CA2180730A1 - Composes 3-arylidene-7-azaoxindoles substitues et leur procede de preparation - Google Patents
Composes 3-arylidene-7-azaoxindoles substitues et leur procede de preparationInfo
- Publication number
- CA2180730A1 CA2180730A1 CA002180730A CA2180730A CA2180730A1 CA 2180730 A1 CA2180730 A1 CA 2180730A1 CA 002180730 A CA002180730 A CA 002180730A CA 2180730 A CA2180730 A CA 2180730A CA 2180730 A1 CA2180730 A1 CA 2180730A1
- Authority
- CA
- Canada
- Prior art keywords
- nch2oh
- choh
- alkyl
- arylidene
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 7
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- MVXVYAKCVDQRLW-UHFFFAOYSA-N 1h-pyrrolo[2,3-b]pyridine Chemical compound C1=CN=C2NC=CC2=C1 MVXVYAKCVDQRLW-UHFFFAOYSA-N 0.000 abstract 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 abstract 2
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 abstract 2
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 abstract 2
- AWJUIBRHMBBTKR-UHFFFAOYSA-N isoquinoline Chemical compound C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 abstract 2
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 abstract 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000003944 tolyl group Chemical group 0.000 abstract 1
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 abstract 1
- 239000005483 tyrosine kinase inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9423997A GB9423997D0 (en) | 1994-11-28 | 1994-11-28 | Substituted 3-arylidene-7-azaoxindole compounds and process for their preparation |
| GB9423997.7 | 1994-11-28 | ||
| PCT/EP1995/004247 WO1996016964A1 (fr) | 1994-11-28 | 1995-10-30 | Composes 3-arylidene-7-azaoxindoles substitues et leur procede de preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2180730A1 true CA2180730A1 (fr) | 1996-06-06 |
| CA2180730C CA2180730C (fr) | 2006-09-12 |
Family
ID=10765093
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002180730A Expired - Fee Related CA2180730C (fr) | 1994-11-28 | 1995-10-30 | Composes 3-arylidene-7-azaoxindoles substitues et leur procede de preparation |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5719135A (fr) |
| EP (1) | EP0741726B1 (fr) |
| JP (1) | JPH09508924A (fr) |
| CN (1) | CN1139929A (fr) |
| AT (1) | ATE186727T1 (fr) |
| AU (1) | AU3926295A (fr) |
| CA (1) | CA2180730C (fr) |
| DE (1) | DE69513383T2 (fr) |
| DK (1) | DK0741726T3 (fr) |
| ES (1) | ES2140717T3 (fr) |
| FI (1) | FI962954A0 (fr) |
| GB (1) | GB9423997D0 (fr) |
| GR (1) | GR3032535T3 (fr) |
| HU (1) | HUT74875A (fr) |
| IL (1) | IL116002A0 (fr) |
| MX (1) | MX9602838A (fr) |
| NO (1) | NO963066L (fr) |
| NZ (1) | NZ295668A (fr) |
| PL (1) | PL315689A1 (fr) |
| PT (1) | PT741726E (fr) |
| WO (1) | WO1996016964A1 (fr) |
| ZA (1) | ZA959927B (fr) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5880141A (en) * | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
| US6147106A (en) | 1997-08-20 | 2000-11-14 | Sugen, Inc. | Indolinone combinatorial libraries and related products and methods for the treatment of disease |
| US6906093B2 (en) | 1995-06-07 | 2005-06-14 | Sugen, Inc. | Indolinone combinatorial libraries and related products and methods for the treatment of disease |
| US6316635B1 (en) | 1995-06-07 | 2001-11-13 | Sugen, Inc. | 2-indolinone derivatives as modulators of protein kinase activity |
| GB9610964D0 (en) * | 1996-05-24 | 1996-07-31 | Pharmacia & Upjohn Spa | Substituted tetralylmethylen-oxindole analogues as tyrosine kinase inhibitors |
| GB9611797D0 (en) * | 1996-06-06 | 1996-08-07 | Pharmacia Spa | Substituted quinolylmethylen-oxindole analogues as tyrosine kinase inhibitors |
| GB9613021D0 (en) * | 1996-06-21 | 1996-08-28 | Pharmacia Spa | Bicyclic 4-aralkylaminopyrimidine derivatives as tyrosine kinase inhibitors |
| US6316429B1 (en) | 1997-05-07 | 2001-11-13 | Sugen, Inc. | Bicyclic protein kinase inhibitors |
| US6486185B1 (en) | 1997-05-07 | 2002-11-26 | Sugen, Inc. | 3-heteroarylidene-2-indolinone protein kinase inhibitors |
| US6987113B2 (en) | 1997-06-11 | 2006-01-17 | Sugen, Inc. | Tyrosine kinase inhibitors |
| GB9718913D0 (en) | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Substituted oxindole derivatives |
| GB9721437D0 (en) * | 1997-10-10 | 1997-12-10 | Glaxo Group Ltd | Heteroaromatic compounds and their use in medicine |
| US6531502B1 (en) | 1998-01-21 | 2003-03-11 | Sugen, Inc. | 3-Methylidenyl-2-indolinone modulators of protein kinase |
| JP2002507598A (ja) * | 1998-03-26 | 2002-03-12 | スージェン・インコーポレーテッド | チロシン蛋白質キナーゼを調節するためのヘテロ環式化合物のファミリー |
| US6514981B1 (en) | 1998-04-02 | 2003-02-04 | Sugen, Inc. | Methods of modulating tyrosine protein kinase function with indolinone compounds |
| US6569868B2 (en) | 1998-04-16 | 2003-05-27 | Sugen, Inc. | 2-indolinone derivatives as modulators of protein kinase activity |
| CO5031249A1 (es) | 1998-05-29 | 2001-04-27 | Sugen Inc | Pirrol substituido-2-indolinonas inhibidoras de proteinci-nasas |
| CN1261098C (zh) | 1998-08-28 | 2006-06-28 | 西奥斯股份有限公司 | p38－α激酶的抑制剂 |
| KR20010101266A (ko) | 1998-12-17 | 2001-11-14 | 프리돌린 클라우스너, 롤란드 비. 보레르 | Ｊｎｋ 단백질 키나제의 억제제로서의 4-아릴옥신돌 |
| PT1157019E (pt) * | 1998-12-17 | 2003-06-30 | Hoffmann La Roche | 4-alcenil (e alcinil) oxindolos como inibidores dequinases dependentes de ciclina em particular cdk2 |
| AU767138B2 (en) | 1998-12-17 | 2003-10-30 | F. Hoffmann-La Roche Ag | 4,5-pyrazinoxindoles as protein kinase inhibitors |
| US6153634A (en) | 1998-12-17 | 2000-11-28 | Hoffmann-La Roche Inc. | 4,5-azolo-oxindoles |
| US6624171B1 (en) | 1999-03-04 | 2003-09-23 | Smithkline Beecham Corporation | Substituted aza-oxindole derivatives |
| GB9904933D0 (en) | 1999-03-04 | 1999-04-28 | Glaxo Group Ltd | Compounds |
| US6492398B1 (en) | 1999-03-04 | 2002-12-10 | Smithkline Beechman Corporation | Thiazoloindolinone compounds |
| US6689806B1 (en) | 1999-03-24 | 2004-02-10 | Sugen, Inc. | Indolinone compounds as kinase inhibitors |
