CA2260752A1 - Induction of t cell tolerance using a soluble molecule that can simultaneously block two costimulatory pathways - Google Patents
Induction of t cell tolerance using a soluble molecule that can simultaneously block two costimulatory pathways Download PDFInfo
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- CA2260752A1 CA2260752A1 CA 2260752 CA2260752A CA2260752A1 CA 2260752 A1 CA2260752 A1 CA 2260752A1 CA 2260752 CA2260752 CA 2260752 CA 2260752 A CA2260752 A CA 2260752A CA 2260752 A1 CA2260752 A1 CA 2260752A1
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Classifications
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/626—Diabody or triabody
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
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- Neurology (AREA)
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- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Optical Measuring Cells (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2207096P | 1996-07-23 | 1996-07-23 | |
| US60/022,070 | 1996-07-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2260752A1 true CA2260752A1 (en) | 1998-01-29 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 2260752 Abandoned CA2260752A1 (en) | 1996-07-23 | 1997-07-23 | Induction of t cell tolerance using a soluble molecule that can simultaneously block two costimulatory pathways |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20020150559A1 (OSRAM) |
| EP (1) | EP0922111B1 (OSRAM) |
| JP (1) | JP4219985B2 (OSRAM) |
| AT (1) | ATE283925T1 (OSRAM) |
| CA (1) | CA2260752A1 (OSRAM) |
| DE (1) | DE69731836T2 (OSRAM) |
| WO (1) | WO1998003670A1 (OSRAM) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106661108A (zh) * | 2014-04-13 | 2017-05-10 | 阿菲姆德股份有限公司 | 三功能抗原结合分子 |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2292415A1 (en) * | 1997-06-20 | 1998-12-30 | Innogenetics N.V. | B7-binding molecules for treating immune diseases |
| US6514513B1 (en) * | 1998-02-04 | 2003-02-04 | The General Hospital Corporation | Costimulatory blockade and mixed chimerism in transplantation |
| FR2789089A1 (fr) * | 1999-02-02 | 2000-08-04 | Pf Medicament | Lymphocytes t humains effecteurs exprimant la molecule cd86 et possedant des proprietes immunodulatrices, costimulatrices et cytotoxiques, leurs procedes d'obtention et leurs applications |
| JP2003510371A (ja) * | 1999-10-04 | 2003-03-18 | カイロン コーポレイション | 乾癬を処置するためのｃｄ４０アンタゴニスト |
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| CA2516832A1 (en) * | 2003-02-27 | 2004-09-10 | Theravision Gmbh | A molecule which binds cd80 and cd86 |
| WO2005018668A1 (en) * | 2003-08-25 | 2005-03-03 | Pangenetics B.V. | Method of inducing immune tolerance |
| EP1854810A1 (en) | 2006-05-09 | 2007-11-14 | PanGenetics B.V. | Deimmunized antagonistic anti-human CD40 monoclonal antibody from the ch5D12 antibody |
| CA2700714C (en) | 2007-09-26 | 2018-09-11 | Ucb Pharma S.A. | Dual specificity antibody fusions |
| CA2737241C (en) * | 2008-09-26 | 2017-08-29 | Ucb Pharma S.A. | Multivalent antibody fusion proteins |
| CN107056951A (zh) * | 2008-10-02 | 2017-08-18 | 阿帕特夫研究和发展有限公司 | Cd86拮抗物多靶点结合蛋白 |
| AU2009303318B2 (en) * | 2008-10-10 | 2016-06-30 | Aptevo Research And Development Llc | TCR complex immunotherapeutics |
| RU2673153C2 (ru) | 2012-04-20 | 2018-11-22 | АПТЕВО РИСЁРЧ ЭНД ДИВЕЛОПМЕНТ ЭлЭлСи | Полипептиды, связывающиеся с cd3 |
| US20140242077A1 (en) * | 2013-01-23 | 2014-08-28 | Abbvie, Inc. | Methods and compositions for modulating an immune response |
| EP2883883A1 (en) | 2013-12-16 | 2015-06-17 | Cardio3 Biosciences S.A. | Therapeutic targets and agents useful in treating ischemia reperfusion injury |
| EP3152235B1 (en) | 2014-05-29 | 2021-08-25 | MacroGenics, Inc. | Tri-specific binding molecules and methods of use thereof |
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| US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
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| EP0098110B1 (en) * | 1982-06-24 | 1989-10-18 | NIHON CHEMICAL RESEARCH KABUSHIKI KAISHA also known as JAPAN CHEMICAL RESEARCH CO., LTD | Long-acting composition |
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| US5397703A (en) * | 1992-07-09 | 1995-03-14 | Cetus Oncology Corporation | Method for generation of antibodies to cell surface molecules |
| ATE199392T1 (de) * | 1992-12-04 | 2001-03-15 | Medical Res Council | Multivalente und multispezifische bindungsproteine, deren herstellung und verwendung |
| GB9412166D0 (en) * | 1993-09-22 | 1994-08-10 | Medical Res Council | Retargetting antibodies |
| US6051228A (en) * | 1998-02-19 | 2000-04-18 | Bristol-Myers Squibb Co. | Antibodies against human CD40 |
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1997
- 1997-07-23 WO PCT/NL1997/000438 patent/WO1998003670A1/en not_active Ceased
- 1997-07-23 JP JP50683098A patent/JP4219985B2/ja not_active Expired - Fee Related
- 1997-07-23 EP EP19970930902 patent/EP0922111B1/en not_active Expired - Lifetime
- 1997-07-23 DE DE1997631836 patent/DE69731836T2/de not_active Expired - Lifetime
- 1997-07-23 AT AT97930902T patent/ATE283925T1/de not_active IP Right Cessation
- 1997-07-23 CA CA 2260752 patent/CA2260752A1/en not_active Abandoned
-
2001
- 2001-10-15 US US09/978,752 patent/US20020150559A1/en not_active Abandoned
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106661108A (zh) * | 2014-04-13 | 2017-05-10 | 阿菲姆德股份有限公司 | 三功能抗原结合分子 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO1998003670A1 (en) | 1998-01-29 |
| DE69731836D1 (de) | 2005-01-05 |
| ATE283925T1 (de) | 2004-12-15 |
| EP0922111A1 (en) | 1999-06-16 |
| DE69731836T2 (de) | 2005-12-01 |
| EP0922111B1 (en) | 2004-12-01 |
| HK1017905A1 (en) | 1999-12-03 |
| JP4219985B2 (ja) | 2009-02-04 |
| US20020150559A1 (en) | 2002-10-17 |
| JP2000515374A (ja) | 2000-11-21 |
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