CA2238954A1 - Discontinuous countercurrent chromatographic process and apparatus - Google Patents

Discontinuous countercurrent chromatographic process and apparatus Download PDF

Info

Publication number
CA2238954A1
CA2238954A1 CA002238954A CA2238954A CA2238954A1 CA 2238954 A1 CA2238954 A1 CA 2238954A1 CA 002238954 A CA002238954 A CA 002238954A CA 2238954 A CA2238954 A CA 2238954A CA 2238954 A1 CA2238954 A1 CA 2238954A1
Authority
CA
Canada
Prior art keywords
pump
solvent
chromatographic
columns
mobile phase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002238954A
Other languages
English (en)
French (fr)
Inventor
Charles M. Grill
Thomas W. Hampton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Merck Patent GmbH
EMD Chemicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH, EMD Chemicals Inc filed Critical Merck Patent GmbH
Publication of CA2238954A1 publication Critical patent/CA2238954A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1814—Recycling of the fraction to be distributed
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1864—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/44—Flow patterns using recycling of the fraction to be distributed
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1814—Recycling of the fraction to be distributed
    • B01D15/1857—Reactive simulated moving beds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Sustainable Development (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
CA002238954A 1995-11-30 1996-11-12 Discontinuous countercurrent chromatographic process and apparatus Abandoned CA2238954A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/566,425 US5630943A (en) 1995-11-30 1995-11-30 Discontinuous countercurrent chromatographic process and apparatus
US08/566,425 1995-11-30

Publications (1)

Publication Number Publication Date
CA2238954A1 true CA2238954A1 (en) 1997-06-05

Family

ID=24262836

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002238954A Abandoned CA2238954A1 (en) 1995-11-30 1996-11-12 Discontinuous countercurrent chromatographic process and apparatus

Country Status (6)

Country Link
US (1) US5630943A (enExample)
EP (1) EP0877936B1 (enExample)
JP (1) JP4009671B2 (enExample)
CA (1) CA2238954A1 (enExample)
DE (1) DE69631903T2 (enExample)
WO (1) WO1997020206A1 (enExample)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6063284A (en) * 1997-05-15 2000-05-16 Em Industries, Inc. Single column closed-loop recycling with periodic intra-profile injection
JPH1190106A (ja) * 1997-09-26 1999-04-06 Daicel Chem Ind Ltd 擬似移動床式クロマト分離装置
ATE255555T1 (de) * 1998-05-01 2003-12-15 Pfizer Prod Inc Verfahren zur herstellung von enantiomeren reinem oder optisch angereicherter sertraline-tetralon durch kontinuierliche chromatographie
US6136197A (en) * 1998-05-27 2000-10-24 Battelle Memorial Institute Systems for column-based separations, methods of forming packed columns, and methods of purifying sample components
FR2781860B1 (fr) * 1998-07-31 2000-09-01 Inst Francais Du Petrole Systeme de mise en communication alternee d'au moins quatre fluides et son application dans un procede de separation en lit mobile simule
DE19858892A1 (de) * 1998-12-19 2000-06-21 Merck Patent Gmbh Kontinuierliches Verfahren zur Trennung von Stoffen nach Molekülgröße
US6641783B1 (en) 1999-02-08 2003-11-04 Charles Pidgeon Chromatographic systems with pre-detector eluent switching
DE60041331D1 (de) 1999-04-23 2009-02-26 Advion Biosystems Inc Parallel ausgeführte flüssigkeitschromatographievorrichtung mit hohem durchsatz
JP4176240B2 (ja) * 1999-07-02 2008-11-05 オルガノ株式会社 クロマト分離装置
FR2809490B1 (fr) * 2000-05-23 2002-11-29 Hocer Installation et procede pour la preparation automatique d'echantillons
JP3476417B2 (ja) * 2000-06-05 2003-12-10 株式会社島津製作所 液体クロマトグラフによる分析方法
US6635173B2 (en) * 2000-12-28 2003-10-21 Cohesive Technologies, Inc. Multi column chromatography system
US8414774B2 (en) * 2001-04-25 2013-04-09 Agilent Technologies, Inc. Systems and methods for high-throughput screening of fluidic samples
US20050123970A1 (en) * 2001-04-25 2005-06-09 Can Ozbal High throughput autosampler
US6812030B2 (en) * 2001-04-25 2004-11-02 Biotrove, Inc. System and method for high throughput sample preparation and analysis using column chromatography
US7588725B2 (en) * 2001-04-25 2009-09-15 Biotrove, Inc. High throughput autosampler
JP3693324B2 (ja) * 2001-10-30 2005-09-07 ダイセル化学工業株式会社 擬似移動床式クロマトグラフィー用試料供給装置
US7104112B2 (en) * 2002-09-27 2006-09-12 Honeywell International Inc. Phased micro analyzer IV
US7530257B2 (en) * 2002-09-27 2009-05-12 Honeywell International Inc. Phased micro analyzer VIII
EP1544612A1 (en) * 2003-12-09 2005-06-22 Agilent Technologies, Inc. Chromatography system and method for operating the same
BRPI0512251A (pt) * 2004-07-23 2008-02-19 Pharmacia & Upjohn Co Llc método enantioseletivo para separação de derivados do ácido 2-trifluormetil-2h-cromeno-3-carboxìlico substituìdo
US20060086667A1 (en) * 2004-09-13 2006-04-27 Cephalon, Inc., U.S. Corporation Methods for the separation of enantiomeric sulfinylacetamides
US8802035B2 (en) * 2005-06-21 2014-08-12 Waters Technologies Corporation Apparatus and methods for performing steps of a multi-step process in parallel
FR2889077B1 (fr) * 2005-07-26 2007-10-12 Novasep Soc Par Actions Simpli Procede et dispositif de separation chromatographique de fractions d'un melange
US8123394B2 (en) * 2005-10-17 2012-02-28 Evonik Degussa Gmbh Mixer for liquid colorants and method for mixing liquid colorants
CN103214484B (zh) 2005-12-13 2016-07-06 因塞特控股公司 作为两面神激酶抑制剂的杂芳基取代的吡咯并[2,3-b]吡啶和吡咯并[2,3-b]嘧啶
WO2008025887A1 (fr) * 2006-08-28 2008-03-06 Novasep Procede d'enrichissement d'un ou plusieurs composes d'un melange utilisant une phase mobile liquide contenant un gaz
US20080053908A1 (en) * 2006-09-01 2008-03-06 Lalit Chordia High pressure flash chromatography
FR2907687B1 (fr) * 2006-10-30 2008-12-26 Applexion Procede de purification de sialyllactose par chromatographie
HUE029236T2 (en) 2007-06-13 2017-02-28 Incyte Holdings Corp (R) -3- (4- (7H-Pyrrolo [2,3-d] pyrimidin-4-yl) -1H-pyrazol-1-yl) -3-cyclopentylpropanenitrile Crystalline salts of Janus kinase inhibitor
WO2008153472A1 (en) * 2007-06-15 2008-12-18 Ge Healthcare Bio-Sciences Ab Chromatography method
CA2703991A1 (en) * 2007-11-02 2009-05-07 Biotrove, Inc. Devices and methods for coupling mass spectrometry devices with chromatography systems
FR2929533B1 (fr) * 2008-04-03 2010-04-30 Novasep Procede de separation multicolonnes a gradient.
CL2009001884A1 (es) * 2008-10-02 2010-05-14 Incyte Holdings Corp Uso de 3-ciclopentil-3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)propanonitrilo, inhibidor de janus quinasa, y uso de una composición que lo comprende para el tratamiento del ojo seco.
PE20211639A1 (es) 2009-01-15 2021-08-24 Incyte Holdings Corp Procesos para preparar inhibidores de jak y compuestos intermediarios relacionado
WO2010124159A1 (en) * 2009-04-23 2010-10-28 Xcellerex, Inc. System and method for variable speed feedback control chromatography loading
EP2432472B1 (en) 2009-05-22 2019-10-02 Incyte Holdings Corporation 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octane- or heptane-nitrile as jak inhibitors
MY156727A (en) * 2009-05-22 2016-03-15 Incyte Corp N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
TW201113285A (en) * 2009-09-01 2011-04-16 Incyte Corp Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
EP3354652B1 (en) 2010-03-10 2020-05-06 Incyte Holdings Corporation Piperidin-4-yl azetidine derivatives as jak1 inhibitors
AR084691A1 (es) 2010-05-21 2013-06-05 Incyte Corp Formulacion de uso topico para un inhibidor de jak y metodo para tratar trastorno de la piel
WO2012068440A1 (en) 2010-11-19 2012-05-24 Incyte Corporation Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as jak inhibitors
CA2818542A1 (en) 2010-11-19 2012-05-24 Incyte Corporation Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as jak inhibitors
MY165963A (en) 2011-06-20 2018-05-18 Incyte Holdings Corp Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as jak inhibitors
TW201313721A (zh) 2011-08-18 2013-04-01 Incyte Corp 作為ｊａｋ抑制劑之環己基氮雜環丁烷衍生物
UA111854C2 (uk) 2011-09-07 2016-06-24 Інсайт Холдінгс Корпорейшн Способи і проміжні сполуки для отримання інгібіторів jak
EP2578286A1 (en) * 2011-10-04 2013-04-10 Merck Patent GmbH Method and apparatus for chromatographic purification
WO2013083482A1 (en) * 2011-12-05 2013-06-13 Chromacon Ag Chromatographic method for the separation of fatty acid mixtures
TW201406761A (zh) 2012-05-18 2014-02-16 Incyte Corp 做爲ｊａｋ抑制劑之哌啶基環丁基取代之吡咯并吡啶及吡咯并嘧啶衍生物
TWI761825B (zh) 2012-11-15 2022-04-21 美商英塞特控股公司 盧梭利替尼之緩釋性劑型
EP2772289B1 (en) * 2013-03-01 2015-05-06 ChromaCon AG Chromatographic process for enrichment and isolation
MX384910B (es) 2013-03-06 2025-03-14 Incyte Holdings Corp Procesos e intermedios para hacer un inhibidor de jak.
CA2911273C (en) 2013-05-07 2021-04-27 Groupe Novasep Chromatographic process for the production of highly purified polyunsaturated fatty acids
US9428711B2 (en) 2013-05-07 2016-08-30 Groupe Novasep Chromatographic process for the production of highly purified polyunsaturated fatty acids
US8802880B1 (en) 2013-05-07 2014-08-12 Group Novasep Chromatographic process for the production of highly purified polyunsaturated fatty acids
EP2801604B1 (en) 2013-05-07 2017-04-12 Groupe Novasep Chromatographic process for the production of highly purified polyunsaturated fatty acids
SG11201600815WA (en) 2013-08-07 2016-03-30 Incyte Corp Sustained release dosage forms for a jak1 inhibitor
CN103424488B (zh) * 2013-08-21 2015-04-01 利穗科技(苏州)有限公司 一种双柱或多柱串联的色谱系统
EP2883860B1 (fr) 2013-12-11 2016-08-24 Novasep Process Procédé chromatographique de production d'acides gras polyinsaturés
FR3014436B1 (fr) * 2013-12-11 2016-10-21 Novasep Process Procede de purification chromatographique d'un acide gras
FR3014435B1 (fr) * 2013-12-11 2016-10-21 Novasep Process Purification d'acides gras par un procede chromatographique
CN105980026B (zh) * 2013-12-19 2018-09-28 通用电气健康护理生物科学股份公司 色谱系统和方法
JP6303017B2 (ja) 2014-01-07 2018-03-28 ノヴァセプ プロセスＮｏｖａｓｅｐ Ｐｒｏｃｅｓｓ 芳香族アミノ酸を精製する方法
CH709709A1 (de) * 2014-05-30 2015-11-30 Werner Döbelin Systemkonfiguration für die Injektion von Proben mit automatischer Festphasenextraktion mit nur einem binären Pumpensystem für den Betrieb im Bereich der HPLC, ultra-, mikro- und nano- HPLC.
WO2015184305A1 (en) 2014-05-30 2015-12-03 Incyte Corporation TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1
CN106053689B (zh) * 2016-07-18 2017-10-20 华南理工大学 可精确获取采样时间的手动停流型二维液相色谱及其应用
US10596161B2 (en) 2017-12-08 2020-03-24 Incyte Corporation Low dose combination therapy for treatment of myeloproliferative neoplasms
JP7393348B2 (ja) 2018-01-30 2023-12-06 インサイト・コーポレイション （１－（３－フルオロ－２（トリフルオロメチル）イソニコチニル）ピぺリジン―４－オン）を作製するためのプロセス及び中間体
US11119076B2 (en) * 2018-02-26 2021-09-14 Valco Instruments Company, L.P. System and valve for liquid chromatography
CN108254475A (zh) * 2018-03-09 2018-07-06 山东省分析测试中心 一种用于复杂样品循环分离的高速逆流色谱仪及工作方法
CN113768934A (zh) 2018-03-30 2021-12-10 因赛特公司 使用jak抑制剂治疗化脓性汗腺炎
JP2021525872A (ja) * 2018-05-31 2021-09-27 ウオーターズ・テクノロジーズ・コーポレイシヨン 医薬品中の未知微量不純物の単離及び分取のための高分解能セミ分取リサイクリングクロマトグラフィーシステム
US11324718B2 (en) 2018-10-09 2022-05-10 Sartorius Chromatography Equipment Method for purifying cannabinoids
US11833155B2 (en) 2020-06-03 2023-12-05 Incyte Corporation Combination therapy for treatment of myeloproliferative neoplasms
WO2023165947A1 (en) 2022-03-03 2023-09-07 Chromacon Ag Chromatographic purification method and uses thereof
AU2023245599A1 (en) * 2022-03-27 2024-11-14 Purdue Research Foundation Chromatography methods for producing high purity, high yield lithium, cobalt, nickel, manganese salts from waste lithium-ion batteries

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4001112A (en) * 1972-06-14 1977-01-04 Philip Edwin Barker Method of operating a chromatographic apparatus
US3992175A (en) * 1974-02-11 1976-11-16 Toe Jokhannesovich Klementi Method of and device for chromatographic separation of fluid mixtures into fractions
JPS6055162B2 (ja) * 1977-05-26 1985-12-04 参松工業株式会社 カラムクロマト分離法
US4359323A (en) * 1980-10-31 1982-11-16 W. R. Grace & Co. Single pump liquid chromatograph analytical system for amines
US4412866A (en) * 1981-05-26 1983-11-01 The Amalgamated Sugar Company Method and apparatus for the sorption and separation of dissolved constituents
JPS5838857A (ja) * 1981-08-31 1983-03-07 Shimadzu Corp ガスクロマトグラフ用カラム切換コツク
FR2527934A1 (fr) * 1982-06-03 1983-12-09 Elf Aquitaine Procede de fractionnement de melanges par chromatographie d'elution avec fluide en etat supercritique et installation pour sa mise en oeuvre
JPS59222764A (ja) * 1983-06-01 1984-12-14 Yokogawa Hokushin Electric Corp ガスクロマトグラフ
EP0127926B1 (en) * 1983-06-03 1986-11-26 Hewlett-Packard Company Chromatographic separation
US4530234A (en) * 1983-06-30 1985-07-23 Mobil Oil Corporation Method and system for measuring properties of fluids
US4528101A (en) * 1983-09-09 1985-07-09 Illinois Water Treatment Company Method of separating acid from salt by adsorption with recycling
US4536199A (en) * 1984-01-05 1985-08-20 Mobil Oil Corporation Gas chromatograph for reseparating a sampel into pure components
US4498991A (en) * 1984-06-18 1985-02-12 Uop Inc. Serial flow continuous separation process
US5122275A (en) * 1986-05-08 1992-06-16 A. E. Staley Manufacturing Company Simulated moving bed chromatographic separation
US4840730A (en) * 1986-07-25 1989-06-20 Sepragen Corporation Chromatography system using horizontal flow columns
JPH0669521B2 (ja) * 1986-12-23 1994-09-07 三菱化成エンジニアリング株式会社 クロマト分離法
US4919595A (en) * 1987-03-03 1990-04-24 Beckman Instruments, Inc. Fluid delivery system with deficit flow compensation
US5180487A (en) * 1987-09-25 1993-01-19 Nihon Bunko Kogyo Kabushiki Kaisha Pump apparatus for transferring a liquified gas used in a recycle chromatograph
DE3735814A1 (de) * 1987-10-22 1989-05-11 Siemens Ag Einrichtung und verfahren zum dosieren von proben fuer die gaschromatographische analyse
JPH0746097B2 (ja) * 1988-05-17 1995-05-17 三菱化成エンジニアリング株式会社 クロマト分離法
JP2845909B2 (ja) * 1988-12-09 1999-01-13 株式会社日立製作所 液体クロマトグラフおよびそれを用いる方法
US4990259A (en) * 1988-12-16 1991-02-05 The Amalgamated Sugar Company Chromatographic separator sorbent bed preparation
US5089126A (en) * 1989-03-31 1992-02-18 Lehigh University Method and apparatus for capillary hydrodynamic fractionation
FR2651148B1 (fr) * 1989-08-28 1992-05-07 Inst Francais Du Petrole Procede continu et dispositif de separation chromatographique d'un melange d'au moins trois constituants en trois effluents purifies au moyen de deux solvants.
FR2651149B1 (fr) * 1989-08-28 1992-06-05 Inst Francais Du Petrole Procede continu et dispositif de separation chromatographique d'un melange d'au moins trois constituants en trois effluents purifies au moyen d'un seul solvant a deux temperatures et/ou a deux pressions differentes.
US5071547A (en) * 1990-03-23 1991-12-10 Separations Technology, Inc. Column chromatographic column apparatus with switching capability
US5108466A (en) * 1990-12-21 1992-04-28 Hewlett-Packard Company Apparatus and methods for controlling fluids provided to a chromatographic detector
US5196039A (en) * 1991-01-30 1993-03-23 Southern Illinois University At Carbondale Apparatus and method of multi-dimensional chemical separation
US5253981A (en) * 1992-03-05 1993-10-19 Frank Ji-Ann Fu Yang Multichannel pump apparatus with microflow rate capability
DE4231149C1 (de) * 1992-09-17 1993-12-16 Amino Gmbh Verfahren zur Weiterverarbeitung von technischen Restabläufen der melasseverarbeitenden Industrie
US5415489A (en) * 1993-01-11 1995-05-16 Zymark Corporation Reciprocating driver apparatus
US5398539A (en) * 1993-08-02 1995-03-21 Hewlett-Packard Company Correlated multi-dimensional chromatography with confirmatory hybrid run

