CA2217708A1 - Methods of synthesizing gm2 - Google Patents

Methods of synthesizing gm2 Download PDF

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Publication number
CA2217708A1
CA2217708A1 CA002217708A CA2217708A CA2217708A1 CA 2217708 A1 CA2217708 A1 CA 2217708A1 CA 002217708 A CA002217708 A CA 002217708A CA 2217708 A CA2217708 A CA 2217708A CA 2217708 A1 CA2217708 A1 CA 2217708A1
Authority
CA
Canada
Prior art keywords
compound
group
trifluoromethanesulfonate
catalyst
trisaccharide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002217708A
Other languages
English (en)
French (fr)
Inventor
Richard Schmidt
Julio C. Castro-Palomino
Andreas Doll
Gerd Ritter
Lloyd J. Old
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ludwig Cancer Research
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2217708A1 publication Critical patent/CA2217708A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Lock And Its Accessories (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Glass Compositions (AREA)
  • Catalysts (AREA)
CA002217708A 1996-02-16 1997-02-05 Methods of synthesizing gm2 Abandoned CA2217708A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/602,580 US5756695A (en) 1996-02-16 1996-02-16 Methods of synthesizing GM2
US08/602,580 1996-02-16

Publications (1)

Publication Number Publication Date
CA2217708A1 true CA2217708A1 (en) 1997-08-21

Family

ID=24411928

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002217708A Abandoned CA2217708A1 (en) 1996-02-16 1997-02-05 Methods of synthesizing gm2

Country Status (8)

Country Link
US (1) US5756695A (enExample)
EP (1) EP0821691B1 (enExample)
JP (2) JP3220704B2 (enExample)
AT (1) ATE246697T1 (enExample)
AU (1) AU712149B2 (enExample)
CA (1) CA2217708A1 (enExample)
DE (1) DE69723926T2 (enExample)
WO (1) WO1997030061A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5977329A (en) * 1996-02-16 1999-11-02 Ludwig Institute For Cancer Research Methods of synthesizing GM3
US5951317A (en) * 1998-04-13 1999-09-14 Motorola, Inc. Accessory connector assembly
CN1300158C (zh) * 2005-03-22 2007-02-14 重庆邮电学院 一类非天然活性寡糖类化合物及其制备方法和应用
WO2011053614A1 (en) * 2009-10-30 2011-05-05 Merck Sharp & Dohme Corp. Crystalline cdm-nag and methods for producing same

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0508493A1 (en) * 1986-08-06 1992-10-14 Mect Corporation Ganglioside related compounds and method of producing the same
US5371202A (en) * 1991-02-28 1994-12-06 The Nisshin Oil Mills, Ltd. Processes of preparing sialoglycosyl compounds

Also Published As

Publication number Publication date
DE69723926D1 (de) 2003-09-11
JP2001316397A (ja) 2001-11-13
DE69723926T2 (de) 2004-07-15
AU1858697A (en) 1997-09-02
EP0821691A4 (en) 2001-10-04
US5756695A (en) 1998-05-26
EP0821691B1 (en) 2003-08-06
AU712149B2 (en) 1999-10-28
JP3220704B2 (ja) 2001-10-22
ATE246697T1 (de) 2003-08-15
JPH11504348A (ja) 1999-04-20
EP0821691A1 (en) 1998-02-04
WO1997030061A1 (en) 1997-08-21

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued