CA2278200A1 - Polymeres - Google Patents

Polymeres Download PDF

Info

Publication number
CA2278200A1
CA2278200A1 CA002278200A CA2278200A CA2278200A1 CA 2278200 A1 CA2278200 A1 CA 2278200A1 CA 002278200 A CA002278200 A CA 002278200A CA 2278200 A CA2278200 A CA 2278200A CA 2278200 A1 CA2278200 A1 CA 2278200A1
Authority
CA
Canada
Prior art keywords
compound
polymer backbone
reporter
amino acid
moiety
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002278200A
Other languages
English (en)
Inventor
Kenneth Kellar
Henry Wolfe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare AS
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9701813.9A external-priority patent/GB9701813D0/en
Application filed by Individual filed Critical Individual
Publication of CA2278200A1 publication Critical patent/CA2278200A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/124—Macromolecular compounds dendrimers, dendrons, hyperbranched compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0442—Polymeric X-ray contrast-enhancing agent comprising a halogenated group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polyethers (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La présente invention concerne des composés renfermant un squelette polymère linéaire, ramifié ou dendrimère auquel est liée au moins une fraction reporter, ledit squelette polymère comprenant plusieurs acides contenant des amines. De tels composés peuvent être liés à un ou plusieurs agents de ciblage et sont utiles comme agents thérapeutiques et diagnostiques, en particulier dans les techniques d'imagerie médicale.
CA002278200A 1997-01-29 1998-01-29 Polymeres Abandoned CA2278200A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB9701813.9A GB9701813D0 (en) 1997-01-29 1997-01-29 Polymers
GB9701813.9 1997-01-29
US5707497P 1997-08-27 1997-08-27
US60/057,074 1997-08-27
PCT/GB1998/000270 WO1998032469A2 (fr) 1997-01-29 1998-01-29 Polymeres

Publications (1)

Publication Number Publication Date
CA2278200A1 true CA2278200A1 (fr) 1998-07-30

Family

ID=26310882

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002278200A Abandoned CA2278200A1 (fr) 1997-01-29 1998-01-29 Polymeres

Country Status (8)

Country Link
EP (1) EP1011736A2 (fr)
JP (1) JP2001509796A (fr)
KR (1) KR20000070544A (fr)
CN (1) CN1246059A (fr)
AU (1) AU5871798A (fr)
CA (1) CA2278200A1 (fr)
NO (1) NO993662L (fr)
WO (1) WO1998032469A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69912827T2 (de) * 1998-09-29 2004-10-21 Loke Diagnostics Aps Aarhus "ligand presenting assembly" (lpa), verfahren zu dessen herstellung und verwendungen
AU5522600A (en) * 1999-06-29 2001-01-22 Dako A/S Detection using dendrimers bearing labels and probes
ITFO990015A1 (it) * 1999-07-23 2001-01-23 Verdini Antonio "dendrimeri polipeptidici quali trasportatori unimolecolari di farmaci e sostanze biologicamente attive".
KR100379720B1 (ko) * 2000-10-14 2003-04-11 주식회사 마크로젠 덴드리머 단일층 지지체 및 그의 제조방법
ATE494913T1 (de) * 2004-11-22 2011-01-15 Ge Healthcare As Kontrastmittel für eine extrazelluläre matrix
JP4870941B2 (ja) * 2005-05-09 2012-02-08 公立大学法人大阪府立大学 高分子化合物
KR101334780B1 (ko) * 2010-08-13 2013-12-02 한국생명공학연구원 요오드를 함유한 방사형상의 고분자 화합물, 이의 제조방법 및 이를 포함하는 ｃｔ용 조영제 조성물
US20200215198A1 (en) * 2019-01-03 2020-07-09 Ionpath, Inc. Compositions and reagents for ion beam imaging
CN113307863B (zh) * 2021-05-25 2022-12-16 华南农业大学 一种聚天冬氨酸及其盐类抗体的制备方法和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA839512B (en) * 1983-12-12 1984-08-29 Scripps Clinic Res Synthetic heat-stable enterotoxin polypeptide of escherichia coli and multimers thereof
DE3806795A1 (de) * 1988-02-29 1989-09-07 Schering Ag Polymer-gebundene komplexbildner, deren komplexe und konjugate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
US5914095A (en) * 1989-04-07 1999-06-22 Salutar, Inc. Polychelants containg amide bonds
US5364613A (en) * 1989-04-07 1994-11-15 Sieving Paul F Polychelants containing macrocyclic chelant moieties
AU3354993A (en) * 1991-12-04 1993-06-28 Guerbet S.A. Novel macromolecular polyamine iodine-containing compound, process for its preparation and its use as a contrast agent
AU5085793A (en) * 1992-09-04 1994-03-29 General Hospital Corporation, The Biocompatible polymers containing diagnostic or therapeutic moieties
DE19521940A1 (de) * 1995-06-07 1996-12-12 Schering Ag Iodhaltige lineare Polyamine und Polyamide
US5756066A (en) * 1995-06-07 1998-05-26 Schering Aktiengesellschaft Iodine-containing peptides

Also Published As

Publication number Publication date
AU5871798A (en) 1998-08-18
WO1998032469A2 (fr) 1998-07-30
NO993662L (no) 1999-09-28
NO993662D0 (no) 1999-07-28
CN1246059A (zh) 2000-03-01
WO1998032469A3 (fr) 1998-11-05
KR20000070544A (ko) 2000-11-25
EP1011736A2 (fr) 2000-06-28
JP2001509796A (ja) 2001-07-24

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Legal Events

Date Code Title Description
FZDE Dead