CA2228308A1 - Microsondes optiques et procedes d'analyse spectrale des materiaux - Google Patents

Microsondes optiques et procedes d'analyse spectrale des materiaux Download PDF

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Publication number
CA2228308A1
CA2228308A1 CA 2228308 CA2228308A CA2228308A1 CA 2228308 A1 CA2228308 A1 CA 2228308A1 CA 2228308 CA2228308 CA 2228308 CA 2228308 A CA2228308 A CA 2228308A CA 2228308 A1 CA2228308 A1 CA 2228308A1
Authority
CA
Canada
Prior art keywords
optical
volume element
tissue
sample
response
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA 2228308
Other languages
English (en)
Inventor
Mark Modell
Gregory Debaryshe
A. Ze'ev Hed
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medispectra Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/510,041 external-priority patent/US5713364A/en
Application filed by Individual filed Critical Individual
Publication of CA2228308A1 publication Critical patent/CA2228308A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0062—Arrangements for scanning
    • A61B5/0068—Confocal scanning
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/4795—Scattering, i.e. diffuse reflection spatially resolved investigating of object in scattering medium

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Optics & Photonics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Endoscopes (AREA)

Abstract

Une sonde optique recueille la lumière émanant d'un spécimen qui représente de façon sélective et préférentielle un volume localisé dans l'échantillon, l'intensité d'éclairage et l'efficacité de collecte diminuant à mesure qu'on s'éloigne de ce volume localisé, ce qui limite la contribution intégrée en provenance de l'extérieur du volume considéré. Par exemple, l'optique assure un éclairage de crête élevé et une efficacité de collecte élevée qui se recouvrent dans des volumes de dimension limitée correspondant à une structure ou à un processus se rapportant au spécimen. Le signal résultant recueilli, comportant un ou plusieurs segments spectraux, est fortement corrélé avec des caractéristiques optiques, telles que les caractéristiques d'absorbance, de diffusion et de fluorescence du matériau dans les petits volumes. Un processeur peut appliquer une transformée de vecteur ou de matrice dérivée précédemment aux réponses recueillies de façon à obtenir un résultat. Les spectres recueillis ou les autres réponses présentent une grande intensité de signal et représentent des effets optiques réduits, ou inaccessibles pour une autre raison, ou masqués, présents dans l'échantillon, qui sont corrélés facilement aux éléments recherchés.
CA 2228308 1995-08-01 1996-08-01 Microsondes optiques et procedes d'analyse spectrale des materiaux Abandoned CA2228308A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US51004395A 1995-08-01 1995-08-01
US08/510,041 US5713364A (en) 1995-08-01 1995-08-01 Spectral volume microprobe analysis of materials
US08/510,043 1995-08-01
US08/510,041 1995-08-01

Publications (1)

Publication Number Publication Date
CA2228308A1 true CA2228308A1 (fr) 1997-02-13

Family

ID=27056762

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2228308 Abandoned CA2228308A1 (fr) 1995-08-01 1996-08-01 Microsondes optiques et procedes d'analyse spectrale des materiaux

Country Status (6)

Country Link
EP (1) EP0842412A1 (fr)
JP (2) JP3923080B2 (fr)
AU (1) AU6645796A (fr)
CA (1) CA2228308A1 (fr)
MX (1) MX9800874A (fr)
WO (1) WO1997005473A1 (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6104945A (en) * 1995-08-01 2000-08-15 Medispectra, Inc. Spectral volume microprobe arrays
US6084671A (en) * 1997-05-06 2000-07-04 Holcomb; Matthew J. Surface analysis using Gaussian beam profiles
DE19834279C2 (de) * 1998-07-30 2002-09-26 Europ Lab Molekularbiolog Kompaktes Einzelobjektiv Theta-Mikroskop
FR2784749B1 (fr) * 1998-10-14 2000-12-29 Instruments Sa Appareil de caracterisation optique de materiau en couche mince
AU2001229916A1 (en) 2000-01-27 2001-08-07 National Research Council Of Canada Visible-near infrared spectroscopy in burn injury assessment
JP3592182B2 (ja) 2000-02-29 2004-11-24 株式会社睦コーポレーション 撮像装置
US20020010401A1 (en) * 2000-05-18 2002-01-24 Andrew Bushmakin Pre- and post-processing of spectral data for calibration using mutivariate analysis techniques
WO2002004929A2 (fr) * 2000-07-10 2002-01-17 University Health Network Technique et appareil relatifs a une imagerie optique coherente a haute resolution
JP4018063B2 (ja) * 2000-10-12 2007-12-05 アムニス コーポレイション 画像化システム及びその方法
US10595710B2 (en) 2001-10-19 2020-03-24 Visionscope Technologies Llc Portable imaging system employing a miniature endoscope
US20070167681A1 (en) 2001-10-19 2007-07-19 Gill Thomas J Portable imaging system employing a miniature endoscope
US6863651B2 (en) * 2001-10-19 2005-03-08 Visionscope, Llc Miniature endoscope with imaging fiber system
DE10246967A1 (de) * 2002-10-09 2004-04-22 Heinrich, Hermann, Dr.rer.nat. Verfahren und Vorrichtung zur nichtinvasiven Untersuchung von Stoffwechselprozessen
US20060258934A1 (en) * 2003-04-23 2006-11-16 Michael Zenge Magnetic resonance locating method
WO2004106985A2 (fr) * 2003-05-29 2004-12-09 The Regents Of The University Of Michigan Microscope electronique a balayage avec fibres double gaine
US8026942B2 (en) 2004-10-29 2011-09-27 Johnson & Johnson Consumer Companies, Inc. Skin imaging system with probe
US7558416B2 (en) 2006-10-02 2009-07-07 Johnson & Johnson Consumer Companies, Inc. Apparatus and method for measuring photodamage to skin
JP5435532B2 (ja) * 2007-07-17 2014-03-05 富士フイルム株式会社 画像処理システム
US9282926B2 (en) * 2008-12-18 2016-03-15 Sirona Dental Systems Gmbh Camera for recording surface structures, such as for dental purposes
EP2430415B1 (fr) * 2009-05-16 2020-05-27 INSION GmbH Spectrometre confocal miniaturise
DE102010036447A1 (de) * 2010-03-26 2011-09-29 Degudent Gmbh Verfahren zur Ermittlung von Materialcharakteristika
JPWO2012057150A1 (ja) * 2010-10-29 2014-05-12 オリンパス株式会社 光学測定装置およびプローブ
JP2014021274A (ja) * 2012-07-18 2014-02-03 Hamamatsu Photonics Kk 共焦点光生成レンズユニット、光学装置および顕微鏡
CA3008240A1 (fr) 2015-12-15 2017-06-22 Koninklijke Philips N.V. Procedes et appareil de calibrage d'un dispositif de surveillance medicale

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3013467A (en) * 1957-11-07 1961-12-19 Minsky Marvin Microscopy apparatus
US4810875A (en) * 1987-02-02 1989-03-07 Wyatt Technology Corporation Method and apparatus for examining the interior of semi-opaque objects
FR2626383B1 (fr) * 1988-01-27 1991-10-25 Commissariat Energie Atomique Procede de microscopie optique confocale a balayage et en profondeur de champ etendue et dispositifs pour la mise en oeuvre du procede
US4934811A (en) * 1988-04-01 1990-06-19 Syntex (U.S.A.) Inc. Apparatus and method for detection of fluorescence or light scatter
JPH0217429A (ja) * 1988-07-05 1990-01-22 Fujitsu Ltd レーザ方式ガスセンサによる濃度測定方法
DE3843876A1 (de) * 1988-12-24 1990-07-12 Leitz Wild Gmbh Spektralmikroskop mit einem photometer
US5257085A (en) * 1991-04-24 1993-10-26 Kaman Aerospace Corporation Spectrally dispersive imaging lidar system
JPH0534086A (ja) * 1991-07-26 1993-02-09 Mitsubishi Heavy Ind Ltd 伝熱フイン
JP2982472B2 (ja) * 1992-03-11 1999-11-22 日産自動車株式会社 塗装面性状測定装置
US5598842A (en) * 1993-09-03 1997-02-04 Toa Medical Electronics Co., Ltd. Non-invasive blood analyzer and method using the same

Also Published As

Publication number Publication date
WO1997005473A1 (fr) 1997-02-13
MX9800874A (es) 1998-09-30
AU6645796A (en) 1997-02-26
JP3923080B2 (ja) 2007-05-30
EP0842412A1 (fr) 1998-05-20
JP2006138860A (ja) 2006-06-01
JPH11510254A (ja) 1999-09-07

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