CA2253313A1 - Procede de traitement ou de prevention des lesions lors d'une reperfusion au cours d'une ischemie - Google Patents

Procede de traitement ou de prevention des lesions lors d'une reperfusion au cours d'une ischemie Download PDF

Info

Publication number
CA2253313A1
CA2253313A1 CA002253313A CA2253313A CA2253313A1 CA 2253313 A1 CA2253313 A1 CA 2253313A1 CA 002253313 A CA002253313 A CA 002253313A CA 2253313 A CA2253313 A CA 2253313A CA 2253313 A1 CA2253313 A1 CA 2253313A1
Authority
CA
Canada
Prior art keywords
ischemia
repair
injury
reperfusion injury
aortic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002253313A
Other languages
English (en)
Inventor
Lyle L. Moldawer
Satwant K. Narula
James M. Seeger
Timothy R. Harward
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2253313A1 publication Critical patent/CA2253313A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2066—IL-10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pretreatment Of Seeds And Plants (AREA)

Abstract

L'invention concerne un procédé de fabrication d'une composition pharmaceutique destinée au traitement des lésions lors d'une reperfusion au cours d'une ischémie, ce procédé consistant à mélanger un excipient acceptable sur le plan pharmacologique et une quantité suffisante d'interleukine-10.
CA002253313A 1996-05-02 1997-05-01 Procede de traitement ou de prevention des lesions lors d'une reperfusion au cours d'une ischemie Abandoned CA2253313A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64185996A 1996-05-02 1996-05-02
US08/641,859 1996-05-02

Publications (1)

Publication Number Publication Date
CA2253313A1 true CA2253313A1 (fr) 1997-11-06

Family

ID=24574163

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002253313A Abandoned CA2253313A1 (fr) 1996-05-02 1997-05-01 Procede de traitement ou de prevention des lesions lors d'une reperfusion au cours d'une ischemie

Country Status (9)

Country Link
EP (1) EP0906117A1 (fr)
JP (1) JP2000509073A (fr)
KR (1) KR20000065178A (fr)
AU (1) AU721943B2 (fr)
BR (1) BR9709752A (fr)
CA (1) CA2253313A1 (fr)
IL (1) IL126657A0 (fr)
NZ (1) NZ332412A (fr)
WO (1) WO1997040849A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6113629A (en) * 1998-05-01 2000-09-05 Micrus Corporation Hydrogel for the therapeutic treatment of aneurysms
CA2356010A1 (fr) * 1998-12-22 2000-06-29 Schering Corporation Traitement des infections du virus de l'hepatite c avec interleukine-10
EP1153301A1 (fr) * 1999-02-19 2001-11-14 University Of Iowa Research Foundation Procedes de diagnostic et de therapie pour les maladies affectant la paroi arterielle
US7108982B1 (en) 1999-02-19 2006-09-19 University Of Iowa Research Foundation Diagnostics and the therapeutics for macular degeneration
JP2006524701A (ja) * 2003-04-25 2006-11-02 ミトス・インコーポレーテッド 酸化防止剤による予防的前処置
EP3533450A4 (fr) 2016-10-31 2020-06-17 Samsung Life Public Welfare Foundation Composition pharmaceutique destinée à prévenir ou à traiter une lésion d'ischémie-reperfusion, contenant de l'acide biliaire

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT769054E (pt) * 1994-07-05 2000-11-30 Steeno Res Group A S Imunoreguladores

Also Published As

Publication number Publication date
EP0906117A1 (fr) 1999-04-07
BR9709752A (pt) 1999-08-10
NZ332412A (en) 2000-05-26
WO1997040849A1 (fr) 1997-11-06
KR20000065178A (ko) 2000-11-06
IL126657A0 (en) 1999-08-17
JP2000509073A (ja) 2000-07-18
AU721943B2 (en) 2000-07-20
AU2740597A (en) 1997-11-19

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Legal Events

Date Code Title Description
FZDE Discontinued