CA2253313A1 - Procede de traitement ou de prevention des lesions lors d'une reperfusion au cours d'une ischemie - Google Patents

Procede de traitement ou de prevention des lesions lors d'une reperfusion au cours d'une ischemie Download PDF

Info

Publication number
CA2253313A1
CA2253313A1 CA002253313A CA2253313A CA2253313A1 CA 2253313 A1 CA2253313 A1 CA 2253313A1 CA 002253313 A CA002253313 A CA 002253313A CA 2253313 A CA2253313 A CA 2253313A CA 2253313 A1 CA2253313 A1 CA 2253313A1
Authority
CA
Canada
Prior art keywords
ischemia
repair
injury
reperfusion injury
aortic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002253313A
Other languages
English (en)
Inventor
Lyle L. Moldawer
Satwant K. Narula
James M. Seeger
Timothy R. Harward
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2253313A1 publication Critical patent/CA2253313A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2066—IL-10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pretreatment Of Seeds And Plants (AREA)

Abstract

L'invention concerne un procédé de fabrication d'une composition pharmaceutique destinée au traitement des lésions lors d'une reperfusion au cours d'une ischémie, ce procédé consistant à mélanger un excipient acceptable sur le plan pharmacologique et une quantité suffisante d'interleukine-10.
CA002253313A 1996-05-02 1997-05-01 Procede de traitement ou de prevention des lesions lors d'une reperfusion au cours d'une ischemie Abandoned CA2253313A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64185996A 1996-05-02 1996-05-02
US08/641,859 1996-05-02

Publications (1)

Publication Number Publication Date
CA2253313A1 true CA2253313A1 (fr) 1997-11-06

Family

ID=24574163

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002253313A Abandoned CA2253313A1 (fr) 1996-05-02 1997-05-01 Procede de traitement ou de prevention des lesions lors d'une reperfusion au cours d'une ischemie

Country Status (9)

Country Link
EP (1) EP0906117A1 (fr)
JP (1) JP2000509073A (fr)
KR (1) KR20000065178A (fr)
AU (1) AU721943B2 (fr)
BR (1) BR9709752A (fr)
CA (1) CA2253313A1 (fr)
IL (1) IL126657A0 (fr)
NZ (1) NZ332412A (fr)
WO (1) WO1997040849A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6113629A (en) * 1998-05-01 2000-09-05 Micrus Corporation Hydrogel for the therapeutic treatment of aneurysms
JP2002532556A (ja) * 1998-12-22 2002-10-02 シェリング・コーポレーション Ｃ型肝炎ウイルス感染のインターロイキン−１０での処置
WO2001006262A1 (fr) * 1999-02-19 2001-01-25 University Of Iowa Research Foundation Agents diagnostiques et therapeutiques appliques a la degenerescence de la macula
US7108982B1 (en) 1999-02-19 2006-09-19 University Of Iowa Research Foundation Diagnostics and the therapeutics for macular degeneration
JP2006524701A (ja) * 2003-04-25 2006-11-02 ミトス・インコーポレーテッド 酸化防止剤による予防的前処置
JP6999664B2 (ja) 2016-10-31 2022-01-18 サムスン ライフ パブリック ウェルフェア ファウンデーション 胆汁酸を含む虚血性再灌流損傷の予防または治療用薬学的組成物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9508243A (pt) * 1994-07-05 1997-10-21 Steeno Res Group As Imunomoduladores

Also Published As

Publication number Publication date
WO1997040849A1 (fr) 1997-11-06
BR9709752A (pt) 1999-08-10
JP2000509073A (ja) 2000-07-18
NZ332412A (en) 2000-05-26
AU721943B2 (en) 2000-07-20
AU2740597A (en) 1997-11-19
IL126657A0 (en) 1999-08-17
KR20000065178A (ko) 2000-11-06
EP0906117A1 (fr) 1999-04-07

Similar Documents

Publication Publication Date Title
RU2166955C2 (ru) Способ лечения и профилактики заболеваний, обусловленных повышением уровня фактора, вызывающего некроз опухолевых клеток
AU672606B2 (en) Methods for treating interleukin-1 and tumor necrosis factor mediated diseases
EP2349310B1 (fr) Polypeptide pour traiter ou prévenir les adhésions
JP2000507917A (ja) 持続的低用量サイトカイン注入治療
Block et al. Passive immunization of mice against D factor blocks lethality and cytokine release during endotoxemia.
JP2002532556A (ja) Ｃ型肝炎ウイルス感染のインターロイキン−１０での処置
JP2000511190A (ja) 外傷に起因する出血に見舞われたヒトにおけるｂｐｉタンパク質産物の治療用途
CA2253312A1 (fr) Methode de traitement de l'inflammation
US7645733B2 (en) Tissue protective cytokines for the treatment and prevention of sepsis and the formation of adhesions
AU721943B2 (en) Method for treating or preventing ischemia-reperfusion injury
US6086868A (en) Method for treating or preventing ischemia-reperfusion injury
JPH02264730A (ja) Ａｔｌｌ治療用吸入剤
MXPA98008946A (en) Method of treatment or prevention of the injury caused by isquemia-reperfus
US6497870B1 (en) Therapeutic uses of il-1 receptor antagonist
EP1948216B1 (fr) Traitement d'une insuffisance renale aigue avec la thrombomoduline soluble
EP0763360B1 (fr) Utilisation de la thrombomoduline contre l'hepatopathie
JP4023863B2 (ja) Ｉｌ−６を含む血清尿酸値低下剤
EP2089050A2 (fr) Utilisation de l'il-17b pour la cicatrisation des plaies
Oshita et al. Randomized study of dose or schedule modification of granulocyte colony-stimulating factor in platinum-based chemotherapy for elderly patients with lung cancer
JPH083065A (ja) 肝臓障害に対する治療剤
Block et al. Endogenous D‐factor activity partially mediates the toxic but not the therapeutic effects of tumor necrosis factor
CN1223587A (zh) 治疗或预防局部缺血－再灌注损伤的方法
JP2003501396A (ja) 出血性ショックを処置するためのインターロイキン−１１の使用
Block et al. Passive Immunization of Mice against D Factor Blocks Lethality and Cytoklne Release during

Legal Events

Date Code Title Description
FZDE Discontinued