CA2159070A1 - Cyclic compounds useful as inhibitors of platelet glycoprotein iib/iiia - Google Patents

Cyclic compounds useful as inhibitors of platelet glycoprotein iib/iiia

Info

Publication number
CA2159070A1
CA2159070A1 CA002159070A CA2159070A CA2159070A1 CA 2159070 A1 CA2159070 A1 CA 2159070A1 CA 002159070 A CA002159070 A CA 002159070A CA 2159070 A CA2159070 A CA 2159070A CA 2159070 A1 CA2159070 A1 CA 2159070A1
Authority
CA
Canada
Prior art keywords
alkyl
asp
substituted
compound
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002159070A
Other languages
English (en)
French (fr)
Inventor
William Frank Degrado
Sharon Anne Jackson
Shaker Ahmed Mousa
Anju Parthasarathy
Michael Sworin
Maria Rafalski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Pharma Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2159070A1 publication Critical patent/CA2159070A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA002159070A 1993-03-29 1994-03-28 Cyclic compounds useful as inhibitors of platelet glycoprotein iib/iiia Abandoned CA2159070A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3844893A 1993-03-29 1993-03-29
US08/038,448 1993-03-29

Publications (1)

Publication Number Publication Date
CA2159070A1 true CA2159070A1 (en) 1994-10-13

Family

ID=21900014

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002159070A Abandoned CA2159070A1 (en) 1993-03-29 1994-03-28 Cyclic compounds useful as inhibitors of platelet glycoprotein iib/iiia

Country Status (10)

Country Link
EP (1) EP0691987A1 (ja)
JP (1) JPH08508498A (ja)
AU (1) AU6415894A (ja)
CA (1) CA2159070A1 (ja)
FI (1) FI954556A0 (ja)
HU (1) HUT72896A (ja)
NO (1) NO953832L (ja)
NZ (1) NZ263456A (ja)
PL (1) PL310896A1 (ja)
WO (1) WO1994022910A1 (ja)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU682857B2 (en) * 1993-03-29 1997-10-23 Du Pont Pharmaceuticals Company Novel processes and intermediate compounds for the preparation of platelet clycoprotein IIb/IIIa inhibitors
US5879657A (en) * 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
AP1390A (en) * 1996-11-27 2005-04-15 Aventis Pharmaceuticals Products Inc Pharmaceutical composition comprising a compound having anti-Xa activity and a platelet aggregation antagonist compound.
US6010911A (en) * 1997-04-30 2000-01-04 Medtronic, Inc. Apparatus for performing a heparin-independent high sensitivity platelet function evaluation technique
US6537520B1 (en) 1998-03-31 2003-03-25 Bristol-Myers Squibb Pharma Company Pharmaceuticals for the imaging of angiogenic disorders
GB0623607D0 (en) 2006-11-27 2007-01-03 Haemostatix Ltd Tissue adhesive
JP5649825B2 (ja) 2007-01-31 2015-01-07 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド 安定化させたｐ５３ペプチドおよびその使用法
ES2430067T3 (es) 2007-03-28 2013-11-18 President And Fellows Of Harvard College Polipéptidos cosidos
NZ599899A (en) 2009-11-10 2014-10-31 Allegro Pharmaceuticals Inc Compositions and methods for inhibiting cellular adhesion or directing diagnostic or therapeutic agents to rgd binding sites
US11673914B2 (en) 2009-11-10 2023-06-13 Allegro Pharmaceuticals, LLC Peptide therapies for reduction of macular thickening
KR20170058446A (ko) 2010-08-13 2017-05-26 에일러론 테라퓨틱스 인코포레이티드 펩티도미메틱 거대고리
ES2820855T3 (es) 2011-05-09 2021-04-22 Allegro Pharmaceuticals Llc Antagonistas del receptor de integrina y sus métodos de uso
RU2639523C2 (ru) 2011-10-18 2017-12-21 Эйлерон Терапьютикс, Инк. Пептидомиметические макроциклы и их применение
CA2864120A1 (en) 2012-02-15 2013-08-22 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
CA2862038C (en) 2012-02-15 2021-05-25 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
JP6526563B2 (ja) 2012-11-01 2019-06-05 エイルロン セラピューティクス，インコーポレイテッド 二置換アミノ酸ならびにその調製および使用の方法
CA2961029A1 (en) 2014-09-24 2016-03-31 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and formulations thereof
MX2017003797A (es) 2014-09-24 2017-06-15 Aileron Therapeutics Inc Macrociclos peptidomimeticos y usos de los mismos.
CN107614003A (zh) 2015-03-20 2018-01-19 艾瑞朗医疗公司 拟肽大环化合物及其用途
US10023613B2 (en) 2015-09-10 2018-07-17 Aileron Therapeutics, Inc. Peptidomimetic macrocycles as modulators of MCL-1

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2636066B1 (fr) * 1988-09-02 1991-10-25 Centre Nat Rech Scient Derives de cyclopeptides, utilisables comme inhibiteurs selectifs vis-a-vis de proteases a serine active
US5384309A (en) * 1989-07-17 1995-01-24 Genentech, Inc. Cyclized peptides and their use as platelet aggregation inhibitors
AU6470590A (en) * 1989-10-23 1991-04-26 Smithkline Beecham Corporation Cyclic anti-aggregatory peptides
IL103252A (en) * 1991-09-30 1997-03-18 Du Pont Merck Pharma CYCLIC COMPOUNDS USEFUL AS INHIBITORS OF PLATELET GLYCOPROTEIN IIb/IIIa AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Also Published As

Publication number Publication date
HU9502832D0 (en) 1995-11-28
NZ263456A (en) 1996-11-26
HUT72896A (en) 1996-06-28
FI954556A (fi) 1995-09-26
NO953832D0 (no) 1995-09-28
EP0691987A1 (en) 1996-01-17
JPH08508498A (ja) 1996-09-10
FI954556A0 (fi) 1995-09-26
WO1994022910A1 (en) 1994-10-13
PL310896A1 (en) 1996-01-08
NO953832L (no) 1995-11-28
AU6415894A (en) 1994-10-24

Similar Documents

Publication Publication Date Title
CA2159070A1 (en) Cyclic compounds useful as inhibitors of platelet glycoprotein iib/iiia
AU672178B2 (en) Cyclic compounds useful as inhibitors of platelet glycoprotein IIb/IIIa
Koivunen et al. Phage libraries displaying cyclic peptides with different ring sizes: ligand specificities of the RGD-directed integrins
EP0692982B1 (en) RADIOLABELED PLATELET GPIIb/IIIa RECEPTOR ANTAGONISTS AS IMAGING AGENTS FOR THE DIAGNOSIS OF THROMBOEMBOLIC DISORDERS
RU2157379C2 (ru) Циклопептиды, способ их получения, содержащая их фармацевтическая композиция, способ ее получения
US5635477A (en) Cyclic compounds useful as inhibitors of platelet glycoprotein IIB/IIIA
CZ397991A3 (en) Cyclic anti-aggregation peptides
US5693612A (en) Cyclopeptides of the formula I
US5849693A (en) Cyclic compounds linked by a heterocyclic ring useful as inhibitors of platelet glycoprotein IIb/IIIa
US6056958A (en) Method of treatment of arterial and venous thromboembolic disorders
WO1995023811A1 (en) Novel carbocyclic compounds which inhibit platelet aggregation by interaction with the gpiib/iiia receptor complex
NZ265753A (en) Preparation of platelet glycoprotein iib/iiia inhibitors containing methylarginine
US5817749A (en) Processes and intermediate compounds for the preparation of platelet glycoprotein IIb/IIIa inhibitors
RU2096415C1 (ru) Циклические пептиды или их фармацевтически приемлемые соли, фармацевтическая композиция
AU6663794A (en) Processes and intermediate compounds useful for the preparation of platelet glycoprotein iib/iiia inhibitors

Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead