CA2265885A1 - Therapie a but immunitaire - Google Patents
Therapie a but immunitaire Download PDFInfo
- Publication number
- CA2265885A1 CA2265885A1 CA002265885A CA2265885A CA2265885A1 CA 2265885 A1 CA2265885 A1 CA 2265885A1 CA 002265885 A CA002265885 A CA 002265885A CA 2265885 A CA2265885 A CA 2265885A CA 2265885 A1 CA2265885 A1 CA 2265885A1
- Authority
- CA
- Canada
- Prior art keywords
- amino acid
- glu
- asp
- sequence
- arg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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- C07K4/00—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
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- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
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- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
- G01N33/56988—HIV or HTLV
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Abstract
L'invention concerne une séquence d'acides aminés présentant des groupes de paires d'ions spécifiques (ponts) ceints au moins d'un côté par des segments transmembranaires hydrophobes non polaires, en tant que mécanisme utilisé par de nombreux agents infectieux et plusieurs facteurs d'inhibition de la cytokine, tels que l'interleukine 10, le facteur d'inhibition de la prolactine et l'alpha-foeto-protéine. Ladite séquence n'est pas seulement utilisée pour amoindrir les défenses immunitaires des hôtes mais également pour permettre l'infection de tissus lymphoïdes cibles. Il a été prouvé que certains vaccins, lorsqu'ils sont inoculés à un hôte, produisent un certaine gamme d'anticorps neutralisants mais n'empêchent pas l'infection lorsque cet hôte est ensuite exposé à un organisme infectieux vivant. Dans la thérapie de l'invention, lorsque l'inoculation de ce type de vaccin est combinée à une immunisation passive au moyen d'anticorps mono ou polyclonaux dirigés contre lesdites séquences d'acides aminés, l'hôte est capable de surmonter l'agression infectieuse. L'invention se rapporte à l'utilisation thérapeutique d'anticorps mono ou polyclonaux dirigés contre lesdites séquences spécifiques, comme traitement du syndrome d'immunodéficience acquise (SIDA) et d'autres états pathologiques qui persistent en raison de la présence d'un facteur d'inhibition de la cytokine d'origine virale, bactérienne ou provenant de l'hôte, tel que le syndrome de fatigue chronique dans lequel les molécules d'imitation de l'interleukine 10 sont responsables d'une multitudes de symptômes identifiés comme indicateurs de l'encéphalomyélite. L'invention se rapporte à l'utilisation thérapeutique d'anticorps mono ou polyclonaux dirigés contre ces séquences d'acides aminés spécifiques, sous forme de thérapie associée au moyen de vaccins et d'agents antiviraux pour la prévention des effets secondaires de certains agents de modulation des défenses immunitaires et antiviraux (ex: DHEA et IL-12) qui provoquent la production accrue de molécules d'imitation de l'interleukine 10 ou de l'alpha-foetoprotéine pendant la thérapie. L'invention se rapporte encore à l'utilisation thérapeutique de ces séquences spécifiques, soit isolées de la source de l'organisme source, soit produites par synthèse directe ou synthèse de protéines recombinaison. Ces peptides, lorsqu'ils sont administrés à un patient souffrant d'une maladie auto-immune, tels que, entre autres, la sclérose en plaques, le lupus érythémateux (lupus érythémateux systémique), le diabète ou la polyarthrite rhumatoïde ou à des receveurs de transplant, permettent de modifier l'état immunitaire du patient de sorte que soit produite une réponse immunitaire dépendante de l'anticorps Th¿2? et que soit inhibée l'attaque immunitaire de Th¿1? (dépendant des lymphocytes) qui se manifeste dans ces types de déficiences immunitaires, telles que la sclérose en plaques et la réaction du greffon contre l'hôte. Certaines affections dermatologiques qui sont aujourd'hui traitées au moyen de crèmes et d'onguents corticostéroïdes peuvent être également traitées avec succès par le remplacement des corticostéroïdes par ces séquences immunosuppressives d'imitation de l'interleukine 10 et de l'alpha-foet?E?otéine de l'invention.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2518096P | 1996-09-11 | 1996-09-11 | |
US60/025,180 | 1996-09-11 | ||
PCT/IB1997/001086 WO1998010787A2 (fr) | 1996-09-11 | 1997-09-10 | Therapie a but immunitaire |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2265885A1 true CA2265885A1 (fr) | 1998-03-19 |
Family
ID=21824510
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002265885A Abandoned CA2265885A1 (fr) | 1996-09-11 | 1997-09-10 | Therapie a but immunitaire |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0929568A2 (fr) |
JP (1) | JP2001503613A (fr) |
CN (1) | CN1230195A (fr) |
AU (2) | AU6887096A (fr) |
CA (1) | CA2265885A1 (fr) |
IL (1) | IL128806A0 (fr) |
NZ (1) | NZ335039A (fr) |
SE (1) | SE9900812L (fr) |