| US6541477B2 (en) | 1999-08-27 | 2003-04-01 | Scios, Inc. | Inhibitors of p38-a kinase |
| US6878733B1 (en) | 1999-11-24 | 2005-04-12 | Sugen, Inc. | Formulations for pharmaceutical agents ionizable as free acids or free bases |
| US6313310B1 (en) | 1999-12-15 | 2001-11-06 | Hoffmann-La Roche Inc. | 4-and 5-alkynyloxindoles and 4-and 5-alkenyloxindoles |
| EP1244672B1 (fr) * | 1999-12-21 | 2005-07-20 | Sugen, Inc. | 7-aza-indoline-2-ones substitues en 4 et leur utilisation comme inhibiteurs de proteine kinase |
| US6620818B1 (en) | 2000-03-01 | 2003-09-16 | Smithkline Beecham Corporation | Method for reducing the severity of side effects of chemotherapy and/or radiation therapy |
| MY128450A (en) | 2000-05-24 | 2007-02-28 | Upjohn Co | 1-(pyrrolidin-1-ylmethyl)-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives |
| CA2410509A1 (fr) | 2000-06-02 | 2001-12-13 | Sugen, Inc. | Derives d'indolinone comme inhibiteurs de phosphatase/proteine kinase |
| US6335342B1 (en) | 2000-06-19 | 2002-01-01 | Pharmacia & Upjohn S.P.A. | Azaindole derivatives, process for their preparation, and their use as antitumor agents |
| EP1353693B1 (fr) | 2001-01-16 | 2005-03-16 | Glaxo Group Limited | Combinaison pharmaceutique contenant de l'amino-4 quinazoline et paclitaxel, carboplatin or vinorelbine pour le traitement du cancer |
| US6504034B2 (en) | 2001-01-23 | 2003-01-07 | Hoffmann-La Roche Inc. | Naphthostyrils |
| JP2005508337A (ja) * | 2001-09-27 | 2005-03-31 | スミスクライン ビーチャム コーポレーション | 化合物 |
| BRPI0707312B1 (pt) * | 2006-01-27 | 2022-06-07 | Shanghai Hengrui Pharmacetical Co., Ltd | Inibidores de pirrolo [3,2-c] piridina-4-ona 2-indolinona proteína cinase, seu uso e seu processo de fabricação, intermediário e seus processos de fabricação, composição farmacêutica e seu uso |
| CN101367801B (zh) * | 2007-08-15 | 2011-01-12 | 上海恒瑞医药有限公司 | 吡咯并六元n杂环羟基吗啡啉类衍生物的制备方法及其在医药上的应用 |
| US9493452B2 (en) * | 2011-03-24 | 2016-11-15 | Southern Methodist University | Compounds and derivatives of 2H-pyrido (3,2-b)(1, 4) oxazin 3)4H)-ones as raf kinase and LRRK2 inhibitors |
| US8669363B2 (en) | 2011-03-24 | 2014-03-11 | Southern Methodist University | Quinoxaline compounds and derivatives |
| WO2013142831A1 (fr) | 2012-03-23 | 2013-09-26 | Southern Methodist University | Procédés permettant de fabriquer et d'utiliser des dérivés de thioxothiazolidine et de rhodanine en tant qu'inhibiteurs de vih-1 et de jsp-1 |
| CN103864784B (zh) * | 2014-02-28 | 2017-05-03 | 温州医科大学 | 一种新型氮杂吲哚‑2‑酮类fgfr1抑制剂及其抗肿瘤活性 |
| WO2022006238A1 (fr) * | 2020-07-01 | 2022-01-06 | Angion Biomedica Corp. | Formes solides de (z)-méthyl 3-(((4-(n-méthyl-2-(4-méthylpipérazin-1-yl)acétamido)phényl)amino)(phényl)méthylène)-2-oxo-2, 3-dihydro-1h-pyrrolo[2,3-b]pyridine-6-carboxylate et des sels de celui-ci |
| WO2022120181A1 (fr) | 2020-12-03 | 2022-06-09 | Mydecine Innovations Group Inc. | Nouvelles compositions d'analogue de psilocine et leurs procédés de synthèse |
| WO2024071415A1 (fr) * | 2022-09-30 | 2024-04-04 | 日本ポリケム株式会社 | Composé, complexe métallique, composition de catalyseur pour la polymérisation d'oléfines, catalyseur pour la polymérisation d'oléfines et procédé de production de polymère d'oléfine |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9226855D0 (en) * | 1992-12-23 | 1993-02-17 | Erba Carlo Spa | Vinylene-azaindole derivatives and process for their preparation |
-
1994
- 1994-11-28 GB GB9423997A patent/GB9423997D0/en active Pending
-
1995
- 1995-10-30 AU AU39262/95A patent/AU3926295A/en not_active Abandoned
- 1995-10-30 MX MX9602838A patent/MX9602838A/es not_active Application Discontinuation
- 1995-10-30 CN CN95191374A patent/CN1139929A/zh active Pending
- 1995-10-30 DE DE69513383T patent/DE69513383T2/de not_active Expired - Fee Related
- 1995-10-30 AT AT95937030T patent/ATE186727T1/de not_active IP Right Cessation
- 1995-10-30 CA CA002180730A patent/CA2180730C/fr not_active Expired - Fee Related
- 1995-10-30 HU HU9602357A patent/HUT74875A/hu unknown
- 1995-10-30 PT PT95937030T patent/PT741726E/pt unknown
- 1995-10-30 JP JP8518113A patent/JPH09508924A/ja not_active Ceased
- 1995-10-30 DK DK95937030T patent/DK0741726T3/da active
- 1995-10-30 ES ES95937030T patent/ES2140717T3/es not_active Expired - Lifetime
- 1995-10-30 PL PL95315689A patent/PL315689A1/xx unknown
- 1995-10-30 EP EP95937030A patent/EP0741726B1/fr not_active Expired - Lifetime
- 1995-10-30 WO PCT/EP1995/004247 patent/WO1996016964A1/fr active IP Right Grant
- 1995-10-30 NZ NZ295668A patent/NZ295668A/en unknown
- 1995-10-30 US US08/669,315 patent/US5719135A/en not_active Expired - Fee Related
- 1995-11-15 IL IL11600295A patent/IL116002A0/xx unknown
- 1995-11-22 ZA ZA959927A patent/ZA959927B/xx unknown
-
1996
- 1996-07-23 NO NO963066A patent/NO963066L/no unknown
- 1996-07-24 FI FI962954A patent/FI962954A0/fi not_active Application Discontinuation
-
2000
- 2000-02-02 GR GR20000400231T patent/GR3032535T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NO963066D0 (no) | 1996-07-23 |
| ES2140717T3 (es) | 2000-03-01 |
| DE69513383T2 (de) | 2000-05-18 |
| IL116002A0 (en) | 1996-01-31 |
| DK0741726T3 (da) | 2000-04-17 |
| ATE186727T1 (de) | 1999-12-15 |
| EP0741726B1 (fr) | 1999-11-17 |
| FI962954A (fi) | 1996-07-24 |
| EP0741726A1 (fr) | 1996-11-13 |
| CA2180730C (fr) | 2006-09-12 |
| AU3926295A (en) | 1996-06-19 |
| MX9602838A (es) | 1997-06-28 |
| ZA959927B (en) | 1996-06-10 |
| PL315689A1 (en) | 1996-11-25 |
| US5719135A (en) | 1998-02-17 |
| GR3032535T3 (en) | 2000-05-31 |
| HU9602357D0 (en) | 1996-11-28 |
| JPH09508924A (ja) | 1997-09-09 |
| PT741726E (pt) | 2000-04-28 |
| GB9423997D0 (en) | 1995-01-11 |
| NZ295668A (en) | 1997-11-24 |
| HUT74875A (en) | 1997-02-28 |
| CN1139929A (zh) | 1997-01-08 |
| WO1996016964A1 (fr) | 1996-06-06 |
| NO963066L (no) | 1996-07-23 |
| DE69513383D1 (de) | 1999-12-23 |
| FI962954A0 (fi) | 1996-07-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |