CA2267943A1 - Derives d'alkyle-substitue-3-oxo-pyrido (1,2-a)benzimidazole-4-carboxamide contenant 5 heteroatomes, utiles pour traiter des maladies du systeme nerveux central - Google Patents

Derives d'alkyle-substitue-3-oxo-pyrido (1,2-a)benzimidazole-4-carboxamide contenant 5 heteroatomes, utiles pour traiter des maladies du systeme nerveux central Download PDF

Info

Publication number
CA2267943A1
CA2267943A1 CA002267943A CA2267943A CA2267943A1 CA 2267943 A1 CA2267943 A1 CA 2267943A1 CA 002267943 A CA002267943 A CA 002267943A CA 2267943 A CA2267943 A CA 2267943A CA 2267943 A1 CA2267943 A1 CA 2267943A1
Authority
CA
Canada
Prior art keywords
alkyl
phenyl
alkoxy
substituted
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002267943A
Other languages
English (en)
Inventor
Allen B. Reitz
Alfonzo D. Jordan
Pauline J. Sanfilippo
Anna V. Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceuticals Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2267943A1 publication Critical patent/CA2267943A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Composé représenté par la formule (1). Ce composé est utile pour traiter des maladies du système nerveux central. Compositions pharmaceutiques et procédés de traitement.
CA002267943A 1996-10-07 1997-10-03 Derives d'alkyle-substitue-3-oxo-pyrido (1,2-a)benzimidazole-4-carboxamide contenant 5 heteroatomes, utiles pour traiter des maladies du systeme nerveux central Abandoned CA2267943A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2751196P 1996-10-07 1996-10-07
US60/027,511 1996-10-07
PCT/US1997/018045 WO1998015553A1 (fr) 1996-10-07 1997-10-03 DERIVES D'ALKYLE-SUBSTITUE-3-OXO-PYRIDO (1,2-a)BENZIMIDAZOLE-4-CARBOXAMIDE CONTENANT 5 HETEROATOMES, UTILES POUR TRAITER DES MALADIES DU SYSTEME NERVEUX CENTRAL

Publications (1)

Publication Number Publication Date
CA2267943A1 true CA2267943A1 (fr) 1998-04-16

Family

ID=21838133

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002267943A Abandoned CA2267943A1 (fr) 1996-10-07 1997-10-03 Derives d'alkyle-substitue-3-oxo-pyrido (1,2-a)benzimidazole-4-carboxamide contenant 5 heteroatomes, utiles pour traiter des maladies du systeme nerveux central

Country Status (13)

Country Link
US (1) US5817668A (fr)
EP (1) EP0935598B1 (fr)
JP (1) JP2001501949A (fr)
AR (1) AR013844A1 (fr)
AT (1) ATE256126T1 (fr)
AU (1) AU719333B2 (fr)
CA (1) CA2267943A1 (fr)
DE (1) DE69726749T2 (fr)
DK (1) DK0935598T3 (fr)
ES (1) ES2212081T3 (fr)
NZ (1) NZ335060A (fr)
PT (1) PT935598E (fr)
WO (1) WO1998015553A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5922731A (en) * 1997-06-30 1999-07-13 Ortho Pharmaceutical Corporation 5- (heteroaryl)alkyl!-3-oxo-pyrido 1,2-a!benzimidazole-4-carboxamide derivatives useful in treating central nervous system disorders
ATE229953T1 (de) * 1997-10-07 2003-01-15 Ortho Mcneil Pharm Inc Naphtho-imidazo(1,2-a)pyridin derivate, deren herstellung und deren verwendung in der behandlung von störungen des zentralnervensystems
EP1023291B1 (fr) * 1997-10-07 2004-05-26 Ortho-McNeil Pharmaceutical, Inc. Derives de dipyrido-imidazole utiles pour le traitement de troubles du systeme nerveux central
US6177569B1 (en) 1998-08-25 2001-01-23 Neurogen Corporation Oxo-pyridoimidazole-carboxamides: GABA brain receptor ligands
DE69926378T2 (de) * 1998-08-25 2005-12-29 Neurogen Corp., Branford Oxo-pyridoimidazol-carboxamide: gaba-rezeptor-liganden im gehirn
AU779686B2 (en) 1999-08-02 2005-02-03 Ortho-Mcneil Pharmaceutical, Inc. C-6 ring-substituted pyrido(1,2-a)benzimidazole derivatives useful in treating central nervous system disorders
GB0008696D0 (en) * 2000-04-07 2000-05-31 Merck Sharp & Dohme Therapeutic agents
ATE443699T1 (de) * 2002-12-06 2009-10-15 Purdue Research Foundation Pyridine zur behandlung von verletztemsäugetiernervengewebe
US8729107B2 (en) * 2002-12-06 2014-05-20 Purdue Research Foundation Pyridines for treating injured mammalian nerve tissue

