CA2218816A1 - Inhibiteurs de thrombine bicycliques de type uree et de faible poids moleculaire - Google Patents

Inhibiteurs de thrombine bicycliques de type uree et de faible poids moleculaire Download PDF

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Publication number
CA2218816A1
CA2218816A1 CA002218816A CA2218816A CA2218816A1 CA 2218816 A1 CA2218816 A1 CA 2218816A1 CA 002218816 A CA002218816 A CA 002218816A CA 2218816 A CA2218816 A CA 2218816A CA 2218816 A1 CA2218816 A1 CA 2218816A1
Authority
CA
Canada
Prior art keywords
alkyl
mmol
solution
compound according
carbonyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002218816A
Other languages
English (en)
Inventor
Benoit Bachand
John W. Gillard
John Dimaio
M. Arshad Siddiqui
Annette Marian Doherty
Jeremy John Edmunds
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shire Canada Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2218816A1 publication Critical patent/CA2218816A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Inhibiteurs hétérocycliques de l'enzyme thrombine, leur préparation et compositions pharmaceutiques contenant lesdits inhibiteurs de formule générale (I) dans laquelle X, R2, R3, R4, R6, R7 et R8 sont tels que définis dans la présente demande. La présente invention concerne en outre l'utilisation de ces composés et compositions en tant qu'anticoagulants et en tant qu'agents pour le traitement et la prophylaxie des troubles thrombotiques telle que la thrombose veineuse, l'embolie pulmonaire et la thrombose artérielle entraînant des accidents ischémiques aigus tels que l'infarctus du myocarde ou l'infarctus cérébral.
CA002218816A 1995-05-22 1996-05-22 Inhibiteurs de thrombine bicycliques de type uree et de faible poids moleculaire Abandoned CA2218816A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9510264.6 1995-05-22
GBGB9510264.6A GB9510264D0 (en) 1995-05-22 1995-05-22 Low molecular weight bicyclic-urea type thrombin inhibitors

Publications (1)

Publication Number Publication Date
CA2218816A1 true CA2218816A1 (fr) 1996-11-28

Family

ID=10774799

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002218816A Abandoned CA2218816A1 (fr) 1995-05-22 1996-05-22 Inhibiteurs de thrombine bicycliques de type uree et de faible poids moleculaire

Country Status (7)

Country Link
EP (1) EP0846120A1 (fr)
JP (1) JPH11505260A (fr)
AU (1) AU5682596A (fr)
CA (1) CA2218816A1 (fr)
GB (1) GB9510264D0 (fr)
WO (1) WO1996037497A1 (fr)
ZA (1) ZA964090B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998028326A1 (fr) * 1996-12-23 1998-07-02 Biochem Pharma Inc. Inhibiteurs bicycliques de thrombine
US6323219B1 (en) 1998-04-02 2001-11-27 Ortho-Mcneil Pharmaceutical, Inc. Methods for treating immunomediated inflammatory disorders
US8106094B2 (en) 1998-07-06 2012-01-31 Johnson & Johnson Consumer Companies, Inc. Compositions and methods for treating skin conditions
US8093293B2 (en) 1998-07-06 2012-01-10 Johnson & Johnson Consumer Companies, Inc. Methods for treating skin conditions
EA200100815A1 (ru) 1999-01-27 2002-08-29 Орто-Макнейл Фармасьютикал, Инк. Пептидильные гетероциклические кетоны, применимые в качестве ингибиторов триптазы
US8431550B2 (en) 2000-10-27 2013-04-30 Johnson & Johnson Consumer Companies, Inc. Topical anti-cancer compositions and methods of use thereof
US7192615B2 (en) 2001-02-28 2007-03-20 J&J Consumer Companies, Inc. Compositions containing legume products
MXPA04009228A (es) 2002-03-22 2005-08-16 Gpc Biotech Ag Compuestos inmunosupresores, metodos y usos relacionados con los mismos.
WO2016057413A2 (fr) 2014-10-06 2016-04-14 Cortexyme, Inc. Inhibiteurs de lysine gingipaïne
WO2017083433A1 (fr) 2015-11-09 2017-05-18 Cortexyme, Inc. Inhibiteurs d'arginine gingipaïne
MX2019003087A (es) 2016-09-16 2019-08-12 Cortexyme Inc Inhibidores cetónicos de gingipain de lisina.

Also Published As

Publication number Publication date
JPH11505260A (ja) 1999-05-18
AU5682596A (en) 1996-12-11
ZA964090B (en) 1997-05-13
WO1996037497A1 (fr) 1996-11-28
EP0846120A1 (fr) 1998-06-10
GB9510264D0 (en) 1995-07-19

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Legal Events

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FZDE Dead