CA2283184A1 - Derives d'acides benzoyle-cycloalkyl-1-carboxyliques-2-substitues - Google Patents

Derives d'acides benzoyle-cycloalkyl-1-carboxyliques-2-substitues Download PDF

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Publication number
CA2283184A1
CA2283184A1 CA002283184A CA2283184A CA2283184A1 CA 2283184 A1 CA2283184 A1 CA 2283184A1 CA 002283184 A CA002283184 A CA 002283184A CA 2283184 A CA2283184 A CA 2283184A CA 2283184 A1 CA2283184 A1 CA 2283184A1
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CA
Canada
Prior art keywords
compound
hydrogen
cyclopropane
formula
dichlorobenzoyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002283184A
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English (en)
Inventor
Carmela Speciale
Roberto Pellicciari
Mario Varasi
Paolo Pevarello
Antonio Giordani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
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Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2283184A1 publication Critical patent/CA2283184A1/fr
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/18—Saturated compounds containing keto groups
    • C07C62/20—Saturated compounds containing keto groups with a saturated six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C229/48—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms of the same non-condensed ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/60—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/82—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/62—Compounds containing any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylcarbamates
    • C07C271/64—Y being a hydrogen or a carbon atom, e.g. benzoylcarbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/51—Y being a hydrogen or a carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/38—Unsaturated compounds containing keto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C69/757—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des acides 2-(benzoyl substitué)-cycloalkyl-1-carboxyliques de formule (I), où E est une chaîne alcylène C¿1?-C¿4? dans laquelle un atome de carbone est éventuellement substitué; chacun des radicaux R ou R¿1?, qu'il soit identique ou différent, désigne hydrogène, halogène, hydroxy, trifluorométhyle, cyano, nitro, phényle, benzyle, alkyle C¿1?-C¿6?, alkoxy C¿1?-C¿6?, alcylthio C¿1?-C¿6?, SOR¿4? ou SO¿2?R¿4?; R¿2? désigne hydrogène ou -N(R¿7?R¿8?) où chacun des radicaux R¿7? ou R¿8? désigne indépendamment, hydrogène, alkyle C¿1?-C¿6? benzyle, phényle, hydroxy, alkoxy C¿1?-C¿6?, benzyloxy ou un de R¿7? ou de R¿8? désigne hydrogène, l'autre désignant COR¿9?; R¿3? désigne hydroxy, alkoxy C¿1?-C¿6?, phénoxy, benzyloxy ou un groupe -N(R¿12?R¿13?). L'invention concerne également leurs sels pharmaceutiquement acceptables. Ces dérivés et leurs sels ont une activité inhibitrice de l'enzyme cynurénine-3-hydroxylase.
CA002283184A 1997-03-11 1998-02-16 Derives d'acides benzoyle-cycloalkyl-1-carboxyliques-2-substitues Abandoned CA2283184A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9705031.4 1997-03-11
GBGB9705031.4A GB9705031D0 (en) 1997-03-11 1997-03-11 2-substituted benzoyl-cycloalkyl-1-carboxylic acid derivatives
PCT/EP1998/000883 WO1998040344A1 (fr) 1997-03-11 1998-02-16 Derives d'acides benzoyle-cycloalkyl-1-carboxyliques-2-substitues

Publications (1)

Publication Number Publication Date
CA2283184A1 true CA2283184A1 (fr) 1998-09-17

Family

ID=10809053

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002283184A Abandoned CA2283184A1 (fr) 1997-03-11 1998-02-16 Derives d'acides benzoyle-cycloalkyl-1-carboxyliques-2-substitues

Country Status (15)

Country Link
EP (1) EP0973720A1 (fr)
JP (1) JP2001514634A (fr)
KR (1) KR20000076096A (fr)
CN (1) CN1252049A (fr)
AU (1) AU6497998A (fr)
CA (1) CA2283184A1 (fr)
EA (1) EA199900809A1 (fr)
GB (1) GB9705031D0 (fr)
HU (1) HUP0001023A3 (fr)
IL (1) IL131676A0 (fr)
NO (1) NO994386L (fr)
PL (1) PL335601A1 (fr)
TW (1) TW407146B (fr)
WO (1) WO1998040344A1 (fr)
ZA (1) ZA981972B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1424333A1 (fr) * 2002-11-28 2004-06-02 Newron Pharmaceuticals S.p.A. Dérivés d'acide halothénoyl-cyclopropane-1-carboxylique
EP1475088A1 (fr) * 2003-05-05 2004-11-10 Newron Pharmaceuticals S.p.A. Inhibiteurs de la kynurenine-3-hydroxylase pour le traitement des désordres locomoteurs induits par la L-DOPA, dyskinésies, accoutumance aux médicaments, douleurs et cataract
EP1475385A1 (fr) * 2003-05-05 2004-11-10 Newron Pharmaceuticals S.p.A. Derivés de glycoside d'acide carboxylique de 2-(3,4-dichlorobenzoyl)-cyclopropane
WO2013151707A1 (fr) * 2012-04-05 2013-10-10 Chdi Foundation, Inc. Inhibiteurs de kynurénine-3-monooxygénase, compositions pharmaceutiques, et procédés d'utilisation de ceux-ci
CN103373911B (zh) * 2012-04-27 2016-12-14 中国科学院上海有机化学研究所 单氟代环丙烷类化合物及其制备方法和应用
CN104119246A (zh) * 2013-04-26 2014-10-29 中国科学院上海有机化学研究所 环丙烷衍生物及其制备方法和应用
WO2015047982A2 (fr) 2013-09-26 2015-04-02 Chdi Foundation, Inc. Inhibiteurs de kynurénine-3-monooxygénase, compositions pharmaceutiques et procédés d'utilisation de ces compositions
JP6449893B2 (ja) * 2013-09-26 2019-01-09 シーエイチディーアイ ファウンデーション，インコーポレーテッド キヌレニン−３−モノオキシゲナーゼ阻害薬、医薬組成物、及びこれらの使用方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3655667A (en) * 1968-04-04 1972-04-11 Smith Kline French Lab 1-(2-benzoylcyclopropylmethyl)-4-phenylpiperazines

Also Published As

Publication number Publication date
KR20000076096A (ko) 2000-12-26
AU6497998A (en) 1998-09-29
EA199900809A1 (ru) 2000-08-28
WO1998040344A1 (fr) 1998-09-17
JP2001514634A (ja) 2001-09-11
IL131676A0 (en) 2001-03-19
NO994386L (no) 1999-11-02
HUP0001023A3 (en) 2001-03-28
PL335601A1 (en) 2000-05-08
TW407146B (en) 2000-10-01
GB9705031D0 (en) 1997-04-30
ZA981972B (en) 1998-09-09
CN1252049A (zh) 2000-05-03
EP0973720A1 (fr) 2000-01-26
HUP0001023A2 (hu) 2000-09-28
NO994386D0 (no) 1999-09-10

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Legal Events

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FZDE Discontinued