CA2167842A1 - Method of inhibiting the replication of human immunodeficiency viruses with substituted azaspiranes - Google Patents

Method of inhibiting the replication of human immunodeficiency viruses with substituted azaspiranes

Info

Publication number
CA2167842A1
CA2167842A1 CA002167842A CA2167842A CA2167842A1 CA 2167842 A1 CA2167842 A1 CA 2167842A1 CA 002167842 A CA002167842 A CA 002167842A CA 2167842 A CA2167842 A CA 2167842A CA 2167842 A1 CA2167842 A1 CA 2167842A1
Authority
CA
Canada
Prior art keywords
compound
hiv
replication
inhibiting
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002167842A
Other languages
English (en)
French (fr)
Inventor
Alison Mary Badger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2167842A1 publication Critical patent/CA2167842A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA002167842A 1993-07-23 1994-07-22 Method of inhibiting the replication of human immunodeficiency viruses with substituted azaspiranes Abandoned CA2167842A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939315340A GB9315340D0 (en) 1993-07-23 1993-07-23 Methods
GB9315340.1 1993-07-23

Publications (1)

Publication Number Publication Date
CA2167842A1 true CA2167842A1 (en) 1995-02-02

Family

ID=10739357

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002167842A Abandoned CA2167842A1 (en) 1993-07-23 1994-07-22 Method of inhibiting the replication of human immunodeficiency viruses with substituted azaspiranes

Country Status (9)

Country Link
EP (1) EP0711160A4 (ja)
JP (1) JPH09500648A (ja)
CN (1) CN1130871A (ja)
AU (1) AU7370994A (ja)
CA (1) CA2167842A1 (ja)
GB (1) GB9315340D0 (ja)
NZ (1) NZ269991A (ja)
WO (1) WO1995003042A1 (ja)
ZA (1) ZA945418B (ja)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9315306D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
GB9315351D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
BR9601909A (pt) * 1995-07-13 1999-10-13 Smithkline Beecham Corp N,n-dietil-8,8-dipropil-2-azaspiro(4,5)decano-2-propan amina dimaleato
US6025364A (en) * 1996-05-17 2000-02-15 Anormed, Inc. Method of treating asthma

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4963557A (en) * 1987-09-28 1990-10-16 Smithkline Beecham Corporation Immunomodulatory azaspiranes
ZA921120B (en) * 1991-02-19 1993-01-27 Smithkline Beecham Corp Cytokine inhibitors
GB9201803D0 (en) * 1992-01-28 1992-03-11 Smithkline Beecham Corp Methods
GB9201804D0 (en) * 1992-01-28 1992-03-11 Smithkline Beecham Corp Methods
GB9315306D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
GB9315351D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
GB9315298D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods

Also Published As

Publication number Publication date
JPH09500648A (ja) 1997-01-21
WO1995003042A1 (en) 1995-02-02
GB9315340D0 (en) 1993-09-08
EP0711160A1 (en) 1996-05-15
CN1130871A (zh) 1996-09-11
NZ269991A (en) 1999-07-29
AU7370994A (en) 1995-02-20
EP0711160A4 (en) 1998-09-09
ZA945418B (en) 1995-05-10

Similar Documents

Publication Publication Date Title
Datema et al. Antiviral efficacy in vivo of the anti-human immunodeficiency virus bicyclam SDZ SID 791 (JM 3100), an inhibitor of infectious cell entry
GB2170707A (en) An immuno-regulator
CA2060474C (en) Pharmaceutical use
CA1261272A (en) Dihydropyridine combination product
CA2167842A1 (en) Method of inhibiting the replication of human immunodeficiency viruses with substituted azaspiranes
WO1994022307A1 (en) Suppresion of hiv expression by organic thiophosphate
CA1120400A (en) Method of treating hypertension and medicaments therefor
EP1161255A2 (en) Methods and compositions for treating erectile dysfunction
WO1995003041A1 (en) Method of inhibiting the production of human immunodeficiency viruses with substituted azaspiranes
CA2167843A1 (en) Method of treating hiv with azaspiranes
PT605700E (pt) Composicao farmacutica a base de flavopereirina e sua utilizacao no tratamento contra o virus hiv
US5482959A (en) Method for delaying aids in an HIV infected individual by administration of substituted azaspirane compounds
WO1993014760A2 (en) Methods
NL8700191A (nl) Immunosuppressieve middelen, farmaceutische preparaten die ze bevatten en het toepassen van deze middelen.
AU652583B2 (en) Methods
WO1993014771A1 (en) Macrocyclic compounds in the prophylactic treatment of aids
Prochaska et al. Inhibition of human immunodeficiency virus type 1 replication by 7-methyl-6, 8-bis (methylthio) pyrrolo [1, 2-a] pyrazine, an in vivo metabolite of oltipraz.
JP2545279B2 (ja) 血小板減少予防及び治療剤
JPH09500647A (ja) 置換アザスピランによるヒト免疫不全ウイルス産生の阻害法
AU684384B2 (en) Method of treating opportunistic infections with azaspiranes
GB2235382A (en) Pharmaceutical composition for use against hypertension and congestive heart failure

Legal Events

Date Code Title Description
FZDE Dead