CA2186486A1 - An equilin double bond isomer from the acid isomerization of equilin - Google Patents
An equilin double bond isomer from the acid isomerization of equilinInfo
- Publication number
- CA2186486A1 CA2186486A1 CA002186486A CA2186486A CA2186486A1 CA 2186486 A1 CA2186486 A1 CA 2186486A1 CA 002186486 A CA002186486 A CA 002186486A CA 2186486 A CA2186486 A CA 2186486A CA 2186486 A1 CA2186486 A1 CA 2186486A1
- Authority
- CA
- Canada
- Prior art keywords
- bone
- rate
- pharmaceutically acceptable
- acceptable salt
- isoestrone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- 230000003637 steroidlike Effects 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 210000000623 ulna Anatomy 0.000 description 1
- 238000002211 ultraviolet spectrum Methods 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 230000001457 vasomotor Effects 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 238000010626 work up procedure Methods 0.000 description 1
- ORZHVTYKPFFVMG-UHFFFAOYSA-N xylenol orange Chemical compound OC(=O)CN(CC(O)=O)CC1=C(O)C(C)=CC(C2(C3=CC=CC=C3S(=O)(=O)O2)C=2C=C(CN(CC(O)=O)CC(O)=O)C(O)=C(C)C=2)=C1 ORZHVTYKPFFVMG-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J15/00—Stereochemically pure steroids containing carbon, hydrogen, halogen or oxygen having a partially or totally inverted skeleton, e.g. retrosteroids, L-isomers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/224,849 | 1994-04-08 | ||
| US08/224,849 US5395831A (en) | 1994-04-08 | 1994-04-08 | Treating cardiac disorders with Δ9(11)-dehydro-8-isoestrone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2186486A1 true CA2186486A1 (en) | 1995-10-19 |
Family
ID=22842497
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002186486A Abandoned CA2186486A1 (en) | 1994-04-08 | 1995-04-06 | An equilin double bond isomer from the acid isomerization of equilin |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US5395831A (enExample) |
| EP (1) | EP0754190B1 (enExample) |
| JP (1) | JPH09511748A (enExample) |
| KR (1) | KR970702291A (enExample) |
| CN (1) | CN1149298A (enExample) |
| AT (1) | ATE177111T1 (enExample) |
| AU (1) | AU688029B2 (enExample) |
| CA (1) | CA2186486A1 (enExample) |
| DE (1) | DE69508068T2 (enExample) |
| DK (1) | DK0754190T3 (enExample) |
| ES (1) | ES2128051T3 (enExample) |
| GR (1) | GR3030185T3 (enExample) |
| HU (1) | HUT76338A (enExample) |
| IL (1) | IL113178A (enExample) |
| NZ (1) | NZ283951A (enExample) |
| TW (1) | TW314468B (enExample) |
| WO (1) | WO1995027724A1 (enExample) |
| ZA (1) | ZA952771B (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5395831A (en) * | 1994-04-08 | 1995-03-07 | American Home Products Corporation | Treating cardiac disorders with Δ9(11)-dehydro-8-isoestrone |
| AU7013296A (en) * | 1995-08-30 | 1997-03-19 | Eli Lilly And Company | N-butylsulfonate esters of estrogens |
| ZA968873B (en) | 1995-11-06 | 1997-05-28 | Akzo Nobel Nv | Isomerisation of equillin |
| US5998639A (en) * | 1995-11-06 | 1999-12-07 | Akzo Nobel, N.V. | Sulfatation of estrogen mixtures |
| AU703814B2 (en) * | 1995-12-04 | 1999-04-01 | Wyeth | Antioxidant |
| EP0785212A1 (en) * | 1996-01-22 | 1997-07-23 | Laboratoire Theramex | New 19-nor-pregnene derivatives |
| ID18256A (id) * | 1996-09-16 | 1998-03-19 | American Home Prod | Penggunaan dari 8,9-dehidro estron sebagai estrogen dengan hasil netral pada tingkat prolaktin |
| IL124213A (en) * | 1997-05-02 | 2004-12-15 | Akzo Nobel Nv | Sulfation of estrogen mixtures |
| DE19723794A1 (de) * | 1997-06-06 | 1998-12-10 | Jenapharm Gmbh | Nichtestrogene Derivate des Estradiols mit antioxidativer Aktivität |
| US5866561A (en) * | 1997-08-21 | 1999-02-02 | Scimed Life Systems, Inc. | Local delivery of estrogen for angiogenesis |
| GB9817623D0 (en) * | 1998-08-13 | 1998-10-07 | Glaxo Group Ltd | Pharmaceutical compounds |
| EP1330467B1 (en) | 2000-11-03 | 2007-05-02 | Washington University | Modified, hydroxy-substituted aromatic structures having cytoprotective activity |
| US20020132802A1 (en) * | 2000-11-17 | 2002-09-19 | Washington Univeristy | Cytoprotective polycyclic compounds |
| US20030158432A1 (en) * | 2002-01-08 | 2003-08-21 | Leonard Thomas W. | Synthesis of a mixture of sulfated estrogens using a sulfur trioxide complex |
| US6855735B2 (en) | 2002-03-20 | 2005-02-15 | Temple University Of The Commonwealth System Of Higher Education | Ketamine treatment of restless legs syndrome |
| WO2003084978A1 (en) * | 2002-04-01 | 2003-10-16 | University Of Florida | Steroidal quinols as prodrugs of antioxidants |
| US20070213310A1 (en) * | 2002-04-01 | 2007-09-13 | Laszlo Prokai | Prodrugs for Use as Ophthalmic Agents |
| US7300926B2 (en) * | 2002-04-01 | 2007-11-27 | University Of Florida Research Foundation, Inc. | Steroidal quinols and their use for estrogen replacement therapy |
| US7186707B2 (en) | 2002-04-01 | 2007-03-06 | University Of Florida | Prodrugs for use as ophthalmic agents |
| US20240183014A1 (en) | 2022-12-03 | 2024-06-06 | Arthur Craig Reardon | High Speed Steel Composition |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE205169C (enExample) * | ||||
| US3394153A (en) * | 1965-08-18 | 1968-07-23 | Merck & Co Inc | Process for the preparation of d, 1-8-dehydroestrone, and intermediates obtained therefrom |
| US3391170A (en) * | 1965-09-21 | 1968-07-02 | Smith | 13-alkylogona-1, 3, 5 (10), 9 (11)-tetraenes |
| US3385872A (en) * | 1966-08-29 | 1968-05-28 | Syntex Corp | Process for the preparation of 3-hydroxy-19-nor-delta1, 3, 5(10), 9(11)-tetraene steroids |
| US3471528A (en) * | 1968-02-21 | 1969-10-07 | Lilly Co Eli | Method for producing delta**9(11) unsaturation in estrone and related compound |
| US3542819A (en) * | 1968-06-11 | 1970-11-24 | American Home Prod | Process for preparing 8-isoestrone |
| US3649621A (en) * | 1969-12-19 | 1972-03-14 | American Home Prod | Novel 3-cyclopentyl ethers of 13-alkylgon-poly-enes |
| US3689512A (en) * | 1970-10-06 | 1972-09-05 | American Home Prod | Novel 3-etherified-1,3,5(10)-triene-steroids and process thereof |
| DE3014120A1 (de) * | 1980-04-12 | 1981-10-29 | Hoechst Ag, 6000 Frankfurt | Verfahren zur synthese von oestron bzw. oestronderivaten |
| DD205169A1 (de) * | 1982-05-26 | 1983-12-21 | Adw Ddr | Verfahren zur herstellung von 9(11)-dehydro-oestra-1,3,5(10)-trienen |
| US5210081A (en) * | 1992-02-26 | 1993-05-11 | American Home Products Corporation | Alkali metal 8,9-dehydroestrone sulfate esters |
| US5395831A (en) * | 1994-04-08 | 1995-03-07 | American Home Products Corporation | Treating cardiac disorders with Δ9(11)-dehydro-8-isoestrone |
-
1994
- 1994-04-08 US US08/224,849 patent/US5395831A/en not_active Expired - Lifetime
- 1994-12-01 US US08/347,742 patent/US5496814A/en not_active Expired - Lifetime
-
1995
- 1995-02-20 TW TW084101526A patent/TW314468B/zh active
- 1995-03-29 IL IL11317895A patent/IL113178A/xx not_active IP Right Cessation
- 1995-04-04 ZA ZA952771A patent/ZA952771B/xx unknown
- 1995-04-06 DE DE69508068T patent/DE69508068T2/de not_active Expired - Fee Related
- 1995-04-06 DK DK95915579T patent/DK0754190T3/da active
- 1995-04-06 KR KR1019960705688A patent/KR970702291A/ko not_active Ceased
- 1995-04-06 CN CN95193322A patent/CN1149298A/zh active Pending
- 1995-04-06 CA CA002186486A patent/CA2186486A1/en not_active Abandoned
- 1995-04-06 WO PCT/US1995/004252 patent/WO1995027724A1/en not_active Ceased
- 1995-04-06 AU AU22421/95A patent/AU688029B2/en not_active Ceased
- 1995-04-06 EP EP95915579A patent/EP0754190B1/en not_active Expired - Lifetime
- 1995-04-06 HU HU9602755A patent/HUT76338A/hu unknown
- 1995-04-06 NZ NZ283951A patent/NZ283951A/en unknown
- 1995-04-06 JP JP7526442A patent/JPH09511748A/ja not_active Withdrawn
- 1995-04-06 AT AT95915579T patent/ATE177111T1/de not_active IP Right Cessation
- 1995-04-06 ES ES95915579T patent/ES2128051T3/es not_active Expired - Lifetime
- 1995-05-25 US US08/450,960 patent/US5552395A/en not_active Expired - Lifetime
-
1999
- 1999-05-11 GR GR990401273T patent/GR3030185T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0754190B1 (en) | 1999-03-03 |
| EP0754190A1 (en) | 1997-01-22 |
| HUT76338A (en) | 1997-08-28 |
| DE69508068T2 (de) | 1999-10-28 |
| US5496814A (en) | 1996-03-05 |
| WO1995027724A1 (en) | 1995-10-19 |
| JPH09511748A (ja) | 1997-11-25 |
| ATE177111T1 (de) | 1999-03-15 |
| GR3030185T3 (en) | 1999-08-31 |
| TW314468B (enExample) | 1997-09-01 |
| IL113178A0 (en) | 1995-06-29 |
| US5395831A (en) | 1995-03-07 |
| HU9602755D0 (en) | 1996-11-28 |
| CN1149298A (zh) | 1997-05-07 |
| ES2128051T3 (es) | 1999-05-01 |
| KR970702291A (ko) | 1997-05-13 |
| DE69508068D1 (de) | 1999-04-08 |
| IL113178A (en) | 2000-07-26 |
| AU688029B2 (en) | 1998-03-05 |
| DK0754190T3 (da) | 1999-09-27 |
| AU2242195A (en) | 1995-10-30 |
| NZ283951A (en) | 1998-07-28 |
| ZA952771B (en) | 1996-10-04 |
| US5552395A (en) | 1996-09-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |