CA2259183C - Reaction fluoritique et systemes de separation - Google Patents

Reaction fluoritique et systemes de separation Download PDF

Info

Publication number
CA2259183C
CA2259183C CA002259183A CA2259183A CA2259183C CA 2259183 C CA2259183 C CA 2259183C CA 002259183 A CA002259183 A CA 002259183A CA 2259183 A CA2259183 A CA 2259183A CA 2259183 C CA2259183 C CA 2259183C
Authority
CA
Canada
Prior art keywords
fluorous
organic
mmol
phase
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002259183A
Other languages
English (en)
Other versions
CA2259183A1 (fr
Inventor
Dennis P. Curran
Sabine Hadida Ruah
Masahide Hashino
Armido Studer
Peter Wipf
Patrick Jeger
Sun-Young Kim
Rafael Ferritto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pittsburgh
Original Assignee
University of Pittsburgh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/671,945 external-priority patent/US5777121A/en
Application filed by University of Pittsburgh filed Critical University of Pittsburgh
Priority claimed from PCT/US1997/011215 external-priority patent/WO1998000376A1/fr
Publication of CA2259183A1 publication Critical patent/CA2259183A1/fr
Application granted granted Critical
Publication of CA2259183C publication Critical patent/CA2259183C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/22—Tin compounds
    • C07F7/2284—Compounds with one or more Sn-N linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B61/00—Other general methods
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B63/00—Purification; Separation; Stabilisation; Use of additives
    • C07B63/02—Purification; Separation; Stabilisation; Use of additives by treatment giving rise to a chemical modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/06—Compounds containing nitro groups bound to a carbon skeleton having nitro groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/10—Preparation of carboxylic acid amides from compounds not provided for in groups C07C231/02 - C07C231/08
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/12—Organo silicon halides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/12—Organo silicon halides
    • C07F7/121—Preparation or treatment not provided for in C07F7/14, C07F7/16 or C07F7/20
    • C07F7/123—Preparation or treatment not provided for in C07F7/14, C07F7/16 or C07F7/20 by reactions involving the formation of Si-halogen linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
    • C07F7/188—Preparation; Treatments not provided for in C07F7/20 by reactions involving the formation of Si-O linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/22—Tin compounds
    • C07F7/2208—Compounds having tin linked only to carbon, hydrogen and/or halogen
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/08—Liquid phase synthesis, i.e. wherein all library building blocks are in liquid phase or in solution during library creation; Particular methods of cleavage from the liquid support
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Structural Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Carbon And Carbon Compounds (AREA)
  • Silicon Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La présente invention concerne divers procédés de synthèse et de séparation dans lesquels on a recours à des techniques de séparation des phases organique/fluoritique pour effectuer les séparations. L'invention concerne aussi de nouvelles compositions de matière comprenant des composés fluoritiques de silicium (Si), d'étain (Sn) et de germanium (Ge).
CA002259183A 1996-06-28 1997-06-26 Reaction fluoritique et systemes de separation Expired - Fee Related CA2259183C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/671,945 US5777121A (en) 1996-06-28 1996-06-28 Fluorous reaction systems
US08/671,945 1996-06-28
US08/690,491 US5859247A (en) 1996-06-28 1996-07-31 Fluorous reaction and separation systems
US08/690,491 1996-07-31
PCT/US1997/011215 WO1998000376A1 (fr) 1996-06-28 1997-06-26 Reaction fluoritique et systemes de separation

Publications (2)

Publication Number Publication Date
CA2259183A1 CA2259183A1 (fr) 1998-01-08
CA2259183C true CA2259183C (fr) 2006-06-20

Family

ID=37393277

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002259183A Expired - Fee Related CA2259183C (fr) 1996-06-28 1997-06-26 Reaction fluoritique et systemes de separation

Country Status (1)

Country Link
CA (1) CA2259183C (fr)

Also Published As

Publication number Publication date
CA2259183A1 (fr) 1998-01-08

Similar Documents

Publication Publication Date Title
US6156896A (en) Fluorous reaction and separation systems
US5859247A (en) Fluorous reaction and separation systems
JP2007314576A6 (ja) フッ素系反応及び分離システム
Studer et al. A strategic alternative to solid phase synthesis: preparation of a small isoxazoline library by “fluorous synthesis”
CA2500206A1 (fr) Compositions contenant des liquides ioniques et leurs utilisations, notamment en synthese organique
CN106336349A (zh) 溴代三氟甲氧基化合物及其合成方法
WO2005005345A2 (fr) Utilisation de sels d'onium fonctionnalises en tant que support soluble pour la synthese organique
WO2001061332A1 (fr) Methodes de reaction chimique et de separation
Lothian et al. ipso-Fluorination of aryltrimethylsilanes using xenon difluoride
US6803475B2 (en) Fluorous tagging compounds and methods of use thereof
JP4242764B2 (ja) アルコールのフルオラス求核置換反応および反応に使用する求核試薬
CA2259183C (fr) Reaction fluoritique et systemes de separation
US6861544B1 (en) Fluorous tin compounds an methods of using fluorous tin compounds
CN104817591B (zh) 一种手性叔膦化合物及其全构型、其制备方法和应用
JP2004529981A (ja) フルオロ三相及び他の多相系
CN109096338A (zh) 苯并氮杂磷杂茂膦氧配体及含其络合物、制备方法和应用
CN114957323B (zh) 一种芳基膦类化合物的合成方法
WO1998005671A1 (fr) Composes organosilicies et leur utilisation en chimie combinatoire
CN110317220A (zh) 一种双手性中心环丙基硅烷化合物及其制备方法和应用
Kim Detailed studies of fluorous tin compounds and combinatorial approach to the synthesis of discodermolide analogs
JP2620185B2 (ja) ２−トリフルオロメチル−３−トリメチルシリルメトキシプロピオン酸トリメチルシリルメチルエステル
He et al. Experimental techniques in fluorous synthesis: a user's
Mandal Stereoselective synthesis of trifluoromethylated amines, allylic amines, diamines and amino alcohols using (trifluoromethyl) trimethylsilane
JP2005247818A (ja) 置換アセチレンの製造方法
Zhang Fluorous mixture synthesis approach to natural product stereoisomers: Synthesis of both enantiomers of pyridovericin and mappicine and eight isomers of murisolin

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed