CA2150256A1 - Method of producing .alpha.,.alpha.-trehalose - Google Patents
Method of producing .alpha.,.alpha.-trehaloseInfo
- Publication number
- CA2150256A1 CA2150256A1 CA 2150256 CA2150256A CA2150256A1 CA 2150256 A1 CA2150256 A1 CA 2150256A1 CA 2150256 CA2150256 CA 2150256 CA 2150256 A CA2150256 A CA 2150256A CA 2150256 A1 CA2150256 A1 CA 2150256A1
- Authority
- CA
- Canada
- Prior art keywords
- alpha
- trehalose
- membrane
- ethanol
- microfiltration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000000034 method Methods 0.000 title claims abstract description 22
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 title claims abstract description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 41
- 239000012528 membrane Substances 0.000 claims abstract description 22
- 238000000108 ultra-filtration Methods 0.000 claims abstract description 18
- 238000001914 filtration Methods 0.000 claims abstract description 15
- 238000001471 micro-filtration Methods 0.000 claims abstract description 15
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims abstract description 14
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims abstract description 14
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract description 12
- 238000000926 separation method Methods 0.000 claims abstract description 10
- 239000011148 porous material Substances 0.000 claims abstract description 8
- 150000002500 ions Chemical class 0.000 claims abstract description 7
- 238000002955 isolation Methods 0.000 claims abstract description 7
- 238000004519 manufacturing process Methods 0.000 claims abstract description 7
- 229920001577 copolymer Polymers 0.000 claims abstract description 6
- 150000001450 anions Chemical class 0.000 claims abstract description 5
- 150000001768 cations Chemical class 0.000 claims abstract description 4
- 239000007787 solid Substances 0.000 claims abstract description 4
- 239000002253 acid Substances 0.000 claims abstract description 3
- 238000005115 demineralization Methods 0.000 claims abstract description 3
- 230000002328 demineralizing effect Effects 0.000 claims abstract description 3
- 238000005374 membrane filtration Methods 0.000 claims abstract description 3
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 claims abstract description 3
- 239000000469 ethanolic extract Substances 0.000 claims description 2
- 150000002016 disaccharides Chemical class 0.000 abstract description 5
- 239000002994 raw material Substances 0.000 abstract description 5
- 235000013305 food Nutrition 0.000 abstract description 4
- 239000000284 extract Substances 0.000 abstract description 2
- 238000000605 extraction Methods 0.000 abstract description 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N neotrehalose Chemical compound OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 abstract description 2
- UEEJHVSXFDXPFK-UHFFFAOYSA-N N-dimethylaminoethanol Chemical group CN(C)CCO UEEJHVSXFDXPFK-UHFFFAOYSA-N 0.000 abstract 1
- DPVHGFAJLZWDOC-PVXXTIHASA-N (2r,3s,4s,5r,6r)-2-(hydroxymethyl)-6-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxane-3,4,5-triol;dihydrate Chemical compound O.O.O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DPVHGFAJLZWDOC-PVXXTIHASA-N 0.000 description 23
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 15
- 239000000243 solution Substances 0.000 description 9
- 239000000706 filtrate Substances 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 238000002425 crystallisation Methods 0.000 description 5
- 230000008025 crystallization Effects 0.000 description 5
- 239000006188 syrup Substances 0.000 description 5
- 235000020357 syrup Nutrition 0.000 description 5
- 229940074410 trehalose Drugs 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 239000000047 product Substances 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 3
- OILXMJHPFNGGTO-UHFFFAOYSA-N (22E)-(24xi)-24-methylcholesta-5,22-dien-3beta-ol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)C=CC(C)C(C)C)C1(C)CC2 OILXMJHPFNGGTO-UHFFFAOYSA-N 0.000 description 2
- RQOCXCFLRBRBCS-UHFFFAOYSA-N (22E)-cholesta-5,7,22-trien-3beta-ol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CCC(C)C)CCC33)C)C3=CC=C21 RQOCXCFLRBRBCS-UHFFFAOYSA-N 0.000 description 2
- OQMZNAMGEHIHNN-UHFFFAOYSA-N 7-Dehydrostigmasterol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CC(CC)C(C)C)CCC33)C)C3=CC=C21 OQMZNAMGEHIHNN-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- DNVPQKQSNYMLRS-NXVQYWJNSA-N Ergosterol Natural products CC(C)[C@@H](C)C=C[C@H](C)[C@H]1CC[C@H]2C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@@H]3CC[C@]12C DNVPQKQSNYMLRS-NXVQYWJNSA-N 0.000 description 2
- 238000002242 deionisation method Methods 0.000 description 2
- 230000003544 deproteinization Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- DNVPQKQSNYMLRS-SOWFXMKYSA-N ergosterol Chemical compound C1[C@@H](O)CC[C@]2(C)[C@H](CC[C@]3([C@H]([C@H](C)/C=C/[C@@H](C)C(C)C)CC[C@H]33)C)C3=CC=C21 DNVPQKQSNYMLRS-SOWFXMKYSA-N 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 241000195974 Selaginella Species 0.000 description 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 1
- RQPZNWPYLFFXCP-UHFFFAOYSA-L barium dihydroxide Chemical compound [OH-].[OH-].[Ba+2] RQPZNWPYLFFXCP-UHFFFAOYSA-L 0.000 description 1
- 229910001863 barium hydroxide Inorganic materials 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000010805 inorganic waste Substances 0.000 description 1
- 239000005445 natural material Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 229920002492 poly(sulfone) Polymers 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- -1 sulfate anions Chemical class 0.000 description 1
- 238000005292 vacuum distillation Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- 229960001763 zinc sulfate Drugs 0.000 description 1
- 229910000368 zinc sulfate Inorganic materials 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/12—Disaccharides
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CZ932025A CZ281723B6 (cs) | 1993-09-28 | 1993-09-28 | Způsob izolace krystalické alfa, alfa-trehalosy |
| CZPV2025-93 | 1993-09-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2150256A1 true CA2150256A1 (en) | 1995-04-06 |
Family
ID=5464225
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 2150256 Abandoned CA2150256A1 (en) | 1993-09-28 | 1994-09-23 | Method of producing .alpha.,.alpha.-trehalose |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0674717A1 (cs) |
| JP (1) | JPH08506248A (cs) |
| CA (1) | CA2150256A1 (cs) |
| CZ (1) | CZ281723B6 (cs) |
| SK (1) | SK279610B6 (cs) |
| WO (1) | WO1995009243A1 (cs) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1053670C (zh) * | 1997-09-18 | 2000-06-21 | 大连理工大学 | 海藻糖的生产方法 |
| WO2013042587A1 (ja) | 2011-09-21 | 2013-03-28 | 株式会社林原 | α，α－トレハロース二含水結晶含有粉末の製造方法 |
| CN102504040A (zh) * | 2011-11-16 | 2012-06-20 | 华南理工大学 | 一种从生产甾醇后的废弃酵母中提取海藻糖的方法 |
| EP3744853A1 (en) * | 2019-05-29 | 2020-12-02 | Ohly GmbH | Trehalose-rich yeast hydrolysate |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04360692A (ja) * | 1991-06-07 | 1992-12-14 | Kanegafuchi Chem Ind Co Ltd | トレハロースの製造方法 |
| JPH0591890A (ja) * | 1991-08-27 | 1993-04-16 | Kanji Matsumoto | トレハロースの製造方法 |
| JPH05292986A (ja) * | 1992-02-21 | 1993-11-09 | Takeda Chem Ind Ltd | トレハロースの製造法 |
| JPH06145186A (ja) * | 1992-11-05 | 1994-05-24 | Nippon Shokuhin Kako Co Ltd | α，α−トレハロースの製造法 |
| BR9400368A (pt) * | 1993-02-02 | 1994-08-23 | Ajinomoto Kk | Processo para isolamento e purificação de trehalose |
-
1993
- 1993-09-28 CZ CZ932025A patent/CZ281723B6/cs not_active IP Right Cessation
-
1994
- 1994-09-23 EP EP94926769A patent/EP0674717A1/en not_active Withdrawn
- 1994-09-23 WO PCT/CZ1994/000022 patent/WO1995009243A1/en not_active Application Discontinuation
- 1994-09-23 CA CA 2150256 patent/CA2150256A1/en not_active Abandoned
- 1994-09-23 SK SK697-95A patent/SK279610B6/sk unknown
- 1994-09-23 JP JP7510039A patent/JPH08506248A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JPH08506248A (ja) | 1996-07-09 |
| EP0674717A1 (en) | 1995-10-04 |
| SK279610B6 (sk) | 1999-01-11 |
| CZ281723B6 (cs) | 1996-12-11 |
| SK69795A3 (en) | 1996-05-08 |
| CZ202593A3 (en) | 1996-10-16 |
| WO1995009243A1 (en) | 1995-04-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Dead |