CA2139864C - Utilisation d'un materiau poreux a base de carbonate de calcium comme support pour un facteur de croissance dans la preparation d'un implant bioresorbable - Google Patents

Utilisation d'un materiau poreux a base de carbonate de calcium comme support pour un facteur de croissance dans la preparation d'un implant bioresorbable Download PDF

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Publication number
CA2139864C
CA2139864C CA002139864A CA2139864A CA2139864C CA 2139864 C CA2139864 C CA 2139864C CA 002139864 A CA002139864 A CA 002139864A CA 2139864 A CA2139864 A CA 2139864A CA 2139864 C CA2139864 C CA 2139864C
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CA
Canada
Prior art keywords
implant
use according
growth factor
cells
calcium carbonate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002139864A
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English (en)
French (fr)
Other versions
CA2139864A1 (fr
Inventor
Jean-Louis Patat
Jean-Pierre Ouhayoun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bio Holdings International Ltd
Original Assignee
Bio Holdings International Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9305783A external-priority patent/FR2705235B1/fr
Application filed by Bio Holdings International Ltd filed Critical Bio Holdings International Ltd
Publication of CA2139864A1 publication Critical patent/CA2139864A1/fr
Application granted granted Critical
Publication of CA2139864C publication Critical patent/CA2139864C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A61K33/10—Carbonates; Bicarbonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/42—Phosphorus; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1841—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/025—Other specific inorganic materials not covered by A61L27/04 - A61L27/12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00179—Ceramics or ceramic-like structures
    • A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/10—Mineral substrates
    • C12N2533/18—Calcium salts, e.g. apatite, Mineral components from bones, teeth, shells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials For Medical Uses (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002139864A 1993-05-13 1994-05-11 Utilisation d'un materiau poreux a base de carbonate de calcium comme support pour un facteur de croissance dans la preparation d'un implant bioresorbable Expired - Fee Related CA2139864C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
FR9305783A FR2705235B1 (fr) 1993-05-13 1993-05-13 Utilisation de particules d'un sel de calcium biocompatible et biorésorbable comme ingrédient actif dans la préparation d'un médicament destiné au traitement local des maladies déminéralisantes de l'os.
FR93/05783 1993-05-13
FR93/13740 1993-11-17
FR9313740A FR2706768B1 (enExample) 1993-05-13 1993-11-17
PCT/FR1994/000565 WO1994026322A1 (fr) 1993-05-13 1994-05-11 Utilisation d'un materiau poreux a base de carbonate de calcium comme support pour un facteur de croissance dans la preparation d'un implant bioresorbable

Publications (2)

Publication Number Publication Date
CA2139864A1 CA2139864A1 (fr) 1994-11-24
CA2139864C true CA2139864C (fr) 2003-07-15

Family

ID=26230324

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002139864A Expired - Fee Related CA2139864C (fr) 1993-05-13 1994-05-11 Utilisation d'un materiau poreux a base de carbonate de calcium comme support pour un facteur de croissance dans la preparation d'un implant bioresorbable

Country Status (13)

Country Link
US (1) US5711957A (enExample)
EP (1) EP0650374B1 (enExample)
JP (1) JP2957281B2 (enExample)
AT (1) ATE194922T1 (enExample)
AU (1) AU676056B2 (enExample)
CA (1) CA2139864C (enExample)
DE (1) DE69425358T2 (enExample)
DK (1) DK0650374T3 (enExample)
ES (1) ES2150492T3 (enExample)
FR (1) FR2706768B1 (enExample)
GR (1) GR3034667T3 (enExample)
PT (1) PT650374E (enExample)
WO (1) WO1994026322A1 (enExample)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030077825A1 (en) * 1994-07-22 2003-04-24 Bhatnagar Rajendra S. Structures useful for bone engineering and methods
US5563124A (en) * 1991-04-22 1996-10-08 Intermedics Orthopedics/ Denver, Inc. Osteogenic product and process
FR2737850A1 (fr) * 1995-08-14 1997-02-21 Biomat Produit de revetement pour prothese
FR2737851B1 (fr) * 1995-08-14 1997-10-24 Biomat Produit de revetement pour prothese
FR2743496B1 (fr) * 1996-01-15 1998-04-10 Univ Rennes Composite macroporeux support de substance(s) medicamenteuse(s) utilisable comme materiau de reconstitution osseuse et procede d'elaboration
ATE273723T1 (de) 1996-02-29 2004-09-15 Bioactive Bone Substitute Oy A Osteogene vorrichtungen und methode zur herstellung derselben
MY114945A (en) * 1997-04-24 2003-02-28 Sunstar Inc Oral composition
US20030147860A1 (en) * 2002-02-07 2003-08-07 Marchosky J. Alexander Compositions and methods for forming and strengthening bone
AU4093399A (en) * 1998-05-22 1999-12-13 Isolagen Technologies, Inc. Compositions for regenerating tissue that has degenerated, and methods for using such compositions
US6432710B1 (en) 1998-05-22 2002-08-13 Isolagen Technologies, Inc. Compositions for regenerating tissue that has deteriorated, and methods for using such compositions
WO1999060837A2 (en) 1998-05-27 1999-12-02 Nuvasive, Inc. Bone blocks and methods for inserting
US6251140B1 (en) 1998-05-27 2001-06-26 Nuvasive, Inc. Interlocking spinal inserts
WO1999060957A1 (en) 1998-05-27 1999-12-02 Nuvasive, Inc. Methods and apparatus for separating and stabilizing adjacent vertebrae
GB9823307D0 (en) 1998-10-23 1998-12-23 Regent Genus Organisms Interna Composition for traetment of periodontopathy and related diseases
WO2000053077A2 (en) * 1999-03-07 2000-09-14 Discure Ltd. Method and apparatus for computerized surgery
AU6406700A (en) * 1999-03-16 2000-10-04 Regeneration Technologies, Inc. Molded implants for orthopedic applications
WO2001000792A1 (en) 1999-06-29 2001-01-04 Marchosky J Alexander Compositions and methods for forming and strengthening bone
DE19944681A1 (de) * 1999-08-20 2001-03-01 Metz Stavenhagen Peter Knochenersatzstoff zur Implantation im menschlichen oder tierischen Körper
US6630153B2 (en) * 2001-02-23 2003-10-07 Smith & Nephew, Inc. Manufacture of bone graft substitutes
WO2001082773A2 (en) * 2000-04-28 2001-11-08 The Regents Of The University Of California Structures useful for bone engineering and methods
US6852126B2 (en) 2000-07-17 2005-02-08 Nuvasive, Inc. Stackable interlocking intervertebral support system
MY133943A (en) 2000-08-22 2007-11-30 Synthes Gmbh Bone replacement material
US20020114795A1 (en) * 2000-12-22 2002-08-22 Thorne Kevin J. Composition and process for bone growth and repair
US7763769B2 (en) 2001-02-16 2010-07-27 Kci Licensing, Inc. Biocompatible wound dressing
US7700819B2 (en) 2001-02-16 2010-04-20 Kci Licensing, Inc. Biocompatible wound dressing
FR2830249B1 (fr) 2001-10-03 2004-08-13 Toulouse Inst Nat Polytech Composition de ciment hydraulique a base de carbonates de calcium
US6923814B1 (en) 2001-10-30 2005-08-02 Nuvasive, Inc. System and methods for cervical spinal fusion
AU2003235938A1 (en) * 2002-05-13 2003-11-11 Mmt.Co., Ltd Member for regenerating joint cartilage and process for producing the same, method of regenerating joint cartilage and aritficial cartilage for transplantation
US7166133B2 (en) 2002-06-13 2007-01-23 Kensey Nash Corporation Devices and methods for treating defects in the tissue of a living being
US7618423B1 (en) 2002-06-15 2009-11-17 Nuvasive, Inc. System and method for performing spinal fusion
DE10241572B4 (de) * 2002-09-07 2007-02-08 Werner Scholz Stütz- oder Halteteil zum Einbringen in ein Knochenteil
US7776049B1 (en) 2002-10-02 2010-08-17 Nuvasive, Inc. Spinal implant inserter, implant, and method
FR2850282B1 (fr) * 2003-01-27 2007-04-06 Jerome Asius Implant injectable a base de ceramique pour le comblement de rides, depressions cutanees et cicatrices, et sa preparation
WO2004084742A1 (en) * 2003-03-24 2004-10-07 Theken Surgical Llc Spinal implant adjustment device
US20050020506A1 (en) * 2003-07-25 2005-01-27 Drapeau Susan J. Crosslinked compositions comprising collagen and demineralized bone matrix, methods of making and methods of use
US7918891B1 (en) 2004-03-29 2011-04-05 Nuvasive Inc. Systems and methods for spinal fusion
US7544208B1 (en) 2004-05-03 2009-06-09 Theken Spine, Llc Adjustable corpectomy apparatus
EP1604694A1 (en) * 2004-06-09 2005-12-14 Scil Technology GmbH Composite device having osteoinductive and osteoconductive properties
USD530423S1 (en) 2005-03-29 2006-10-17 Nuvasive, Inc. Intervertebral implant
WO2006109137A1 (en) * 2005-04-12 2006-10-19 Sureshan Sivananthan Tissue regeneration by endocultivation
AU2006236548A1 (en) * 2005-04-15 2006-10-26 Musculoskeletal Transplant Foundation Vertebral disc repair
US8623088B1 (en) 2005-07-15 2014-01-07 Nuvasive, Inc. Spinal fusion implant and related methods
US8328851B2 (en) * 2005-07-28 2012-12-11 Nuvasive, Inc. Total disc replacement system and related methods
US8641667B2 (en) 2005-10-20 2014-02-04 DePuy Synthes Products, LLC Perfusion device and method
US7838022B2 (en) 2006-05-01 2010-11-23 Warsaw Orthopedic, Inc Malleable implants containing demineralized bone matrix
US7771741B2 (en) * 2006-05-01 2010-08-10 Warsaw Orthopedic, Inc Demineralized bone matrix devices
US8506983B2 (en) * 2006-05-01 2013-08-13 Warsaw Orthopedic, Inc. Bone filler material
US20100209470A1 (en) * 2006-05-01 2010-08-19 Warsaw Orthopedic, Inc. An Indiana Corporation Demineralized bone matrix devices
USD741488S1 (en) 2006-07-17 2015-10-20 Nuvasive, Inc. Spinal fusion implant
CA2658934A1 (en) * 2006-07-25 2008-01-31 Musculoskeletal Transplant Foundation Packed demineralized cancellous tissue forms for disc nucleus augmentation, restoration, or replacement and methods of implantation
US7718616B2 (en) 2006-12-21 2010-05-18 Zimmer Orthobiologics, Inc. Bone growth particles and osteoinductive composition thereof
US8673005B1 (en) 2007-03-07 2014-03-18 Nuvasive, Inc. System and methods for spinal fusion
USD671645S1 (en) 2007-09-18 2012-11-27 Nuvasive, Inc. Intervertebral implant
WO2009066283A2 (en) * 2007-11-19 2009-05-28 Ben Gurion University Of The Negev Research And Development Authority Calcium-mediated effects of coral and methods of use thereof
US9056150B2 (en) 2007-12-04 2015-06-16 Warsaw Orthopedic, Inc. Compositions for treating bone defects
US8083796B1 (en) 2008-02-29 2011-12-27 Nuvasive, Inc. Implants and methods for spinal fusion
USD599019S1 (en) 2008-03-07 2009-08-25 Nuvasive, Inc. Spinal fusion implant
EP2257163A4 (en) 2008-03-10 2012-01-18 Marfly 2 Lp BONE PASTE COMPOSITION
US8840913B2 (en) * 2008-03-27 2014-09-23 Warsaw Orthopedic, Inc. Malleable multi-component implants and materials therefor
PT2367556T (pt) * 2008-11-20 2019-03-25 Cartiheal 2009 Ltd Formas sólidas para reparação de tecido
USD754346S1 (en) 2009-03-02 2016-04-19 Nuvasive, Inc. Spinal fusion implant
US9387090B2 (en) 2009-03-12 2016-07-12 Nuvasive, Inc. Vertebral body replacement
US9687357B2 (en) 2009-03-12 2017-06-27 Nuvasive, Inc. Vertebral body replacement
US9351845B1 (en) 2009-04-16 2016-05-31 Nuvasive, Inc. Method and apparatus for performing spine surgery
US8287597B1 (en) 2009-04-16 2012-10-16 Nuvasive, Inc. Method and apparatus for performing spine surgery
US8802115B2 (en) * 2009-06-15 2014-08-12 Cartiheal (2009) Ltd. Solid forms for tissue repair
USD731063S1 (en) 2009-10-13 2015-06-02 Nuvasive, Inc. Spinal fusion implant
CA2817584C (en) 2010-11-15 2018-01-02 Zimmer Orthobiologics, Inc. Bone void fillers
US9198765B1 (en) 2011-10-31 2015-12-01 Nuvasive, Inc. Expandable spinal fusion implants and related methods
USD721808S1 (en) 2011-11-03 2015-01-27 Nuvasive, Inc. Intervertebral implant
GB2549714A (en) * 2016-04-25 2017-11-01 Pharmaceutical Business Consultants Ltd Vascularity affinity precursor structure for musculo-skeletal tissue healing

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3919971A (en) * 1974-03-07 1975-11-18 August Kolbus Gluing apparatus
FR2460657A1 (fr) * 1979-07-12 1981-01-30 Anvar Implant biodegradable utilisable comme piece de prothese osseuse
DE3433210C1 (de) * 1984-09-10 1986-06-05 Hans Dr.med. Dr.med.dent. 8000 München Scheicher Mittel zur Fuellung von Knochen- und Zahndefekten,zum Knochenaufbau,fuer Knochenkontaktschichten und fuer Knochen- und Zahnwurzelersatz und Verwendung von Carbonatapatit fuer diesen Zweck
US4563350A (en) * 1984-10-24 1986-01-07 Collagen Corporation Inductive collagen based bone repair preparations
DE3542744C1 (de) * 1985-12-03 1987-05-27 Ewers Rolf Poroeses Hydroxylapatit-Material
AU3046289A (en) * 1988-01-26 1989-08-25 Thierry Rainier Besins System for forming subperiostal deposits for facial restoration
DK505588D0 (da) * 1988-02-26 1988-09-09 Jesper Hamburger Middel og anvendelse af samme
FR2637502A1 (fr) * 1988-10-12 1990-04-13 Duroselle Patrick Materiau de xenogreffe osseuse et procede d'obtention
US5264214A (en) * 1988-11-21 1993-11-23 Collagen Corporation Composition for bone repair
US4976736A (en) * 1989-04-28 1990-12-11 Interpore International Coated biomaterials and methods for making same
US5071655A (en) * 1990-01-12 1991-12-10 Baylink David J Pharmaceutical combination for treatment of bone-wasting diseases

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AU676056B2 (en) 1997-02-27
FR2706768A1 (enExample) 1994-12-30
DE69425358D1 (de) 2000-08-31
JPH08503157A (ja) 1996-04-09
FR2706768B1 (enExample) 1995-12-01
DE69425358T2 (de) 2001-03-29
JP2957281B2 (ja) 1999-10-04
ES2150492T3 (es) 2000-12-01
ATE194922T1 (de) 2000-08-15
EP0650374A1 (fr) 1995-05-03
GR3034667T3 (en) 2001-01-31
AU6788794A (en) 1994-12-12
US5711957A (en) 1998-01-27
WO1994026322A1 (fr) 1994-11-24
EP0650374B1 (fr) 2000-07-26
DK0650374T3 (da) 2000-11-06
PT650374E (pt) 2000-12-29
CA2139864A1 (fr) 1994-11-24

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