CA2270118A1 - Composes nitroses et nitrosyles inhibiteurs de la phosphodiesterase, compositions comprenant ces composes et utilisations correspondantes - Google Patents
Composes nitroses et nitrosyles inhibiteurs de la phosphodiesterase, compositions comprenant ces composes et utilisations correspondantes Download PDFInfo
- Publication number
- CA2270118A1 CA2270118A1 CA002270118A CA2270118A CA2270118A1 CA 2270118 A1 CA2270118 A1 CA 2270118A1 CA 002270118 A CA002270118 A CA 002270118A CA 2270118 A CA2270118 A CA 2270118A CA 2270118 A1 CA2270118 A1 CA 2270118A1
- Authority
- CA
- Canada
- Prior art keywords
- compound
- formula
- defined above
- group
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Reproductive Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Paper (AREA)
- Cosmetics (AREA)
Abstract
La présente invention concerne des inhibiteurs nitrosés et/ou nitrosylés de la phosphodiestérase, l'inhibiteur étant représenté par la formule NO¿n?-PDE dans laquelle "n" vaut 1 ou 2. Un tel inhibiteur de la phosphodiestérase peut être nitrosé ou nitrosylé par des sites tels que l'oxygène (condensation hydroxyl), le soufre (condensation sulfhydryl), le carbone et de l'azote. L'invention concerne également des compositions comprenant de tels composés associés à un excipient pharmaceutiquement admis. L'invention concerne par ailleurs une composition comprenant une quantité thérapeutiquement active d'un inhibiteur de la phosphodiestérase (inhibiteur PDE) qui peut être éventuellement substitué par un ou plusieurs groupes fonctionnels NO ou NO¿2? et un excédant molaire de un à dix fois d'un composé qui donne, transfère ou libère du monoxyde d'azote sous forme d'espèce chargée, en l'occurrence de nitrosinium (NO?+¿) ou de nitroxyl (NO?-¿), ou sous forme d'espèce neutre, en l'occurrence l'oxyde nitrique (NO?.¿), qui stimule la production endogène d'EDRF. L'invention concerne en outre des compositions intégrant de tels composés dans un excipient pharmaceutiquement admis. L'invention concerne enfin un traitement dirigé contre l'impuissance masculine et consistant à administrer ces composés et des compositions à base de tels composés.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/740,764 US5874437A (en) | 1996-11-01 | 1996-11-01 | Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses |
US08/740,764 | 1996-11-01 | ||
PCT/US1997/019870 WO1998019672A1 (fr) | 1996-11-01 | 1997-10-31 | Composes nitroses et nitrosyles inhibiteurs de la phosphodiesterase, compositions comprenant ces composes et utilisations correspondantes |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2270118A1 true CA2270118A1 (fr) | 1998-05-14 |
Family
ID=26792881
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002270118A Abandoned CA2270118A1 (fr) | 1996-11-01 | 1997-10-31 | Composes nitroses et nitrosyles inhibiteurs de la phosphodiesterase, compositions comprenant ces composes et utilisations correspondantes |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0941086A4 (fr) |
JP (1) | JP2001504457A (fr) |
AU (1) | AU722480B2 (fr) |
CA (1) | CA2270118A1 (fr) |
WO (1) | WO1998019672A1 (fr) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE37234E1 (en) * | 1996-11-01 | 2001-06-19 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiestrase inhibitor compounds, compositions and their uses |
US6331543B1 (en) | 1996-11-01 | 2001-12-18 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use |
US5958926A (en) * | 1996-11-01 | 1999-09-28 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses |
EP1535611A3 (fr) * | 1997-06-23 | 2009-09-16 | Strakan International Limited | Thérapie de conditions vasculaires par des microdoses de doneurs de NO |
WO1999021558A2 (fr) * | 1997-10-28 | 1999-05-06 | Vivus, Inc. | Apport local d'inhibiteurs de phosphodiesterases, dans le traitement du dysfonctionnement erectile |
US6472425B1 (en) | 1997-10-31 | 2002-10-29 | Nitromed, Inc. | Methods for treating female sexual dysfunctions |
US6200591B1 (en) * | 1998-06-25 | 2001-03-13 | Anwar A. Hussain | Method of administration of sildenafil to produce instantaneous response for the treatment of erectile dysfunction |
EP1143956A3 (fr) * | 1998-12-14 | 2001-12-12 | Cellegy Pharmaceuticals, Inc | Compositions et techniques de traitement de troubles anorectaux |
US6627632B2 (en) | 1998-12-14 | 2003-09-30 | Cellegy Pharmaceuticals, Inc. | Compositions and methods for the treatment of anorectal disorders |
US6476037B1 (en) * | 2000-03-23 | 2002-11-05 | The Regents Of The University Of California | L-arginine and phosphodiesterase (PDE) inhibitor synergism |
WO2002022127A1 (fr) * | 2000-09-13 | 2002-03-21 | Isis Innovation Limited | Utilisation d"inhibiteurs de phosphodiesterase pour le traitement de trouble ano-rectal |
JP2004528337A (ja) | 2001-05-02 | 2004-09-16 | ニトロメド インコーポレーテッド | ニトロソ化およびニトロシル化ネビボロール、ならびにその代謝産物、組成物、および使用方法 |
MXPA03011629A (es) * | 2001-06-15 | 2004-07-01 | Yamanouchi Pharmaceuticals Co | Derivado de fenilpiridincarbonilpiperazina. |
SI1448205T1 (sl) | 2001-10-05 | 2011-07-29 | Zalicus Inc | Kombinacije za zdravljenje imunoinflamatornih motenj |
TW200517114A (en) | 2003-10-15 | 2005-06-01 | Combinatorx Inc | Methods and reagents for the treatment of immunoinflammatory disorders |
US7875268B2 (en) | 2004-04-06 | 2011-01-25 | L'oreal S.A. | Dimercaptoamides, compositions comprising them as reducing agents, and processes for permanently reshaping keratin fibers therewith |
US7067659B2 (en) * | 2004-04-23 | 2006-06-27 | Duke University | Reactive oxygen generating enzyme inhibitor with nitric oxide bioactivity and uses thereof |
ATE462703T1 (de) | 2004-08-25 | 2010-04-15 | Actelion Pharmaceuticals Ltd | Bicyclononen-derivate als renin-inhibitoren |
WO2006041855A2 (fr) | 2004-10-04 | 2006-04-20 | Nitromed, Inc. | Compositions et procedes faisant intervenir des composes apocynine et des donneurs d'oxyde nitrique |
KR100963455B1 (ko) | 2005-05-27 | 2010-06-18 | 액테리온 파마슈티칼 리미티드 | 신규한 피페리딘 카르복실산 아미드 유도체 |
US20090018091A1 (en) | 2005-08-02 | 2009-01-15 | Nitromed, Inc. | Nitric Oxide Enhancing Antimicrobial Compounds, Compositions and Methods of Use |
KR20080091273A (ko) | 2006-02-02 | 2008-10-09 | 액테리온 파마슈티칼 리미티드 | 레닌 저해제로서의 2차 아민 |
AU2007243765A1 (en) | 2006-03-29 | 2007-11-08 | Nicox S.A. | Nitric oxide enhancing prostaglandin compounds, compositions and methods of use |
SG192543A1 (en) | 2008-05-05 | 2013-08-30 | Merck Canada Inc | 3, 4 - substituted piperidine derivatives as renin inhibitors |
ME02979B (fr) | 2009-06-09 | 2018-10-20 | Prolong Pharmaceuticals Llc | Compositions d'hémoglobine |
RU2758373C2 (ru) * | 2017-05-22 | 2021-10-28 | Топадур Фарма Аг | Новые активаторы растворимой гуанилатциклазы и ингибиторы фосфодиэстеразы с двойным механизмом действия и их применение |
EP4175943A4 (fr) | 2020-07-30 | 2023-11-15 | Biofront Therapeutics (Beijing) Co., Ltd. | Composés à double fonction et leurs procédés d'utilisation |
WO2022022669A1 (fr) * | 2020-07-30 | 2022-02-03 | Biofront Therapeutics (Beijing) Co., Ltd. | Composés à double fonction et leurs procédés d'utilisation |
WO2023005180A1 (fr) * | 2021-07-30 | 2023-02-02 | Biofront Therapeutics (Beijing) Co., Ltd. | Composés à double fonction et leurs procédés d'utilisation |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU179019B (en) * | 1978-11-01 | 1982-08-28 | Gyogyszekutato Intezet | Process for preparing 4-//3,4-dialkoxy-phenyl/-alkyl/- 2imidazolidinone derivatives |
US5459145A (en) * | 1988-01-19 | 1995-10-17 | Pfizer Inc. | Calcium independent camp phosphodiesterase inhibitor antidepressant |
US4714705A (en) * | 1986-07-07 | 1987-12-22 | Ortho Pharmaceutical Corporation | 4-nitrogen substituted isoquinolinol compounds having cardiotonic, phosphodiesterase fraction III inhibiting properties and/or renal vasodilating properties |
GB8817651D0 (en) * | 1988-07-25 | 1988-09-01 | Smith Kline French Lab | Chemical compounds |
GB8928346D0 (en) * | 1989-12-15 | 1990-02-21 | Smith Kline French Lab | Chemical compounds |
GB8929208D0 (en) * | 1989-12-27 | 1990-02-28 | Almirall Lab | New xanthine derivatives |
GB9013750D0 (en) * | 1990-06-20 | 1990-08-08 | Pfizer Ltd | Therapeutic agents |
IE73235B1 (en) * | 1991-03-25 | 1997-05-21 | Akzo Nv | 4-aryl-thiazole or imidazole derivatives |
US5380758A (en) * | 1991-03-29 | 1995-01-10 | Brigham And Women's Hospital | S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof |
GB9114760D0 (en) * | 1991-07-09 | 1991-08-28 | Pfizer Ltd | Therapeutic agents |
AU3237193A (en) * | 1991-12-11 | 1993-07-19 | Brigham And Women's Hospital | S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof |
GB9212693D0 (en) * | 1992-06-15 | 1992-07-29 | Celltech Ltd | Chemical compounds |
GB9222253D0 (en) * | 1992-10-23 | 1992-12-09 | Celltech Ltd | Chemical compounds |
ES2176252T3 (es) * | 1993-07-02 | 2002-12-01 | Altana Pharma Ag | Benzamidas sustituidas con fluoro-alcoxi y su utilizacion como agentes inhibidores de fosfodiesterasas de nucleotidos ciclicos. |
US5728705A (en) * | 1993-10-04 | 1998-03-17 | The Trustees Of Columbia University In The City Of New York | Method of inducing vasorelaxation to treat pulmonary hypertension |
CA2143143A1 (fr) * | 1994-03-08 | 1995-09-09 | Toshihiko Tanaka | Derives de la 3-phenylpyrrolidine |
US6063407A (en) * | 1995-02-16 | 2000-05-16 | The General Hospital Corporation | Treatment of vascular thrombosis and restenosis with inhaled nitric oxide |
US5824669A (en) * | 1996-03-22 | 1998-10-20 | Nitromed, Inc. | Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders |
GB9608408D0 (en) * | 1996-04-23 | 1996-06-26 | Adams Michael A | Treatment of erectile dysfunction |
-
1997
- 1997-10-31 CA CA002270118A patent/CA2270118A1/fr not_active Abandoned
- 1997-10-31 EP EP97946871A patent/EP0941086A4/fr not_active Withdrawn
- 1997-10-31 JP JP52161698A patent/JP2001504457A/ja not_active Ceased
- 1997-10-31 WO PCT/US1997/019870 patent/WO1998019672A1/fr active Application Filing
- 1997-10-31 AU AU51962/98A patent/AU722480B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
WO1998019672A1 (fr) | 1998-05-14 |
AU722480B2 (en) | 2000-08-03 |
EP0941086A1 (fr) | 1999-09-15 |
EP0941086A4 (fr) | 2000-07-12 |
JP2001504457A (ja) | 2001-04-03 |
AU5196298A (en) | 1998-05-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
FZDE | Dead |