Also Published As

Publication number Publication date
DE69631903D1 (de) 2004-04-22
JP2000503112A (ja) 2000-03-14
WO1997020206A1 (en) 1997-06-05
EP0877936A1 (en) 1998-11-18
DE69631903T2 (de) 2004-08-19
JP4009671B2 (ja) 2007-11-21
EP0877936B1 (en) 2004-03-17
US5630943A (en) 1997-05-20

Similar Documents

Publication Publication Date Title
US5630943A (en) Discontinuous countercurrent chromatographic process and apparatus
US6063284A (en) Single column closed-loop recycling with periodic intra-profile injection
Ma et al. Standing wave analysis of SMB chromatography: linear systems
US4840730A (en) Chromatography system using horizontal flow columns
Seidel‐Morgenstern et al. New developments in simulated moving bed chromatography
US20130134095A1 (en) Two-dimensional liquid chromatography with control of injection in relation to a state of the second dimension chromatograph
Balannec et al. From batch elution to simulated countercurrent chromatography
CN207586196U (zh) 基于同一检测器的全在线检测的多维液相色谱分离系统
US20030094415A1 (en) Preparative chromatography system and separation/purification method using same
Yun et al. Simulated moving bed under linear conditions: Experimental vs. calculated results
CN109557219A (zh) 一种多维液相色谱分离系统
EP3427046B1 (en) Systems, methods and devices for reducing band dispersion in chromatography
CN106075954B (zh) 以一个多通阀为切换装置的停流型二维液相色谱及其应用
CN109900840A (zh) 基于双两位四通阀的多维液相色谱分离系统
CN116068093B (zh) 一种在线固相萃取-高效液相色谱联用的检测系统及检测方法
CN109541090A (zh) 一种基于双两位四通阀的多维液相色谱分离系统
CN215415249U (zh) 一种生产型循环多维液相色谱分离系统
US20220308020A1 (en) Automated semi-preparative gradient recycling liquid chromatography
Kika Low pressure separations using automated flow and sequential injection analysis coupled to monolithic columns
EP3773968B1 (en) Automated two-column recycling chromatography method for unlocking challenging separation problems
CN211402260U (zh) 基于两位六通阀的多维液相色谱分离系统
CN211043264U (zh) 基于两位多通阀的多维液相色谱分离系统
Ghrist et al. Design of optimized high-performance liquid chromatographic gradients for the separation of either small or large molecules: I. Minimizing errors in computer simulations
CN208902668U (zh) 一种多维液相色谱分离系统
CN105749583A (zh) 一种通用制备型二维液相色谱装置及其操作方法

Legal Events

Date Code Title Description
FZDE Discontinued