CA2155320A1 - Derive de substitution de l'acetamide - Google Patents

Derive de substitution de l'acetamide

Info

Publication number
CA2155320A1
CA2155320A1 CA 2155320 CA2155320A CA2155320A1 CA 2155320 A1 CA2155320 A1 CA 2155320A1 CA 2155320 CA2155320 CA 2155320 CA 2155320 A CA2155320 A CA 2155320A CA 2155320 A1 CA2155320 A1 CA 2155320A1
Authority
CA
Canada
Prior art keywords
methyl
nmr
ethyl
mass
hydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA 2155320
Other languages
English (en)
Inventor
Youichi Shiokawa
Kiyoshi Taniguchi
Kazuhiko Take
Kazunori Tsubaki
Hiroaki Mizuno
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2155320A1 publication Critical patent/CA2155320A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA 2155320 1992-02-05 1993-02-04 Derive de substitution de l'acetamide Abandoned CA2155320A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9202443.9 1992-02-05
GB929202443A GB9202443D0 (en) 1992-02-05 1992-02-05 A novel substituted-acetamide compound and a process for the preparation thereof

Publications (1)

Publication Number Publication Date
CA2155320A1 true CA2155320A1 (fr) 1993-08-19

Family

ID=10709880

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2155320 Abandoned CA2155320A1 (fr) 1992-02-05 1993-02-04 Derive de substitution de l'acetamide

Country Status (3)

Country Link
CA (1) CA2155320A1 (fr)
GB (1) GB9202443D0 (fr)
WO (1) WO1993016048A1 (fr)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6140333A (en) * 1998-02-04 2000-10-31 Banyu Pharmaceutical Co Ltd N-acyl cyclic amine derivatives
EP1302458A1 (fr) * 2000-07-11 2003-04-16 Banyu Pharmaceutical Co., Ltd. Derives d'ester
WO2004005285A1 (fr) * 2002-07-02 2004-01-15 Almirall Prodesfarma Ag Derives de quinuclidine amide
WO2004089364A1 (fr) * 2003-04-11 2004-10-21 Ranbaxy Laboratories Limited Derives d’azabicyclo en tant qu’antagonistes des recepteurs muscariniques
US7208501B2 (en) 2000-12-22 2007-04-24 Almirall Prodesfarma Ag Quinuclidine carbamate derivatives and their use as M3 antagonists
EA009942B1 (ru) * 2002-07-08 2008-04-28 Рэнбакси Лабораториз Лтд. Азабициклические производные в качестве антагонистов мускаринового рецептора
US7435742B2 (en) 2002-06-21 2008-10-14 Laboratorios Almirall S.A. Quinuclidine derivatives and pharmaceutical compositions containing the same
US7517905B2 (en) 2003-04-09 2009-04-14 Ranbaxy Laboratories Limited Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
WO2015181837A3 (fr) * 2014-05-30 2016-02-18 Sphaera Pharma Pvt. Ltd. Nouveaux composés utilisés comme agents anti-tuberculeux

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9122988D0 (en) * 1991-10-30 1991-12-18 Ici Plc Heterocyclic compounds
CA2093778A1 (fr) * 1992-04-10 1993-10-11 George R. Brown Composes heterocycliques
GB9211796D0 (en) * 1992-06-04 1992-07-15 Ici Plc Heterocyclic derivatives
GB9216721D0 (en) * 1992-08-06 1992-09-23 Ici Plc Therapeutic heterocyclic derivatives
GB9218334D0 (en) * 1992-08-28 1992-10-14 Ici Plc Heterocyclic compounds
GB9226573D0 (en) * 1992-12-21 1993-02-17 Ici Plc Heterocyclic compounds
AU7545894A (en) * 1993-09-02 1995-03-22 Yamanouchi Pharmaceutical Co., Ltd. Carbamate derivative and medicine containing the same
NO2005012I1 (no) 1994-12-28 2005-06-06 Debio Rech Pharma Sa Triptorelin og farmasoytisk akseptable salter derav
KR19990008109A (ko) * 1995-04-28 1999-01-25 나가사까 겐지로 1,4-이치환 피페리딘 유도체
CA2179574A1 (fr) * 1995-06-26 1996-12-27 Tomomi Okada Derive de substitution de la piperidine et medicament a base de ce derive
KR19990037220A (ko) * 1997-10-31 1999-05-25 타이도 나오카타 아릴아세트산 아미드 유도체 또는 그 염 및 이를 함유하는 의약
AU1185400A (en) * 1998-11-20 2000-06-13 Banyu Pharmaceutical Co., Ltd. 1-acylazetidine derivatives
AU2002368152A1 (en) 2002-07-31 2004-02-25 Ranbaxy Laboratories Limited 3,6-disubstituted azabicyclo (3.1.0)hexane derivatives useful as muscarinic receptor antagonists
EP1545508A4 (fr) 2002-08-09 2009-11-25 Ranbaxy Lab Ltd Derives d'azabicyclo ¬3.1.0 hexane 3,6-disubstitues, utiles en tant qu'agonistes de recepteurs muscariniques
US7288562B2 (en) 2002-08-23 2007-10-30 Ranbaxy Laboratories Limited Fluoro and sulphonylamino containing 3,6-disubstituted azabicyclo (3.1.0) hexane derivatives as muscarinic receptor antagonists
DE60227576D1 (de) 2002-12-10 2008-08-21 Ranbaxy Lab Ltd 3,6-DISUBSTITUIERTE AZABICYCLO i3.1.0 -HEXANDERIVATIVE ALS ANTAGONISTEN DES MUSCARINREZEPTORS
EP1581522B1 (fr) 2002-12-23 2008-02-20 Ranbaxy Laboratories Limited Derives de flavaxate comme antagonistes de recepteurs muscariniques
AU2002347552A1 (en) 2002-12-23 2004-07-14 Ranbaxy Laboratories Limited 1-substituted-3-pyrrolidine derivatives as muscarinic receptor antagonists
US7488748B2 (en) 2003-01-28 2009-02-10 Ranbaxy Laboratories Limited 3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists
AU2003223010A1 (en) 2003-04-10 2004-11-01 Ranbaxy Laboratories Limited Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
DE60313898T2 (de) 2003-04-10 2008-01-17 Ranbaxy Laboratories, Ltd. Substituierte azabicyclo hexane derivate als muscarin rezeptor antagonisten
WO2007045979A1 (fr) 2005-10-19 2007-04-26 Ranbaxy Laboratories Limited Compositions pharmaceutiques d'antagonistes du recepteur muscarinique

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1220937B (it) * 1979-05-30 1990-06-21 Italiana Schoum Spa Composti spasmolitici analoghi della fenpiramina
US5066680A (en) * 1989-02-14 1991-11-19 Fujisawa Pharmaceutical Co., Ltd. Novel substituted-acetamide compound and a process for the preparation thereof

Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6140333A (en) * 1998-02-04 2000-10-31 Banyu Pharmaceutical Co Ltd N-acyl cyclic amine derivatives
EP1302458A1 (fr) * 2000-07-11 2003-04-16 Banyu Pharmaceutical Co., Ltd. Derives d'ester
EP1302458A4 (fr) * 2000-07-11 2005-10-19 Banyu Pharma Co Ltd Derives d'ester
US7208501B2 (en) 2000-12-22 2007-04-24 Almirall Prodesfarma Ag Quinuclidine carbamate derivatives and their use as M3 antagonists
US7776879B2 (en) 2000-12-22 2010-08-17 Almirall, S.A. Quinuclidine carbamate derivatives and their use as M3 antagonists
US7312231B2 (en) 2000-12-22 2007-12-25 Almirall Prodesfarma Ag Quinuclidine carbamate derivatives and their use as M3 antagonists
US7435742B2 (en) 2002-06-21 2008-10-14 Laboratorios Almirall S.A. Quinuclidine derivatives and pharmaceutical compositions containing the same
ES2204295A1 (es) * 2002-07-02 2004-04-16 Almirall Prodesfarma, S.A. Nuevos derivados de quinuclidina-amida.
ES2204295B1 (es) * 2002-07-02 2005-08-01 Almirall Prodesfarma, S.A. Nuevos derivados de quinuclidina-amida.
US7718670B2 (en) 2002-07-02 2010-05-18 Laboratorios Almirall S.A Quinuclidine amide derivatives
AU2003242757B2 (en) * 2002-07-02 2009-01-08 Laboratorios Almirall, S.A. New quinuclidine amide derivatives
WO2004005285A1 (fr) * 2002-07-02 2004-01-15 Almirall Prodesfarma Ag Derives de quinuclidine amide
US7488735B2 (en) 2002-07-02 2009-02-10 Laboratorios Almirall S.A. Quinuclidine amide derivatives
US7399779B2 (en) 2002-07-08 2008-07-15 Ranbaxy Laboratories Limited 3,6-disubstituted azabicyclo [3.1.0] hexane derivatives useful as muscarinic receptor antagonists
US7544708B2 (en) 2002-07-08 2009-06-09 Ranbaxy Laboratories Limited Azabicyclo derivatives as muscarinic receptor antagonists
EA009942B1 (ru) * 2002-07-08 2008-04-28 Рэнбакси Лабораториз Лтд. Азабициклические производные в качестве антагонистов мускаринового рецептора
US7517905B2 (en) 2003-04-09 2009-04-14 Ranbaxy Laboratories Limited Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
US7446123B2 (en) 2003-04-11 2008-11-04 Ranbaxy Laboratories Limited Azabicyclo derivatives as muscarinic receptor antagonists
WO2004089364A1 (fr) * 2003-04-11 2004-10-21 Ranbaxy Laboratories Limited Derives d’azabicyclo en tant qu’antagonistes des recepteurs muscariniques
WO2015181837A3 (fr) * 2014-05-30 2016-02-18 Sphaera Pharma Pvt. Ltd. Nouveaux composés utilisés comme agents anti-tuberculeux
US10100012B2 (en) 2014-05-30 2018-10-16 Sphaera Pharma Pvt. Ltd. Compounds as anti-tubercular agents
US10207993B2 (en) 2014-05-30 2019-02-19 Sphaera Pharma Pvt. Ltd. Compounds as anti-tubercular agents

Also Published As

Publication number Publication date
WO1993016048A1 (fr) 1993-08-19
GB9202443D0 (en) 1992-03-18

Similar Documents

Publication Publication Date Title
CA2155320A1 (fr) Derive de substitution de l'acetamide
AU678023B2 (en) Substituted pyrrolidin-3-yl-alkyl-piperidines useful as tachykinin antagonists
US5340822A (en) Polycyclic amine compounds and their enantiomers, their method of preparation and pharmaceutical compositions in which they are present
US6037352A (en) Muscarinic antagonists
FI114470B (fi) Uusia allergisten sairauksien hoidossa käyttökelpoisia substituoituja piperidiinejä
US5270328A (en) Peripherally selective piperidine opioid antagonists
RU2089547C1 (ru) Производные n-алкиленпиперидина, способ их получения, фармацевтическая композиция на их основе, оптически чистые производные n-алкиленпиперидина
DE60123420T2 (de) Cyclohexylderivate und ihre anwendung als therapeutische mittel
DE68920482T2 (de) 1-Indolylalkyl-4-(substituierte Pyridinyl)-Piperazine.
AU675786B2 (en) Azacyclic compounds
EP0506468B1 (fr) Antagonistes opioides de 4-phénylpipéridine-N-substituée
AU675447B2 (en) Carboxamidomethyl piperidine and analogues
AU2005202257B2 (en) Azacyclic compounds for use in the treatment of serotonin related diseases
DE69400824T2 (de) Indol-derivate als 5-ht1-ähnliche antagonisten zur behandlung von migräne
US7601868B2 (en) Amine derivative
TW531537B (en) 1-(1,2-disubstituted piperidinyl)-4-substituted piperidine derivatives
KR100904829B1 (ko) 4-아미노피페리딘 유도체
US8293770B2 (en) Pyrrolidine derivatives as NK-3 receptor antagonists
HRP970426A2 (en) Fluorine containing 1,4-disubstituted piperidine derivatives
KR20060094079A (ko) Ｎ-[페닐(피페리딘-2-일)메틸]벤즈아미드의 유도체, 그의제조 방법 및 치료법에서의 그의 용도
CZ293134B6 (cs) Substituované heterocyklické sloučeniny, způsob jejich přípravy, meziprodukty tohoto způsobu a farmaceutický prostředek obsahující tyto sloučeniny
AU2001256509A1 (en) Cyclohexane derivatives and their use as therapeutic agents
SI9300513A (en) Basic quaternary amids, procedure for their preparation and pharmaceutical compositions comprising them
NO303448B1 (no) 1-acylpiperidinforbindelser, deres anvendelse for fremstilling av legemidler samt legemidler inneholdende dem
US5556860A (en) Quinazolinone derivatives possessing calcium uptake inhibiting activity

Legal Events

Date Code Title Description
FZDE Dead