WO (2) | WO1998010792A1 (fr) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU5297299A (en) * | 1998-08-17 | 2000-03-06 | Patrick T. Prendergast | Cytokine and cytokine receptor, agonist, antagonist and/or antibody combination for therapeutic use |
WO2000035472A2 (fr) * | 1998-12-15 | 2000-06-22 | Hollis-Eden Pharmaceuticals, Inc. | Cytokinotherapie combinee |
EP1265634A4 (fr) * | 2000-03-14 | 2005-12-28 | Nat Jewish Med & Res Center | Procede et composition pour traiter une hyperreactivite bronchique |
FI118263B (fi) * | 2002-10-09 | 2007-09-14 | Timo Kalevi Korpela | Kaspaasiaktiivisuutta säätelevät peptidit |
WO2005116081A2 (fr) | 2004-05-24 | 2005-12-08 | Genvault Corporation | Stockage proteique stable et stockage d'acides nucleiques stable sous forme recuperable |
EA008925B1 (ru) * | 2004-12-14 | 2007-08-31 | Товарищество С Ограниченной Ответственностью "Реал Мед Компани" | Способ коррекции иммунного состояния организма при сахарном диабете |
US7989590B2 (en) * | 2005-03-22 | 2011-08-02 | Rohto Pharmaceutical Co., Ltd | Peptides that increase collagen or hyaluronic acid production |
US7553932B1 (en) | 2005-04-25 | 2009-06-30 | La Jolla Institute For Allergy And Immunology | Methods of treating viral infection with IL-10 receptor antagonists |
US8932829B2 (en) | 2005-07-07 | 2015-01-13 | Elena Dudich | Recombinant alpha-fetoprotein and compositions thereof |
US8283165B2 (en) | 2008-09-12 | 2012-10-09 | Genvault Corporation | Matrices and media for storage and stabilization of biomolecules |
US9850278B2 (en) | 2013-04-25 | 2017-12-26 | Carmel-Haifa University Economic Corp. | Synthetic anti-inflammatory peptides and use thereof |
CN103275222B (zh) * | 2013-05-15 | 2014-04-16 | 中山康方生物医药有限公司 | 一种阻断白介素12 p40功能的单克隆抗体及其编码基因和应用 |
CN114163493B (zh) * | 2021-11-18 | 2023-09-15 | 浙大宁波理工学院 | 一种可作为5型磷酸二酯酶抑制剂的多肽及其应用 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0056249B1 (fr) * | 1981-01-09 | 1985-06-26 | New York Blood Center, Inc. | Composition synthétique d'antigènes et leur procédé de préparation |
US4822606A (en) * | 1986-04-07 | 1989-04-18 | Duke University | Immunosuppressive synthetic peptides and analogs thereof based on retroviral envelope sequences |
AU1366088A (en) * | 1987-01-28 | 1988-08-24 | Ortho Pharmaceutical Corporation | Immunosuppressive peptides and methods of use |
AU620804B2 (en) * | 1987-03-23 | 1992-02-27 | Hiver Limited | Novel vaccines |
SE8705197D0 (sv) * | 1987-12-30 | 1987-12-30 | Jonas Blomberg | New peptides, two diagnostic methods using the peptides and a medicament based on the peptides |
IL97629A0 (en) * | 1990-03-26 | 1992-06-21 | Schering Corp | Bcrf1 antagonists for treating epstein-barr virus infections |
WO1993011157A1 (fr) * | 1991-11-27 | 1993-06-10 | The Council Of The Queensland Institute Of Medical Research | VACCIN ET PEPTIDES CONTRE LA MALARIA COMPRENANT UN EPITOPE DE CELLULE T HUMAINE DE PROTEINE CIRCUMSPOROZOITE DE $i(P.VIVAX) |
ZA931489B (en) * | 1992-03-04 | 1993-10-28 | Schering Corp | Use of interleuken-10 to suppress graft-vs-host disease |
WO1993018783A1 (fr) * | 1992-03-20 | 1993-09-30 | Schering Corporation | Utilisation d'interleukine 10 pour induire la production d'antagoniste des recepteurs de l'interleukine 1 |
CA2144648A1 (fr) * | 1992-09-18 | 1994-03-31 | Mario Clerici | Retablissement de l'immunocompetence des cellules t auxiliaires chez les sujets infectes par le vih |
NZ269766A (en) * | 1993-07-28 | 1998-01-26 | Medvet Science Pty Ltd | Haemopoietic growth factor antagonists; relates to modified forms of such factors |
DE69536065D1 (de) * | 1994-01-14 | 2010-05-27 | Rath Matthias | Hydrophile Signal-Oligopeptide und Verfahren der therapeutischen Anwendung |
AU4385696A (en) * | 1996-01-18 | 1997-08-11 | Christian Gronhoj Larsen | Synthetic il-10 analogues |
-
1996
- 1996-09-13 AU AU68870/96A patent/AU6887096A/en not_active Abandoned
- 1996-09-13 WO PCT/IB1996/000945 patent/WO1998010792A1/fr active Application Filing
-
1997
- 1997-09-10 IL IL12880697A patent/IL128806A0/xx unknown
- 1997-09-10 WO PCT/IB1997/001086 patent/WO1998010787A2/fr not_active Application Discontinuation
- 1997-09-10 JP JP51343598A patent/JP2001503613A/ja active Pending
- 1997-09-10 NZ NZ335039A patent/NZ335039A/en unknown
- 1997-09-10 EP EP97939105A patent/EP0929568A2/fr not_active Withdrawn
- 1997-09-10 CA CA002265885A patent/CA2265885A1/fr not_active Abandoned
- 1997-09-10 AU AU41320/97A patent/AU4132097A/en not_active Abandoned
- 1997-09-10 CN CN97197816A patent/CN1230195A/zh active Pending
-
1999
- 1999-03-08 SE SE9900812A patent/SE9900812L/xx not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP0929568A2 (fr) | 1999-07-21 |
AU4132097A (en) | 1998-04-02 |
NZ335039A (en) | 2001-04-27 |
SE9900812D0 (sv) | 1999-03-08 |
WO1998010787A3 (fr) | 1998-07-30 |
CN1230195A (zh) | 1999-09-29 |
JP2001503613A (ja) | 2001-03-21 |
AU6887096A (en) | 1998-04-02 |
IL128806A0 (en) | 2000-01-31 |
WO1998010792A1 (fr) | 1998-03-19 |
WO1998010787A2 (fr) | 1998-03-19 |
SE9900812L (sv) | 1999-03-08 |
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