CA2253934A1 - Inhibitors of protein farnesyl transferase - Google Patents

Info

Publication number

CA2253934A1

CA2253934A1 CA002253934A CA2253934A CA2253934A1 CA 2253934 A1 CA2253934 A1 CA 2253934A1 CA 002253934 A CA002253934 A CA 002253934A CA 2253934 A CA2253934 A CA 2253934A CA 2253934 A1 CA2253934 A1 CA 2253934A1

Authority

CA

Canada

Prior art keywords

methyl

phenyl

imidazole

carbamoyl

benzyl

Prior art date

1996-05-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• CIPO
• Discuss

• 108010054353 p21(ras) farnesyl-protein transferase Proteins 0.000 title abstract description 10
• 239000003112 inhibitor Substances 0.000 title abstract description 6
• 238000000034 method Methods 0.000 claims abstract description 43
• 206010028980 Neoplasm Diseases 0.000 claims abstract description 35
• 201000011510 cancer Diseases 0.000 claims abstract description 26
• 208000037803 restenosis Diseases 0.000 claims abstract description 23
• 201000004681 Psoriasis Diseases 0.000 claims abstract description 11
• 208000036142 Viral infection Diseases 0.000 claims abstract description 11
• 230000009385 viral infection Effects 0.000 claims abstract description 11
• 150000001875 compounds Chemical class 0.000 claims description 237
• -1 -OC1-C6 alkyl Chemical group 0.000 claims description 107
• 229910052739 hydrogen Inorganic materials 0.000 claims description 60
• 239000001257 hydrogen Substances 0.000 claims description 60
• 239000000203 mixture Substances 0.000 claims description 46
• 150000002431 hydrogen Chemical class 0.000 claims description 35
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 32
• 150000002148 esters Chemical class 0.000 claims description 30
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 25
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 22
• 150000003839 salts Chemical class 0.000 claims description 21
• 150000001408 amides Chemical class 0.000 claims description 18
• 229910052736 halogen Inorganic materials 0.000 claims description 18
• 150000002367 halogens Chemical class 0.000 claims description 18
• 229940002612 prodrug Drugs 0.000 claims description 16
• 239000000651 prodrug Substances 0.000 claims description 16
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 16
• 125000000217 alkyl group Chemical group 0.000 claims description 13
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 13
• 125000004093 cyano group Chemical group *C#N 0.000 claims description 7
• 229910052760 oxygen Inorganic materials 0.000 claims description 6
• 125000006340 pentafluoro ethyl group Chemical group FC(F)(F)C(F)(F)* 0.000 claims description 6
• BMXRIUNRNBDEIQ-RDFKHQOOSA-N (2s)-2-(benzylcarbamoylamino)-3-(1h-imidazol-5-yl)-n-[2-oxo-2-(2-phenylpropylamino)ethyl]-n-[(4-phenylmethoxyphenyl)methyl]propanamide Chemical compound C=1C=CC=CC=1C(C)CNC(=O)CN(C(=O)[C@H](CC=1N=CNC=1)NC(=O)NCC=1C=CC=CC=1)CC(C=C1)=CC=C1OCC1=CC=CC=C1 BMXRIUNRNBDEIQ-RDFKHQOOSA-N 0.000 claims description 4
• 206010005003 Bladder cancer Diseases 0.000 claims description 4
• 206010009944 Colon cancer Diseases 0.000 claims description 4
• 229910052794 bromium Inorganic materials 0.000 claims description 4
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 4
• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 4
• 125000006283 4-chlorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1Cl)C([H])([H])* 0.000 claims description 3
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 3
• PUJDIJCNWFYVJX-UHFFFAOYSA-N benzyl carbamate Chemical compound NC(=O)OCC1=CC=CC=C1 PUJDIJCNWFYVJX-UHFFFAOYSA-N 0.000 claims description 3
• OIDZVPMBRLHMFX-FZNWDQQTSA-N benzyl n-[(2s)-3-(1h-imidazol-5-yl)-1-[(4-methoxyphenyl)methyl-[2-oxo-2-(2-phenylpropylamino)ethyl]amino]-1-oxopropan-2-yl]carbamate Chemical compound C1=CC(OC)=CC=C1CN(C(=O)[C@H](CC=1NC=NC=1)NC(=O)OCC=1C=CC=CC=1)CC(=O)NCC(C)C1=CC=CC=C1 OIDZVPMBRLHMFX-FZNWDQQTSA-N 0.000 claims description 3
• 229910052801 chlorine Inorganic materials 0.000 claims description 3
• 229910052731 fluorine Inorganic materials 0.000 claims description 3
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 3
• 208000008443 pancreatic carcinoma Diseases 0.000 claims description 3
• DHJHUEZBKNEGLV-PMERELPUSA-N (2s)-2-(benzylcarbamothioylamino)-3-(1h-imidazol-5-yl)-n-[(4-methylphenyl)methyl]-n-[2-[(2-methyl-2-phenylpropyl)amino]-2-oxoethyl]propanamide Chemical compound C1=CC(C)=CC=C1CN(C(=O)[C@H](CC=1NC=NC=1)NC(=S)NCC=1C=CC=CC=1)CC(=O)NCC(C)(C)C1=CC=CC=C1 DHJHUEZBKNEGLV-PMERELPUSA-N 0.000 claims description 2
• GKJYLSQGRPYXPA-LJAQVGFWSA-N (2s)-2-(benzylcarbamoylamino)-n-[(4-chlorophenyl)methyl]-3-(1h-imidazol-5-yl)-n-[2-[(2-methyl-2-phenylpropyl)amino]-2-oxoethyl]propanamide Chemical compound C=1C=CC=CC=1C(C)(C)CNC(=O)CN(C(=O)[C@H](CC=1NC=NC=1)NC(=O)NCC=1C=CC=CC=1)CC1=CC=C(Cl)C=C1 GKJYLSQGRPYXPA-LJAQVGFWSA-N 0.000 claims description 2
• IZRIZSLRLYZTAQ-QNGWXLTQSA-N (2s)-2-[[benzyl(methyl)carbamoyl]amino]-3-(1h-imidazol-5-yl)-n-[2-[(2-methyl-2-phenylpropyl)amino]-2-oxoethyl]-n-[(4-phenylmethoxyphenyl)methyl]propanamide Chemical compound N([C@@H](CC=1N=CNC=1)C(=O)N(CC(=O)NCC(C)(C)C=1C=CC=CC=1)CC=1C=CC(OCC=2C=CC=CC=2)=CC=1)C(=O)N(C)CC1=CC=CC=C1 IZRIZSLRLYZTAQ-QNGWXLTQSA-N 0.000 claims description 2
• RAMJUHYLONAILT-PMERELPUSA-N (2s)-2-[[benzyl(methyl)carbamoyl]amino]-n-[(4-chlorophenyl)methyl]-3-(1h-imidazol-5-yl)-n-[2-[(2-methyl-2-phenylpropyl)amino]-2-oxoethyl]propanamide Chemical compound N([C@@H](CC=1N=CNC=1)C(=O)N(CC(=O)NCC(C)(C)C=1C=CC=CC=1)CC=1C=CC(Cl)=CC=1)C(=O)N(C)CC1=CC=CC=C1 RAMJUHYLONAILT-PMERELPUSA-N 0.000 claims description 2
• FYZLYRZHHZRXRN-HKBQPEDESA-N (2s)-2-acetamido-3-(1h-imidazol-5-yl)-n-[2-[(2-methyl-2-phenylpropyl)amino]-2-oxoethyl]-n-[(4-phenylmethoxyphenyl)methyl]propanamide Chemical compound C([C@H](NC(=O)C)C(=O)N(CC(=O)NCC(C)(C)C=1C=CC=CC=1)CC=1C=CC(OCC=2C=CC=CC=2)=CC=1)C1=CN=CN1 FYZLYRZHHZRXRN-HKBQPEDESA-N 0.000 claims description 2
• PDKDLUYROFHYGS-AZPJNPSPSA-N (2s)-3-(1h-imidazol-5-yl)-n-[2-oxo-2-(2-phenylpropylamino)ethyl]-n-[(4-phenylmethoxyphenyl)methyl]-2-(3-phenylpropanoylamino)propanamide Chemical compound C=1C=CC=CC=1C(C)CNC(=O)CN(C(=O)[C@H](CC=1N=CNC=1)NC(=O)CCC=1C=CC=CC=1)CC(C=C1)=CC=C1OCC1=CC=CC=C1 PDKDLUYROFHYGS-AZPJNPSPSA-N 0.000 claims description 2
• GZDQXBPGVLDSMB-QNGWXLTQSA-N (4-methoxyphenyl)methyl n-[(2s)-3-(1h-imidazol-5-yl)-1-[[2-[(2-methyl-2-phenylpropyl)amino]-2-oxoethyl]-[(4-phenylmethoxyphenyl)methyl]amino]-1-oxopropan-2-yl]carbamate Chemical compound C1=CC(OC)=CC=C1COC(=O)N[C@H](C(=O)N(CC(=O)NCC(C)(C)C=1C=CC=CC=1)CC=1C=CC(OCC=2C=CC=CC=2)=CC=1)CC1=CN=CN1 GZDQXBPGVLDSMB-QNGWXLTQSA-N 0.000 claims description 2
• 206010006187 Breast cancer Diseases 0.000 claims description 2
• 208000026310 Breast neoplasm Diseases 0.000 claims description 2
• 229910003204 NH2 Inorganic materials 0.000 claims description 2
• 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 2
• 208000024770 Thyroid neoplasm Diseases 0.000 claims description 2
• 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 2
• GDNMFXNLQJTIBN-SFCXHYMASA-N benzyl n-[(2s)-1-[(1-amino-1-oxo-4-phenylbutan-2-yl)-[(4-phenylmethoxyphenyl)methyl]amino]-3-(1h-imidazol-5-yl)-1-oxopropan-2-yl]carbamate Chemical compound C=1C=C(OCC=2C=CC=CC=2)C=CC=1CN(C(=O)[C@H](CC=1NC=NC=1)NC(=O)OCC=1C=CC=CC=1)C(C(=O)N)CCC1=CC=CC=C1 GDNMFXNLQJTIBN-SFCXHYMASA-N 0.000 claims description 2
• RDXDECXODBTMOR-IZCXSWDTSA-N benzyl n-[(2s)-1-[(2-chlorophenyl)methyl-[2-oxo-2-(2-phenylpropylamino)ethyl]amino]-3-(1h-imidazol-5-yl)-1-oxopropan-2-yl]carbamate Chemical compound C=1C=CC=CC=1C(C)CNC(=O)CN(C(=O)[C@H](CC=1NC=NC=1)NC(=O)OCC=1C=CC=CC=1)CC1=CC=CC=C1Cl RDXDECXODBTMOR-IZCXSWDTSA-N 0.000 claims description 2
• RNRQOBDRZWCHDI-LJAQVGFWSA-N benzyl n-[(2s)-1-[(4-aminophenyl)methyl-[2-[(2-methyl-2-phenylpropyl)amino]-2-oxoethyl]amino]-3-(1h-imidazol-5-yl)-1-oxopropan-2-yl]carbamate Chemical compound C=1C=CC=CC=1C(C)(C)CNC(=O)CN(C(=O)[C@H](CC=1NC=NC=1)NC(=O)OCC=1C=CC=CC=1)CC1=CC=C(N)C=C1 RNRQOBDRZWCHDI-LJAQVGFWSA-N 0.000 claims description 2
• NQVJXBFXQFGIHU-IZCXSWDTSA-N benzyl n-[(2s)-1-[(4-bromophenyl)methyl-[2-oxo-2-(2-phenylpropylamino)ethyl]amino]-3-(1h-imidazol-5-yl)-1-oxopropan-2-yl]carbamate Chemical compound C=1C=CC=CC=1C(C)CNC(=O)CN(C(=O)[C@H](CC=1NC=NC=1)NC(=O)OCC=1C=CC=CC=1)CC1=CC=C(Br)C=C1 NQVJXBFXQFGIHU-IZCXSWDTSA-N 0.000 claims description 2
• ILMZVWUPVVZVEF-FZNWDQQTSA-N benzyl n-[(2s)-1-[(4-chlorophenyl)methyl-[1-[(2-methyl-2-phenylpropyl)amino]-1-oxopropan-2-yl]amino]-3-(1h-imidazol-5-yl)-1-oxopropan-2-yl]carbamate Chemical compound C=1C=CC=CC=1C(C)(C)CNC(=O)C(C)N(C(=O)[C@H](CC=1NC=NC=1)NC(=O)OCC=1C=CC=CC=1)CC1=CC=C(Cl)C=C1 ILMZVWUPVVZVEF-FZNWDQQTSA-N 0.000 claims description 2
• SSXFUPUONWGRIP-IZCXSWDTSA-N benzyl n-[(2s)-1-[(4-chlorophenyl)methyl-[2-oxo-2-(2-phenylpropylamino)ethyl]amino]-3-(1h-imidazol-5-yl)-1-oxopropan-2-yl]carbamate Chemical compound C=1C=CC=CC=1C(C)CNC(=O)CN(C(=O)[C@H](CC=1NC=NC=1)NC(=O)OCC=1C=CC=CC=1)CC1=CC=C(Cl)C=C1 SSXFUPUONWGRIP-IZCXSWDTSA-N 0.000 claims description 2
• ZYYZYRPGMHCHED-LJAQVGFWSA-N benzyl n-[(2s)-1-[(4-fluorophenyl)methyl-[2-[(2-methyl-2-phenylpropyl)amino]-2-oxoethyl]amino]-3-(1h-imidazol-5-yl)-1-oxopropan-2-yl]carbamate Chemical compound C=1C=CC=CC=1C(C)(C)CNC(=O)CN(C(=O)[C@H](CC=1N=CNC=1)NC(=O)OCC=1C=CC=CC=1)CC1=CC=C(F)C=C1 ZYYZYRPGMHCHED-LJAQVGFWSA-N 0.000 claims description 2
• NPVIMMQTVLPHKV-RWYGWLOXSA-N benzyl n-[(2s)-1-[[2-(2,2-diphenylethylamino)-2-oxoethyl]-[(4-phenylmethoxyphenyl)methyl]amino]-3-(1h-imidazol-5-yl)-1-oxopropan-2-yl]carbamate Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)CNC(=O)CN(C(=O)[C@H](CC=1N=CNC=1)NC(=O)OCC=1C=CC=CC=1)CC(C=C1)=CC=C1OCC1=CC=CC=C1 NPVIMMQTVLPHKV-RWYGWLOXSA-N 0.000 claims description 2
• SMBHALUVUUYXQI-CRGCAJGSSA-N benzyl n-[(2s)-1-[[2-[(2-cyano-2-phenylethyl)amino]-2-oxoethyl]-[(4-phenylmethoxyphenyl)methyl]amino]-3-(1h-imidazol-5-yl)-1-oxopropan-2-yl]carbamate Chemical compound C=1C=CC=CC=1C(C#N)CNC(=O)CN(C(=O)[C@H](CC=1N=CNC=1)NC(=O)OCC=1C=CC=CC=1)CC(C=C1)=CC=C1OCC1=CC=CC=C1 SMBHALUVUUYXQI-CRGCAJGSSA-N 0.000 claims description 2
• KESDVVHGRDVTAS-LHEWISCISA-N benzyl n-[(2s)-1-[[2-[(2-ethyl-2-phenylbutyl)amino]-2-oxoethyl]-[(4-phenylmethoxyphenyl)methyl]amino]-3-(1h-imidazol-5-yl)-1-oxopropan-2-yl]carbamate Chemical compound C=1C=CC=CC=1C(CC)(CC)CNC(=O)CN(C(=O)[C@H](CC=1NC=NC=1)NC(=O)OCC=1C=CC=CC=1)CC(C=C1)=CC=C1OCC1=CC=CC=C1 KESDVVHGRDVTAS-LHEWISCISA-N 0.000 claims description 2
• GXIVMLAXZNKACQ-NPJBGSGMSA-N benzyl n-[(2s)-1-[[2-[2-(2-aminophenyl)propylamino]-2-oxoethyl]-[(4-phenylmethoxyphenyl)methyl]amino]-3-(1h-imidazol-5-yl)-1-oxopropan-2-yl]carbamate Chemical compound C=1C=CC=C(N)C=1C(C)CNC(=O)CN(C(=O)[C@H](CC=1NC=NC=1)NC(=O)OCC=1C=CC=CC=1)CC(C=C1)=CC=C1OCC1=CC=CC=C1 GXIVMLAXZNKACQ-NPJBGSGMSA-N 0.000 claims description 2
• YHHYADBNHFMKAY-DHUJRADRSA-N benzyl n-[(2s)-1-[[2-[2-(2-chlorophenyl)ethylamino]-2-oxoethyl]-[(4-phenylmethoxyphenyl)methyl]amino]-3-(1h-imidazol-5-yl)-1-oxopropan-2-yl]carbamate Chemical compound ClC1=CC=CC=C1CCNC(=O)CN(C(=O)[C@H](CC=1N=CNC=1)NC(=O)OCC=1C=CC=CC=1)CC(C=C1)=CC=C1OCC1=CC=CC=C1 YHHYADBNHFMKAY-DHUJRADRSA-N 0.000 claims description 2
• BNSYCEGVHLCVSI-NPJBGSGMSA-N benzyl n-[(2s)-1-[[2-[2-(2-chlorophenyl)propylamino]-2-oxoethyl]-[(4-phenylmethoxyphenyl)methyl]amino]-3-(1h-imidazol-5-yl)-1-oxopropan-2-yl]carbamate Chemical compound C=1C=CC=C(Cl)C=1C(C)CNC(=O)CN(C(=O)[C@H](CC=1N=CNC=1)NC(=O)OCC=1C=CC=CC=1)CC(C=C1)=CC=C1OCC1=CC=CC=C1 BNSYCEGVHLCVSI-NPJBGSGMSA-N 0.000 claims description 2
• PTKJTIDQTQECRF-DHUJRADRSA-N benzyl n-[(2s)-1-[[2-[2-(2-fluorophenyl)ethylamino]-2-oxoethyl]-[(4-phenylmethoxyphenyl)methyl]amino]-3-(1h-imidazol-5-yl)-1-oxopropan-2-yl]carbamate Chemical compound FC1=CC=CC=C1CCNC(=O)CN(C(=O)[C@H](CC=1N=CNC=1)NC(=O)OCC=1C=CC=CC=1)CC(C=C1)=CC=C1OCC1=CC=CC=C1 PTKJTIDQTQECRF-DHUJRADRSA-N 0.000 claims description 2
• YDVQFZBNLASSIP-PQEJLDEPSA-N benzyl n-[(2s)-1-[[2-[[2-(2-chlorophenyl)-2-phenylethyl]amino]-2-oxoethyl]-[(4-phenylmethoxyphenyl)methyl]amino]-3-(1h-imidazol-5-yl)-1-oxopropan-2-yl]carbamate Chemical compound ClC1=CC=CC=C1C(C=1C=CC=CC=1)CNC(=O)CN(C(=O)[C@H](CC=1NC=NC=1)NC(=O)OCC=1C=CC=CC=1)CC(C=C1)=CC=C1OCC1=CC=CC=C1 YDVQFZBNLASSIP-PQEJLDEPSA-N 0.000 claims description 2
• AQPCQRZCFKAMCG-KHTLXAHUSA-N benzyl n-[(2s)-1-[[4-(dimethylamino)phenyl]methyl-[2-oxo-2-(2-phenylpropylamino)ethyl]amino]-3-(1h-imidazol-5-yl)-1-oxopropan-2-yl]carbamate Chemical compound C=1C=CC=CC=1C(C)CNC(=O)CN(C(=O)[C@H](CC=1NC=NC=1)NC(=O)OCC=1C=CC=CC=1)CC1=CC=C(N(C)C)C=C1 AQPCQRZCFKAMCG-KHTLXAHUSA-N 0.000 claims description 2
• HLTPZABIYJFBEX-XIFFEERXSA-N benzyl n-[(2s)-1-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl-[2-[(2-methyl-2-phenylpropyl)amino]-2-oxoethyl]amino]-3-(1h-imidazol-5-yl)-1-oxopropan-2-yl]carbamate Chemical compound C1=CC(OCCN(C)C)=CC=C1CN(C(=O)[C@H](CC=1NC=NC=1)NC(=O)OCC=1C=CC=CC=1)CC(=O)NCC(C)(C)C1=CC=CC=C1 HLTPZABIYJFBEX-XIFFEERXSA-N 0.000 claims description 2
• JHMAXHXLKSHTKI-PEFOLFAWSA-N benzyl n-[(2s)-1-[benzyl-[2-oxo-2-(2-phenylpropylamino)ethyl]amino]-3-(1h-imidazol-5-yl)-1-oxopropan-2-yl]carbamate Chemical compound C=1C=CC=CC=1C(C)CNC(=O)CN(C(=O)[C@H](CC=1NC=NC=1)NC(=O)OCC=1C=CC=CC=1)CC1=CC=CC=C1 JHMAXHXLKSHTKI-PEFOLFAWSA-N 0.000 claims description 2
• BJFPFQSGVXNSND-QNGWXLTQSA-N benzyl n-[(2s)-3-(1-methylimidazol-4-yl)-1-[[2-[(2-methyl-2-phenylpropyl)amino]-2-oxoethyl]-[(4-phenylmethoxyphenyl)methyl]amino]-1-oxopropan-2-yl]carbamate Chemical compound CN1C=NC(C[C@H](NC(=O)OCC=2C=CC=CC=2)C(=O)N(CC(=O)NCC(C)(C)C=2C=CC=CC=2)CC=2C=CC(OCC=3C=CC=CC=3)=CC=2)=C1 BJFPFQSGVXNSND-QNGWXLTQSA-N 0.000 claims description 2
• CYTUTAVSMWREOX-LJAQVGFWSA-N benzyl n-[(2s)-3-(1h-imidazol-5-yl)-1-[(2-methoxyphenyl)methyl-[2-[(2-methyl-2-phenylpropyl)amino]-2-oxoethyl]amino]-1-oxopropan-2-yl]carbamate Chemical compound COC1=CC=CC=C1CN(C(=O)[C@H](CC=1N=CNC=1)NC(=O)OCC=1C=CC=CC=1)CC(=O)NCC(C)(C)C1=CC=CC=C1 CYTUTAVSMWREOX-LJAQVGFWSA-N 0.000 claims description 2
• SWQCEXAJIWYVJG-PEFOLFAWSA-N benzyl n-[(2s)-3-(1h-imidazol-5-yl)-1-[(2-methoxyphenyl)methyl-[2-oxo-2-(2-phenylpropylamino)ethyl]amino]-1-oxopropan-2-yl]carbamate Chemical compound COC1=CC=CC=C1CN(C(=O)[C@H](CC=1NC=NC=1)NC(=O)OCC=1C=CC=CC=1)CC(=O)NCC(C)C1=CC=CC=C1 SWQCEXAJIWYVJG-PEFOLFAWSA-N 0.000 claims description 2
• ZPDCUCCWBTXENB-QNGSWNHHSA-N benzyl n-[(2s)-3-(1h-imidazol-5-yl)-1-[(2-methylphenyl)methyl-[2-oxo-2-(2-phenylpropylamino)ethyl]amino]-1-oxopropan-2-yl]carbamate Chemical compound C=1C=CC=CC=1C(C)CNC(=O)CN(C(=O)[C@H](CC=1NC=NC=1)NC(=O)OCC=1C=CC=CC=1)CC1=CC=CC=C1C ZPDCUCCWBTXENB-QNGSWNHHSA-N 0.000 claims description 2
• BMNVZAQJODUKBF-PMERELPUSA-N benzyl n-[(2s)-3-(1h-imidazol-5-yl)-1-[(3-methoxyphenyl)methyl-[2-[(2-methyl-2-phenylpropyl)amino]-2-oxoethyl]amino]-1-oxopropan-2-yl]carbamate Chemical compound COC1=CC=CC(CN(CC(=O)NCC(C)(C)C=2C=CC=CC=2)C(=O)[C@H](CC=2N=CNC=2)NC(=O)OCC=2C=CC=CC=2)=C1 BMNVZAQJODUKBF-PMERELPUSA-N 0.000 claims description 2
• JFRDYWFPSQJTNE-FZNWDQQTSA-N benzyl n-[(2s)-3-(1h-imidazol-5-yl)-1-[(3-methoxyphenyl)methyl-[2-oxo-2-(2-phenylpropylamino)ethyl]amino]-1-oxopropan-2-yl]carbamate Chemical compound COC1=CC=CC(CN(CC(=O)NCC(C)C=2C=CC=CC=2)C(=O)[C@H](CC=2NC=NC=2)NC(=O)OCC=2C=CC=CC=2)=C1 JFRDYWFPSQJTNE-FZNWDQQTSA-N 0.000 claims description 2
• NNRXKWAHWANQLM-QNGSWNHHSA-N benzyl n-[(2s)-3-(1h-imidazol-5-yl)-1-[(3-methylphenyl)methyl-[2-oxo-2-(2-phenylpropylamino)ethyl]amino]-1-oxopropan-2-yl]carbamate Chemical compound C=1C=CC=CC=1C(C)CNC(=O)CN(C(=O)[C@H](CC=1NC=NC=1)NC(=O)OCC=1C=CC=CC=1)CC1=CC=CC(C)=C1 NNRXKWAHWANQLM-QNGSWNHHSA-N 0.000 claims description 2
• QGXVHBXRVCWIAD-NDEPHWFRSA-N benzyl n-[(2s)-3-(1h-imidazol-5-yl)-1-[(4-iodophenyl)methyl-[2-oxo-2-(2-phenylethylamino)ethyl]amino]-1-oxopropan-2-yl]carbamate Chemical compound C1=CC(I)=CC=C1CN(C(=O)[C@H](CC=1NC=NC=1)NC(=O)OCC=1C=CC=CC=1)CC(=O)NCCC1=CC=CC=C1 QGXVHBXRVCWIAD-NDEPHWFRSA-N 0.000 claims description 2
• LDKNRMHCDWFIOW-PMERELPUSA-N benzyl n-[(2s)-3-(1h-imidazol-5-yl)-1-[(4-methoxyphenyl)methyl-[2-[(2-methyl-2-phenylpropyl)amino]-2-oxoethyl]amino]-1-oxopropan-2-yl]carbamate Chemical compound C1=CC(OC)=CC=C1CN(C(=O)[C@H](CC=1N=CNC=1)NC(=O)OCC=1C=CC=CC=1)CC(=O)NCC(C)(C)C1=CC=CC=C1 LDKNRMHCDWFIOW-PMERELPUSA-N 0.000 claims description 2
• NWSAOVCSJUGBPY-PMERELPUSA-N benzyl n-[(2s)-3-(1h-imidazol-5-yl)-1-[(4-methylphenyl)methyl-[2-[(2-methyl-2-phenylpropyl)amino]-2-oxoethyl]amino]-1-oxopropan-2-yl]carbamate Chemical compound C1=CC(C)=CC=C1CN(C(=O)[C@H](CC=1N=CNC=1)NC(=O)OCC=1C=CC=CC=1)CC(=O)NCC(C)(C)C1=CC=CC=C1 NWSAOVCSJUGBPY-PMERELPUSA-N 0.000 claims description 2
• ABXXMASKQPMUOQ-QNGSWNHHSA-N benzyl n-[(2s)-3-(1h-imidazol-5-yl)-1-[(4-methylphenyl)methyl-[2-oxo-2-(2-phenylpropylamino)ethyl]amino]-1-oxopropan-2-yl]carbamate Chemical compound C=1C=CC=CC=1C(C)CNC(=O)CN(C(=O)[C@H](CC=1N=CNC=1)NC(=O)OCC=1C=CC=CC=1)CC1=CC=C(C)C=C1 ABXXMASKQPMUOQ-QNGSWNHHSA-N 0.000 claims description 2
• UKDHPFDMEXGIKI-HKBQPEDESA-N benzyl n-[(2s)-3-(1h-imidazol-5-yl)-1-[2-(4-methoxyphenyl)ethyl-[2-[(2-methyl-2-phenylpropyl)amino]-2-oxoethyl]amino]-1-oxopropan-2-yl]carbamate Chemical compound C1=CC(OC)=CC=C1CCN(C(=O)[C@H](CC=1NC=NC=1)NC(=O)OCC=1C=CC=CC=1)CC(=O)NCC(C)(C)C1=CC=CC=C1 UKDHPFDMEXGIKI-HKBQPEDESA-N 0.000 claims description 2
• WCLYIHLHKOUOND-NDEPHWFRSA-N benzyl n-[(2s)-3-(1h-imidazol-5-yl)-1-[[2-[(2-methyl-2-phenylpropyl)amino]-2-oxoethyl]-(pyridin-2-ylmethyl)amino]-1-oxopropan-2-yl]carbamate Chemical compound C=1C=CC=CC=1C(C)(C)CNC(=O)CN(C(=O)[C@H](CC=1N=CNC=1)NC(=O)OCC=1C=CC=CC=1)CC1=CC=CC=N1 WCLYIHLHKOUOND-NDEPHWFRSA-N 0.000 claims description 2
• UQLQRUIIDDIQBK-NDEPHWFRSA-N benzyl n-[(2s)-3-(1h-imidazol-5-yl)-1-[[2-[(2-methyl-2-phenylpropyl)amino]-2-oxoethyl]-(pyridin-3-ylmethyl)amino]-1-oxopropan-2-yl]carbamate Chemical compound C=1C=CC=CC=1C(C)(C)CNC(=O)CN(C(=O)[C@H](CC=1N=CNC=1)NC(=O)OCC=1C=CC=CC=1)CC1=CC=CN=C1 UQLQRUIIDDIQBK-NDEPHWFRSA-N 0.000 claims description 2
• XSNSVLNJHGTYTL-NDEPHWFRSA-N benzyl n-[(2s)-3-(1h-imidazol-5-yl)-1-[[2-[(2-methyl-2-phenylpropyl)amino]-2-oxoethyl]-(pyridin-4-ylmethyl)amino]-1-oxopropan-2-yl]carbamate Chemical compound C=1C=CC=CC=1C(C)(C)CNC(=O)CN(C(=O)[C@H](CC=1NC=NC=1)NC(=O)OCC=1C=CC=CC=1)CC1=CC=NC=C1 XSNSVLNJHGTYTL-NDEPHWFRSA-N 0.000 claims description 2
• MYBBTGORNPKHDT-BHVANESWSA-N benzyl n-[(2s)-3-(1h-imidazol-5-yl)-1-[[2-[(2-methyl-2-phenylpropyl)amino]-2-oxoethyl]-[(4-phenylmethoxyphenyl)methyl]amino]-1-oxopropan-2-yl]carbamate Chemical compound C=1C=CC=CC=1C(C)(C)CNC(=O)CN(C(=O)[C@H](CC=1NC=NC=1)NC(=O)OCC=1C=CC=CC=1)CC(C=C1)=CC=C1OCC1=CC=CC=C1 MYBBTGORNPKHDT-BHVANESWSA-N 0.000 claims description 2
• JSWNMMOTWDSNJE-QNGWXLTQSA-N benzyl n-[(2s)-3-(1h-imidazol-5-yl)-1-[[2-[(2-methyl-2-phenylpropyl)amino]-2-oxoethyl]-[2-(4-phenylmethoxyphenyl)ethyl]amino]-1-oxopropan-2-yl]carbamate Chemical compound C=1C=CC=CC=1C(C)(C)CNC(=O)CN(C(=O)[C@H](CC=1NC=NC=1)NC(=O)OCC=1C=CC=CC=1)CCC(C=C1)=CC=C1OCC1=CC=CC=C1 JSWNMMOTWDSNJE-QNGWXLTQSA-N 0.000 claims description 2
• LFTQDNBHSGZGTD-UMSFTDKQSA-N benzyl n-[(2s)-3-(1h-imidazol-5-yl)-1-[[2-[(2-methyl-2-phenylpropyl)amino]-2-oxoethyl]-[[2-(pyridin-4-ylmethoxy)phenyl]methyl]amino]-1-oxopropan-2-yl]carbamate Chemical compound C=1C=CC=CC=1C(C)(C)CNC(=O)CN(C(=O)[C@H](CC=1N=CNC=1)NC(=O)OCC=1C=CC=CC=1)CC1=CC=CC=C1OCC1=CC=NC=C1 LFTQDNBHSGZGTD-UMSFTDKQSA-N 0.000 claims description 2
• CTZLGBVIEJFEMU-DHUJRADRSA-N benzyl n-[(2s)-3-(1h-imidazol-5-yl)-1-[[2-[(2-methyl-2-phenylpropyl)amino]-2-oxoethyl]-[[4-(pyridin-3-ylmethoxy)phenyl]methyl]amino]-1-oxopropan-2-yl]carbamate Chemical compound C=1C=CC=CC=1C(C)(C)CNC(=O)CN(C(=O)[C@H](CC=1N=CNC=1)NC(=O)OCC=1C=CC=CC=1)CC(C=C1)=CC=C1OCC1=CC=CN=C1 CTZLGBVIEJFEMU-DHUJRADRSA-N 0.000 claims description 2
• MDHGWUKTVUNWAA-DHUJRADRSA-N benzyl n-[(2s)-3-(1h-imidazol-5-yl)-1-[[2-[(2-methyl-2-phenylpropyl)amino]-2-oxoethyl]-[[4-(pyridin-4-ylmethoxy)phenyl]methyl]amino]-1-oxopropan-2-yl]carbamate Chemical compound C=1C=CC=CC=1C(C)(C)CNC(=O)CN(C(=O)[C@H](CC=1N=CNC=1)NC(=O)OCC=1C=CC=CC=1)CC(C=C1)=CC=C1OCC1=CC=NC=C1 MDHGWUKTVUNWAA-DHUJRADRSA-N 0.000 claims description 2
• JRRUOMUYZWMQNH-VKPSHWPRSA-N benzyl n-[(2s)-3-(1h-imidazol-5-yl)-1-[naphthalen-1-ylmethyl-[2-oxo-2-(2-phenylpropylamino)ethyl]amino]-1-oxopropan-2-yl]carbamate Chemical compound C([C@@H](C(=O)N(CC=1C2=CC=CC=C2C=CC=1)CC(=O)NCC(C)C=1C=CC=CC=1)NC(=O)OCC=1C=CC=CC=1)C1=CN=CN1 JRRUOMUYZWMQNH-VKPSHWPRSA-N 0.000 claims description 2
• HWLKYGTXYNWEPH-NYZBEGEVSA-N benzyl n-[(2s)-3-(1h-imidazol-5-yl)-1-oxo-1-[[2-oxo-2-(2-phenylbutylamino)ethyl]-[(4-phenylmethoxyphenyl)methyl]amino]propan-2-yl]carbamate Chemical compound C=1C=CC=CC=1C(CC)CNC(=O)CN(C(=O)[C@H](CC=1N=CNC=1)NC(=O)OCC=1C=CC=CC=1)CC(C=C1)=CC=C1OCC1=CC=CC=C1 HWLKYGTXYNWEPH-NYZBEGEVSA-N 0.000 claims description 2
• HOBCNABKXVPKMF-SHXCFHCCSA-N benzyl n-[(2s)-3-(1h-imidazol-5-yl)-1-oxo-1-[[2-oxo-2-(2-phenylpentylamino)ethyl]-[(4-phenylmethoxyphenyl)methyl]amino]propan-2-yl]carbamate Chemical compound C=1C=CC=CC=1C(CCC)CNC(=O)CN(C(=O)[C@H](CC=1N=CNC=1)NC(=O)OCC=1C=CC=CC=1)CC(C=C1)=CC=C1OCC1=CC=CC=C1 HOBCNABKXVPKMF-SHXCFHCCSA-N 0.000 claims description 2
• QNJNKUWNOFITIZ-DEGOBNMZSA-N benzyl n-[(2s)-3-(1h-imidazol-5-yl)-1-oxo-1-[[2-oxo-2-(2-phenylpropylamino)ethyl]-[[4-(pyridin-4-ylmethoxy)phenyl]methyl]amino]propan-2-yl]carbamate Chemical compound C=1C=CC=CC=1C(C)CNC(=O)CN(C(=O)[C@H](CC=1NC=NC=1)NC(=O)OCC=1C=CC=CC=1)CC(C=C1)=CC=C1OCC1=CC=NC=C1 QNJNKUWNOFITIZ-DEGOBNMZSA-N 0.000 claims description 2
• BHXXBIYDHJUWAL-IZCXSWDTSA-N benzyl n-[(2s)-3-(1h-imidazol-5-yl)-1-oxo-1-[[2-oxo-2-(2-phenylpropylamino)ethyl]-[[4-(trifluoromethyl)phenyl]methyl]amino]propan-2-yl]carbamate Chemical compound C=1C=CC=CC=1C(C)CNC(=O)CN(C(=O)[C@H](CC=1NC=NC=1)NC(=O)OCC=1C=CC=CC=1)CC1=CC=C(C(F)(F)F)C=C1 BHXXBIYDHJUWAL-IZCXSWDTSA-N 0.000 claims description 2
• RHROIJBSDKKFAG-UMSFTDKQSA-N benzyl n-[(2s)-3-(1h-imidazol-5-yl)-1-oxo-1-[[2-oxo-2-(2-pyridin-2-ylethylamino)ethyl]-[(4-phenylmethoxyphenyl)methyl]amino]propan-2-yl]carbamate Chemical compound C=1C=CC=NC=1CCNC(=O)CN(C(=O)[C@H](CC=1N=CNC=1)NC(=O)OCC=1C=CC=CC=1)CC(C=C1)=CC=C1OCC1=CC=CC=C1 RHROIJBSDKKFAG-UMSFTDKQSA-N 0.000 claims description 2
• UWFCOLWQGPRBMI-KFNHLEGPSA-N benzyl n-[(2s)-3-(1h-imidazol-5-yl)-1-oxo-1-[[2-oxo-2-[(2-phenyl-2-pyridin-2-ylethyl)amino]ethyl]-[(4-phenylmethoxyphenyl)methyl]amino]propan-2-yl]carbamate Chemical compound C=1C=CC=CC=1C(C=1N=CC=CC=1)CNC(=O)CN(C(=O)[C@H](CC=1NC=NC=1)NC(=O)OCC=1C=CC=CC=1)CC(C=C1)=CC=C1OCC1=CC=CC=C1 UWFCOLWQGPRBMI-KFNHLEGPSA-N 0.000 claims description 2
• NTZXVMHXDJIXPY-QNGWXLTQSA-N benzyl n-[(2s)-3-(3-methylimidazol-4-yl)-1-[[2-[(2-methyl-2-phenylpropyl)amino]-2-oxoethyl]-[(4-phenylmethoxyphenyl)methyl]amino]-1-oxopropan-2-yl]carbamate Chemical compound CN1C=NC=C1C[C@@H](C(=O)N(CC(=O)NCC(C)(C)C=1C=CC=CC=1)CC=1C=CC(OCC=2C=CC=CC=2)=CC=1)NC(=O)OCC1=CC=CC=C1 NTZXVMHXDJIXPY-QNGWXLTQSA-N 0.000 claims description 2
• JLCNKOBKJBWEIC-UHFFFAOYSA-N benzyl n-[3-(1h-imidazol-5-yl)-1-[2-methylpropyl-[2-oxo-2-(2-phenylpropylamino)ethyl]amino]-1-oxopropan-2-yl]carbamate Chemical compound C=1NC=NC=1CC(NC(=O)OCC=1C=CC=CC=1)C(=O)N(CC(C)C)CC(=O)NCC(C)C1=CC=CC=C1 JLCNKOBKJBWEIC-UHFFFAOYSA-N 0.000 claims description 2
• VTFSOKULTDVFRM-UHFFFAOYSA-N benzyl n-[3-(1h-imidazol-5-yl)-1-[[2-[(2-methyl-2-phenylpropyl)amino]-2-oxoethyl]-(2-methylpropyl)amino]-1-oxopropan-2-yl]carbamate Chemical compound C=1NC=NC=1CC(NC(=O)OCC=1C=CC=CC=1)C(=O)N(CC(C)C)CC(=O)NCC(C)(C)C1=CC=CC=C1 VTFSOKULTDVFRM-UHFFFAOYSA-N 0.000 claims description 2
• 208000029742 colonic neoplasm Diseases 0.000 claims description 2
• BPJWSBYOKNFUGW-UMSFTDKQSA-N furan-2-ylmethyl n-[(2s)-3-(1h-imidazol-5-yl)-1-[[2-[(2-methyl-2-phenylpropyl)amino]-2-oxoethyl]-[(4-phenylmethoxyphenyl)methyl]amino]-1-oxopropan-2-yl]carbamate Chemical compound C=1C=CC=CC=1C(C)(C)CNC(=O)CN(C(=O)[C@H](CC=1NC=NC=1)NC(=O)OCC=1OC=CC=1)CC(C=C1)=CC=C1OCC1=CC=CC=C1 BPJWSBYOKNFUGW-UMSFTDKQSA-N 0.000 claims description 2
• 201000005202 lung cancer Diseases 0.000 claims description 2
• 208000020816 lung neoplasm Diseases 0.000 claims description 2
• 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 2
• 201000002528 pancreatic cancer Diseases 0.000 claims description 2
• XGTRBPFMSCBERG-UMSFTDKQSA-N thiophen-3-ylmethyl n-[(2s)-3-(1h-imidazol-5-yl)-1-[[2-[(2-methyl-2-phenylpropyl)amino]-2-oxoethyl]-[(4-phenylmethoxyphenyl)methyl]amino]-1-oxopropan-2-yl]carbamate Chemical compound C=1C=CC=CC=1C(C)(C)CNC(=O)CN(C(=O)[C@H](CC=1N=CNC=1)NC(=O)OCC1=CSC=C1)CC(C=C1)=CC=C1OCC1=CC=CC=C1 XGTRBPFMSCBERG-UMSFTDKQSA-N 0.000 claims description 2
• 201000002510 thyroid cancer Diseases 0.000 claims description 2
• 201000005112 urinary bladder cancer Diseases 0.000 claims description 2
• YVTDNPWQYJVXBZ-NYZBEGEVSA-N (2s)-2-(benzylcarbamoylamino)-3-(1h-imidazol-5-yl)-n-[2-oxo-2-(2-phenylbutylamino)ethyl]-n-[(4-phenylmethoxyphenyl)methyl]propanamide Chemical compound C=1C=CC=CC=1C(CC)CNC(=O)CN(C(=O)[C@H](CC=1N=CNC=1)NC(=O)NCC=1C=CC=CC=1)CC(C=C1)=CC=C1OCC1=CC=CC=C1 YVTDNPWQYJVXBZ-NYZBEGEVSA-N 0.000 claims 1
• DMGJRELNPSPIKC-IZCXSWDTSA-N benzyl n-[(2s)-1-[(3-chlorophenyl)methyl-[2-oxo-2-(2-phenylpropylamino)ethyl]amino]-3-(1h-imidazol-5-yl)-1-oxopropan-2-yl]carbamate Chemical compound C=1C=CC=CC=1C(C)CNC(=O)CN(C(=O)[C@H](CC=1NC=NC=1)NC(=O)OCC=1C=CC=CC=1)CC1=CC=CC(Cl)=C1 DMGJRELNPSPIKC-IZCXSWDTSA-N 0.000 claims 1
• MFVRMBXVDCCSLM-LJAQVGFWSA-N benzyl n-[(2s)-1-[(4-chlorophenyl)methyl-[2-[(2-methyl-2-phenylpropyl)amino]-2-oxoethyl]amino]-3-(1h-imidazol-5-yl)-1-oxopropan-2-yl]carbamate Chemical compound C=1C=CC=CC=1C(C)(C)CNC(=O)CN(C(=O)[C@H](CC=1N=CNC=1)NC(=O)OCC=1C=CC=CC=1)CC1=CC=C(Cl)C=C1 MFVRMBXVDCCSLM-LJAQVGFWSA-N 0.000 claims 1
• MGAFFZTYMAFERW-HKBQPEDESA-N benzyl n-[(2s)-1-[(4-ethoxyphenyl)methyl-[2-[(2-methyl-2-phenylpropyl)amino]-2-oxoethyl]amino]-3-(1h-imidazol-5-yl)-1-oxopropan-2-yl]carbamate Chemical compound C1=CC(OCC)=CC=C1CN(C(=O)[C@H](CC=1NC=NC=1)NC(=O)OCC=1C=CC=CC=1)CC(=O)NCC(C)(C)C1=CC=CC=C1 MGAFFZTYMAFERW-HKBQPEDESA-N 0.000 claims 1
• QCNOUBMNVDBZBN-IZCXSWDTSA-N benzyl n-[(2s)-1-[(4-fluorophenyl)methyl-[2-oxo-2-(2-phenylpropylamino)ethyl]amino]-3-(1h-imidazol-5-yl)-1-oxopropan-2-yl]carbamate Chemical compound C=1C=CC=CC=1C(C)CNC(=O)CN(C(=O)[C@H](CC=1NC=NC=1)NC(=O)OCC=1C=CC=CC=1)CC1=CC=C(F)C=C1 QCNOUBMNVDBZBN-IZCXSWDTSA-N 0.000 claims 1
• YFOGKUOUUGQZPV-DHUJRADRSA-N benzyl n-[(2s)-1-[[2-[2-(2-aminophenyl)ethylamino]-2-oxoethyl]-[(4-phenylmethoxyphenyl)methyl]amino]-3-(1h-imidazol-5-yl)-1-oxopropan-2-yl]carbamate Chemical compound NC1=CC=CC=C1CCNC(=O)CN(C(=O)[C@H](CC=1NC=NC=1)NC(=O)OCC=1C=CC=CC=1)CC(C=C1)=CC=C1OCC1=CC=CC=C1 YFOGKUOUUGQZPV-DHUJRADRSA-N 0.000 claims 1
• UYCQJDCAUDGFKR-DHUJRADRSA-N benzyl n-[(2s)-1-[[2-[2-(2-bromophenyl)ethylamino]-2-oxoethyl]-[(4-phenylmethoxyphenyl)methyl]amino]-3-(1h-imidazol-5-yl)-1-oxopropan-2-yl]carbamate Chemical compound BrC1=CC=CC=C1CCNC(=O)CN(C(=O)[C@H](CC=1N=CNC=1)NC(=O)OCC=1C=CC=CC=1)CC(C=C1)=CC=C1OCC1=CC=CC=C1 UYCQJDCAUDGFKR-DHUJRADRSA-N 0.000 claims 1
• XSLKWQLVMQDCMX-LJAQVGFWSA-N benzyl n-[(2s)-1-[benzyl-[2-[(2-methyl-2-phenylpropyl)amino]-2-oxoethyl]amino]-3-(1h-imidazol-5-yl)-1-oxopropan-2-yl]carbamate Chemical compound C=1C=CC=CC=1C(C)(C)CNC(=O)CN(C(=O)[C@H](CC=1N=CNC=1)NC(=O)OCC=1C=CC=CC=1)CC1=CC=CC=C1 XSLKWQLVMQDCMX-LJAQVGFWSA-N 0.000 claims 1
• WTWAOQOUPSTNDO-PEFOLFAWSA-N benzyl n-[(2s)-1-[cyclohexylmethyl-[2-oxo-2-(2-phenylpropylamino)ethyl]amino]-3-(1h-imidazol-5-yl)-1-oxopropan-2-yl]carbamate Chemical compound C=1C=CC=CC=1C(C)CNC(=O)CN(C(=O)[C@H](CC=1NC=NC=1)NC(=O)OCC=1C=CC=CC=1)CC1CCCCC1 WTWAOQOUPSTNDO-PEFOLFAWSA-N 0.000 claims 1
• VTDGRAHGAAMRGX-DHUJRADRSA-N benzyl n-[(2s)-3-(1h-imidazol-5-yl)-1-[[2-[(2-methyl-2-phenylpropyl)amino]-2-oxoethyl]-[(4-phenylphenyl)methyl]amino]-1-oxopropan-2-yl]carbamate Chemical compound C=1C=CC=CC=1C(C)(C)CNC(=O)CN(C(=O)[C@H](CC=1N=CNC=1)NC(=O)OCC=1C=CC=CC=1)CC(C=C1)=CC=C1C1=CC=CC=C1 VTDGRAHGAAMRGX-DHUJRADRSA-N 0.000 claims 1
• ZZRLVJNHLQRVBB-DHUJRADRSA-N benzyl n-[(2s)-3-(1h-imidazol-5-yl)-1-[[2-[(2-methyl-2-phenylpropyl)amino]-2-oxoethyl]-[[4-(pyridin-2-ylmethoxy)phenyl]methyl]amino]-1-oxopropan-2-yl]carbamate Chemical compound C=1C=CC=CC=1C(C)(C)CNC(=O)CN(C(=O)[C@H](CC=1N=CNC=1)NC(=O)OCC=1C=CC=CC=1)CC(C=C1)=CC=C1OCC1=CC=CC=N1 ZZRLVJNHLQRVBB-DHUJRADRSA-N 0.000 claims 1
• QBYRWRXKLWORHI-DEGOBNMZSA-N benzyl n-[(2s)-3-(1h-imidazol-5-yl)-1-oxo-1-[[2-oxo-2-(2-phenylpropylamino)ethyl]-[(4-phenylphenyl)methyl]amino]propan-2-yl]carbamate Chemical compound C=1C=CC=CC=1C(C)CNC(=O)CN(C(=O)[C@H](CC=1N=CNC=1)NC(=O)OCC=1C=CC=CC=1)CC(C=C1)=CC=C1C1=CC=CC=C1 QBYRWRXKLWORHI-DEGOBNMZSA-N 0.000 claims 1
• SXAHBNXBXIAPKN-DEGOBNMZSA-N benzyl n-[(2s)-3-(1h-imidazol-5-yl)-1-oxo-1-[[2-oxo-2-(2-phenylpropylamino)ethyl]-[[4-(pyridin-3-ylmethoxy)phenyl]methyl]amino]propan-2-yl]carbamate Chemical compound C=1C=CC=CC=1C(C)CNC(=O)CN(C(=O)[C@H](CC=1NC=NC=1)NC(=O)OCC=1C=CC=CC=1)CC(C=C1)=CC=C1OCC1=CC=CN=C1 SXAHBNXBXIAPKN-DEGOBNMZSA-N 0.000 claims 1
• LHWFFKQEXHJCEB-ZADIWHOSSA-N benzyl n-[(2s)-3-(1h-imidazol-5-yl)-1-oxo-1-[[2-oxo-2-[[(2r)-1-phenylpropan-2-yl]amino]ethyl]-[(4-phenylmethoxyphenyl)methyl]amino]propan-2-yl]carbamate Chemical compound C([C@@H](C)NC(=O)CN(CC=1C=CC(OCC=2C=CC=CC=2)=CC=1)C(=O)[C@H](CC=1N=CNC=1)NC(=O)OCC=1C=CC=CC=1)C1=CC=CC=C1 LHWFFKQEXHJCEB-ZADIWHOSSA-N 0.000 claims 1
• FDLIQPPVQBMJOV-DHUJRADRSA-N pyridin-3-ylmethyl n-[(2s)-3-(1h-imidazol-5-yl)-1-[[2-[(2-methyl-2-phenylpropyl)amino]-2-oxoethyl]-[(4-phenylmethoxyphenyl)methyl]amino]-1-oxopropan-2-yl]carbamate Chemical compound C=1C=CC=CC=1C(C)(C)CNC(=O)CN(C(=O)[C@H](CC=1NC=NC=1)NC(=O)OCC=1C=NC=CC=1)CC(C=C1)=CC=C1OCC1=CC=CC=C1 FDLIQPPVQBMJOV-DHUJRADRSA-N 0.000 claims 1
• VKXMBBOHXRDTPM-UMSFTDKQSA-N thiophen-2-ylmethyl n-[(2s)-3-(1h-imidazol-5-yl)-1-[[2-[(2-methyl-2-phenylpropyl)amino]-2-oxoethyl]-[(4-phenylmethoxyphenyl)methyl]amino]-1-oxopropan-2-yl]carbamate Chemical compound C=1C=CC=CC=1C(C)(C)CNC(=O)CN(C(=O)[C@H](CC=1NC=NC=1)NC(=O)OCC=1SC=CC=1)CC(C=C1)=CC=C1OCC1=CC=CC=C1 VKXMBBOHXRDTPM-UMSFTDKQSA-N 0.000 claims 1
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