CA2268381A1 - Inhibiteurs selectifs du facteur xa - Google Patents

Inhibiteurs selectifs du facteur xa Download PDF

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Publication number
CA2268381A1
CA2268381A1 CA002268381A CA2268381A CA2268381A1 CA 2268381 A1 CA2268381 A1 CA 2268381A1 CA 002268381 A CA002268381 A CA 002268381A CA 2268381 A CA2268381 A CA 2268381A CA 2268381 A1 CA2268381 A1 CA 2268381A1
Authority
CA
Canada
Prior art keywords
compound
group
aryl
6alkyl
3alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002268381A
Other languages
English (en)
Inventor
Bing-Yan Zhu
Robert M. Scarborough
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
COR Therapeutics Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2268381A1 publication Critical patent/CA2268381A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne des composés nouveaux, leurs sels et des compositions qui y sont associées, qui présentent une activité contre le facteur mammalien Xa. Ces composés sont utilisés in vitro ou in vivo dans le traitement préventif ou curatif de troubles de la coagulation.
CA002268381A 1996-10-11 1997-10-10 Inhibiteurs selectifs du facteur xa Abandoned CA2268381A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US73064096A 1996-10-11 1996-10-11
US3633796P 1996-10-11 1996-10-11
US08/730,640 1996-10-11
US60/036,337 1996-10-11
PCT/US1997/018312 WO1998016547A1 (fr) 1996-10-11 1997-10-10 INHIBITEURS SELECTIFS DU FACTEUR Xa

Publications (1)

Publication Number Publication Date
CA2268381A1 true CA2268381A1 (fr) 1998-04-23

Family

ID=26713083

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002268381A Abandoned CA2268381A1 (fr) 1996-10-11 1997-10-10 Inhibiteurs selectifs du facteur xa

Country Status (4)

Country Link
EP (1) EP0932615A1 (fr)
AU (1) AU743735B2 (fr)
CA (1) CA2268381A1 (fr)
WO (1) WO1998016547A1 (fr)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6063794A (en) * 1996-10-11 2000-05-16 Cor Therapeutics Inc. Selective factor Xa inhibitors
US6369080B2 (en) * 1996-10-11 2002-04-09 Cor Therapeutics, Inc. Selective factor Xa inhibitors
US6194435B1 (en) 1996-10-11 2001-02-27 Cor Therapeutics, Inc. Lactams as selective factor Xa inhibitors
US6262047B1 (en) 1996-10-11 2001-07-17 Cor Therapeutics, Inc. Selective factor Xa inhibitors
JP2001523226A (ja) 1997-04-14 2001-11-20 シーオーアール セラピューティクス インコーポレイテッド 選択的Ｘａ因子阻害剤
WO1998046627A1 (fr) 1997-04-14 1998-10-22 Cor Therapeutics, Inc. INHIBITEURS SELECTIFS DU FACTEUR Xa
JP2001521524A (ja) * 1997-04-14 2001-11-06 シーオーアール セラピューティクス インコーポレイテッド 選択的Ｘａ因子阻害剤
EP0975625A1 (fr) 1997-04-14 2000-02-02 Cor Therapeutics, Inc. INHIBITEURS SELECTIFS DU FACTEUR Xa
US6228854B1 (en) 1997-08-11 2001-05-08 Cor Therapeutics, Inc. Selective factor Xa inhibitors
US6333321B1 (en) 1997-08-11 2001-12-25 Cor Therapeutics, Inc. Selective factor Xa inhibitors
US6218382B1 (en) 1997-08-11 2001-04-17 Cor Therapeutics, Inc Selective factor Xa inhibitors
DE69912379T2 (de) 1998-08-14 2004-05-06 Pfizer Inc. Antithrombosemittel
US6653316B1 (en) 1999-05-19 2003-11-25 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
US6716838B1 (en) 1999-05-19 2004-04-06 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents
US6664255B1 (en) 1999-05-19 2003-12-16 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade
US6867217B1 (en) 1999-05-19 2005-03-15 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade
US7015230B1 (en) 1999-05-19 2006-03-21 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade
US6458952B1 (en) 1999-05-19 2002-10-01 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade
US6750342B1 (en) 1999-05-19 2004-06-15 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
MXPA01011956A (es) * 1999-05-27 2002-06-21 Dimensional Pharm Inc Oxazaheterociclos como inhibidores de proteasas.
ATE250056T1 (de) * 1999-07-09 2003-10-15 Dimensional Pharm Inc Heteroaryl protease inhibitoren und diagnostische bilderzeugungsmittel
WO2001068605A1 (fr) 2000-03-13 2001-09-20 Pharmacia Corporation Benzenes polycycliques substitues aryle et heteroaryle utiles pour l'inhibition selective de la cascade de coagulation
US20020022604A1 (en) 2000-04-05 2002-02-21 South Michael S. Polycyclic aryl and heteroaryl substituted 4-pyrones useful for selective inhibition of the coagulation cascade
US6693121B2 (en) 2000-04-05 2004-02-17 Pharmacia Corporation Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the coagulation cascade
EP1274676A2 (fr) 2000-04-17 2003-01-15 Pharmacia Corporation 1,4-quinones polycycliques substituees par aryle et heteroaryles utiles pour l'inhibition selective des reactions en cascade provoquant la coagulation
WO2001087851A1 (fr) * 2000-05-18 2001-11-22 Pharmacia Corporation Aryle polycyclique substitue et pyrimidinones d'heteroaryle utiles a l'inhibition selective de la coagulation
AU2001217827A1 (en) * 2000-05-18 2001-11-26 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade
WO2002006248A2 (fr) 2000-07-17 2002-01-24 3-Dimensional Pharmaceuticals, Inc. Pyrazinones oxyguanidines cycliques comme inhibiteurs de protease
AU2001277242A1 (en) * 2000-08-04 2002-02-18 3-Dimensional Pharmaceuticals, Inc. Cyclic oxyguanidine protease inhibitors
CA2430037A1 (fr) 2000-11-20 2002-05-30 Michael S. South Aryl-et-heteroaryl-pyridines polycycliques substituees utiles dans l'inhibition selective de la cascade de la coagulation
US7119094B1 (en) 2000-11-20 2006-10-10 Warner-Lambert Company Substituted polycyclic aryl and heteroarpyl pyrazinones useful for selective inhibition of the coagulation cascade
US7015223B1 (en) 2000-11-20 2006-03-21 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl 1,2,4-triazinones useful for selective inhibition of the coagulation cascade
US7105559B2 (en) 2001-10-03 2006-09-12 Pharmacia Corporation Substituted 5-membered polycyclic compounds useful for selective inhibition of the coagulation cascade
EP1438292A1 (fr) 2001-10-03 2004-07-21 Pharmacia Corporation Composes heterocycliques a 6 chainons utiles dans l'inhibition selective de la cascade de la coagulation
US7479502B2 (en) 2002-12-03 2009-01-20 Pharmacyclics, Inc. 2-(2-hydroxybiphenyl-3-yl)-1H-benzoimidazole-5-carboxamidine derivatives as factor VIIA inhibitors
UA116336C2 (uk) 2011-11-29 2018-03-12 Перосфіе Фармасьютікалз Інк. Агенти, реверсуючі дію антикоагулянтів
EP2687511A1 (fr) * 2012-07-17 2014-01-22 Zedira GmbH Dérivés de pyridinon comme inhibiteurs de transglutaminase tissulaire
AR114489A1 (es) 2018-04-12 2020-09-09 Morphic Therapeutic Inc ANTAGONISTAS DE LA INTEGRINA a4b7 HUMANA
JP7437490B2 (ja) 2019-10-16 2024-02-22 モーフィック セラピューティック，インコーポレイテッド ヒトインテグリン（アルファ－４）（ベータ－７）の阻害
JP2023509452A (ja) 2020-01-03 2023-03-08 バーグ エルエルシー がんを処置するためのｕｂｅ２ｋモジュレータとしての多環式アミド

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9017694D0 (en) * 1990-08-13 1990-09-26 Sandoz Ltd Improvements in or relating to organic chemistry
WO1995035311A1 (fr) * 1994-06-17 1995-12-28 Corvas International, Inc. Derives de l'acide 3-amino-2-oxo-1-piperidineacetique
EP0804464B1 (fr) * 1994-12-13 2002-05-08 Corvas International, Inc. Derives aromatiques heterocycliques utilisables comme inhibiteurs d'enzymes
CA2208773A1 (fr) * 1994-12-22 1996-06-27 John Dimaio Peptides de cetoarginine heterocycliques utilises comme inhibiteurs de thrombine
US5523308A (en) * 1995-06-07 1996-06-04 Costanzo; Michael J. Peptidyl heterocycles useful in the treatment of thrombin related disorders

Also Published As

Publication number Publication date
AU4898897A (en) 1998-05-11
EP0932615A1 (fr) 1999-08-04
WO1998016547A1 (fr) 1998-04-23
AU743735B2 (en) 2002-02-07

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Legal Events

Date Code Title Description
FZDE Discontinued