CA2160877A1 - Traitement prolonge grace a la liberation-retard d'oligodesoxyribonucleotides antisens a partir de microparticules biodegradables - Google Patents
Traitement prolonge grace a la liberation-retard d'oligodesoxyribonucleotides antisens a partir de microparticules biodegradablesInfo
- Publication number
- CA2160877A1 CA2160877A1 CA 2160877 CA2160877A CA2160877A1 CA 2160877 A1 CA2160877 A1 CA 2160877A1 CA 2160877 CA2160877 CA 2160877 CA 2160877 A CA2160877 A CA 2160877A CA 2160877 A1 CA2160877 A1 CA 2160877A1
- Authority
- CA
- Canada
- Prior art keywords
- antisense
- microparticle
- oligodeoxyribonucleotide
- lactic acid
- poly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4767293A | 1993-04-19 | 1993-04-19 | |
US08/047,672 | 1993-04-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2160877A1 true CA2160877A1 (fr) | 1994-10-27 |
Family
ID=21950303
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA 2160877 Abandoned CA2160877A1 (fr) | 1993-04-19 | 1994-04-19 | Traitement prolonge grace a la liberation-retard d'oligodesoxyribonucleotides antisens a partir de microparticules biodegradables |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0695170A4 (fr) |
JP (1) | JPH08511418A (fr) |
AU (1) | AU6637394A (fr) |
CA (1) | CA2160877A1 (fr) |
NZ (1) | NZ265555A (fr) |
WO (1) | WO1994023699A1 (fr) |
Families Citing this family (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6911216B1 (en) | 1994-10-12 | 2005-06-28 | Genzyme Corporation | Targeted delivery via biodegradable polymers |
NZ311175A (en) * | 1995-07-03 | 1999-11-29 | Koken Co | Gene preparation comprising a gene incorporated into a biocompatible carrier which preferably contains collagen |
AU714584B2 (en) | 1995-07-21 | 2000-01-06 | Brown University Research Foundation | A method for gene therapy using nucleic acid loaded polymeric microparticles |
US6143211A (en) * | 1995-07-21 | 2000-11-07 | Brown University Foundation | Process for preparing microparticles through phase inversion phenomena |
US6248720B1 (en) | 1996-07-03 | 2001-06-19 | Brown University Research Foundation | Method for gene therapy using nucleic acid loaded polymeric microparticles |
US6265389B1 (en) | 1995-08-31 | 2001-07-24 | Alkermes Controlled Therapeutics, Inc. | Microencapsulation and sustained release of oligonucleotides |
WO1997014440A1 (fr) * | 1995-10-19 | 1997-04-24 | Johnson & Johnson Interventional Systems | Conjugaison d'oligonucleotides anti-sens c-myc avec le cholesterol pour renforcer de maniere importante leur effet inhibiteur sur l'hyperplasie de la neo-intima |
US6270795B1 (en) | 1995-11-09 | 2001-08-07 | Microbiological Research Authority | Method of making microencapsulated DNA for vaccination and gene therapy |
EP0965336A1 (fr) | 1995-11-09 | 1999-12-22 | Microbiological Research Authority | ADN microencapsulé s'appliquant dans des procédés de thérapie génique |
GB9607035D0 (en) * | 1996-04-03 | 1996-06-05 | Andaris Ltd | Spray-dried microparticles as therapeutic vehicles |
US6143037A (en) * | 1996-06-12 | 2000-11-07 | The Regents Of The University Of Michigan | Compositions and methods for coating medical devices |
PT1005374E (pt) * | 1997-01-22 | 2007-07-18 | Mgi Pharma Biolog Inc | Micropartículas para administração de ácido nucleico |
US5783567A (en) * | 1997-01-22 | 1998-07-21 | Pangaea Pharmaceuticals, Inc. | Microparticles for delivery of nucleic acid |
US6406719B1 (en) | 1998-05-13 | 2002-06-18 | Microbiological Research Authority | Encapsulation of bioactive agents |
