CA2187768A1 - Aqueous solvent encapsulation method, apparatus and microcapsules - Google Patents
Aqueous solvent encapsulation method, apparatus and microcapsulesInfo
- Publication number
- CA2187768A1 CA2187768A1 CA 2187768 CA2187768A CA2187768A1 CA 2187768 A1 CA2187768 A1 CA 2187768A1 CA 2187768 CA2187768 CA 2187768 CA 2187768 A CA2187768 A CA 2187768A CA 2187768 A1 CA2187768 A1 CA 2187768A1
- Authority
- CA
- Canada
- Prior art keywords
- microcapsule
- water soluble
- amine
- microcapsules
- anionic polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000003094 microcapsule Substances 0.000 title claims abstract description 263
- 238000000034 method Methods 0.000 title claims abstract description 49
- 238000005538 encapsulation Methods 0.000 title description 13
- 239000003125 aqueous solvent Substances 0.000 title description 4
- 150000001412 amines Chemical class 0.000 claims abstract description 134
- 229920000642 polymer Polymers 0.000 claims abstract description 134
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 112
- 150000003839 salts Chemical class 0.000 claims abstract description 96
- 229920006318 anionic polymer Polymers 0.000 claims abstract description 91
- 241000702670 Rotavirus Species 0.000 claims abstract description 68
- 239000007864 aqueous solution Substances 0.000 claims abstract description 29
- 230000002163 immunogen Effects 0.000 claims abstract description 27
- -1 amine salt Chemical class 0.000 claims abstract description 22
- 239000007795 chemical reaction product Substances 0.000 claims abstract description 6
- 239000004480 active ingredient Substances 0.000 claims abstract 8
- 239000000356 contaminant Substances 0.000 claims abstract 3
- 239000000243 solution Substances 0.000 claims description 164
- 241000700605 Viruses Species 0.000 claims description 84
- 210000004027 cell Anatomy 0.000 claims description 57
- PFNFFQXMRSDOHW-UHFFFAOYSA-N spermine Chemical compound NCCCNCCCCNCCCN PFNFFQXMRSDOHW-UHFFFAOYSA-N 0.000 claims description 56
- 229920000615 alginic acid Polymers 0.000 claims description 52
- 108090000623 proteins and genes Proteins 0.000 claims description 47
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- 235000010443 alginic acid Nutrition 0.000 claims description 40
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- QAOWNCQODCNURD-UHFFFAOYSA-L sulfate group Chemical group S(=O)(=O)([O-])[O-] QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 29
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- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims description 21
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- REYJJPSVUYRZGE-UHFFFAOYSA-N Octadecylamine Chemical compound CCCCCCCCCCCCCCCCCCN REYJJPSVUYRZGE-UHFFFAOYSA-N 0.000 claims description 20
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- 239000004475 Arginine Substances 0.000 claims description 6
- MHZGKXUYDGKKIU-UHFFFAOYSA-N Decylamine Chemical compound CCCCCCCCCCN MHZGKXUYDGKKIU-UHFFFAOYSA-N 0.000 claims description 6
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- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 6
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 6
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- FJLUATLTXUNBOT-UHFFFAOYSA-N 1-Hexadecylamine Chemical compound CCCCCCCCCCCCCCCCN FJLUATLTXUNBOT-UHFFFAOYSA-N 0.000 claims description 4
- PLZVEHJLHYMBBY-UHFFFAOYSA-N Tetradecylamine Chemical compound CCCCCCCCCCCCCCN PLZVEHJLHYMBBY-UHFFFAOYSA-N 0.000 claims description 4
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- 238000003306 harvesting Methods 0.000 claims description 4
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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Landscapes
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22848194A | 1994-04-15 | 1994-04-15 | |
| US08/228,481 | 1994-04-15 | ||
| US22952094A | 1994-04-18 | 1994-04-18 | |
| US22928394A | 1994-04-18 | 1994-04-18 | |
| US08/229,520 | 1994-04-18 | ||
| US08/229,283 | 1994-04-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2187768A1 true CA2187768A1 (en) | 1995-10-26 |
Family
ID=27397849
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 2187768 Abandoned CA2187768A1 (en) | 1994-04-15 | 1995-04-17 | Aqueous solvent encapsulation method, apparatus and microcapsules |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0804283B1 (OSRAM) |
| JP (1) | JPH10500889A (OSRAM) |
| AT (1) | ATE235959T1 (OSRAM) |
| AU (1) | AU2386595A (OSRAM) |
| CA (1) | CA2187768A1 (OSRAM) |
| DE (1) | DE69530227T2 (OSRAM) |
| WO (1) | WO1995028227A1 (OSRAM) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9814657B2 (en) | 2009-04-27 | 2017-11-14 | Premier Dental Products Company | Buffered microencapsulated compositions and methods |
| US10434047B2 (en) | 2009-04-27 | 2019-10-08 | Premier Dental Products Company | Buffered microencapsulated compositions and methods |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU717113B2 (en) * | 1995-11-09 | 2000-03-16 | Health Protection Agency | Microencapsulated DNA for vaccination and gene therapy |
| EP0867188A1 (en) * | 1996-08-20 | 1998-09-30 | Freund Industrial Co., Ltd. | Microspheres containing immunogens, process for producing the same, and method for immunizing animals with the use of the same |
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| US4352883A (en) * | 1979-03-28 | 1982-10-05 | Damon Corporation | Encapsulation of biological material |
| EP0299205B1 (en) * | 1987-06-19 | 1992-04-15 | Temple University - Of The Commonwealth System Higher Education | Sustained release microcapsules and method for the production thereof |
| US5093198A (en) * | 1987-06-19 | 1992-03-03 | Temple University | Adjuvant-enhanced sustained release composition and method for making |
| US4917892A (en) * | 1988-06-28 | 1990-04-17 | Temple University | Encapsulated topical delivery system |
| WO1993001806A1 (en) * | 1991-07-23 | 1993-02-04 | Temple University Of The Commonwealth System Of Higher Education | Encapsulated perfluorocarbons |
-
1995
- 1995-04-17 CA CA 2187768 patent/CA2187768A1/en not_active Abandoned
- 1995-04-17 DE DE1995630227 patent/DE69530227T2/de not_active Expired - Fee Related
- 1995-04-17 JP JP52715195A patent/JPH10500889A/ja not_active Ceased
- 1995-04-17 AU AU23865/95A patent/AU2386595A/en not_active Abandoned
- 1995-04-17 AT AT95917018T patent/ATE235959T1/de not_active IP Right Cessation
- 1995-04-17 EP EP19950917018 patent/EP0804283B1/en not_active Expired - Lifetime
- 1995-04-17 WO PCT/US1995/004711 patent/WO1995028227A1/en not_active Ceased
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| US9814657B2 (en) | 2009-04-27 | 2017-11-14 | Premier Dental Products Company | Buffered microencapsulated compositions and methods |
| US10434044B2 (en) | 2009-04-27 | 2019-10-08 | Premier Dental Products Company | Buffered microencapsulated compositions and methods |
| US10434047B2 (en) | 2009-04-27 | 2019-10-08 | Premier Dental Products Company | Buffered microencapsulated compositions and methods |
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| US10675227B2 (en) | 2009-04-27 | 2020-06-09 | Premier Dental Products Company | Buffered microencapsulated compositions and methods |
| US10688026B2 (en) | 2009-04-27 | 2020-06-23 | Premier Dental Products Company | Buffered microencapsulated compositions and methods |
| US11185480B2 (en) | 2009-04-27 | 2021-11-30 | Premier Dental Products Company | Buffered microencapsulated compositions and methods |
| US11185479B2 (en) | 2009-04-27 | 2021-11-30 | Premier Dental Products Company | Buffered microencapsulated compositions and methods |
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| US11850294B2 (en) | 2009-04-27 | 2023-12-26 | Premier Dental Products Company | Buffered microencapsulated compositions and methods |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH10500889A (ja) | 1998-01-27 |
| DE69530227D1 (de) | 2003-05-08 |
| AU2386595A (en) | 1995-11-10 |
| HK1001965A1 (en) | 1998-07-24 |
| EP0804283A1 (en) | 1997-11-05 |
| WO1995028227A1 (en) | 1995-10-26 |
| ATE235959T1 (de) | 2003-04-15 |
| DE69530227T2 (de) | 2004-04-01 |
| EP0804283A4 (OSRAM) | 1997-11-12 |
| EP0804283B1 (en) | 2003-04-02 |
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| EEER | Examination request | ||
| FZDE | Discontinued |