CA2237314A1 - Novel tricyclic compounds for the inhibition of the ice/ced-3 protease family of enzymes - Google Patents

Info

Publication number

CA2237314A1

CA2237314A1 CA002237314A CA2237314A CA2237314A1 CA 2237314 A1 CA2237314 A1 CA 2237314A1 CA 002237314 A CA002237314 A CA 002237314A CA 2237314 A CA2237314 A CA 2237314A CA 2237314 A1 CA2237314 A1 CA 2237314A1

Authority

CA

Canada

Prior art keywords

alkyl

group

formula

compound

cycloalkyl

Prior art date

1996-09-12

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• CIPO
• Discuss

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• 108090000790 Enzymes Proteins 0.000 title description 11
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• 125000000217 alkyl group Chemical group 0.000 claims description 143
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• 125000000753 cycloalkyl group Chemical group 0.000 claims description 67
• 125000001072 heteroaryl group Chemical group 0.000 claims description 61
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 44
• 125000003884 phenylalkyl group Chemical group 0.000 claims description 42
• 238000000034 method Methods 0.000 claims description 28
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 20
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• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 18
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 12
• 150000003839 salts Chemical class 0.000 claims description 12
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• 125000003118 aryl group Chemical group 0.000 claims description 8
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 6
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• 238000001704 evaporation Methods 0.000 description 9
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• 125000003277 amino group Chemical group 0.000 description 8
• 238000002360 preparation method Methods 0.000 description 8
• 230000002441 reversible effect Effects 0.000 description 8
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