CA2204277C - Combined meningitis vaccine - Google Patents
Combined meningitis vaccine Download PDFInfo
- Publication number
- CA2204277C CA2204277C CA002204277A CA2204277A CA2204277C CA 2204277 C CA2204277 C CA 2204277C CA 002204277 A CA002204277 A CA 002204277A CA 2204277 A CA2204277 A CA 2204277A CA 2204277 C CA2204277 C CA 2204277C
- Authority
- CA
- Canada
- Prior art keywords
- vaccine
- conjugate
- meningitis
- neisseria meningitidis
- oligosaccharide conjugate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 229940014135 meningitis vaccine Drugs 0.000 title claims description 7
- 229960005486 vaccine Drugs 0.000 claims abstract description 63
- 229920001542 oligosaccharide Polymers 0.000 claims abstract description 47
- 150000002482 oligosaccharides Chemical class 0.000 claims abstract description 46
- 238000002255 vaccination Methods 0.000 claims abstract description 25
- 241000606768 Haemophilus influenzae Species 0.000 claims abstract description 17
- 206010013023 diphtheria Diseases 0.000 claims abstract description 14
- 230000037452 priming Effects 0.000 claims abstract description 12
- 229940045808 haemophilus influenzae type b Drugs 0.000 claims abstract description 10
- 238000011282 treatment Methods 0.000 claims abstract description 9
- 201000009906 Meningitis Diseases 0.000 claims abstract description 8
- 206010043376 Tetanus Diseases 0.000 claims abstract description 8
- 238000006116 polymerization reaction Methods 0.000 claims abstract description 6
- 238000011321 prophylaxis Methods 0.000 claims abstract description 6
- 206010027202 Meningitis bacterial Diseases 0.000 claims abstract description 5
- 201000005702 Pertussis Diseases 0.000 claims abstract description 5
- 201000009904 bacterial meningitis Diseases 0.000 claims abstract description 5
- 241000588650 Neisseria meningitidis Species 0.000 claims description 18
- 108010078791 Carrier Proteins Proteins 0.000 claims description 11
- 102000014914 Carrier Proteins Human genes 0.000 claims description 11
- 229960000814 tetanus toxoid Drugs 0.000 claims description 10
- 239000002671 adjuvant Substances 0.000 claims description 7
- 108010071134 CRM197 (non-toxic variant of diphtheria toxin) Proteins 0.000 claims description 4
- 229960003983 diphtheria toxoid Drugs 0.000 claims description 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 4
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- 241000588677 Neisseria meningitidis serogroup B Species 0.000 abstract 1
- 241000947238 Neisseria meningitidis serogroup C Species 0.000 abstract 1
- 108010060123 Conjugate Vaccines Proteins 0.000 description 14
- 229940031670 conjugate vaccine Drugs 0.000 description 14
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- 210000002966 serum Anatomy 0.000 description 10
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- 239000007924 injection Substances 0.000 description 6
- 241000894007 species Species 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 229940032024 DPT vaccine Drugs 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 5
- 238000010790 dilution Methods 0.000 description 5
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- 229960004443 hemophilus influenzae b vaccines Drugs 0.000 description 5
- 229920001282 polysaccharide Polymers 0.000 description 5
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- 206010067484 Adverse reaction Diseases 0.000 description 4
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- 150000003839 salts Chemical class 0.000 description 3
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- 102000016607 Diphtheria Toxin Human genes 0.000 description 2
- 108010053187 Diphtheria Toxin Proteins 0.000 description 2
- 238000002965 ELISA Methods 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
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- 229940047650 haemophilus influenzae Drugs 0.000 description 2
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- GPRLSGONYQIRFK-UHFFFAOYSA-N hydron Chemical compound [H+] GPRLSGONYQIRFK-UHFFFAOYSA-N 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
