CA2212127A1 - Formulations et procedes permettant de reduire l'irritation cutanee - Google Patents

Formulations et procedes permettant de reduire l'irritation cutanee

Info

Publication number
CA2212127A1
CA2212127A1 CA002212127A CA2212127A CA2212127A1 CA 2212127 A1 CA2212127 A1 CA 2212127A1 CA 002212127 A CA002212127 A CA 002212127A CA 2212127 A CA2212127 A CA 2212127A CA 2212127 A1 CA2212127 A1 CA 2212127A1
Authority
CA
Canada
Prior art keywords
composition
irritant
skin
irritation
skin irritation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002212127A
Other languages
English (en)
Inventor
Gary Scott Hahn
David Orel Thueson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cosmederm Technologies Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2212127A1 publication Critical patent/CA2212127A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/223Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of alpha-aminoacids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/4172Imidazole-alkanecarboxylic acids, e.g. histidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41Amines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/16Otologicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74Biological properties of particular ingredients
    • A61K2800/75Anti-irritant

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Detergent Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne des compositions et formulations contenant des polyamines organiques à protons multiples (tels que des acides aminés dont les groupes latéraux portent des groupes amines). L'invention concerne également des procédés pour l'utilisation de ces formulations. Ces formulations et procédés permettent d'inhiber l'irritation cutanée chez les animaux.
CA002212127A 1995-02-03 1996-02-02 Formulations et procedes permettant de reduire l'irritation cutanee Abandoned CA2212127A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38426395A 1995-02-03 1995-02-03
US08/384,263 1995-02-03

Publications (1)

Publication Number Publication Date
CA2212127A1 true CA2212127A1 (fr) 1996-08-08

Family

ID=23516632

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002212127A Abandoned CA2212127A1 (fr) 1995-02-03 1996-02-02 Formulations et procedes permettant de reduire l'irritation cutanee

Country Status (6)

Country Link
EP (1) EP0806947A4 (fr)
JP (1) JPH10513452A (fr)
AU (1) AU4861196A (fr)
CA (1) CA2212127A1 (fr)
MX (1) MX9705954A (fr)
WO (1) WO1996023490A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019232644A1 (fr) * 2018-06-08 2019-12-12 Vivier Canada Inc. Formulation de putrescine saline topique stérile et ses utilisations

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5837224A (en) * 1996-01-19 1998-11-17 The Regents Of The University Of Michigan Method of inhibiting photoaging of skin
EP0884046A1 (fr) * 1997-05-30 1998-12-16 Sara Lee/DE N.V. Composition cosmétique à propriétés photoprotectrices
TWI234467B (en) 1997-06-04 2005-06-21 Univ Michigan Composition for inhibiting photoaging of skin
DE19757826A1 (de) * 1997-12-24 1999-07-01 Beiersdorf Ag Neue Verwendung von chaotropen Verbindungen und chaotrope Verbindungen enthaltende Zubereitungen
US6060471A (en) * 1998-01-21 2000-05-09 Styczynski; Peter Reduction of hair growth
US20040067212A1 (en) 1998-03-11 2004-04-08 Kabushiki Kaisha Soken Skin conditioner
IL138732A0 (en) * 1998-04-03 2001-10-31 Univ Manitoba The use of polyamines in the treatment of dermatological symptoms
FR2783423B1 (fr) * 1998-09-23 2002-06-14 Oreal Systeme de delivrance d'actif comprenant, sur une structure en film, une composition a base d'un derive d'acide salicylique, et ses utilisations
WO2000062741A2 (fr) * 1999-04-19 2000-10-26 The Procter & Gamble Company Compositions de soin pour la peau contenant une combinaison de principes actifs de soin pour la peau
AU4647200A (en) * 1999-04-19 2000-11-02 Procter & Gamble Company, The Skin care compositions containing combination of skin care actives
US6444647B1 (en) * 1999-04-19 2002-09-03 The Procter & Gamble Company Skin care compositions containing combination of skin care actives
US6492326B1 (en) 1999-04-19 2002-12-10 The Procter & Gamble Company Skin care compositions containing combination of skin care actives
FR2807645B1 (fr) * 2000-04-12 2005-06-03 Oreal Utilisation d'inhibiteurs de l'alcool deshydrogenase dans le traitement cosmetique des matieres keratiniques
FR2816837A1 (fr) * 2000-11-17 2002-05-24 Oreal Utilisation d'au moins un derive amino sulfonique dans une composition destinee a favoriser la desquamation de la peau
DE10106852A1 (de) * 2001-02-14 2002-09-05 T Luger Entzündungshemmende Verbindungen
CN100350977C (zh) 2001-06-14 2007-11-28 大塚制药株式会社 药物组合物
US7045550B2 (en) 2001-08-07 2006-05-16 Wisconsin Alumni Research Foundation Polyamines and analogs for protecting cells during cancer chemotherapy and radiotherapy
ITMI20020189A1 (it) * 2002-02-01 2003-08-01 Giuliani Spa Composizione per uso farmaceutico o dietetico per contrastare la caduta dei capelli
US20040161392A1 (en) * 2003-02-19 2004-08-19 L'oreal S.A. Skin peeling composition and method
AU2003211520A1 (en) * 2003-02-19 2004-09-09 Kuniyasu Soda Lfa-1 inhibitors and use thereof
ITMI20031570A1 (it) * 2003-07-31 2005-02-01 Giuliani Spa Composizione per uso dietetico, farmaceutico o cosmetico
FR2860716B1 (fr) * 2003-10-13 2005-12-09 Oreal Composition cosmetique comprenant un hydroxyacide, un polyholoside et un compose amino-sulfonique
DE102004028599A1 (de) * 2004-06-12 2005-12-29 Henkel Kgaa Milde Bleichmittel mit erhöhter Aufhellleistung
NO20044818D0 (no) * 2004-11-05 2004-11-05 Bioforsk As Spermin i kosmetiske preparater
ITUD20050211A1 (it) 2005-12-13 2007-06-14 Rossana Castellana Prodotto per il trattamento della pelle relativo procedimento di preparazione
DE102006003926A1 (de) * 2006-01-26 2007-08-02 Henkel Kgaa Aufhell- und/oder Färbemittel mit reduziertem Irritationspotential
DE102006003924A1 (de) * 2006-01-26 2007-08-02 Henkel Kgaa Aufhell- und/oder Färbemittel mit reduziertem Irritationspotential
DE102006003927A1 (de) * 2006-01-26 2007-08-02 Henkel Kgaa Aufhell- und/oder Färbemittel mit reduziertem Irritationspotential
DE102006017901A1 (de) * 2006-04-13 2007-10-25 Henkel Kgaa Aufhell- und/oder Färbemittel mit verbesserter Hautverträglichkeit
JP2008156330A (ja) * 2006-04-26 2008-07-10 Toyobo Co Ltd 賦活化剤及び抗老化剤
DE102006020789A1 (de) * 2006-05-03 2007-11-08 Henkel Kgaa Aufhell- und/oder Färbemittel mit Imidazolen und Aminoalkoholen
DE102006035252A1 (de) * 2006-07-26 2008-01-31 Henkel Kgaa Haarfärbemittel mit Shea Butter
WO2008051080A1 (fr) * 2006-10-25 2008-05-02 Fridtjof Bjerke Crème pour l'épiderme comprenant une combinaison d'aloès officinal et de spermine
WO2008091161A1 (fr) * 2007-01-26 2008-07-31 Fridtjof Bjerke Composition cosmétique contenant de la spermine et de l'huile d'émeu
EP2219594A4 (fr) * 2007-11-27 2015-01-14 Univ Manitoba Utilisation d'un inhibiteur de transglutaminase pour le traitement de la peau
KR20170129808A (ko) * 2015-03-17 2017-11-27 디에스엠 아이피 어셋츠 비.브이. 다이아미노부탄의 제조 방법
JP5966231B1 (ja) * 2015-12-14 2016-08-10 有限会社アント アミノ酸配合顔用皮膚外用剤

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3861868A (en) * 1971-03-30 1975-01-21 Procter & Gamble Dyeing human hair with oxidation dyes and arginine or a protamine protein
US4076799A (en) * 1972-12-27 1978-02-28 Cincinnati Milacron, Inc. Method of inhibiting skin irritation
JPS6025479B2 (ja) * 1977-03-31 1985-06-18 三洋化成工業株式会社 香粧品・洗浄剤用界面活性剤組成物
JPS54163819A (en) * 1978-06-14 1979-12-26 Meito Sangyo Kk Digestive tract ulcer and injury treating agent
US4507321A (en) * 1982-02-17 1985-03-26 The Research Foundation Of State University Of New York Epithelial cell growth regulating composition containing polyamines and a method of using same
EP0100827B1 (fr) * 1982-08-17 1986-09-03 Rosical Limited Composition pharmaceutique contenant un acide aminosulfonique aliphatique
US4704234A (en) * 1983-01-17 1987-11-03 American Cyanamid Company Compositions comprising imidazole, pyrazole or derivatives thereof for removing undesirable organic matter from a surface
IT1190348B (it) * 1986-06-16 1988-02-16 Lisapharma Spa Impiego topico vaginale del p-isobutilfenilpropionato di lisina nel trattamento antiinfiammatorio
US5091171B2 (en) * 1986-12-23 1997-07-15 Tristrata Inc Amphoteric compositions and polymeric forms of alpha hydroxyacids and their therapeutic use
US5252322A (en) * 1989-09-22 1993-10-12 The Gillette Company Skin tanning compositions containing imidazoles
AU641529B2 (en) * 1990-07-30 1993-09-23 Bloomfield D.A. Zwitterionic compounds and their N-halo derivatives for use in the treatment of clinical conditions
JP3575084B2 (ja) * 1994-11-29 2004-10-06 味の素株式会社 殺菌消毒剤配合組成物

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019232644A1 (fr) * 2018-06-08 2019-12-12 Vivier Canada Inc. Formulation de putrescine saline topique stérile et ses utilisations

Also Published As

Publication number Publication date
JPH10513452A (ja) 1998-12-22
EP0806947A4 (fr) 1998-10-14
AU4861196A (en) 1996-08-21
MX9705954A (es) 1998-02-28
EP0806947A1 (fr) 1997-11-19
WO1996023490A1 (fr) 1996-08-08

Similar Documents

Publication Publication Date Title
CA2212127A1 (fr) Formulations et procedes permettant de reduire l'irritation cutanee
CA2208078C (fr) Formulations et procedes pour diminuer l'irritation de la peau
US5756107A (en) Formulations and methods for reducing skin irritation
WO1996023490A9 (fr) Formulations et procedes permettant de reduire l'irritation cutanee
EP0806933B1 (fr) Formulations et procedes pour diminuer l'irritation de la peau
US6139850A (en) Formulations and methods for reducing skin irritation
US5958436A (en) Formulations and methods for reducing skin irritation
WO1996019183A9 (fr) Formulations et procedes pour diminuer l'irritation de la peau
EP0799018A1 (fr) Formulations et procedes pour diminuer l'irritation de la peau
WO1996019184A9 (fr) Formulations et procedes pour diminuer l'irritation de la peau
EP0801570B1 (fr) Formulations et procedes pour diminuer l'irritation de la peau
MXPA97005954A (en) Formulations and methods to reduce irritation of the p
WO1996019228A9 (fr) Formulations et procedes pour diminuer l'irritation de la peau
AU1487500A (en) Formulations and methods for reducing skin irritation
AU1362800A (en) Formulations and methods for reducing skin irritation

Legal Events

Date Code Title Description
FZDE Dead