CA2147869A1 - Bradykinin antagonists - Google Patents

Bradykinin antagonists

Info

Publication number
CA2147869A1
CA2147869A1 CA002147869A CA2147869A CA2147869A1 CA 2147869 A1 CA2147869 A1 CA 2147869A1 CA 002147869 A CA002147869 A CA 002147869A CA 2147869 A CA2147869 A CA 2147869A CA 2147869 A1 CA2147869 A1 CA 2147869A1
Authority
CA
Canada
Prior art keywords
bkan
pharmacophore
heterodimer
peptide
heterodimer according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002147869A
Other languages
English (en)
French (fr)
Inventor
John C. Cheronis
James K. Blodgett
Val Smith Goodfellow
Manoj V. Marathe
Lyle W. Spruce
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cortech Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2147869A1 publication Critical patent/CA2147869A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/18—Kallidins; Bradykinins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002147869A 1992-11-10 1993-10-29 Bradykinin antagonists Abandoned CA2147869A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97400092A 1992-11-10 1992-11-10
US07/974,000 1992-11-10

Publications (1)

Publication Number Publication Date
CA2147869A1 true CA2147869A1 (en) 1994-05-26

Family

ID=25521455

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002147869A Abandoned CA2147869A1 (en) 1992-11-10 1993-10-29 Bradykinin antagonists

Country Status (11)

Country Link
EP (1) EP0671941A4 (xx)
JP (1) JPH08503460A (xx)
CN (1) CN1094058A (xx)
AU (1) AU5410994A (xx)
CA (1) CA2147869A1 (xx)
IL (1) IL107400A0 (xx)
MX (1) MX9306988A (xx)
NZ (1) NZ257477A (xx)
PL (1) PL304654A1 (xx)
WO (1) WO1994011021A1 (xx)
ZA (1) ZA938014B (xx)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995003308A1 (en) * 1993-07-23 1995-02-02 Toray Industries, Inc. Morphinan derivative and medicinal use
AU6044496A (en) * 1995-06-05 1996-12-24 Cortech, Inc. Compounds having bradykinin antagonistic activity and mu-opi oid agonistic activity
DE69627191T2 (de) * 1995-06-09 2004-01-08 The Regents Of The University Of Michigan, Ann Arbor Bradikininanaloge als selektive thrombininhibitoren
FR2739553B1 (fr) * 1995-10-06 1998-01-02 Oreal Utilisation d'antagonistes de la bradykinine pour stimuler ou induire la pousse des cheveux et/ou stopper leur chute
DE19612067A1 (de) * 1996-03-27 1997-10-02 Hoechst Ag Verwendung von Bradykinin-Antagonisten zur Herstellung von Arzneimitteln zur Behandlung von chronisch fibrogenetischen Lebererkrankungen und akuten Lebererkrankungen
DE19642289A1 (de) 1996-10-14 1998-04-16 Hoechst Ag Verwendung von Bradykinin-Antagonisten zur Herstellung von Arzneimitteln zur Behandlung und Prävention der Alzheimer'schen Krankheit
US6982249B1 (en) 1997-04-23 2006-01-03 The Regents Of The University Of Michigan Bradykinin analogs as selective inhibitors of cell activation
US6359111B1 (en) * 1998-05-28 2002-03-19 Neorx Corporation Opioid receptor targeting
US6716452B1 (en) 2000-08-22 2004-04-06 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
US7060708B2 (en) 1999-03-10 2006-06-13 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
EP2080511A3 (en) * 2000-08-22 2009-09-30 Shire LLC Active agent delivery systems and methods for protecting and administering active agents
WO2003020200A2 (en) 2000-11-16 2003-03-13 New River Pharmaceuticals Inc. A novel pharmaceutical compound and methods of making and using same
EP1357928B1 (en) * 2000-11-16 2011-11-16 Shire LLC A novel pharmaceutical compound and methods of making and using same
AU2001297565B2 (en) * 2000-11-16 2008-06-05 Takeda Pharmaceutical Company Limited A novel pharmaceutical compound and methods of making and using same
US7169752B2 (en) 2003-09-30 2007-01-30 New River Pharmaceuticals Inc. Compounds and compositions for prevention of overdose of oxycodone
US7375082B2 (en) 2002-02-22 2008-05-20 Shire Llc Abuse-resistant hydrocodone compounds
US7338939B2 (en) 2003-09-30 2008-03-04 New River Pharmaceuticals Inc. Abuse-resistant hydrocodone compounds
WO2003072046A2 (en) 2002-02-22 2003-09-04 New River Pharmaceuticals Inc. Novel sustained release pharmaceutical compounds to prevent abuse of controlled substances
US7700561B2 (en) 2002-02-22 2010-04-20 Shire Llc Abuse-resistant amphetamine prodrugs
AR040956A1 (es) 2002-07-31 2005-04-27 Schering Ag Nuevos conjugados de efectores, procedimientos para su preparacion y su uso farmaceutico
JP2006505627A (ja) * 2002-07-31 2006-02-16 シエーリング アクチエンゲゼルシャフト 新規エフェクター接合体、それらの生成方法及びそれらの医薬使用
EA008864B1 (ru) 2003-09-30 2007-08-31 Нью Ривер Фармасьютикалз Инк. Фармацевтические композиции для предотвращения передозировки или неправильного употребления лекарственных средств
GB0624880D0 (en) * 2006-12-14 2007-01-24 Johnson Matthey Plc Improved method for making analgesics

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4894443A (en) * 1984-02-08 1990-01-16 Cetus Corporation Toxin conjugates
IE63490B1 (en) * 1988-11-24 1995-05-03 Hoechst Ag Peptides having bradykinin antagonist action
CZ203693A3 (en) * 1991-04-01 1994-07-13 Cortech Bradykinin antagonists
SE9101472D0 (sv) * 1991-05-15 1991-05-15 Trion Forskning & Utveckling Galanin antagonist

Also Published As

Publication number Publication date
PL304654A1 (en) 1995-01-09
EP0671941A4 (en) 1996-05-29
CN1094058A (zh) 1994-10-26
MX9306988A (es) 1995-01-31
ZA938014B (en) 1994-07-11
JPH08503460A (ja) 1996-04-16
NZ257477A (en) 1996-07-26
IL107400A0 (en) 1994-01-25
EP0671941A1 (en) 1995-09-20
WO1994011021A1 (en) 1994-05-26
AU5410994A (en) 1994-06-08

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Legal Events

Date Code Title Description
FZDE Discontinued