
US5607676A (en) * 1989-01-24 1997-03-04 Aphton Corporation Immunogenic compositions against gastrin peptides

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5472945A (en) * 1991-08-13 1995-12-05 Temple University- Of The Commonwealth System Of Higher Education Modulation of blood pressure and inhibition of platelet activation with kininogen fragment

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4585757A (en) * 1984-07-27 1986-04-29 Texas Tech University Health Sciences Center Hypotensive active peptides
US5607676A (en) * 1989-01-24 1997-03-04 Aphton Corporation Immunogenic compositions against gastrin peptides
US5489575A (en) * 1991-06-14 1996-02-06 Hans G. Boman Polypeptides and their use
WO1996041640A1 (en) * 1995-06-09 1996-12-27 The Regents Of The University Of Michigan Bradykinin analogs as selective thrombin inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9847522A1 *

Also Published As

Publication number Publication date
EP1019070A1 (en) 2000-07-19
IL132546A0 (en) 2001-03-19
AU7252898A (en) 1998-11-13
AU734935B2 (en) 2001-06-28
CA2288027A1 (en) 1998-10-29
JP2001518119A (en) 2001-10-09
WO1998047522A1 (en) 1998-10-29

Similar Documents

Publication Publication Date Title
EP0998282A4 (en) Sulfonamides as cell adhesion inhibitors
EP0969840A4 (en) Thrombin inhibitors
PL334846A1 (en) Sulphamidic inhibitors of metaloproteases
ZA98376B (en) Sulfamide-metalloprotease inhibitors
SI0948541T1 (en) Analogs of PTHrP
SI1007512T1 (en) Branched alkoxy-subsituted 2-aminopyridines as nos inhibitors
PL337091A1 (en) Cyanoguanidines as inhibitors of cell proliferation
GB9827604D0 (en) Methods of immunosuppression
PL337031A1 (en) Cyanoguanidines as inhibitors of cell proliferation
IL132546A0 (en) Bradykinin analogs as selective inhibitors of cell activation
HUP0004799A3 (en) Use of electrolyte mixtures as sequestering agents
EP1017383A4 (en) Thrombin inhibitors
PL337612A1 (en) Crystalline form of roxyfiban
ZA989394B (en) Selective functionalization of sodium glycinate
EP1039907A4 (en) Thrombin inhibitors
GB9714335D0 (en) Sulfonamides as cell adhesion inhibitors
PL336896A1 (en) Cyanoamidines as inhibitors of cell proliferation
TW328252U (en) Improved structure of pliers
TW319017U (en) Improved structure of mousetraps
TW312301U (en) Improved structure of earmask
NZ288940A (en) 4-amino-2-oxo-1-piperidineacetic acid tripeptide derivatives as thrombin inhibitors
GB9719956D0 (en) Aid to finding anagrams
GB9716872D0 (en) Thrombin Inhibitors
GB9704209D0 (en) Thrombin inhibitors
AU137522S (en) Set of covered modules

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19991101

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

A4 Supplementary search report drawn up and despatched

Effective date: 20010404

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

RIC1 Information provided on ipc code assigned before grant

Free format text: 7C 07K 14/81 A, 7C 07K 7/18 B, 7C 07K 5/08 B, 7A 61K 38/04 B, 7A 61K 38/06 B, 7A 61K 38/57 B

17Q First examination report despatched

Effective date: 20040604

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20090218

REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1030876

Country of ref document: HK