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU679938B2 (en) * 1992-08-19 1997-07-17 Mcneilab, Inc. 3-oxo-pyrido(1-2-A)benzimidazole-4-carboxyl and 4-oxo-azepino(1-2-A)benzimidazole-5-carboxyl derivatives in treating central nervous system disorders
US5521200A (en) * 1993-12-30 1996-05-28 Ho; Winston 2-oxo-pyrrolo[1,2-A]benzimidazole-3-carboxyl derivatives useful in treating central nervous system disorders

Also Published As

Publication number Publication date
DE69726749T2 (de) 2005-07-21
ATE256126T1 (de) 2003-12-15
NZ335060A (en) 2000-05-26
PT935598E (pt) 2004-03-31
DE69726749D1 (de) 2004-01-22
ES2212081T3 (es) 2004-07-16
AU719333B2 (en) 2000-05-04
EP0935598A1 (fr) 1999-08-18
JP2001501949A (ja) 2001-02-13
US5817668A (en) 1998-10-06
DK0935598T3 (da) 2004-03-29
WO1998015553A1 (fr) 1998-04-16
EP0935598B1 (fr) 2003-12-10
AU4747397A (en) 1998-05-05
AR013844A1 (es) 2001-01-31

Similar Documents

Publication Publication Date Title
US9403824B2 (en) Pyridonemorphinan analogs and biological activity on opioid receptors
CA2712629C (fr) Derives de carboxamides n-azabicycliques, leur preparation et leur application en therapeutique
JP5247458B2 (ja) ヒドロキシ及びアルコキシ置換１ｈ−イミダゾキノリン及び方法
US7297705B2 (en) Azaindolylalkylamine derivatives as 5-hydroxytryptamine-6 ligands
CA3124678A1 (fr) Inhibiteurs aza-heterobicycliques de mat2a et procedes d'utilisation pour le traitement du cancer
US20040147543A1 (en) Aryl substituted imidazoquinolines
RU2633694C2 (ru) Дейтерированный фениламинопиримидин и фармацевтическая композиция, содержащая такое соединение
JPH0327380A (ja) １ｈ―イミダゾ〔４，５―ｃ〕キノリン―４―アミン類
EP1068206A1 (fr) Derives aminoalkyle substitues de pyrrolo 2,3-b]pyridine et pyrrolo 2,3-d]pyrimidine: modulateurs de recepteurs de crf1
JPH06145170A (ja) ヘテロ環式化合物、その製法及びこれを含有する高血圧及びうつ血性心不全治療用医薬組成物
RU2727194C2 (ru) Гетероциклические соединения для лечения заболевания
CA2267943A1 (fr) Derives d'alkyle-substitue-3-oxo-pyrido (1,2-a)benzimidazole-4-carboxamide contenant 5 heteroatomes, utiles pour traiter des maladies du systeme nerveux central
NZ200931A (en) N-dihydrothiazolyl-3-quinoline carboxamide derivatives and pharmaceutical compositions containing such
EP2493892B1 (fr) Composé de quinuclidine comme ligands du récepteur nicotinique alpha-7 de l'acétylcholine
EP1023291B1 (fr) Derives de dipyrido-imidazole utiles pour le traitement de troubles du systeme nerveux central
EP3027613B1 (fr) Dérivés de pyrroloquinoline comme antagonistes de 5-ht6, son procédé de préparation et son utilisation
JPH09511527A (ja) ２，７−置換オクタヒドロ−１ｈ−ピリド［１，２−ａ］ピラジン誘導体
EP0889044B1 (fr) Dérivés de 5-(hétéroaryl)alkyl-3-oxo-pyrido(1,2-a)benzimidazole-4-carboxamide (PBI) utiles dans le traitement de maladies du système nerveux central
EP1420018A1 (fr) Derives de pyrido[1,2-a]benzimidazole utiles dans le traitement des troubles du systeme nerveux central
CN114945565A (zh) 一种吡咯烷基脲衍生物的晶型及其应用
CN116063305A (zh) 具有btk和/或ret活性的大环化合物及其在医药上的用途
WO2014141118A1 (fr) Dérivés d'imidazo[4,5-c]quinoléine et leurs utilisations
CN118215655A (zh) Ahr激动剂
JPH06234770A (ja) ２−チエニルイミダゾ［２，１−ｂ］ベンゾチアゾール−３−酢酸誘導体、それらの製造および医療への応用

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued