CA2253874A1 - Particules virales masquees ou demasquees vis-a-vis du recepteur cellulaire - Google Patents
Particules virales masquees ou demasquees vis-a-vis du recepteur cellulaire Download PDFInfo
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- CA2253874A1 CA2253874A1 CA002253874A CA2253874A CA2253874A1 CA 2253874 A1 CA2253874 A1 CA 2253874A1 CA 002253874 A CA002253874 A CA 002253874A CA 2253874 A CA2253874 A CA 2253874A CA 2253874 A1 CA2253874 A1 CA 2253874A1
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- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
L'invention concerne l'utilisation d'un peptide en vue d'un transfert de gènes dans une cellule eucaryote cible, lequel peptide présente d'environ 10 à environ 200, notamment d'environ 15 à environ 150 acides aminés, et avantageusement environ 20 acides aminés, dans lequel 30 % au moins des acides aminés sont constitués par des résidus proline, lesquels résidus proline sont régulièrement agencés de manière à induire des repliements de la chaîne polypeptidique à environ 180· (".beta.-turn" ou "reverse-turn"), ces repliements étant régulièrement espacés et s'assemblant en une hélice polyproline à repliement de type .beta. ("polyproline .beta.-turn helix"), dans une construction polypeptidique contenant, du côté N-terminal (en amont) dudit peptide, un domaine protéique N-terminal (amont) susceptible de reconnaître une molécule de surface ciblée ou un antigène exprimé sur une surface cellulaire, notamment un récepteur approprié (récepteur ciblé) situé sur ladite cellule eucaryote, et du côté C-terminal (en aval) dudit peptide, un domaine protéique C-terminal (aval) susceptible de reconnaître un récepteur approprié (récepteur auxiliaire) situé sur la susdite cellule eucaryote, lequel peptide est capable de faciliter ou d'inhiber l'interaction entre le domaine protéique C-terminal (aval) et le récepteur auxiliaire, l'inhibition de cette interaction ayant lieu tant que le domaine protéique N-terminal (amont) n'a pas interagi avec le récepteur ciblé et la favorisation de l'interaction entre le domaine protéique C-terminal (aval) et le récepteur auxiliaire ayant lieu lorsque le domaine protéique N-terminal (amont) a interagi avec le récepteur ciblé.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9606234A FR2748747B1 (fr) | 1996-05-20 | 1996-05-20 | Particules virales recombinantes comportant un peptide ayant des proprietes de masquage et de demasquage vis-a-vis d'un mecanisme biologique |
FR96/06234 | 1996-05-20 | ||
PCT/FR1997/000870 WO1997044474A2 (fr) | 1996-05-20 | 1997-05-16 | Particules virales masquees ou demasquees vis-a-vis du recepteur cellulaire |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2253874A1 true CA2253874A1 (fr) | 1997-11-27 |
Family
ID=9492280
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002253874A Abandoned CA2253874A1 (fr) | 1996-05-20 | 1997-05-16 | Particules virales masquees ou demasquees vis-a-vis du recepteur cellulaire |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0953053A2 (fr) |
JP (1) | JP2000511051A (fr) |
AU (1) | AU725632B2 (fr) |
CA (1) | CA2253874A1 (fr) |
FR (1) | FR2748747B1 (fr) |
WO (1) | WO1997044474A2 (fr) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2773561A1 (fr) * | 1998-01-15 | 1999-07-16 | Centre Nat Rech Scient | Utilisation d'une sequence riche en proline pour augmenter le caractere fusogenique d'enveloppes de retrovirus |
WO2000071578A2 (fr) * | 1999-05-20 | 2000-11-30 | Cnrs Centre National De La Recherche Scientifique | Nouveaux polypeptides et leur utilisation pour le sauvetage de virus ou de glycoproteines virales a defaut de fusion |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2820750B2 (ja) * | 1988-04-21 | 1998-11-05 | ユーエービー リサーチ ファウンデイション | 創傷治療部位における癒着の発生からの保護に適するバイオエラストマー材料 |
US5637481A (en) * | 1993-02-01 | 1997-06-10 | Bristol-Myers Squibb Company | Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell |
JP3533219B2 (ja) * | 1992-11-09 | 2004-05-31 | アメリカ合衆国 | 標的指向ベクター粒子 |
US5773577A (en) * | 1994-03-03 | 1998-06-30 | Protein Polymer Technologies | Products comprising substrates capable of enzymatic cross-linking |
GB9412844D0 (en) * | 1994-06-27 | 1994-08-17 | Medical Res Council | Improvements in or relating to therapeutic methods |
US5662885A (en) * | 1994-07-22 | 1997-09-02 | Resolution Pharmaceuticals Inc. | Peptide derived radionuclide chelators |
-
1996
- 1996-05-20 FR FR9606234A patent/FR2748747B1/fr not_active Expired - Fee Related
-
1997
- 1997-05-16 WO PCT/FR1997/000870 patent/WO1997044474A2/fr not_active Application Discontinuation
- 1997-05-16 EP EP97925095A patent/EP0953053A2/fr not_active Withdrawn
- 1997-05-16 CA CA002253874A patent/CA2253874A1/fr not_active Abandoned
- 1997-05-16 JP JP09541705A patent/JP2000511051A/ja active Pending
- 1997-05-16 AU AU30356/97A patent/AU725632B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
WO1997044474A2 (fr) | 1997-11-27 |
AU3035697A (en) | 1997-12-09 |
AU725632B2 (en) | 2000-10-19 |
EP0953053A2 (fr) | 1999-11-03 |
FR2748747B1 (fr) | 1998-08-07 |
FR2748747A1 (fr) | 1997-11-21 |
JP2000511051A (ja) | 2000-08-29 |
WO1997044474A3 (fr) | 1998-03-05 |
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EEER | Examination request | ||
FZDE | Dead |