CA2226553A1 - Formulation pharmaceutique stabilisee comportant une hormone de croissance et un peptide contenant au moins un reste d'acide amine basique et au moins un reste d'acide amine acide - Google Patents
Formulation pharmaceutique stabilisee comportant une hormone de croissance et un peptide contenant au moins un reste d'acide amine basique et au moins un reste d'acide amine acide Download PDFInfo
- Publication number
- CA2226553A1 CA2226553A1 CA002226553A CA2226553A CA2226553A1 CA 2226553 A1 CA2226553 A1 CA 2226553A1 CA 002226553 A CA002226553 A CA 002226553A CA 2226553 A CA2226553 A CA 2226553A CA 2226553 A1 CA2226553 A1 CA 2226553A1
- Authority
- CA
- Canada
- Prior art keywords
- amino acid
- growth hormone
- acid residue
- formulation
- peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 229960002317 succinimide Drugs 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 239000001117 sulphuric acid Substances 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biomedical Technology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Abstract
Formulation pharmaceutique comportant une hormone de croissance et un peptide contenant au moins un reste d'acide aminé basique et au moins un reste d'acide aminé acide en tant qu'additif ou substance de tamponnage, qui possède une stabilité très élevée contre la déamidation, l'oxydation et le clivage des liaison peptidiques. La stabilité du produit en permet le stockage et le transport sous forme lyophilisée ou sous forme d'une formulation dissoute ou redissoute à température ambiante.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88195P | 1995-07-12 | 1995-07-12 | |
| US60/000,881 | 1995-07-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2226553A1 true CA2226553A1 (fr) | 1997-01-30 |
Family
ID=21693419
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002226553A Abandoned CA2226553A1 (fr) | 1995-07-12 | 1996-06-28 | Formulation pharmaceutique stabilisee comportant une hormone de croissance et un peptide contenant au moins un reste d'acide amine basique et au moins un reste d'acide amine acide |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0837690A1 (fr) |
| JP (1) | JPH11510483A (fr) |
| KR (1) | KR19990028908A (fr) |
| CN (1) | CN1190896A (fr) |
| AU (1) | AU699850B2 (fr) |
| BR (1) | BR9609573A (fr) |
| CA (1) | CA2226553A1 (fr) |
| CZ (1) | CZ6198A3 (fr) |
| HU (1) | HUP9802286A3 (fr) |
| IL (1) | IL122519A0 (fr) |
| NO (1) | NO980103D0 (fr) |
| PL (1) | PL324386A1 (fr) |
| WO (1) | WO1997002833A1 (fr) |
| ZA (1) | ZA965367B (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100236393B1 (ko) * | 1996-02-02 | 1999-12-15 | 나까니시 히로유끼 | 사람성장호르몬을 함유하는 의약제제 |
| US6566329B1 (en) | 1999-06-28 | 2003-05-20 | Novo Nordisk A/S | Freeze-dried preparation of human growth hormone |
| TWI283182B (en) | 2000-08-07 | 2007-07-01 | Nektar Therapeutics | Inhalable spray dried 4-helix bundle protein powders having minimized aggregation |
| WO2004052403A1 (fr) * | 2002-12-11 | 2004-06-24 | Santen Pharmaceutical Co., Ltd. | Conservateur pour l'ophtalmologie |
| CN103751769B (zh) * | 2013-12-25 | 2015-08-19 | 楼秀余 | 一种冻干重组人生长激素胶囊及其制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816568A (en) * | 1986-05-16 | 1989-03-28 | International Minerals & Chemical Corp. | Stabilization of growth hormones |
| DK204791D0 (da) * | 1991-12-20 | 1991-12-20 | Novo Nordisk As | Hidtil ukendt farmaceutisk praeparat |
| WO1993012812A1 (fr) * | 1991-12-20 | 1993-07-08 | Novo Nordisk A/S | Formulation pharmaceutique stabilisee comportant une somatotrophine et de l'histidine |
| KR19980701351A (ko) * | 1995-01-13 | 1998-05-15 | 슈타르 피아 | 성장호르몬 및 Ｘ-Ｌｙｓ를 함유하는 안정화된 약제조제물(A STABILIZED PHARMACEUTICAL FORMULATION COMPRISING A GROWTH HORMONE AND X-Lys |
-
1996
- 1996-06-25 ZA ZA965367A patent/ZA965367B/xx unknown
- 1996-06-28 PL PL96324386A patent/PL324386A1/xx unknown
- 1996-06-28 CN CN96195465A patent/CN1190896A/zh active Pending
- 1996-06-28 JP JP9505422A patent/JPH11510483A/ja active Pending
- 1996-06-28 HU HU9802286A patent/HUP9802286A3/hu unknown
- 1996-06-28 EP EP96922774A patent/EP0837690A1/fr not_active Withdrawn
- 1996-06-28 WO PCT/DK1996/000290 patent/WO1997002833A1/fr not_active Application Discontinuation
- 1996-06-28 KR KR1019980700210A patent/KR19990028908A/ko not_active Application Discontinuation
- 1996-06-28 AU AU63533/96A patent/AU699850B2/en not_active Ceased
- 1996-06-28 BR BR9609573A patent/BR9609573A/pt not_active Application Discontinuation
- 1996-06-28 CA CA002226553A patent/CA2226553A1/fr not_active Abandoned
- 1996-06-28 CZ CZ9861A patent/CZ6198A3/cs unknown
- 1996-06-28 IL IL12251996A patent/IL122519A0/xx unknown
-
1998
- 1998-01-09 NO NO980103A patent/NO980103D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ZA965367B (en) | 1997-01-23 |
| IL122519A0 (en) | 1998-06-15 |
| PL324386A1 (en) | 1998-05-25 |
| WO1997002833A1 (fr) | 1997-01-30 |
| EP0837690A1 (fr) | 1998-04-29 |
| NO980103L (no) | 1998-01-09 |
| NO980103D0 (no) | 1998-01-09 |
| HUP9802286A3 (en) | 1999-06-28 |
| CZ6198A3 (cs) | 1998-06-17 |
| CN1190896A (zh) | 1998-08-19 |
| BR9609573A (pt) | 1999-03-02 |
| AU6353396A (en) | 1997-02-10 |
| HUP9802286A2 (hu) | 1999-02-01 |
| JPH11510483A (ja) | 1999-09-14 |
| AU699850B2 (en) | 1998-12-17 |
| KR19990028908A (ko) | 1999-04-15 |
| MX9800309A (es) | 1998-07-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued | ||
| FZDE | Discontinued |
Effective date: 20030630 |