GB9810236D0 (en) | 1998-05-13 | 1998-07-08 | Microbiological Res Authority | Improvements relating to encapsulation of bioactive agents |
WO1999065531A1 (fr) | 1998-06-18 | 1999-12-23 | Johns Hopkins University School Of Medicine | Methodes et reactifs d'administration intramusculaire d'acides nucleiques |
US6916490B1 (en) | 1998-07-23 | 2005-07-12 | UAB Research Center | Controlled release of bioactive substances |
US6537585B1 (en) | 1999-03-26 | 2003-03-25 | Guilford Pharmaceuticals, Inc. | Methods and compositions for treating solid tumors |
ATE309788T1 (de) * | 2000-12-13 | 2005-12-15 | Merckle Gmbh | Mikropartikel mit verbessertem freisetzungsprofil und verfahren zu deren herstellung |
GB0719367D0 (en) | 2007-10-03 | 2007-11-14 | Procarta Biosystems Ltd | Transcription factor decoys, compositions and methods |
GB0906130D0 (en) * | 2008-10-03 | 2009-05-20 | Procrata Biosystems Ltd | Transcription factor decoys |
GB201002413D0 (en) | 2010-02-12 | 2010-03-31 | Procarta Biosystems Ltd | Nucleic acid complexes |
GB201005545D0 (en) | 2010-04-01 | 2010-05-19 | Procarta Biosystems Ltd | Transcription factor decoys |
US10323279B2 (en) | 2012-08-14 | 2019-06-18 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US9567631B2 (en) | 2012-12-14 | 2017-02-14 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US9701998B2 (en) | 2012-12-14 | 2017-07-11 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US10400280B2 (en) | 2012-08-14 | 2019-09-03 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
KR102090851B1 (ko) | 2012-08-14 | 2020-03-19 | 10엑스 제노믹스, 인크. | 마이크로캡슐 조성물 및 방법 |
US9951386B2 (en) | 2014-06-26 | 2018-04-24 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US10273541B2 (en) | 2012-08-14 | 2019-04-30 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US11591637B2 (en) | 2012-08-14 | 2023-02-28 | 10X Genomics, Inc. | Compositions and methods for sample processing |
US10221442B2 (en) | 2012-08-14 | 2019-03-05 | 10X Genomics, Inc. | Compositions and methods for sample processing |
US10752949B2 (en) | 2012-08-14 | 2020-08-25 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
CN104981236B (zh) * | 2012-09-27 | 2019-01-22 | 珠海圣美生物诊断技术有限公司 | 刺激敏感性微粒和使用方法 |
US10533221B2 (en) | 2012-12-14 | 2020-01-14 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
CN108753766A (zh) | 2013-02-08 | 2018-11-06 | 10X基因组学有限公司 | 多核苷酸条形码生成 |
CN106413896B (zh) | 2014-04-10 | 2019-07-05 | 10X基因组学有限公司 | 用于封装和分割试剂的流体装置、系统和方法及其应用 |
EP3889325A1 (fr) | 2014-06-26 | 2021-10-06 | 10X Genomics, Inc. | Procédés d'analyse d'acides nucléiques provenant de cellules individuelles ou de populations de cellules |
MX2017005267A (es) | 2014-10-29 | 2017-07-26 | 10X Genomics Inc | Metodos y composiciones para la secuenciacion de acidos nucleicos seleccionados como diana. |
US9975122B2 (en) | 2014-11-05 | 2018-05-22 | 10X Genomics, Inc. | Instrument systems for integrated sample processing |
AU2016207023B2 (en) | 2015-01-12 | 2019-12-05 | 10X Genomics, Inc. | Processes and systems for preparing nucleic acid sequencing libraries and libraries prepared using same |
WO2016137973A1 (fr) | 2015-02-24 | 2016-09-01 | 10X Genomics Inc | Procédés et systèmes de traitement de cloisonnement |
EP3262188B1 (fr) | 2015-02-24 | 2021-05-05 | 10X Genomics, Inc. | Procédés pour la couverture ciblée de séquences d'acides nucléiques |
WO2017024111A1 (fr) | 2015-08-04 | 2017-02-09 | The University Of Chicago | Inhibiteurs du site d'entrée interne des ribosomes (ires) cacna1a/alpha1a et procédés de traitement de l'ataxie spinocérébelleuse type 6 |
CN108368522A (zh) * | 2015-10-20 | 2018-08-03 | 10X 基因组学有限公司 | 用于高通量单细胞遗传操作的方法和系统 |
JP6954899B2 (ja) | 2015-12-04 | 2021-10-27 | 10エックス ゲノミクス,インコーポレイテッド | 核酸の解析のための方法及び組成物 |
US10548881B2 (en) | 2016-02-23 | 2020-02-04 | Tarveda Therapeutics, Inc. | HSP90 targeted conjugates and particles and formulations thereof |
WO2017197338A1 (fr) | 2016-05-13 | 2017-11-16 | 10X Genomics, Inc. | Systèmes microfluidiques et procédés d'utilisation |
US10011872B1 (en) | 2016-12-22 | 2018-07-03 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US10815525B2 (en) | 2016-12-22 | 2020-10-27 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
US10550429B2 (en) | 2016-12-22 | 2020-02-04 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
WO2018140966A1 (fr) | 2017-01-30 | 2018-08-02 | 10X Genomics, Inc. | Procédés et systèmes de codage à barres de cellules individuelles sur la base de gouttelettes |
CN109526228B (zh) | 2017-05-26 | 2022-11-25 | 10X基因组学有限公司 | 转座酶可接近性染色质的单细胞分析 |
US20180340169A1 (en) | 2017-05-26 | 2018-11-29 | 10X Genomics, Inc. | Single cell analysis of transposase accessible chromatin |
SG11201913654QA (en) | 2017-11-15 | 2020-01-30 | 10X Genomics Inc | Functionalized gel beads |
US10829815B2 (en) | 2017-11-17 | 2020-11-10 | 10X Genomics, Inc. | Methods and systems for associating physical and genetic properties of biological particles |
EP3775271A1 (fr) | 2018-04-06 | 2021-02-17 | 10X Genomics, Inc. | Systèmes et procédés de contrôle de qualité dans un traitement de cellules uniques |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3887699A (en) * | 1969-03-24 | 1975-06-03 | Seymour Yolles | Biodegradable polymeric article for dispensing drugs |
US4389330A (en) * | 1980-10-06 | 1983-06-21 | Stolle Research And Development Corporation | Microencapsulation process |
US4919929A (en) * | 1984-02-01 | 1990-04-24 | Stolle Research & Development Corporation | Mammal immunization |
US4542025A (en) * | 1982-07-29 | 1985-09-17 | The Stolle Research And Development Corporation | Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents |
US4945050A (en) * | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
EP0248531A3 (fr) * | 1986-05-02 | 1988-09-28 | Southern Research Institute | Acides nucléiques encapsulés |
US4962091A (en) * | 1986-05-23 | 1990-10-09 | Syntex (U.S.A.) Inc. | Controlled release of macromolecular polypeptides |
US5171217A (en) * | 1991-02-28 | 1992-12-15 | Indiana University Foundation | Method for delivery of smooth muscle cell inhibitors |
JPH07501204A (ja) * | 1991-06-28 | 1995-02-09 | マサチューセッツ インスティテュート オブ テクノロジー | 局所的オリゴヌクレオチド療法 |
-
1994
- 1994-04-19 AU AU66373/94A patent/AU6637394A/en not_active Abandoned
- 1994-04-19 JP JP6523540A patent/JPH08511418A/ja active Pending
- 1994-04-19 WO PCT/US1994/004287 patent/WO1994023699A1/fr not_active Application Discontinuation
- 1994-04-19 CA CA 2160877 patent/CA2160877A1/fr not_active Abandoned
- 1994-04-19 EP EP94914216A patent/EP0695170A4/fr not_active Withdrawn
- 1994-04-19 NZ NZ26555594A patent/NZ265555A/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP0695170A4 (fr) | 1998-08-19 |
NZ265555A (en) | 1997-09-22 |
AU6637394A (en) | 1994-11-08 |
EP0695170A1 (fr) | 1996-02-07 |
WO1994023699A1 (fr) | 1994-10-27 |
JPH08511418A (ja) | 1996-12-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |