WO2008051080A1 - Crème pour l'épiderme comprenant une combinaison d'aloès officinal et de spermine - Google Patents

Crème pour l'épiderme comprenant une combinaison d'aloès officinal et de spermine Download PDF

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Publication number
WO2008051080A1
WO2008051080A1 PCT/NO2006/000495 NO2006000495W WO2008051080A1 WO 2008051080 A1 WO2008051080 A1 WO 2008051080A1 NO 2006000495 W NO2006000495 W NO 2006000495W WO 2008051080 A1 WO2008051080 A1 WO 2008051080A1
Authority
WO
WIPO (PCT)
Prior art keywords
skin
spermine
aloe vera
agent
combination
Prior art date
Application number
PCT/NO2006/000495
Other languages
English (en)
Inventor
Fridtjof Bjerke
Original Assignee
Fridtjof Bjerke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fridtjof Bjerke filed Critical Fridtjof Bjerke
Publication of WO2008051080A1 publication Critical patent/WO2008051080A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/132—Amines having two or more amino groups, e.g. spermidine, putrescine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9794—Liliopsida [monocotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/92—Oral administration

Definitions

  • Skin cream comprising a combination of Aloe Vera and spermine .
  • the present invention relates to an agent for topical application onto the skin. More specifically the invention concerns a skin cream with particular beneficial properties.
  • the skin cream according to the invention comprises a combination of Aloe Vera and spermine as important constituents.
  • Aloe Vera is a widely used product within the field of cosmetics and skin care, especially for application and treatment of the human skin.
  • the plant from which the Aloe Vera is extracted, has from ancient time been known as a cosmetic preparation and medicinal plant with alleviating properties.
  • spermine is naturally occurring in all the cells of the body, but the amount is varying strongly between different types of cells.
  • One of the most important properties of spermine is its powerful antioxidant effect.
  • Patent CA 2534102 describes the use of spermine and spermidine as the active ingredients for the preparation of a composition.
  • the composition is applied onto the skin to improve the skin properties like softness, elasticity and the removing of wrinkles.
  • US 2006222620 describes the use of spermidine as an active principle in the preparation of a composition to combat hair loss.
  • WO 2006048671 concerns topical cosmetic compositions comprising polyamines like spermidine and spermine. The compositions are applied onto the skin and improve the elasticity, the colour and plasticity of the skin
  • the skin is often regarded as one of the most important organs in the human body, most of it between 2-3 mm in thickness. For an adult human being the skin has a total surface area of between 1,5 - 2 m 2 , accounting for about 15 % of body weight.
  • the skin is a complex organ comprising many different constituents and cells with various and important functions.
  • the average cm of skin holds among others 300 sweat glands, 10 blood vessels and 60 000 melanocytes, and more than a thousand nerve endings.
  • the skin is rich in lipids, DNA and protein.
  • the skin has many important functions, and the most important is to protect the the body against infections from the surrounding environment of pathogens and infections.
  • the skin is also protecting the underlying cells and tissue, muscles and internal organs.
  • the skin also provides insulation and temperature regulation, body sensation and synthesis of vitamins as B and D. Furthermore the skin contains pigmentation and melanocytes that absorb the potentially dangerous ultra violet radiation in sunlight. The skin contains enzymes which help, repair and reverse injuries caused on the skin from ultra violet radiation, injuries that if not repaired in time may develop to skin cancer.
  • Injured skin will try to recover by the formation of scars, and the injury may give rise to visible scars with discoloring of the skin area.
  • Aloe Vera is a succulent plant naturally growing in dry tropical fields in the world. It is also used as an ornamental potted plant, but is well known as a source for the sap to be used within medicinal areas, cosmetics and especially as an important constituent in creams. Aloe Vera is rich in vitamins and minerals, and is used as a main ingredient in skin creams for daily care, and in creams for the treatment of burns, sunburns, eczema, skin wounds and other skin conditions.
  • Aloe Vera can alleviate and reduce infections and inflammation, and has beneficial properties on eczema, dry, chapped and tired skin. Aloe Vera is therefore used in a wide range of cosmetic products like body lotion, cleansing cream, soap, sun cream, shampoo and ointment. It has also been used in the treatment of fungal infections.
  • Aloe Vera contains mucopolysaccharides.
  • Sperminspermine belongs to the group of polyamines and is naturally found as growth factors and regulation in eukaryotic cells in many organisms.
  • Polyamines are organic compounds with two or more primary amino groups, and examples are putrescine, cadaverine, spermidine and spermine.
  • Spermine is transformed from the related compound spermidin in the cells.
  • Spermine holds antioxidative properties and has shown good results concerning the decreasing of wrinkles in the skin, improvement of the elasticity of the skin, pigmentation, skin colour and softness.
  • the present invention combines the good properties of Aloe Vera and spermine.
  • spermine By combining the strong antioxidative properties of spermine, with the well known nutrition rich Aloe Vera in a skin cream, the oxidation of Aloe Vera will be stopped.
  • a skin cream for topical application according to the invention one will also attain an enhanced transport and penetration into the skin, together with an improved impact of spermine.
  • the skin cream according to the invention can ble applied not only onto the face and hands, but on the entire body.
  • the skin cream according to the invention will minimize wrinkles in the skin, enhance the elasticity of the skin, colour and appearance, confine ageing tendencies and improved humidity, together with renewal of cells.
  • the cream according to the invention can be used as an everyday skin cream (day or night), for general supply of nutritive substances to tired, stressed, contaminated and ageing skin.
  • the cream can be used in connection with sunbathing, prior to and after sunburns, bathing in sea water and fresh water. It can also be applied onto dry and chapped skin, or more severe skin conditions like eczema and psoriasis, or skin lesions.
  • Aloe Vera and spermine are supplied as standard products.
  • the producers and suppliers have approved GMP standard (Good Manufacturing Procedures), which secures good quality control of the production process.
  • Aloe Vera and spermine are mixed in suitable mixing devices until one obtains a homogenous mixture.
  • a suitable dosage for a skin cream is 0,02 g spermine for 50 ml Aloe Vera, but the mixing ratio may vary within a broader concentration range.
  • the mixture may potentially be supplied with additives common within this field.
  • additives are preservatives, exipients, natural colours, vitamins B and D. It is, however, preferred to use as few additives as possible, to limit the possible sensitive reactions in the skin of the user. It is also possible to add the mixture jojoba oil and tocoferol.
  • a combination of Aloe Vera and spermine may be formulated as tablets, pills or as a squash or juice for oral ingestion.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Birds (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medical Informatics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne une combinaison d'aloès officinal et de spermine destinée à fabriquer un remède à appliquer de manière topique sur la peau pour traiter différents troubles de l'épiderme, notamment les rides, le vieillissement et la fragilisation de la peau face aux agressions extérieures, l'eczéma et le psoriasis.
PCT/NO2006/000495 2006-10-25 2006-12-21 Crème pour l'épiderme comprenant une combinaison d'aloès officinal et de spermine WO2008051080A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NO20064870 2006-10-25
NO20064870 2006-10-25

Publications (1)

Publication Number Publication Date
WO2008051080A1 true WO2008051080A1 (fr) 2008-05-02

Family

ID=39324804

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/NO2006/000495 WO2008051080A1 (fr) 2006-10-25 2006-12-21 Crème pour l'épiderme comprenant une combinaison d'aloès officinal et de spermine

Country Status (1)

Country Link
WO (1) WO2008051080A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2924023A1 (fr) * 2007-11-28 2009-05-29 Biolog Vegetale Yves Rocher Sa Utilisation d'un extrait d'aloe pour la promotion et le renfort de la cohesion des cellules de la peau
EP2486920A1 (fr) * 2009-09-28 2012-08-15 Toyo Boseki Kabushiki Kaisha Agent de relâchement du stress comprenant un extrait contenant une polyamine dérivée d'une plante comme ingrédient actif

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996023490A1 (fr) * 1995-02-03 1996-08-08 Cosmederm Technologies Formulations et procedes permettant de reduire l'irritation cutanee
WO1999051213A2 (fr) * 1998-04-03 1999-10-14 Theodore Toney Ilenchuk Utilisation de polyamines dans le traitement de symptomes dermatologiques
WO2002080879A2 (fr) * 2001-04-06 2002-10-17 Etsuko Dinan Traitement pour la peau
WO2006048671A1 (fr) * 2004-11-05 2006-05-11 Bioforskning As Formules de polyamine

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996023490A1 (fr) * 1995-02-03 1996-08-08 Cosmederm Technologies Formulations et procedes permettant de reduire l'irritation cutanee
WO1999051213A2 (fr) * 1998-04-03 1999-10-14 Theodore Toney Ilenchuk Utilisation de polyamines dans le traitement de symptomes dermatologiques
WO2002080879A2 (fr) * 2001-04-06 2002-10-17 Etsuko Dinan Traitement pour la peau
WO2006048671A1 (fr) * 2004-11-05 2006-05-11 Bioforskning As Formules de polyamine

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2924023A1 (fr) * 2007-11-28 2009-05-29 Biolog Vegetale Yves Rocher Sa Utilisation d'un extrait d'aloe pour la promotion et le renfort de la cohesion des cellules de la peau
EP2486920A1 (fr) * 2009-09-28 2012-08-15 Toyo Boseki Kabushiki Kaisha Agent de relâchement du stress comprenant un extrait contenant une polyamine dérivée d'une plante comme ingrédient actif
EP2486920A4 (fr) * 2009-09-28 2013-05-01 Toyo Boseki Agent de relâchement du stress comprenant un extrait contenant une polyamine dérivée d'une plante comme ingrédient actif

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