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- 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 241000282552 Chlorocebus aethiops Species 0.000 description 1
- 206010008631 Cholera Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 241000991587 Enterovirus C Species 0.000 description 1
- 208000002091 Febrile Seizures Diseases 0.000 description 1
- 238000000729 Fisher's exact test Methods 0.000 description 1
- 241000606790 Haemophilus Species 0.000 description 1
- 206010061190 Haemophilus infection Diseases 0.000 description 1
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- 206010016284 febrile convulsion Diseases 0.000 description 1
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- 239000003022 immunostimulating agent Substances 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
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- 238000004949 mass spectrometry Methods 0.000 description 1
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- 239000011159 matrix material Substances 0.000 description 1
- 229960005037 meningococcal vaccines Drugs 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 208000010805 mumps infectious disease Diseases 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
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- 239000006179 pH buffering agent Substances 0.000 description 1
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- 244000052769 pathogen Species 0.000 description 1
- 235000020030 perry Nutrition 0.000 description 1
- 239000007793 ph indicator Substances 0.000 description 1
- 229920000747 poly(lactic acid) Polymers 0.000 description 1
- 229940031937 polysaccharide vaccine Drugs 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 238000000159 protein binding assay Methods 0.000 description 1
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- 238000006268 reductive amination reaction Methods 0.000 description 1
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- 201000005404 rubella Diseases 0.000 description 1
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- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 238000000954 titration curve Methods 0.000 description 1
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/831—Drug, bio-affecting and body treating compositions involving capsular polysaccharide of bacterium, e.g. polyribosyl ribitol phosphate
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2689871A CA2689871A1 (en) | 1994-11-02 | 1995-11-02 | Combined meningitis vaccine |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9422096A GB9422096D0 (en) | 1994-11-02 | 1994-11-02 | Combined meningitis vaccine |
| GB9422096.9 | 1994-11-02 | ||
| PCT/IB1995/001006 WO1996014086A1 (en) | 1994-11-02 | 1995-11-02 | Combined meningitis vaccine |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2689871A Division CA2689871A1 (en) | 1994-11-02 | 1995-11-02 | Combined meningitis vaccine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2204277A1 CA2204277A1 (en) | 1996-05-17 |
| CA2204277C true CA2204277C (en) | 2010-02-02 |
Family
ID=10763774
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002204277A Expired - Fee Related CA2204277C (en) | 1994-11-02 | 1995-11-02 | Combined meningitis vaccine |
| CA2689871A Abandoned CA2689871A1 (en) | 1994-11-02 | 1995-11-02 | Combined meningitis vaccine |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2689871A Abandoned CA2689871A1 (en) | 1994-11-02 | 1995-11-02 | Combined meningitis vaccine |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6251401B1 (cg-RX-API-DMAC7.html) |
| EP (3) | EP2204185A1 (cg-RX-API-DMAC7.html) |
| JP (3) | JP3989951B2 (cg-RX-API-DMAC7.html) |
| AT (1) | ATE246936T1 (cg-RX-API-DMAC7.html) |
| CA (2) | CA2204277C (cg-RX-API-DMAC7.html) |
| CY (1) | CY2423B1 (cg-RX-API-DMAC7.html) |
| DE (1) | DE69531501T3 (cg-RX-API-DMAC7.html) |
| DK (1) | DK0789587T4 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2204967T5 (cg-RX-API-DMAC7.html) |
| GB (1) | GB9422096D0 (cg-RX-API-DMAC7.html) |
| PT (1) | PT789587E (cg-RX-API-DMAC7.html) |
| WO (1) | WO1996014086A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9422096D0 (en) * | 1994-11-02 | 1994-12-21 | Biocine Spa | Combined meningitis vaccine |
| US6048527A (en) * | 1996-08-27 | 2000-04-11 | Chiron Corporation | Antibodies that define unique Meningococcal B epitopes and vaccine compositions |
| DE69708318T3 (de) | 1996-08-27 | 2006-11-16 | Novartis Vaccines and Diagnostics, Inc., Emeryville | Neisseria meningitidis serogruppe b glykokonjugate und verfahren zu deren verwendung |
| JP2002508748A (ja) * | 1997-05-01 | 2002-03-19 | カイロン コーポレイション | アジュバントとしてのウイルス様粒子の使用 |
| US20040087020A1 (en) | 1997-05-28 | 2004-05-06 | Chiron S.P.A. | Culture medium with yeast or soy bean extract as amino acid source and no protein complexes of animal origin |
| EP1849860B1 (en) * | 1997-05-28 | 2010-11-17 | Novartis Vaccines and Diagnostics S.r.l. | Process for preparing an immunogenic factor of Corynebacterium diphtheriae using a culture medium with yeast extract as aminoacid source and no protein complexes of animal origin |
| US20070259007A1 (en) * | 1999-10-19 | 2007-11-08 | Kruzel Marian L | Lactoferrin: an adjuvant for vaccines |
| EP1233784B1 (en) * | 1999-12-02 | 2008-07-09 | Novartis Vaccines and Diagnostics, Inc. | Compositions and methods for stabilizing biological molecules upon lyophilization |
| WO2002000249A2 (en) * | 2000-06-29 | 2002-01-03 | Glaxosmithkline Biologicals S.A. | Multivalent vaccine composition |
| GB0108364D0 (en) * | 2001-04-03 | 2001-05-23 | Glaxosmithkline Biolog Sa | Vaccine composition |
| JP2004529643A (ja) | 2001-04-17 | 2004-09-30 | カイロン コーポレイション | 機能活性抗体を誘発する髄膜炎菌性ｂエピトープの分子模倣物 |
| GB0115176D0 (en) | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
| AR045702A1 (es) | 2001-10-03 | 2005-11-09 | Chiron Corp | Composiciones de adyuvantes. |
| MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
| DE60328481D1 (de) * | 2002-05-14 | 2009-09-03 | Novartis Vaccines & Diagnostic | Schleimhautapplizierter impfstoff, der das adjuvanz chitosan und menigokokkenantigene enthält |
| GB0302218D0 (en) * | 2003-01-30 | 2003-03-05 | Chiron Sri | Vaccine formulation & Mucosal delivery |
| US20030124139A1 (en) * | 2002-11-20 | 2003-07-03 | Irina Esikova | Compositions and methods for stabilizing biological molecules upon lyophilization |
| CN102302776B (zh) | 2003-01-30 | 2014-06-18 | 诺华疫苗和诊断有限公司 | 抗多种脑膜炎球菌血清组的可注射性疫苗 |
| US7731967B2 (en) | 2003-04-30 | 2010-06-08 | Novartis Vaccines And Diagnostics, Inc. | Compositions for inducing immune responses |
| CN103405761A (zh) | 2003-10-02 | 2013-11-27 | 诺华疫苗和诊断有限公司 | 多种脑膜炎球菌血清群的液体疫苗 |
| GB0500787D0 (en) * | 2005-01-14 | 2005-02-23 | Chiron Srl | Integration of meningococcal conjugate vaccination |
| DK2283857T3 (da) | 2005-06-27 | 2019-10-28 | Glaxosmithkline Biologicals Sa | Vaccinesammensætning omfattende konjugerede native N. Meningitidis kapselpolysaccharider |
| AR064642A1 (es) | 2006-12-22 | 2009-04-15 | Wyeth Corp | Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi |
| ES2555786T3 (es) * | 2007-06-04 | 2016-01-08 | Glaxosmithkline Biologicals Sa | Formulación de vacunas contra la meningitis |
| ATE553774T1 (de) * | 2007-10-19 | 2012-05-15 | Novartis Ag | Meningokokkenimpfstoffformulierungen |
| JP2011506334A (ja) | 2007-12-07 | 2011-03-03 | ノバルティス アーゲー | 免疫応答を誘導するための組成物 |
| FI2608805T4 (fi) | 2010-08-23 | 2025-08-07 | Wyeth Llc | NEISSERIA MENINGITIDIS rLP2086 -ANTIGEENIEN STABIILEJA FORMULAATIOITA |
| CA2809758C (en) | 2010-09-10 | 2021-07-13 | Wyeth Llc | Non-lipidated variants of neisseria meningitidis orf2086 antigens |
| MX351993B (es) | 2012-03-09 | 2017-11-03 | Pfizer | Composiciones de neisseria meningitidis y metodos de las mismas. |
| SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
| ES2685894T3 (es) | 2013-03-08 | 2018-10-15 | Pfizer Inc. | Polipéptidos de fusión inmunogénicos |
| MX380129B (es) | 2013-09-08 | 2025-03-11 | Pfizer | Composiciones de neisseria meningitidis y sus metodos |
| CN107249626A (zh) | 2015-02-19 | 2017-10-13 | 辉瑞大药厂 | 脑膜炎奈瑟球菌组合物及其方法 |
| IL267733B2 (en) | 2017-01-31 | 2023-10-01 | Pfizer | Neisseria meningitidis compositions and methods thereof |
| MX2022003682A (es) | 2019-09-27 | 2022-04-25 | Pfizer | Composiciones de neisseria meningitidis y metodos de las mismas. |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4902506A (en) * | 1983-07-05 | 1990-02-20 | The University Of Rochester | Immunogenic conjugates |
| US4451446A (en) * | 1982-03-04 | 1984-05-29 | Smithkline-Rit | Process for the preparation of polysaccharide-protein complexes from bacterial capsules, obtained products and immunogenic compositions containing them |
| US4619828A (en) * | 1982-07-06 | 1986-10-28 | Connaught Laboratories, Inc. | Polysaccharide exotoxoid conjugate vaccines |
| US4459286A (en) * | 1983-01-31 | 1984-07-10 | Merck & Co., Inc. | Coupled H. influenzae type B vaccine |
| IT1187753B (it) * | 1985-07-05 | 1987-12-23 | Sclavo Spa | Coniugati glicoproteici ad attivita' immunogenica trivalente |
| US5371197A (en) * | 1991-09-24 | 1994-12-06 | Merck & Co., Inc. | Protein-dimeric polysaccharide conjugate vaccine |
| GB9202219D0 (en) * | 1992-02-03 | 1992-03-18 | Connaught Lab | A synthetic heamophilus influenzae conjugate vaccine |
| IT1262896B (it) * | 1992-03-06 | 1996-07-22 | Composti coniugati formati da proteine heat shock (hsp) e oligo-poli- saccaridi, loro uso per la produzione di vaccini. | |
| GB9422096D0 (en) * | 1994-11-02 | 1994-12-21 | Biocine Spa | Combined meningitis vaccine |
| US5628496A (en) | 1995-06-07 | 1997-05-13 | Avm, Inc. | Pneumatic spring |
| US6048527A (en) * | 1996-08-27 | 2000-04-11 | Chiron Corporation | Antibodies that define unique Meningococcal B epitopes and vaccine compositions |
-
1994
- 1994-11-02 GB GB9422096A patent/GB9422096D0/en active Pending
-
1995
- 1995-11-02 PT PT95935550T patent/PT789587E/pt unknown
- 1995-11-02 EP EP10075114A patent/EP2204185A1/en not_active Withdrawn
- 1995-11-02 WO PCT/IB1995/001006 patent/WO1996014086A1/en not_active Ceased
- 1995-11-02 EP EP95935550A patent/EP0789587B2/en not_active Expired - Lifetime
- 1995-11-02 CA CA002204277A patent/CA2204277C/en not_active Expired - Fee Related
- 1995-11-02 JP JP51517596A patent/JP3989951B2/ja not_active Expired - Fee Related
- 1995-11-02 DK DK95935550T patent/DK0789587T4/da active
- 1995-11-02 AT AT95935550T patent/ATE246936T1/de active
- 1995-11-02 ES ES95935550T patent/ES2204967T5/es not_active Expired - Lifetime
- 1995-11-02 DE DE69531501T patent/DE69531501T3/de not_active Expired - Lifetime
- 1995-11-02 EP EP03075069A patent/EP1312377A3/en not_active Withdrawn
- 1995-11-02 US US08/836,080 patent/US6251401B1/en not_active Expired - Lifetime
- 1995-11-02 CA CA2689871A patent/CA2689871A1/en not_active Abandoned
-
2004
- 2004-01-30 CY CY0400008A patent/CY2423B1/xx unknown
-
2007
- 2007-03-27 JP JP2007083117A patent/JP4871770B2/ja not_active Expired - Fee Related
-
2010
- 2010-10-21 JP JP2010236921A patent/JP2011016850A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP2204185A8 (en) | 2010-10-27 |
| EP2204185A1 (en) | 2010-07-07 |
| EP0789587A1 (en) | 1997-08-20 |
| ES2204967T3 (es) | 2004-05-01 |
| EP1312377A3 (en) | 2004-02-04 |
| DE69531501T3 (de) | 2008-11-13 |
| CA2204277A1 (en) | 1996-05-17 |
| PT789587E (pt) | 2003-12-31 |
| JPH10509701A (ja) | 1998-09-22 |
| DE69531501D1 (de) | 2003-09-18 |
| JP4871770B2 (ja) | 2012-02-08 |
| CA2689871A1 (en) | 1996-05-17 |
| DK0789587T3 (da) | 2003-12-01 |
| EP1312377A2 (en) | 2003-05-21 |
| DK0789587T4 (da) | 2008-08-04 |
| EP0789587B2 (en) | 2008-04-02 |
| GB9422096D0 (en) | 1994-12-21 |
| JP3989951B2 (ja) | 2007-10-10 |
| ATE246936T1 (de) | 2003-08-15 |
| DE69531501T2 (de) | 2004-06-24 |
| ES2204967T5 (es) | 2008-07-01 |
| JP2011016850A (ja) | 2011-01-27 |
| JP2007169302A (ja) | 2007-07-05 |
| US6251401B1 (en) | 2001-06-26 |
| WO1996014086A1 (en) | 1996-05-17 |
| CY2423B1 (en) | 2004-11-12 |
| EP0789587B1 (en) | 2003-08-13 |
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| EEER | Examination request | ||
| MKLA | Lapsed |
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