CA2136981A1 - Adn codant pour l'enzyme de conversion de l'interleukine 1.beta. precurseur - Google Patents

Adn codant pour l'enzyme de conversion de l'interleukine 1.beta. precurseur

Info

Publication number
CA2136981A1
CA2136981A1 CA 2136981 CA2136981A CA2136981A1 CA 2136981 A1 CA2136981 A1 CA 2136981A1 CA 2136981 CA2136981 CA 2136981 CA 2136981 A CA2136981 A CA 2136981A CA 2136981 A1 CA2136981 A1 CA 2136981A1
Authority
CA
Canada
Prior art keywords
ice
seq
kda
asp
beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA 2136981
Other languages
English (en)
Inventor
Andrew D. Howard
Susan M. Molineaux
Michael J. Tocci
Jimmy R. Calaycay
Douglas K. Miller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2136981A1 publication Critical patent/CA2136981A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)
    • C12N9/6475—Interleukin 1-beta convertase-like enzymes (3.4.22.10; 3.4.22.36; 3.4.22.63)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
CA 2136981 1992-06-24 1993-06-14 Adn codant pour l'enzyme de conversion de l'interleukine 1.beta. precurseur Abandoned CA2136981A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90639292A 1992-06-24 1992-06-24
US906,392 1992-06-24

Publications (1)

Publication Number Publication Date
CA2136981A1 true CA2136981A1 (fr) 1994-01-06

Family

ID=25422367

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2136981 Abandoned CA2136981A1 (fr) 1992-06-24 1993-06-14 Adn codant pour l'enzyme de conversion de l'interleukine 1.beta. precurseur

Country Status (5)

Country Link
EP (1) EP0648128A4 (fr)
JP (1) JPH08500242A (fr)
AU (1) AU4634993A (fr)
CA (1) CA2136981A1 (fr)
WO (1) WO1994000154A1 (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5874424A (en) * 1995-12-20 1999-02-23 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β converting enzyme
US6204261B1 (en) 1995-12-20 2001-03-20 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β Converting enzyme inhibitors
US6008217A (en) * 1995-12-20 1999-12-28 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β converting enzyme
US5847135A (en) * 1994-06-17 1998-12-08 Vertex Pharmaceuticals, Incorporated Inhibitors of interleukin-1β converting enzyme
US5716929A (en) * 1994-06-17 1998-02-10 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1β converting enzyme
AU733479B2 (en) * 1994-06-17 2001-05-17 Vertex Pharmaceuticals Incorporated Crystal structure and mutants of interleukin-1beta converting enzyme
US5856116A (en) * 1994-06-17 1999-01-05 Vertex Pharmaceuticals, Incorporated Crystal structure and mutants of interleukin-1 beta converting enzyme
US5756466A (en) * 1994-06-17 1998-05-26 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1β converting enzyme
US6420522B1 (en) 1995-06-05 2002-07-16 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β converting enzyme
WO1996012025A1 (fr) * 1994-10-14 1996-04-25 Basf Aktiengesellschaft ANIMAL TRANSGENIQUE COMPRENANT UN GENE DE L'ENZYME DE CONVERSION D'INTERLEUKINE-1β A FONCTION PERTURBEE
WO1996026280A1 (fr) * 1995-02-21 1996-08-29 Basf Aktiengesellschaft NOUVELLE CYSTEINE PROTEASE APPARENTEE A L'ENZYME DE CONVERSION D'INTERLEUKINE-1$g(b)
US5869315A (en) 1995-12-18 1999-02-09 Basf Aktiengesellschaft Modified interleukin-1β converting enzyme with increased stability
US5843904A (en) * 1995-12-20 1998-12-01 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1βconverting enzyme
US6288037B1 (en) 1996-01-29 2001-09-11 Basf Aktiengesellschaft Substrates and inhibitors for cysteine protease ICH-1
US6180402B1 (en) * 1996-11-20 2001-01-30 Qlt Inc. Method for inhibiting apoptosis induced by photodynamic therapy using a cysteine or serine protease inhibitor
GB2324529A (en) * 1997-02-21 1998-10-28 Merck & Co Inc A combinatorial library based on a tetrapeptide substituted with aminomethylcoumarin for characterizing proteases
DE69925581T2 (de) 1998-03-09 2006-04-27 Vertex Pharmaceuticals Inc., Cambridge 1,2-diazepanderivate als inhibitoren des interleukin-1beta umwandelnden enzyms
NZ528282A (en) 1998-03-19 2005-05-27 Vertex Pharma Interleukin-1 beta converting enzyme inhibitors
PE20011350A1 (es) 2000-05-19 2002-01-15 Vertex Pharma PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE)
CA2383392A1 (fr) * 2001-04-27 2002-10-27 Matsushita Electric Industrial Co., Ltd. Biodispositif et appareil de mesure quantitative et methode connexe
GB0411056D0 (en) 2004-05-18 2004-06-23 Novartis Ag Organic compounds
US7531570B2 (en) 2004-05-27 2009-05-12 Vertex Pharmaceuticals Incorporated Treatment of diseases using ICE inhibitors
KR102587512B1 (ko) * 2018-05-22 2023-10-11 이뮤너티바이오, 인크. 폴록사머를 사용한 nk-92 세포 성장의 최적화

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN150740B (fr) * 1978-11-24 1982-12-04 Hoffmann La Roche
DE69229252T2 (de) * 1991-08-16 1999-12-16 Merck & Co Inc DNS, welche das Interleukin-1B-Vorläufer-Converting-Enzym kodiert

Also Published As

Publication number Publication date
WO1994000154A1 (fr) 1994-01-06
EP0648128A1 (fr) 1995-04-19
EP0648128A4 (fr) 1995-07-26
JPH08500242A (ja) 1996-01-16
AU4634993A (en) 1994-01-24

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