CA2186243C - Utilisation de derives n-acyle d'amino-alcools dans la fabrication d'un medicament exercant une action neuroprotectrice dans des etats neuropathologiques lies a une excitotoxicite - Google Patents

Utilisation de derives n-acyle d'amino-alcools dans la fabrication d'un medicament exercant une action neuroprotectrice dans des etats neuropathologiques lies a une excitotoxicite Download PDF

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Publication number
CA2186243C
CA2186243C CA002186243A CA2186243A CA2186243C CA 2186243 C CA2186243 C CA 2186243C CA 002186243 A CA002186243 A CA 002186243A CA 2186243 A CA2186243 A CA 2186243A CA 2186243 C CA2186243 C CA 2186243C
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CA
Canada
Prior art keywords
use according
acid
group
pharmaceutical compositions
aromatic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002186243A
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English (en)
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CA2186243A1 (fr
Inventor
Francesco Della Valle
Alberta Leon
Silvana Lorenzi
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LifeGroup SpA
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LifeGroup SpA
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Filing date
Publication date
Priority claimed from ITMI940523A external-priority patent/IT1271623B/it
Application filed by LifeGroup SpA filed Critical LifeGroup SpA
Publication of CA2186243A1 publication Critical patent/CA2186243A1/fr
Application granted granted Critical
Publication of CA2186243C publication Critical patent/CA2186243C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention se rapporte à l'utilisation de dérivés N-acyle d'amino-alcools possédant des acides mono et dicarboxyliques, ces dérivés étant destinés à la prévention et au traitement de maladies associées à une hyperexcitation ou à une excitation prolongée provoquée par des acides aminés excitateurs.
CA002186243A 1994-03-21 1995-03-17 Utilisation de derives n-acyle d'amino-alcools dans la fabrication d'un medicament exercant une action neuroprotectrice dans des etats neuropathologiques lies a une excitotoxicite Expired - Lifetime CA2186243C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITM194A000523 1994-03-21
ITMI940523A IT1271623B (it) 1994-03-21 1994-03-21 N-acilderivati di aminoalcoli con acidi monocarbossilici e bicarbossilici con attivita' neuroprotettiva nelle patologie neurologiche correlate ad eccitotossicita'
PCT/EP1995/001002 WO1995025509A2 (fr) 1994-03-21 1995-03-17 Utilisation de derives n-acyle d'amino-alcools dans la fabrication d'un medicament de maniere a produire une action neuroprotectrice dans des etats neuropathologiques lies a une excitotoxicite

Publications (2)

Publication Number Publication Date
CA2186243A1 CA2186243A1 (fr) 1995-09-28
CA2186243C true CA2186243C (fr) 2007-03-06

Family

ID=37891548

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002186243A Expired - Lifetime CA2186243C (fr) 1994-03-21 1995-03-17 Utilisation de derives n-acyle d'amino-alcools dans la fabrication d'un medicament exercant une action neuroprotectrice dans des etats neuropathologiques lies a une excitotoxicite

Country Status (1)

Country Link
CA (1) CA2186243C (fr)

Also Published As

Publication number Publication date
CA2186243A1 (fr) 1995-09-28

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