CA2247877A1 - Systemes d'administration par solubilisation et methode de fabrication - Google Patents

Systemes d'administration par solubilisation et methode de fabrication Download PDF

Info

Publication number
CA2247877A1
CA2247877A1 CA002247877A CA2247877A CA2247877A1 CA 2247877 A1 CA2247877 A1 CA 2247877A1 CA 002247877 A CA002247877 A CA 002247877A CA 2247877 A CA2247877 A CA 2247877A CA 2247877 A1 CA2247877 A1 CA 2247877A1
Authority
CA
Canada
Prior art keywords
active
solubilizer
parts
eutectic
particles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002247877A
Other languages
English (en)
Inventor
B. Arlie Bogue
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biovail International Ltd USA
Original Assignee
Fuisz International Ltd USA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fuisz International Ltd USA filed Critical Fuisz International Ltd USA
Publication of CA2247877A1 publication Critical patent/CA2247877A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
CA002247877A 1998-02-16 1998-09-23 Systemes d'administration par solubilisation et methode de fabrication Abandoned CA2247877A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IE980115 1998-02-16
IE19980115A IE980115A1 (en) 1998-02-16 1998-02-16 Solubilizing delivery systems and method of manufacture

Publications (1)

Publication Number Publication Date
CA2247877A1 true CA2247877A1 (fr) 1999-08-16

Family

ID=11041714

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002247877A Abandoned CA2247877A1 (fr) 1998-02-16 1998-09-23 Systemes d'administration par solubilisation et methode de fabrication
CA002247994A Abandoned CA2247994A1 (fr) 1998-02-16 1998-09-23 Systemes d'administration par solubilisation et methode de fabrication

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA002247994A Abandoned CA2247994A1 (fr) 1998-02-16 1998-09-23 Systemes d'administration par solubilisation et methode de fabrication

Country Status (6)

Country Link
EP (1) EP1058561A1 (fr)
JP (1) JP2003522097A (fr)
AU (1) AU9498998A (fr)
CA (2) CA2247877A1 (fr)
IE (1) IE980115A1 (fr)
WO (1) WO1999040943A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK285706B6 (sk) * 1999-12-09 2007-06-07 Reckitt Benckiser Healthcare (Uk) Limited Lisovaná tabletová kompozícia, spôsob jej prípravy a jej použitie
US20050232995A1 (en) 2002-07-29 2005-10-20 Yam Nyomi V Methods and dosage forms for controlled delivery of paliperidone and risperidone
MXPA06005461A (es) * 2003-11-13 2006-12-15 Johnson & Johnson Dispersiones de mezclas en estado fundido que comprenden un farmaco de baja solubilidad en agua y un copolimero de bloque de oxido de etileno-oxido de propileno.
EP1727520A2 (fr) * 2003-12-09 2006-12-06 Medcrystalforms, Llc Procede de preparation de cocristaux a phase mixte avec des agents actifs
WO2005065653A1 (fr) * 2003-12-19 2005-07-21 E.I. Du Pont De Nemours And Company Enrobage intime d'ibuprofene avec des poloxameres afin d'ameliorer la dissolution aqueuse
JP5758899B2 (ja) * 2009-09-17 2015-08-05 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ 活性物質を含有するコーティングにより被覆されたペレット
US20140163109A1 (en) 2012-03-26 2014-06-12 Glatt Ag Taste-masked ibupropen granules
RU2694901C2 (ru) * 2013-04-18 2019-07-18 Шаньдун Луе Фармасьютикал Ко., Лтд Фармацевтические композиции микросфер гозерелина с пролонгированным высвобождением

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU87233A1 (fr) * 1988-06-07 1990-02-28 Pharlyse Sa Composition pharmaceutique a base d'un anti-inflammatoire non steroidien,son procede de preparation et son utilisation
KR0182801B1 (ko) * 1991-04-16 1999-05-01 아만 히데아키 고체 분산체의 제조방법
US5340591A (en) * 1992-01-24 1994-08-23 Fujisawa Pharmaceutical Co., Ltd. Method of producing a solid dispersion of the sparingly water-soluble drug, nilvadipine
HUT70952A (en) * 1992-06-10 1995-11-28 Eastman Kodak Co Surface modified nanoparticles based on nosteroidal inflammatory drugs, process for preparing them and pharmaceutical compns. contg. them
IE80467B1 (en) * 1995-07-03 1998-07-29 Elan Corp Plc Controlled release formulations for poorly soluble drugs
TW487582B (en) * 1995-08-11 2002-05-21 Nissan Chemical Ind Ltd Method for converting sparingly water-soluble medical substance to amorphous state

Also Published As

Publication number Publication date
AU9498998A (en) 1999-08-30
CA2247994A1 (fr) 1999-08-16
EP1058561A1 (fr) 2000-12-13
IE980115A1 (en) 2000-02-09
JP2003522097A (ja) 2003-07-22
WO1999040943A1 (fr) 1999-08-19

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Legal Events

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