CA2218360A1 - Inhibiteurs de la synthase d'oxyde nitrique derives des amidines cycliques - Google Patents
Inhibiteurs de la synthase d'oxyde nitrique derives des amidines cycliques Download PDFInfo
- Publication number
- CA2218360A1 CA2218360A1 CA002218360A CA2218360A CA2218360A1 CA 2218360 A1 CA2218360 A1 CA 2218360A1 CA 002218360 A CA002218360 A CA 002218360A CA 2218360 A CA2218360 A CA 2218360A CA 2218360 A1 CA2218360 A1 CA 2218360A1
- Authority
- CA
- Canada
- Prior art keywords
- alkyl
- hydrogen
- hydroxy
- aryl
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/12—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/10—Seven-membered rings having the hetero atoms in positions 1 and 4 not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Communicable Diseases (AREA)
- Transplantation (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
L'invention concerne les composés présentant la formule (I) dans laquelle, R?1¿, R?5¿, R?6¿ et R?7¿ sont de l'hydrogène ou des substituants spécifiés; R?8¿ et R?9¿ sont indépendamment de l'hydrogène, de l'hydroxy ou de l'alkoxy; et X, A et B sont indépendamment du NR?2¿, O, S, SO, SO¿2?, CH=CH ou (CH¿2?)p, p étant compris entre 0 et 6. Ces composés peuvent être utilisés comme inhibiteurs de la synthase d'oxyde nitrique.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43832195A | 1995-05-10 | 1995-05-10 | |
US438,321 | 1995-05-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2218360A1 true CA2218360A1 (fr) | 1996-11-14 |
Family
ID=23740193
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002218360A Abandoned CA2218360A1 (fr) | 1995-05-10 | 1996-05-09 | Inhibiteurs de la synthase d'oxyde nitrique derives des amidines cycliques |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0824523A1 (fr) |
JP (1) | JPH11511741A (fr) |
KR (1) | KR19990014671A (fr) |
CN (1) | CN1190390A (fr) |
AU (1) | AU712995B2 (fr) |
BR (1) | BR9608133A (fr) |
CA (1) | CA2218360A1 (fr) |
MX (1) | MX9708631A (fr) |
NZ (1) | NZ307950A (fr) |
TW (1) | TW415941B (fr) |
WO (1) | WO1996035677A1 (fr) |
ZA (1) | ZA963742B (fr) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6043358A (en) | 1995-11-01 | 2000-03-28 | Merck & Co., Inc. | Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases |
GB9524526D0 (en) * | 1995-11-30 | 1996-01-31 | Zeneca Ltd | Chemical process |
EP0966286B1 (fr) * | 1997-01-09 | 2003-07-30 | G.D. Searle & Co. | Attenuation de la tolerance aux opioides par inhibition des mecanismes d'action de la monoxyde d'azote synthetase inductible, dans le traitement de la douleur |
NO310618B1 (no) * | 1997-04-10 | 2001-07-30 | Ono Pharmaceutical Co | Kondenserte piperidinforbindelser, fremstilling og anvendelse derav, samt preparater omfattende slike forbindelser |
JP2002517502A (ja) | 1998-06-10 | 2002-06-18 | ジー・ディー・サール・アンド・カンパニー | 複素二環状及び三環状一酸化窒素シンターゼ阻害剤 |
US6552052B2 (en) | 1998-06-10 | 2003-04-22 | Monsanto/G.D. Searle | Pyrrolo[2,1-c][1,2,4] thiadiazoles and Pyrollo[2,1-c][1,12,4]oxadiazoles useful as nitric oxide synthase inhibitors |
SE9901530D0 (sv) * | 1999-04-28 | 1999-04-28 | Astra Pharma Prod | Novel compounds |
US6403830B2 (en) | 2000-03-24 | 2002-06-11 | Pharmacia Corporation | Amidino compound and salts thereof useful as nitric oxide synthase inhibitors |
AR032318A1 (es) | 2000-04-13 | 2003-11-05 | Pharmacia Corp | Compuesto derivado halogenado del acido 2-amino-5,6 heptenoico; composicion farmaceutica que lo comprende y su uso en la fabricacion de un medicamento util como inhibidor de la oxido nitrico sintetasa |
US6956131B2 (en) | 2000-04-13 | 2005-10-18 | Pharmacia Corporation | 2-amino-3, 4 heptenoic compounds useful as nitric oxide synthase inhibitors |
AR034120A1 (es) | 2000-04-13 | 2004-02-04 | Pharmacia Corp | Compuesto derivado halogenado del acido 2-amino-4,5 heptenoico, composicion farmaceutica que lo comprende y el uso de dicho compuesto y dicha composicion en la fabricacion de un medicamento para inhibir o modular la sintesis de acido nitrico |
US6545170B2 (en) | 2000-04-13 | 2003-04-08 | Pharmacia Corporation | 2-amino-5, 6 heptenoic acid derivatives useful as nitric oxide synthase inhibitors |
US6787668B2 (en) | 2000-04-13 | 2004-09-07 | Pharmacia Corporation | 2-amino-4,5 heptenoic acid derivatives useful as nitric oxide synthase inhibitors |
AR030416A1 (es) | 2000-04-13 | 2003-08-20 | Pharmacia Corp | COMPUESTO DERIVADO HALOGENADO DEL ACIDO 2-AMINO-3,4 HEPTENOICO, COMPOSICION FARMACEUTICA QUE LO COMPRENDE Y SU USO EN LA FABRICACION DE UN MEDICAMENTO uTIL COMO INHIBIDOR DE LA OXIDO NITRICO SINTETASA |
US7012098B2 (en) | 2001-03-23 | 2006-03-14 | Pharmacia Corporation | Inhibitors of inducible nitric oxide synthase for chemoprevention and treatment of cancers |
US20040235890A1 (en) * | 2001-09-10 | 2004-11-25 | Masaharu Komeno | Remedies for allergic diseases |
JP5662431B2 (ja) * | 2009-06-12 | 2015-01-28 | エラスムス・ユニヴァーシティ・メディカル・センター・ロッテルダム | 癌の光線力学療法のための標的化されたナノフォトメディスン |
WO2011038204A1 (fr) | 2009-09-25 | 2011-03-31 | N30 Pharmaceuticals, Llc | Nouveaux composés dihydropyrimidine-2(1h)-ones en tant qu'inhibiteurs de la s-nitrosoglutathion réductase |
DK2592934T3 (en) | 2010-07-16 | 2015-10-26 | Nivalis Therapeutics Inc | NOVEL dihydropyridin-2 (1H) -one compounds as S-NITROSOGLUTATHIONREDUKTASEINHIBITORER and neurokinin-3 receptor antagonists |
WO2012039718A1 (fr) | 2010-09-24 | 2012-03-29 | N30 Pharmaceuticals, Llc | Composés innovants de dihydropyrimidine-2(1h)-un en tant qu'antagonistes des récepteurs de neurokinine-3 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2049582A (en) * | 1931-11-04 | 1936-08-04 | Rohm & Haas | Amidines |
US3121093A (en) * | 1962-08-31 | 1964-02-11 | Rohm & Haas | Substituted iminopyrrolidines |
JPH09504028A (ja) * | 1993-10-21 | 1997-04-22 | ジー.ディー.サール アンド カンパニー | 酸化窒素シンターゼ抑制剤として有用なアミジノ誘導体 |
US5629322A (en) * | 1994-11-15 | 1997-05-13 | Merck & Co., Inc. | Cyclic amidine analogs as inhibitors of nitric oxide synthase |
-
1996
- 1996-05-09 CN CN96195400A patent/CN1190390A/zh active Pending
- 1996-05-09 KR KR1019970708012A patent/KR19990014671A/ko not_active Application Discontinuation
- 1996-05-09 EP EP96915767A patent/EP0824523A1/fr not_active Withdrawn
- 1996-05-09 JP JP8534320A patent/JPH11511741A/ja not_active Abandoned
- 1996-05-09 NZ NZ307950A patent/NZ307950A/xx unknown
- 1996-05-09 AU AU57454/96A patent/AU712995B2/en not_active Ceased
- 1996-05-09 CA CA002218360A patent/CA2218360A1/fr not_active Abandoned
- 1996-05-09 MX MX9708631A patent/MX9708631A/es unknown
- 1996-05-09 WO PCT/US1996/006831 patent/WO1996035677A1/fr not_active Application Discontinuation
- 1996-05-09 BR BR9608133A patent/BR9608133A/pt not_active Application Discontinuation
- 1996-05-10 ZA ZA963742A patent/ZA963742B/xx unknown
- 1996-08-06 TW TW085109538A patent/TW415941B/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
TW415941B (en) | 2000-12-21 |
JPH11511741A (ja) | 1999-10-12 |
AU5745496A (en) | 1996-11-29 |
MX9708631A (es) | 1998-02-28 |
EP0824523A1 (fr) | 1998-02-25 |
WO1996035677A1 (fr) | 1996-11-14 |
CN1190390A (zh) | 1998-08-12 |
NZ307950A (en) | 1999-06-29 |
AU712995B2 (en) | 1999-11-18 |
KR19990014671A (ko) | 1999-02-25 |
BR9608133A (pt) | 1999-02-09 |
ZA963742B (en) | 1997-07-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2218360A1 (fr) | Inhibiteurs de la synthase d'oxyde nitrique derives des amidines cycliques | |
US6448286B1 (en) | Imino pyrrolidine derivatives useful as nitric oxide synthase inhibitors | |
US5629322A (en) | Cyclic amidine analogs as inhibitors of nitric oxide synthase | |
EP0821674B1 (fr) | Agents amidino cycliques utiles en tant qu'inhibiteurs de synthase de l'oxyde nitrique | |
US5705640A (en) | O-carbamoyl-(d)-phenylalaninol compounds, their pharmaceutically useful salts and process for preparing the same | |
WO2008065500A2 (fr) | Hétéroaryl amides comme inhibiteurs du transport de la glycine de type i | |
AU700078B2 (en) | Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases | |
WO1995024382A1 (fr) | Derives de la l-n6-(1-iminoethyl)lysine utiles comme inhibiteurs de la synthetase generant de l'oxyde nitrique | |
WO2021204800A1 (fr) | Dérivés de difluorocyclohexyle utilisés en tant que modulateurs d'il-17 | |
SK285909B6 (sk) | Deriváty a analógy galantamínu, spôsob ich výroby, ich použitie na výrobu liečiva, spôsob výroby tohto liečiva a spôsob separácie (+) a (-) izomérov racemických derivátov a analógov galantamínu | |
WO1997010204A1 (fr) | Derives de l-n6-(1-iminoethyle)lysine utiles comme inhibiteurs de la synthetase de l'oxyde nitrique | |
ES2313358T3 (es) | Derivados de imidazol tetrasustituidos como moduladores del receptor cannabinoide cb1 con una elevada selectividad de subtipo por el receptor cb1/cb2. | |
JP2001518446A (ja) | 有用な酸化窒素シンターゼ阻害剤としての1,3−ジアゾリノおよび1,3−ジアゾリジノ複素環化合物 | |
US6552052B2 (en) | Pyrrolo[2,1-c][1,2,4] thiadiazoles and Pyrollo[2,1-c][1,12,4]oxadiazoles useful as nitric oxide synthase inhibitors | |
US6489323B1 (en) | Heterobicyclic and tricyclic nitric oxide synthase inhibitors | |
WO2024017880A1 (fr) | Dérivés d'imidazotriazine utilisés comme modulateurs de l'il-17 | |
MXPA00008764A (en) | Halogenated amidino amino acid derivatives useful as nitric oxide synthase inhibitors | |
JPH06271576A (ja) | イミダゾール誘導体の製法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
FZDE | Discontinued | ||
FZDE | Discontinued |
Effective date: 20070509 |