CA2216809A1 - Imidazo[1,2-a]pyridine derivatives - Google Patents
Imidazo[1,2-a]pyridine derivatives Download PDFInfo
- Publication number
- CA2216809A1 CA2216809A1 CA002216809A CA2216809A CA2216809A1 CA 2216809 A1 CA2216809 A1 CA 2216809A1 CA 002216809 A CA002216809 A CA 002216809A CA 2216809 A CA2216809 A CA 2216809A CA 2216809 A1 CA2216809 A1 CA 2216809A1
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- CA
- Canada
- Prior art keywords
- formula
- compounds
- compound
- 4alkyl
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 150000005234 imidazo[1,2-a]pyridines Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 139
- 238000011282 treatment Methods 0.000 claims abstract description 21
- 102100038280 Prostaglandin G/H synthase 2 Human genes 0.000 claims abstract description 19
- 108050003267 Prostaglandin G/H synthase 2 Proteins 0.000 claims abstract description 18
- 229910052799 carbon Inorganic materials 0.000 claims abstract description 11
- 125000001153 fluoro group Chemical group F* 0.000 claims abstract description 9
- 229910052736 halogen Inorganic materials 0.000 claims abstract description 9
- 150000002367 halogens Chemical class 0.000 claims abstract description 9
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims abstract 15
- 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 claims abstract 4
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 48
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 25
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 25
- 229910052794 bromium Inorganic materials 0.000 claims description 25
- 238000000034 method Methods 0.000 claims description 23
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 18
- 229910052801 chlorine Inorganic materials 0.000 claims description 18
- 239000000460 chlorine Substances 0.000 claims description 18
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims description 13
- 229910052731 fluorine Inorganic materials 0.000 claims description 13
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- 101100054666 Streptomyces halstedii sch3 gene Proteins 0.000 claims description 11
- VUWZPRWSIVNGKG-UHFFFAOYSA-N fluoromethane Chemical compound F[CH2] VUWZPRWSIVNGKG-UHFFFAOYSA-N 0.000 claims description 11
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 11
- -1 methyl) Chemical group 0.000 claims description 9
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- KVVJDDVNYVCFDS-UHFFFAOYSA-N 1-[3-(4-fluorophenyl)-2-(4-methylsulfonylphenyl)imidazo[1,2-a]pyridin-8-yl]ethanone Chemical compound N1=C2C(C(=O)C)=CC=CN2C(C=2C=CC(F)=CC=2)=C1C1=CC=C(S(C)(=O)=O)C=C1 KVVJDDVNYVCFDS-UHFFFAOYSA-N 0.000 claims description 2
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- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 8
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- RMBAVIFYHOYIFM-UHFFFAOYSA-M sodium methanethiolate Chemical compound [Na+].[S-]C RMBAVIFYHOYIFM-UHFFFAOYSA-M 0.000 description 1
- LYPGDCWPTHTUDO-UHFFFAOYSA-M sodium;methanesulfinate Chemical compound [Na+].CS([O-])=O LYPGDCWPTHTUDO-UHFFFAOYSA-M 0.000 description 1
- 230000003019 stabilising effect Effects 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 239000006190 sub-lingual tablet Substances 0.000 description 1
- 239000003890 substance P antagonist Substances 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- YBBRCQOCSYXUOC-UHFFFAOYSA-N sulfuryl dichloride Chemical class ClS(Cl)(=O)=O YBBRCQOCSYXUOC-UHFFFAOYSA-N 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 201000004595 synovitis Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
- 201000004415 tendinitis Diseases 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 206010043778 thyroiditis Diseases 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 208000004371 toothache Diseases 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- LLPOLZWFYMWNKH-UHFFFAOYSA-N trans-dihydrocodeinone Natural products C1C(N(CCC234)C)C2CCC(=O)C3OC2=C4C1=CC=C2OC LLPOLZWFYMWNKH-UHFFFAOYSA-N 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 208000019553 vascular disease Diseases 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 208000030401 vitamin deficiency disease Diseases 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
- 229960000833 xylometazoline Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9506965.4A GB9506965D0 (en) | 1995-04-04 | 1995-04-04 | Chemical compounds |
| GB9506965.4 | 1995-04-04 | ||
| GB9512099.4 | 1995-06-14 | ||
| GBGB9512099.4A GB9512099D0 (en) | 1995-06-14 | 1995-06-14 | Chemical compounds |
| GB9516117.0 | 1995-08-05 | ||
| GBGB9516117.0A GB9516117D0 (en) | 1995-08-05 | 1995-08-05 | Chemical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2216809A1 true CA2216809A1 (en) | 1996-10-10 |
Family
ID=27267657
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002216809A Abandoned CA2216809A1 (en) | 1995-04-04 | 1996-04-02 | Imidazo[1,2-a]pyridine derivatives |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0819127A1 (cs) |
| JP (1) | JPH11501049A (cs) |
| KR (1) | KR19980703559A (cs) |
| CN (1) | CN1186492A (cs) |
| AU (1) | AU5276696A (cs) |
| BG (1) | BG101934A (cs) |
| CA (1) | CA2216809A1 (cs) |
| CZ (1) | CZ313397A3 (cs) |
| EA (1) | EA199700209A1 (cs) |
| HU (1) | HUP9801602A3 (cs) |
| IS (1) | IS4570A (cs) |
| NO (1) | NO974595L (cs) |
| NZ (1) | NZ304886A (cs) |
| PL (1) | PL322623A1 (cs) |
| SK (1) | SK133297A3 (cs) |
| TR (1) | TR199701105T1 (cs) |
| WO (1) | WO1996031509A1 (cs) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2764292B1 (fr) * | 1997-06-10 | 2000-12-29 | Innothera Lab Sa | Utilisation de derives de tetracycles dicetoniques, nouveaux composes obtenus et leur application en therapeutique |
| US6307047B1 (en) | 1997-08-22 | 2001-10-23 | Abbott Laboratories | Prostaglandin endoperoxide H synthase biosynthesis inhibitors |
| US6525053B1 (en) | 1997-08-22 | 2003-02-25 | Abbott Laboratories | Prostaglandin endoperoxide H synthase biosynthesis inhibitors |
| ES2203985T3 (es) | 1997-09-05 | 2004-04-16 | Glaxo Group Limited | Derivados de 2,3-diaril-pirazolo(1,5)piridazina, su preparacion y su uso como inhibidores de la ciclooxigenasa 2(cox-2)`. |
| FR2770131A1 (fr) * | 1997-10-27 | 1999-04-30 | Union Pharma Scient Appl | Nouvelle association pharmaceutique a activite analgesique |
| FR2771005B1 (fr) * | 1997-11-18 | 2002-06-07 | Union Pharma Scient Appl | Nouvelle association pharmaceutique a activite analgesique |
| GB9810920D0 (en) * | 1998-05-21 | 1998-07-22 | Merck Sharp & Dohme | Therapeutic use |
| ES2140354B1 (es) * | 1998-08-03 | 2000-11-01 | S A L V A T Lab Sa | Imidazo (1,2a) azinas sustituidas como inhibidores selectivos de la cox-2. |
| TW587079B (en) * | 1998-09-25 | 2004-05-11 | Almirall Prodesfarma Ag | 2-phenylpyran-4-one derivatives |
| CA2349567A1 (en) * | 1998-11-03 | 2000-05-11 | Glaxo Group Limited | Pyrazolopyridine derivatives as selective cox-2 inhibitors |
| US6498166B1 (en) | 1999-02-27 | 2002-12-24 | Smithkline Beecham Corporation | Pyrazolopyridines |
| NZ513960A (en) | 1999-12-08 | 2004-02-27 | Pharmacia Corp | Cyclooxygenase-2 inhibitor compositions having rapid onset of therapeutic effect |
| GB9930358D0 (en) * | 1999-12-22 | 2000-02-09 | Glaxo Group Ltd | Process for the preparation of chemical compounds |
| WO2001045703A1 (en) | 1999-12-23 | 2001-06-28 | Nitromed, Inc. | Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use |
| GB0002312D0 (en) * | 2000-02-01 | 2000-03-22 | Glaxo Group Ltd | Medicaments |
| PE20011333A1 (es) | 2000-03-16 | 2002-01-16 | Almirall Prodesfarma Ag | Derivados de 2-fenilpiran-4-ona como inhibidores de ciclooxigenasa 2 |
| PE20020146A1 (es) * | 2000-07-13 | 2002-03-31 | Upjohn Co | Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2) |
| ATE366569T1 (de) | 2000-07-20 | 2007-08-15 | Lauras As | Verwendung von cox-2 inhibitoren als immunostimulantien zur behandlung von hiv oder aids |
| PE20020506A1 (es) * | 2000-08-22 | 2002-07-09 | Glaxo Group Ltd | Derivados de pirazol fusionados como inhibidores de la proteina cinasa |
| GB0025449D0 (en) * | 2000-10-17 | 2000-11-29 | Glaxo Group Ltd | Chemical compounds |
| AU2002239344A1 (en) | 2000-12-15 | 2002-06-24 | Glaxo Group Limited | Pyrazolopyridines |
| JP2004515550A (ja) | 2000-12-15 | 2004-05-27 | グラクソ グループ リミテッド | 治療用化合物 |
| WO2002072581A2 (en) | 2001-03-08 | 2002-09-19 | Smithkline Beecham Corporation | Pyrazolopyriadine derivatives |
| WO2002078700A1 (en) | 2001-03-30 | 2002-10-10 | Smithkline Beecham Corporation | Pyralopyridines, process for their preparation and use as therapteutic compounds |
| MY137736A (en) | 2001-04-03 | 2009-03-31 | Pharmacia Corp | Reconstitutable parenteral composition |
| WO2002083672A1 (en) | 2001-04-10 | 2002-10-24 | Smithkline Beecham Corporation | Antiviral pyrazolopyridine compounds |
| WO2002088124A2 (en) | 2001-04-27 | 2002-11-07 | Smithkline Beecham Corporation | Pyrazolo'1,5-a!pyridine derivatives |
| US6756498B2 (en) | 2001-04-27 | 2004-06-29 | Smithkline Beecham Corporation | Process for the preparation of chemical compounds |
| CZ20033518A3 (en) | 2001-06-21 | 2004-05-12 | Smithklineábeechamácorporation | Imidazo(1,2-a)pyridine derivatives for the prophylaxis and treatment of herpes viral infections |
| AR038957A1 (es) | 2001-08-15 | 2005-02-02 | Pharmacia Corp | Terapia de combinacion para el tratamiento del cancer |
| EP1432712B1 (en) | 2001-10-05 | 2006-05-17 | SmithKline Beecham Corporation | Imidazo-pyridine derivatives for use in the treatment of herpes viral infection |
| GB0124933D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124936D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124939D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124941D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124931D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124934D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124938D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| DE60222465T2 (de) | 2001-12-11 | 2008-06-05 | Smithkline Beecham Corp. | Pyrazolopyridin-derivate als antiherpesmittel |
| DK1474395T3 (da) | 2002-02-12 | 2008-02-11 | Smithkline Beecham Corp | Nicotinamidderivater, der er nyttige som p38-inhibitorer |
| CA2492066A1 (en) | 2002-06-28 | 2004-01-08 | Nitromed, Inc. | Oxime and/or hydrazone containing nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use |
| GB0217757D0 (en) | 2002-07-31 | 2002-09-11 | Glaxo Group Ltd | Novel compounds |
| US7153863B2 (en) | 2002-10-03 | 2006-12-26 | Smithkline Beecham Corporation | Therapeutic compounds based on pyrazolopyridline derivatives |
| KR20040072004A (ko) | 2003-02-07 | 2004-08-16 | 삼성에스디아이 주식회사 | 유기 전계 발광 소자용 발광 화합물 및 그를 이용한 유기전계발광 소자 |
| GB0308185D0 (en) | 2003-04-09 | 2003-05-14 | Smithkline Beecham Corp | Novel compounds |
| GB0308186D0 (en) | 2003-04-09 | 2003-05-14 | Smithkline Beecham Corp | Novel compounds |
| GB0308201D0 (en) | 2003-04-09 | 2003-05-14 | Smithkline Beecham Corp | Novel compounds |
| CA2519189C (en) | 2003-05-07 | 2012-07-17 | Osteologix A/S | Water-soluble strontium salts for use in treatment of cartilage and/or bone conditions |
| GB0318814D0 (en) | 2003-08-11 | 2003-09-10 | Smithkline Beecham Corp | Novel compounds |
| WO2006041855A2 (en) | 2004-10-04 | 2006-04-20 | Nitromed, Inc. | Compositions and methods using apocynin compounds and nitric oxide donors |
| WO2007016677A2 (en) | 2005-08-02 | 2007-02-08 | Nitromed, Inc. | Nitric oxide enhancing antimicrobial compounds, compositions and methods of use |
| US8067414B2 (en) | 2006-03-29 | 2011-11-29 | Nicox S.A. | Nitric oxide enhancing prostaglandin compounds, compositions and methods of use |
| US7750007B2 (en) | 2006-11-06 | 2010-07-06 | Supergen, Inc. | Imidazo[1,2-beta]pyridazine and pyrazolo[1,5-alpha]pyrimidine derivatives and their use as protein kinase inhibitors |
| WO2013013188A1 (en) | 2011-07-21 | 2013-01-24 | Tolero Pharmaceuticals, Inc. | Heterocyclic protein kinase inhibitors |
| EP3292213A1 (en) | 2015-05-04 | 2018-03-14 | Academisch Medisch Centrum | Biomarkers for the detection of aspirin insensitivity |
| MX2021009371A (es) | 2019-02-12 | 2021-09-10 | Sumitomo Pharma Oncology Inc | Formulaciones que comprenden inhibidores de proteina cinasa heterociclicos. |
| WO2022195579A1 (en) | 2021-03-15 | 2022-09-22 | Saul Yedgar | Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory diseases |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3455924A (en) * | 1967-02-08 | 1969-07-15 | Upjohn Co | Dianisylimidazoles |
-
1996
- 1996-04-02 CZ CZ973133A patent/CZ313397A3/cs unknown
- 1996-04-02 SK SK1332-97A patent/SK133297A3/sk unknown
- 1996-04-02 HU HU9801602A patent/HUP9801602A3/hu unknown
- 1996-04-02 AU AU52766/96A patent/AU5276696A/en not_active Abandoned
- 1996-04-02 EA EA199700209A patent/EA199700209A1/ru unknown
- 1996-04-02 TR TR97/01105T patent/TR199701105T1/xx unknown
- 1996-04-02 CN CN96194403A patent/CN1186492A/zh active Pending
- 1996-04-02 WO PCT/EP1996/001438 patent/WO1996031509A1/en not_active Ceased
- 1996-04-02 NZ NZ304886A patent/NZ304886A/en unknown
- 1996-04-02 JP JP8529971A patent/JPH11501049A/ja active Pending
- 1996-04-02 PL PL96322623A patent/PL322623A1/xx unknown
- 1996-04-02 CA CA002216809A patent/CA2216809A1/en not_active Abandoned
- 1996-04-02 KR KR1019970706963A patent/KR19980703559A/ko not_active Ceased
- 1996-04-02 EP EP96909164A patent/EP0819127A1/en not_active Withdrawn
-
1997
- 1997-09-25 IS IS4570A patent/IS4570A/is unknown
- 1997-09-30 BG BG101934A patent/BG101934A/xx unknown
- 1997-10-03 NO NO974595A patent/NO974595L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO974595L (no) | 1997-12-03 |
| KR19980703559A (ko) | 1998-11-05 |
| SK133297A3 (en) | 1998-07-08 |
| HUP9801602A2 (hu) | 1998-11-30 |
| JPH11501049A (ja) | 1999-01-26 |
| TR199701105T1 (xx) | 1998-02-21 |
| NO974595D0 (no) | 1997-10-03 |
| PL322623A1 (en) | 1998-02-02 |
| HUP9801602A3 (en) | 1999-01-28 |
| NZ304886A (en) | 1998-11-25 |
| AU5276696A (en) | 1996-10-23 |
| IS4570A (is) | 1997-09-25 |
| BG101934A (en) | 1999-04-30 |
| CN1186492A (zh) | 1998-07-01 |
| CZ313397A3 (cs) | 1998-03-18 |
| WO1996031509A1 (en) | 1996-10-10 |
| MX9707379A (es) | 1997-11-29 |
| EP0819127A1 (en) | 1998-01-21 |
| EA199700209A1 (ru) | 1998-04-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |