CA2207334C - Preparations granulaires a liberation prolongee et procede pour leur production - Google Patents

Preparations granulaires a liberation prolongee et procede pour leur production Download PDF

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Publication number
CA2207334C
CA2207334C CA002207334A CA2207334A CA2207334C CA 2207334 C CA2207334 C CA 2207334C CA 002207334 A CA002207334 A CA 002207334A CA 2207334 A CA2207334 A CA 2207334A CA 2207334 C CA2207334 C CA 2207334C
Authority
CA
Canada
Prior art keywords
sustained
granules
polymer
plasticizer
granular preparations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002207334A
Other languages
English (en)
Other versions
CA2207334A1 (fr
Inventor
Hiroaki Nakagami
Masazumi Kojima
Shinji Sagasaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Pharmaceutical Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd
Priority claimed from PCT/JP1995/002594 external-priority patent/WO1996019200A1/fr
Publication of CA2207334A1 publication Critical patent/CA2207334A1/fr
Application granted granted Critical
Publication of CA2207334C publication Critical patent/CA2207334C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

La présente invention concerne une préparation granulaire à libération prolongée qui est excellente pour ce qui concerne la diffusion lente et inoffensive pour l'organisme humain. Elle peut être produite aisément, d'une manière simple, par granulation par voie humide d'une suspension aqueuse contenant un principe actif efficace sur le plan médical, un polymère particulaire ayant un diamètre moyen de particules de 50 <m ou moins, et un plastifiant, et par traitement des granulés obtenus à la plus basse des températures suivantes: la plus basse température de formation d'un film pour un mélange du polymère et du plastifiant, et sa température de transition vitreuse.
CA002207334A 1994-12-19 1995-12-18 Preparations granulaires a liberation prolongee et procede pour leur production Expired - Fee Related CA2207334C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP314414/1994 1994-12-19
JP31441494 1994-12-19
PCT/JP1995/002594 WO1996019200A1 (fr) 1994-12-19 1995-12-18 Preparation granulaire a liberation prolongee et procede de production

Publications (2)

Publication Number Publication Date
CA2207334A1 CA2207334A1 (fr) 1996-06-27
CA2207334C true CA2207334C (fr) 2006-08-22

Family

ID=36939171

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002207334A Expired - Fee Related CA2207334C (fr) 1994-12-19 1995-12-18 Preparations granulaires a liberation prolongee et procede pour leur production

Country Status (1)

Country Link
CA (1) CA2207334C (fr)

Also Published As

Publication number Publication date
CA2207334A1 (fr) 1996-06-27

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